Clinical trials: Physical Activity
Solid Tumors
A Study of Intravenous (IV) Cergutuzumab Amunaleukin and Atezolizumab in Combination in Participants With Locally Advanced and/or Metastatic Solid Tumors
This is an open-label, multi-center, Phase Ib clinical study of cergutuzumab amunaleukin, in combination with atezolizumab, to investigate the safety, pharmacokinetics, and therapeutic activity in participants with locally…
- Trial name
- NCT02350673
- Testing
- Atezolizumab, Cergutuzumab Amunaleukin
- Where
- 14 sites in United States, Canada and 4 more
- Volunteers
- 70 people
- Sponsor
- Hoffmann-La Roche
Vitiligo
Assessment of Vitiligo Lesions Using Polarized Dermoscopy, Sub-Ultraviolet Reflectance Dermoscopy, and Ultraviolet Dermoscopy
The goal of this observational study is to learn how different close-up skin imaging methods show vitiligo spots in adults with vitiligo.
- Trial name
- NCT07846969
- Where
- Turkey (Türkiye)
- Volunteers
- 100 people
- Sponsor
- Istanbul Training and Research Hospital
Parkinson Disease-tremor, Essential Tremor
Mapping Functional Networks of Brain Activity Using EEG in Patients With Essential Tremor or Parkinson Disease Before and After MR-guided Focused Ultrasound Thalamotomy for Tremor
A cornerstone in PD and ET research is the investigation of neurophysiological changes as potential bio-markers that could help in tracking disease progression and response to therapy.
- Trial name
- NCT02692183
- Volunteers
- 100 people
- Sponsor
- Sheba Medical Center
Breast Cancer
Efficacy of Exercise Using Connected Activity Trackers and Therapeutic Education in Localized Breast Cancer
The 3-year DISCO study aims to systematically implement physical activity in breast cancer patients. The primary objective is to investigate the efficacy of a connected device (personalized non-supervised exercise program…
- Trial name
- DISCO (NCT03529383)
- Testing
- Connected device, Therapeutic education
- Where
- 3 sites in France
- Volunteers
- 436 people
- Sponsor
- Centre Leon Berard
Obesity
Improving Cardiovascular Risk Factors in Black Young Adults
The objectives of the study are to conduct a randomized controlled trial to test the efficacy of the Smartphone intervention on % weight loss and maintaining % weight loss at 6 and 12 months in a sample (N=256) of Black community…
- Trial name
- NCT04412954
- Testing
- Smartphone + Text Messaging with Health Coach
- Where
- United States
- Volunteers
- 256 people, healthy volunteers welcome
- Sponsor
- Ohio State University
Neoplasm Malignant, Breast Cancer
Dose Escalation and Expansion Study of SAR443216 in Participants With Relapsed/Refractory HER2 Expressing Solid Tumors
Primary Objectives: Part 1 (Dose Escalation) To determine the MTD/maximum administered dose (MAD) of SAR443216 administered as a single agent in participants with HER2 expressing solid tumors and determine the RD(s) for…
- Conditions
- Neoplasm Malignant, Breast Cancer, Lung Neoplasm Malignant, Gastric Cancer
- Trial name
- NCT05013554
- Testing
- SAR443216 IV, SAR443216 SC
- Where
- 11 sites in United States, Belgium and 4 more
- Volunteers
- 44 people
- Sponsor
- Sanofi
Pediatric Cancer
ATOMIC Mobile App to Increase Physical Activity (PA) Levels in Survivors of Childhood Cancer
Development and Usability Testing of the ATOMIC Mobile App to Increase Physical Activity (PA) Levels in Children, Adolescent and Young Adults (AYA) survivors of childhood cancer
- Trial name
- NCT05792566
- Testing
- Atomic app
- Where
- United States
- Volunteers
- 35 people
- Sponsor
- Connecticut Children's Medical Center
Traumatic Brain Injury (TBI)
Effect of Exercise Training on Physical, Cognitive, and Behavioral Function in People With TBI
Background: Traumatic brain injury (TBI) often causes problems with moving and balance, and thinking and emotions. Exercise can improve these things in people with other brain damage.
- Trial name
- NCT02504866
- Testing
- Vigorous exercise, Light to moderate exercise
- Where
- United States
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- National Institutes of Health Clinical Center (CC)
Cardiovascular Diseases, Sickle Cell Disease
SCD Fit Homebase Program
The purpose of this project is to develop novel approaches to promote health and longevity while enhancing quality of life among persons with Sickle cell disease (SCD).
- Conditions
- Cardiovascular Diseases, Sickle Cell Disease, Exercise
- Trial name
- NCT05228756
- Testing
- Accelerometer
- Sponsor
- University of Alabama at Birmingham
Proximal Humeral Fracture
A Research Study to Understand and Predict the Failure of Shoulder Fracture Fixations Using Computer Simulations
Fractures of the shoulder, the so-called proximal humeral fractures, can be treated with locking plates that have shown good results in clinical practice, but complications can occur.
- Trial name
- PHILOS-SIM (NCT04056351)
- Testing
- Post-Operative (OP) Computer Tomography (CT), Questionnaires on patient activity and comorbidities, Grip strength measurement
- Where
- 2 sites in Austria, Belgium
- Volunteers
- 29 people
- Sponsor
- AO Research Institute Davos
Metabolic Adaptation to High-Intensity Interval Training
Carbonic Anhydrase II Responses to Basketball-Specific High-Intensity Interval Training
This study aims to examine whether erythrocyte carbonic anhydrase II can be used as a biological marker of metabolic adaptation to basketball-specific high-intensity interval training.
- Trial name
- CAII-BASKET (NCT07377851)
- Testing
- Basketball-Specific High-Intensity Interval Training
- Where
- Turkey (Türkiye)
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Karamanoğlu Mehmetbey University
Multiple Sclerosis, Cognitive Deficits
Effects of Cognitive Behavioural Therapy and Exercise on Stress and Cognitive Deficits in Multiple Sclerosis
High levels of psychological stress have been reported by 90% of patients with MS experiencing disease exacerbation, and approximately 39% of those with more stable disease course.
- Conditions
- Multiple Sclerosis, Cognitive Deficits, Stress, Psychological
- Trial name
- NCT01763983
- Testing
- Cognitive Behavioural Therapy, Aerobic Exercise
- Where
- Canada
- Volunteers
- 173 people
- Sponsor
- Sunnybrook Health Sciences Centre
Colon Cancer, Ovarian Cancer
Exercise Intervention Prior to CRS-HIPEC: Feasibility & Impact
Our objective is to initiate an exercise program for patients with advanced GI or Gyn cancer, as prehabilitation prior to surgery.
- Conditions
- Colon Cancer, Ovarian Cancer, GI Cancer, Gynecologic Cancer
- Trial name
- NCT04731441
- Testing
- Home-based Exercise Program Prior to CRS-HIPEC, Exercise Education
- Where
- United States
- Volunteers
- 12 people
- Sponsor
- Milton S. Hershey Medical Center
Sedentary Behavior
Quick Questionnaire to Evaluate Physical Activity
The purpose of this study is to test and validate a new questionnaire (SAPHIR) in order to get an evaluation of patients physical activity.
- Trial name
- SAPHIR (NCT04548141)
- Testing
- Questionnaire
- Where
- France
- Volunteers
- 140 people, healthy volunteers welcome
- Sponsor
- University Hospital, Angers
Knee Osteoarthritis
The Effect of a Group Exercise Intervention on Balance in People With Knee Osteoarthritis: a Pilot Study
In this study, the investigators want to find out if a 12-week exercise program improves balance in people with knee osteoarthritis.
- Trial name
- NCT06807541
- Testing
- Exercise intervention
- Where
- 2 sites in Canada
- Volunteers
- 32 people
- Sponsor
- University of the Fraser Valley
Sedentary Behavior, Frail Elderly Syndrome
Effect of an Intervention on Health in Older Care Home Residents
Care home residents spent 79% of their time being sedentary. Reduced physical activity and lack of mental stimulation causes general weakness and frailty in older adults that can result in increased healthcare needs.
- Conditions
- Sedentary Behavior, Frail Elderly Syndrome, Frailty, Lifestyle, Sedentary
- Trial name
- NCT04659694
- Testing
- Wellness programme provided by Oomph! Wellness company
- Volunteers
- healthy volunteers welcome
- Sponsor
- Bournemouth University
Diabetes Mellitus, Type 2, Physical Activity
Portable Monitoring Device, Physical Activity Motivation and Patients with Type 2 Diabetes
The intervention proposed for this project aims to improve the practice of physical activity (PA) for people with type 2 diabetes by increasing their motivation using a portable device to monitor PA (FitBit).
- Conditions
- Diabetes Mellitus, Type 2, Physical Activity, Motivation
- Trial name
- DBFitbit (NCT03709966)
- Testing
- Portable monitoring device, Routine
- Where
- Canada
- Volunteers
- 30 people
- Sponsor
- Laval University
Insulin Resistance
Basic Research Study to Examine the Relation Between Muscle Insulin Resistance and Lipid Production in the Liver.
The purpose of this study was to examine the pathophysiology of insulin resistance and the relation to the metabolic syndrome in humans.
- Trial name
- NCT02196051
- Testing
- one bout of 45 minutes exercise
- Where
- United States
- Volunteers
- 41 people, healthy volunteers welcome
- Sponsor
- Yale University
Right Ventricular Dysfunction
Right Heart International NETwork During Exercise in Different Clinical Conditions
The aim of this registry will be to compare the pathophysiological response of the morphology and function of the right heart and pulmonary circulation assessed with resting and stress-echocardiography in patients with various…
- Trial name
- RIGHT-Net (NCT03041337)
- Testing
- stress echocardiography
- Where
- Italy
- Volunteers
- 1,000 people, healthy volunteers welcome
- Sponsor
- Azienda Ospedaliera OO.RR. S. Giovanni di Dio e Ruggi D'Aragona
Rectal Cancer
Exercise During and After Neoadjuvant Rectal Cancer Treatment
This study is designed to investigate if aerobic exercise during and after neoadjuvant chemoradiotherapy (NACRT) can improve outcomes for rectal cancer patients.
- Trial name
- EXERT (NCT03082495)
- Testing
- Exercise
- Where
- Canada
- Volunteers
- 36 people
- Sponsor
- University of Alberta
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