Clinical trials: Phrenic Nerves
Vocal Cord Paralysis
Bilateral Laryngeal Paralysis Reinnervation
Bilateral laryngeal reinnervation induces a rise in laryngeal resistance and speech alteration. The aim of this study is to propose laryngeal reinnervation by a phrenic nerve root to patients with bilateral laryngeal paralysis.
- Trial name
- NCT00213616
- Testing
- surgical reinnervation
- Where
- France
- Volunteers
- 10 people
- Sponsor
- University Hospital, Rouen
Acute Pain, Brachial Plexus Block
Out of Plane Approach for Interscalene
Study aims to examine the influence of out of plane interscalene approach to a brachial plexus block on the effect of phrenic nerve blockade.
- Trial name
- NCT03785392
- Testing
- Group 1 In-plane, Group 2 out of plane
- Where
- 2 sites in United States
- Volunteers
- 30 people
- Sponsor
- The University of Texas Medical Branch, Galveston
Heart Failure
PhrenIc Nerve mappinG and Stimulation EP Catheter Study: PING-EP Study
The PING-EP study is designed to evaluate electrode properties on phrenic nerve stimulation (PNS) in coronary sinus using a commercially available diagnostic electrophysiology catheter.
- Trial name
- PING-EP (NCT01109641)
- Testing
- diagnostic electrophysiology catheter
- Where
- 4 sites in Italy
- Volunteers
- 40 people
- Sponsor
- Medtronic Italia
Post-cardiac Surgery
Effect of Neuromuscular Electrical Stimulation on Phrenic Nerve Regeneration Post Cardiac Surgeries
This study will be conducted to investigate the effect of neuromuscular electrical stimulation on phrenic regeneration post cardiac surgery
- Trial name
- NCT06621693
- Testing
- Transcutaneous electrical diaphragmatic stimulation intervention, traditional physiotherapy program
- Where
- Egypt
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Cairo University
Spinal Cord Injuries (SCI), Sleep Disordered Breathing (SDB)
Comparing CPAP and BiPAP for Sleep-Disordered Breathing in People with Cervical Spinal Cord Injuries
Sleep-disordered breathing (SDB) is common in individuals with cervical spinal cord injuries, with studies suggesting prevalence rates ranging from 27% to 62%.
- Conditions
- Spinal Cord Injuries (SCI), Sleep Disordered Breathing (SDB), Sleep Apnea, Cervical Spinal Cord Injruy
- Trial name
- NCT06818604
- Testing
- CPAP, BiPAP
- Where
- Canada
- Volunteers
- 32 people
- Sponsor
- University of British Columbia
Ventilator Induced Diaphragm Dysfunction
A Post-Approval Multicenter Study to Assess the Continued Safety and Effectiveness of the AeroPace® System
A single-arm, prospective, multicenter cohort study to assess the 30-day continued safety and effectiveness of the AeroPace System in patients on mechanical ventilation (MV) at least 96 hours and who have not weaned.
- Trial name
- AERO-PAS (NCT07477054)
- Testing
- Lungpacer Diaphragm Pacing Therapy
- Where
- United States
- Volunteers
- 120 people
- Sponsor
- Lungpacer Medical Inc.
Phrenic Nerve Palsy
Does Saline Injection Around Phrenic Nerve Reduce Incidence of Diaphragmatic Paresis Following Interscalene Block?
Hemi-diaphragmatic palsy is a common undesirable effect of interscalene block, with an incidence of up to 100%. Mechanism of palsy is thought to be related to spread of local anaesthetic anterior to the anterior scalene muscle.
- Trial name
- NCT02893228
- Testing
- Saline, Levobupivacaine
- Where
- Ireland
- Volunteers
- 36 people
- Sponsor
- The Adelaide and Meath Hospital, incorporating The National Children's Hospital
Pulmonary Function Test, Phrenic Nerve Irritation
Physical Therapy on Phrenic Nerve Function
This study was conducted to investigate the effects of a designed physical therapy program on respiratory function and phrenic nerve activity in cervical disc compression.
- Conditions
- Pulmonary Function Test, Phrenic Nerve Irritation, Cervical Disc Lesion
- Trial name
- NCT05817565
- Testing
- Ultrasound (Phyaction 190 I); with a frequency of 3 MHz was used
- Where
- Egypt
- Volunteers
- 20 people
- Sponsor
- Cairo University
Diaphragm Issues
STIMIT Activator 1 IDE Study
The study is a prospective, multi-center, randomized, controlled study using adaptive design to assess the evidence of safety and performance of the STIMIT Activator 1 System in the treatment of patients who have been…
- Trial name
- NCT05883163
- Testing
- Stimit Activator 1
- Where
- 4 sites in United States, Canada
- Volunteers
- 40 people
- Sponsor
- Stimit AG
Sleep Apnea, Central, Heart Failure
Phrenic Nerve Stimulation for Treatment of Central Sleep Apnea
The study objectives are to demonstrate the ease and safety of bilateral cervically implanted phrenic nerve stimulators for Central Sleep Apnea in patients with Heart Failure.
- Trial name
- STIMULATE-CSA (NCT03238937)
- Testing
- Phrenic nerve stimulator
- Where
- United States
- Volunteers
- healthy volunteers welcome
- Sponsor
- Steward St. Elizabeth's Medical Center of Boston, Inc.
Shoulder Pain, Surgery
The Effect of Phrenic Nerve Block on Postoperative Shoulder Pain in Patients for Liver Resection.
The aim of this study is to explore whether the use of ultrasound guided phrenic nerve block can reduce the postoperative pain in the shoulder after liver resection.
- Conditions
- Shoulder Pain, Surgery, Nerve Block
- Trial name
- NCT02903719
- Testing
- Ropivacaine
- Where
- Denmark
- Volunteers
- 30 people
- Sponsor
- Eske Kvanner Aasvang
Hysterectomy
Diaphragmatic Exercises As Treatment of Referred Pain After Total Laparoscopic Hysterectomy: Randomized Clinical Trial.
Through a blinded clinical trial, the aim is to evaluate the efficacy of manual therapy in the treatment of pain referred to after laparoscopic hysterectomy. Control and intervention groups were randomly established.
- Trial name
- NCT05959785
- Testing
- Basic and light cervical mobilization exercises, Abdominal or diaphragmatic breathing exercises
- Where
- 2 sites in Spain
- Volunteers
- 74 people
- Sponsor
- University of Seville
Atrial Fibrillation, Phrenic Nerve Paralysis
Ultrasonography Evaluation of Diaphragm Kinetics in Patients Undergoing Atrial Fibrillation Ablation With Cryoballoon
The purpose of this study to assess the diaphragm kinetics with Tissue Doppler Imaging in patients undergoing atrial fibrillation ablation with cryoballoon
- Trial name
- NCT05513482
- Testing
- Tissue Doppler Imaging, M Mode Imaging
- Where
- Turkey (Türkiye)
- Volunteers
- 80 people
- Sponsor
- Istanbul University - Cerrahpasa
Fibromyalgia
Phrenic Nerve Infiltration in Fibromyalgia
It is known that nociceptive afferences in visceral pain and visceral disorders increase sensitization in subjects suffering from fibromyalgia. These patients use to present visceral comorbidities.
- Trial name
- NCT05792774
- Testing
- Bupivacain
- Where
- 4 sites in Spain
- Volunteers
- 60 people
- Sponsor
- University of Seville
Upper Extremity Problem
Selective Trunk Block: A Study to Evaluate Block Dynamics, Effects and Efficacy for Upper Limb Surgery
Brachial plexus block (BPB) is frequently used as the sole anesthetic technique for upper extremity surgery. The choice of technique often depends on the site of surgery because the extent of sensory-motor blockade after a BPB…
- Trial name
- NCT04752410
- Testing
- Selective Brachial Plexus Block
- Where
- Hong Kong
- Volunteers
- 30 people
- Sponsor
- Chinese University of Hong Kong
Chronic Neck Pain
Phrenic Nerve Infiltration in Neck Pain
Neck pain frequently present comorbidities in peridiaphragmatic organs. The innervation of these organs include the phrenic nerve. It is known that peridiaphragmatic organs trigger referred pain in the neck area.
- Trial name
- PAINOMICS (NCT05605639)
- Testing
- Bupivacaine
- Where
- 2 sites in Spain
- Volunteers
- 60 people
- Sponsor
- University of Seville
Phrenic Nerve Paralysis
Diaphragm Plication in Adults With Phrenic Nerve Paralysis
The purpose of the study is to investigate the impact of unilateral or bilateral diaphragm plication in a prospective randomised controlled way on symptoms, pulmonary function including gas exchange, respiratory muscle strength…
- Trial name
- NCT00689234
- Testing
- diaphragm plication 6 months after inclusion, diaphragm plication at time of inclusion
- Where
- Belgium
- Volunteers
- 12 people
- Sponsor
- KU Leuven
Phrenic Nerve Palsy
Phrenic Nerve Injury During Pulmonary Vein Isolation With the Second-generation Cryoballoon.
To determine the most frequent complication associated with cryoballoon PVI. The main hypothesis is to explore the incidence of phrenic nerve palsy.
- Trial name
- YETI-Registry (NCT03645577)
- Where
- Germany
- Volunteers
- 731 people
- Sponsor
- University of Luebeck
Clavicle Fracture, Postoperative Pain
Effectiveness of Superficial Cervical and Clavipectoral Block for Clavicle Surgery
This study aims to compare two local anesthesia techniques (nerve blocks) for patients undergoing collarbone (clavicle) fracture surgery. Typically, this surgery uses the "Interscalene Block" (ISB) technique.
- Conditions
- Clavicle Fracture, Postoperative Pain, Regional Anesthesia Block
- Trial name
- BSS-BKvsBSS-BI (NCT07548775)
- Testing
- Combination of Superficial Cervical Block and Clavipectoral Block (SCB + CPB), Combination of Superficial Cervical Block and Interscalene Block (SCB + ISB)
- Where
- Indonesia
- Volunteers
- 34 people
- Sponsor
- Udayana University
Mechanical Ventilation, Weaning
Effect of Early Non-invasive Phrenic Nerve Stimulation on Weaning in Mechanically Ventilated Patients
the early application of non-invasive PNS in MV patients can increase the number of days without mechanical ventilation, delay disuse phrenic atrophy, and improve the strength of inspiratory muscle.
- Trial name
- NCT05629819
- Testing
- Non-invasive phrenic nerve stimulation
- Where
- China
- Volunteers
- 104 people
- Sponsor
- Bing Sun