Clinical trials: Phrenic Nerves
Diaphragm
Effects of Transcutaneous Electrical Phrenic Nerve Stimulation and Transcutaneous Electrical Diaphragmatic Stimulation
Transcutaneous electrical phrenic nerve stimulation (TEPNS) and transcutaneous electrical diaphragm stimulation (TEDS) are modalities that use surface electrodes placed on the patients' skin to generate action potentials and…
- Trial name
- NCT06339632
- Testing
- Transcutaneous electrical phrenic nerve stimulation (TEPNS), Transcutaneous electrical diaphragm stimulation (TEDS)
- Where
- Brazil
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- Hospital Sirio-Libanes
Inspiratory Strength Training (IST), Transcutaneous Spinal Stimulation
Rehab and Mechanical Ventilation
The goal of this research study is to evaluate the effects of a single session of rehabilitation in healthy adults, before noninvasive mechanical ventilation (MV). MV can help support breathing function during sleep or illness.
- Conditions
- Inspiratory Strength Training (IST), Transcutaneous Spinal Stimulation, Sham Spinal Stimulation
- Trial name
- REHAB-MV (NCT07427121)
- Testing
- Spinal cord stimulation, Inspiratory Strength Training
- Where
- United States
- Volunteers
- 16 people, healthy volunteers welcome
- Sponsor
- University of Florida
Paresis
Bupivacaine Versus Ropivacaine on Diaphragmatic Motility and Ventilatory Function
Background: Outpatient continuous interscalene brachial plexus blocks are used to control pain after shoulder surgery, with infusions of 0.125% bupivacaine or 0.2% ropivacaine.
- Trial name
- NCT02059070
- Testing
- Ropivacaine, Bupivacaine
- Where
- United States
- Volunteers
- 39 people, healthy volunteers welcome
- Sponsor
- Anesthesiology WSU/DMC-NorthStar
Post-cardiac Surgery
Effect of Neuromuscular Electrical Stimulation on Phrenic Nerve Regeneration Post Cardiac Surgeries
This study will be conducted to investigate the effect of neuromuscular electrical stimulation on phrenic regeneration post cardiac surgery
- Trial name
- NCT06621693
- Testing
- Transcutaneous electrical diaphragmatic stimulation intervention, traditional physiotherapy program
- Where
- Egypt
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Cairo University
Sleep Apnea, Central, Heart Failure
Phrenic Nerve Stimulation for Treatment of Central Sleep Apnea
The study objectives are to demonstrate the ease and safety of bilateral cervically implanted phrenic nerve stimulators for Central Sleep Apnea in patients with Heart Failure.
- Trial name
- STIMULATE-CSA (NCT03238937)
- Testing
- Phrenic nerve stimulator
- Where
- United States
- Volunteers
- healthy volunteers welcome
- Sponsor
- Steward St. Elizabeth's Medical Center of Boston, Inc.
Diaphragmatic Paralysis
Effects of Inspiratory Muscle Training on Exertional Breathlessness in Patients With Unilateral Diaphragm Paralysis
Treatment options for unilateral diaphragm paralysis are limited. Diaphragmatic plication via mini thoracotomy is sometimes considered in the University Hospital Leuven if severe symptoms persist for longer than 12 months after…
- Trial name
- NCT04563468
- Testing
- Strength inspiratory muscle training, Endurance inspiratory muscle training
- Where
- Belgium
- Volunteers
- 15 people, healthy volunteers welcome
- Sponsor
- KU Leuven
Healthy Subjects, Elective Surgical Procedure
"Electromagnetical Stimulation of Phrenic Nerve to Generate Contraction of the Diaphragm"
The scientific study is intended to show that external non-invasive electromagnetic stimulation can be used to safely and effectively stimulate the phrenic nerve in awake healthy subjects as well as in ventilated, anesthetized…
- Trial name
- NCT04884698
- Testing
- Stimit Activator
- Where
- Switzerland
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- Stimit AG
Diaphragm Issues
Comparison of the Interscalene Block Alone Versus Combined With Superior Truncus Block During Shoulder Surgery in Diaphragmatic Function
Primarily, This study aims to compare between interscalene block alone versus combined with superior truncus block in producing diaphragmatic paralysis and Secondarily aims to evaluate 1. Effect on the pulmonary function. 2.
- Trial name
- NCT07338630
- Testing
- Regional anesthesia in shoulder surgery
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Sohag University
Electrical Stimulation, Phrenic Nerve
Transcutaneous Repetitive Phrenic Nerve Stimulation in Healthy Adults
The goal of this observational study is to characterize the standardized stimulation parameter for noninvasive, transcutaneous, repetitive phrenic nerve electrical stimulation.
- Trial name
- NCT05879939
- Testing
- Transcutaneous, repetitive phrenic nerve electrical stimulation
- Where
- South Korea
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- Seoul National University Hospital
Healthy
Optimization of Non-invasive Diaphragm Activation Using Magnetic Phrenic Nerve Stimulation
The use of mechanical ventilation (MV) to replace spontaneous breathing has been associated with respiratory muscle dysfunction and lung injury from positive pressure.
- Trial name
- NCT04176744
- Testing
- Uni- and bilateral magnetic phrenic nerve stimulation
- Where
- Switzerland
- Volunteers
- 17 people, healthy volunteers welcome
- Sponsor
- Swiss Federal Institute of Technology
Healthy
Quantification and Repeatability of Magnetic Stimulation
In this project the quantification and the repeatability of responses to rapid bilateral magnetic stimulation of the phrenic nerves will be investigated in healthy humans.
- Trial name
- NCT05302752
- Testing
- Magnetic phrenic nerve stimulation
- Where
- Switzerland
- Volunteers
- 16 people, healthy volunteers welcome
- Sponsor
- Swiss Federal Institute of Technology
Weaning Failure, Central Respiratory Depression
Exploration of Mechanisms for Weaning Failure
This study is a prospective physiologic study. The primary study population will be adult invasive tracheal intubated patients with COPD, and investigators will collect relevant demographic data, vital signs, and baseline…
- Conditions
- Weaning Failure, Central Respiratory Depression, Diaphragm Injury, Phrenic Nerve Disorder
- Trial name
- NCT06424314
- Testing
- Monitoring of respiratory mechanics parameters
- Where
- China
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- The First Affiliated Hospital of Guangzhou Medical University