Clinical trials: Phrenic Nerve Stimulation
General Anaesthesia, Muscle Weakness
Electromagnetic Stimulation of the Phrenic Nerve of Intubated Patients
Ventilator-induced diaphragmatic dysfunction is a common issue in critically ill patients. Muscle stimulation has shown to have beneficial effects in muscle groups on the extremities.
- Trial name
- STIMIT-I (NCT04946110)
- Testing
- Electromagnetic stimulation
- Where
- Germany
- Volunteers
- 5 people
- Sponsor
- Charite University, Berlin, Germany
Sleep Disordered Breathing, Cheyne-Stokes Respiration
Feasibility Study to Determine the Effects of Phrenic Nerve Stimulation in Patients With Periodic Breathing
The purpose of this feasibility study is to determine the effect of stimulating the phrenic nerve to treat periodic breathing (a pattern of breathing characterized by hyperpneas followed by hypopneas or apneas).
- Conditions
- Sleep Disordered Breathing, Cheyne-Stokes Respiration, Sleep Apnea
- Trial name
- NCT00909259
- Testing
- Phrenic stimulation device
- Where
- 5 sites in United States, China and 1 more
- Volunteers
- 50 people
- Sponsor
- Respicardia, Inc.
Critical Care, Intensive Care
Does Transcutaneous Phrenic Nerve Stimulation Prevent Diaphragm Atrophy?
Dear participant Participants's patient, who is participants's first-degree relative, who is connected to a ventilator in the intensive care unit, unconscious and not authorized to give informed consent, has been invited to…
- Trial name
- NMES (NCT06897774)
- Where
- Turkey (Türkiye)
- Volunteers
- 80 people
- Sponsor
- Bakirkoy Dr. Sadi Konuk Research and Training Hospital
Acute Hypoxemic Respiratory Failure, Diaphragm Injury
Feasibility of Transvenous Phrenic Nerve Stimulation for Diaphragm Protection in Acute Respiratory Failure
This is a single-center proof-of-concept clinical trial designed to establish the feasibility of transvenous phrenic-nerve stimulation (PNS) to maintain diaphragm activation over the first 24 hours and for up to seven days of…
- Conditions
- Acute Hypoxemic Respiratory Failure, Diaphragm Injury, Lung Injury
- Trial name
- STIMULUS (NCT05465083)
- Testing
- Lungpacer AeroPace Protect System
- Where
- Canada
- Volunteers
- 20 people
- Sponsor
- University Health Network, Toronto
Heart Failure
Detection of Phrenic Nerve Stimulation Using Sensors' Signals
The purpose of this study is to collect sensor data from patients with implanted cardiac resynchronization devices who exhibit phrenic nerve stimulation.
- Trial name
- DETECT PS (NCT01233323)
- Where
- Germany
- Volunteers
- 60 people
- Sponsor
- Boston Scientific Corporation
Acute Respiratory Distress Syndrome, Ventilation Therapy; Complications
Phrenic Nerve Stimulation-Induced Lung ReAeration Trial
The Lungpacer PROTECT Diaphragm Pacing Therapy System (DPTS) is a temporary, percutaneously-placed, transvenous, phrenic nerve-stimulating device intended to stimulate the diaphragm to preserve and improve inspiratory muscle…
- Trial name
- PIRAT (NCT04844892)
- Testing
- Lungpacer PROTECT Diaphragm Pacing Therapy
- Where
- France
- Volunteers
- 13 people
- Sponsor
- Lungpacer Medical Inc.
ARDS, Human, Ventilator-Induced Lung Injury
Non-invasive Phrenic Nerve Stimulation in ARDS Patient
Reduced diaphragmatic activity during mechanical ventilation can lead to diaphragmatic disuse atrophy, atelectasis, increased lung stress and strain, and hemodynamic impairment.
- Conditions
- ARDS, Human, Ventilator-Induced Lung Injury, Diaphragm Injury
- Trial name
- NCT06572280
- Testing
- PNS group
- Where
- China
- Volunteers
- 10 people
- Sponsor
- Southeast University, China
Lung, Organ Donation
Pacing In Organ Donors (the POD Trial)
The goal of this clinical trial is to test the feasibility of pacing the phrenic nerve to stimulate the diaphragm in order to improve the lung function in brain dead organ donors.
- Conditions
- Lung, Organ Donation, Mechanical Ventilation
- Trial name
- POD (NCT07505589)
- Testing
- Lungpacer AeroPace catheter and device
- Where
- Canada
- Volunteers
- 3 people
- Sponsor
- Fraser Health
Ventilator Induced Diaphragmatic Dysfunction (VIDD)
PEPNS System Feasibility Study
The purpose of this feasibility study is to evaluate the safety and performance of the PEPNS System in patients that need to be mechanically ventilated for at least 48 hours and up to 7 days in the Intensive Care Unit (ICU).
- Trial name
- NCT03559933
- Testing
- PEPNS System
- Where
- 2 sites in Czechia, Ireland
- Volunteers
- 12 people
- Sponsor
- Stimdia Medical Inc.
Post-cardiac Surgery
Effect of Neuromuscular Electrical Stimulation on Phrenic Nerve Regeneration Post Cardiac Surgeries
This study will be conducted to investigate the effect of neuromuscular electrical stimulation on phrenic regeneration post cardiac surgery
- Trial name
- NCT06621693
- Testing
- Transcutaneous electrical diaphragmatic stimulation intervention, traditional physiotherapy program
- Where
- Egypt
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Cairo University
Amyotrophic Lateral Sclerosis, Respiratory Insufficiency
Early Stage Amyotrophic Lateral Sclerosis Phrenic Stimulation
ALS is is characterized by a progressive degeneration of motor neurons, leading to progressive weakness of muscles, including respiratory muscles, the diaphragm.
- Trial name
- RespiStimALS (NCT01583088)
- Testing
- phenique nerve stimulation NeurX™ (Synapse Biomedical)
- Where
- France
- Volunteers
- 74 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Sleep Apnea, Central, Heart Failure
Phrenic Nerve Stimulation for Treatment of Central Sleep Apnea
The study objectives are to demonstrate the ease and safety of bilateral cervically implanted phrenic nerve stimulators for Central Sleep Apnea in patients with Heart Failure.
- Trial name
- STIMULATE-CSA (NCT03238937)
- Testing
- Phrenic nerve stimulator
- Where
- United States
- Volunteers
- healthy volunteers welcome
- Sponsor
- Steward St. Elizabeth's Medical Center of Boston, Inc.
Ventilator Induced Diaphragm Dysfunction
A Post-Approval Multicenter Study to Assess the Continued Safety and Effectiveness of the AeroPace® System
A single-arm, prospective, multicenter cohort study to assess the 30-day continued safety and effectiveness of the AeroPace System in patients on mechanical ventilation (MV) at least 96 hours and who have not weaned.
- Trial name
- AERO-PAS (NCT07477054)
- Testing
- Lungpacer Diaphragm Pacing Therapy
- Volunteers
- 120 people
- Sponsor
- Lungpacer Medical Inc.
Inspiratory Strength Training (IST), Transcutaneous Spinal Stimulation
Rehab and Mechanical Ventilation
The goal of this research study is to evaluate the effects of a single session of rehabilitation in healthy adults, before noninvasive mechanical ventilation (MV). MV can help support breathing function during sleep or illness.
- Conditions
- Inspiratory Strength Training (IST), Transcutaneous Spinal Stimulation, Sham Spinal Stimulation
- Trial name
- REHAB-MV (NCT07427121)
- Testing
- Spinal cord stimulation, Inspiratory Strength Training
- Where
- United States
- Volunteers
- 16 people, healthy volunteers welcome
- Sponsor
- University of Florida
Heart Failure
ELECTION - The Electrode Configuration Cardiac Resynchronization Therapy (CRT) Study (ELECTION)
The ELECtrode configuraTION CRT Study (ELECTION)
- Trial name
- ELECTION (NCT00848653)
- Testing
- CRT device
- Volunteers
- 260 people
- Sponsor
- Guidant Corporation
Healthy Subjects, Elective Surgical Procedure
"Electromagnetical Stimulation of Phrenic Nerve to Generate Contraction of the Diaphragm"
The scientific study is intended to show that external non-invasive electromagnetic stimulation can be used to safely and effectively stimulate the phrenic nerve in awake healthy subjects as well as in ventilated, anesthetized…
- Trial name
- NCT04884698
- Testing
- Stimit Activator
- Where
- Switzerland
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- Stimit AG
Neuromuscular Diseases, Respiratory Failure
Establishment of a Non-invasive and Indirect Measure of Volitional Pimax
Respiratory failure is the main death cause in muscular diseases. Non-invasive and volitional measures of inspiratory muscles strength include the nasal pressure with an occluded nostril and the maximal inspiratory pressure…
- Trial name
- PI MAX STIM (NCT02242162)
- Testing
- phrenic nerves magnetic stimulations
- Where
- France
- Volunteers
- 75 people
- Sponsor
- Centre d'Investigation Clinique et Technologique 805
Phrenic Nerve, Electrical Stimulation
Repetitive Phrenic Nerve Stimulation in Critically Ill Patients Under Mechanical Ventilation
Subjects: Patients aged 19 and older who are currently in the ICU and undergoing invasive mechanical ventilation. Methods: The study involves performing non-invasive repetitive phrenic nerve stimulation in ICU patients on…
- Trial name
- NCT06491511
- Testing
- Transcutaneous, repetitive phrenic nerve electrical stimulation
- Where
- South Korea
- Volunteers
- 5 people
- Sponsor
- Seoul National University Hospital
Ventilator Lung, Ventilator-Induced Lung Injury
Phrenic Identification in the ICU
This will be a prospective observational study where the investigator will scan patients' necks with an ultrasound and look for anatomical landmarks that may help identify the phrenic nerve.
- Conditions
- Ventilator Lung, Ventilator-Induced Lung Injury, Diaphragm Disease, Phrenic Nerve
- Trial name
- NCT05875883
- Testing
- Neck ultrasound
- Where
- Canada
- Volunteers
- 63 people
- Sponsor
- Unity Health Toronto
Healthy
Optimization of Non-invasive Diaphragm Activation Using Magnetic Phrenic Nerve Stimulation
The use of mechanical ventilation (MV) to replace spontaneous breathing has been associated with respiratory muscle dysfunction and lung injury from positive pressure.
- Trial name
- NCT04176744
- Testing
- Uni- and bilateral magnetic phrenic nerve stimulation
- Where
- Switzerland
- Volunteers
- 17 people, healthy volunteers welcome
- Sponsor
- Swiss Federal Institute of Technology