Clinical trials: Physical Decline
Chronic Pain, Mild Cognitive Impairment
Managing Pain and Cognitions in Older Adults With Early Cognitive Decline and Chronic Pain
The investigators aim to conduct a fully powered randomized controlled trial to compare the efficacy of two symptom management programs for older adults with early cognitive decline (either self-reported or confirmed by testing)…
- Conditions
- Chronic Pain, Mild Cognitive Impairment, Older Adults, Physical Activity
- Trial name
- NCT05373745
- Testing
- Active Brains 1, Active Brains 2
- Where
- United States
- Volunteers
- 267 people
- Sponsor
- Massachusetts General Hospital
Post-Operative Confusion
Braindex Cerebral Tissue Oxygen Saturation (SctO2) Measurement Algorithm Assessment and Improvement
The objective of this clinical trial is to optimize Braindex brain tissue oxygen saturation (SctO2) measurement algorithm compared to a mixed reference value of jugular venous and systemic arterial saturation, during proven…
- Trial name
- POC-SctO2 (NCT05897060)
- Testing
- Venus Jugular O2 Saturation optical fiber
- Where
- France
- Volunteers
- 40 people
- Sponsor
- Braindex
Cognitive Decline
Evaluation of Cognitive State in Seniors Using Neurosteer EEG System
This is an observational study. Patients who fulfill all inclusion criteria and none of the exclusion criteria will be enrolled in the study, be neurologically evaluated and will go through EEG recordings while listening to an…
- Trial name
- NCT05528445
- Testing
- Neurosteer EEG recorder
- Where
- Israel
- Volunteers
- 77 people, healthy volunteers welcome
- Sponsor
- Neurosteer Ltd.
Intra Cerebral Hemorrhage, ICH - Intracerebral Hemorrhage
REpeated ASSEssment of SurvivorS in Intracerebral Hemorrhage Study
The investigators propose to perform serial detailed cognitive, motor, behavioral, and blood collection follow-up using longitudinal structured telephone interviews of an anticipated 350 ICH survivors enrolled in Minimally…
- Conditions
- Intra Cerebral Hemorrhage, ICH - Intracerebral Hemorrhage, ICH, Hemorrhage
- Trial name
- ICH03 (NCT05611918)
- Where
- 26 sites in United States
- Volunteers
- 350 people
- Sponsor
- Johns Hopkins University
Aging, Age-Related Cognitive Decline
Multidomain Interventions for Elderly Individuals in Residential Structures
The "Multidomain Interventions to improve the COgnitive and fUNctional well-being of elderly individuals in residential sTructures" (I-COUNT) study aims to test the feasibility and the effectiveness of a multidisciplinary…
- Conditions
- Aging, Age-Related Cognitive Decline, Sarcopenia, Long Term Care Facility
- Trial name
- I-COUNT (NCT06820710)
- Testing
- Physical activity, Cognitive stimulation, Nutritional Intervention
- Where
- 2 sites in Italy
- Volunteers
- 90 people
- Sponsor
- Istituto di Neuroscienze Consiglio Nazionale delle Ricerche
Aging, Chronic Disease
Active Ageing and Health
Background: 36% of the Italian population will have more than 65 years in 2050. The European Union has indicated among its priorities to increase research on active aging.
- Conditions
- Aging, Chronic Disease, Cognitive Decline, Quality of Life
- Trial name
- NCT03858114
- Testing
- Mild-to-moderate physical activity, Cultural group program
- Where
- 3 sites in Italy
- Volunteers
- 140 people, healthy volunteers welcome
- Sponsor
- University of Cagliari
Mobility Limitation, Fall Injury
Home-based HIFST for Older Adults to Prevent Functional Decline
After an injury, an older adult may experience changes to how they complete their daily activities and participate in physical activity.
- Conditions
- Mobility Limitation, Fall Injury, Slip and Fall
- Trial name
- NCT05266911
- Testing
- high-intensity functional strength training, Lower extremity stretching
- Where
- 2 sites in Canada
- Volunteers
- 24 people
- Sponsor
- McMaster University
Cognitive Decline Prevention in Robust Older Adults, Cognitive Decline Prevention in Pre-frail Older Adults
The StayFitLonger Study: an Innovative Computerized Home-based Training to Foster Independent Life at Home
Multimodal training, including physical and cognitive activities, has been associated with a reduction in age-related physical and cognitive decline.
- Conditions
- Cognitive Decline Prevention in Robust Older Adults, Cognitive Decline Prevention in Pre-frail Older Adults, Physical Decline Prevention in Robust Older Adults, Physical Decline Prevention in Pre-frail Older Adults
- Trial name
- SFL (NCT04237519)
- Testing
- SFL training, Active controlled training
- Where
- 4 sites in Belgium, Canada and 1 more
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- University of Lausanne Hospitals
Sarcopenia, Frailty
BandPass: A Remote Monitoring System for Sarcopenia and Functional Decline Phase II Aim 4
This study evaluates a home-based strengthening program supported by the BandPass system, which includes a Bluetooth-enabled resistance exercise band, a mobile app that provides real-time feedback, and a clinician dashboard for…
- Trial name
- NCT07421648
- Testing
- BandPass System
- Where
- 2 sites in United States
- Volunteers
- 39 people
- Sponsor
- SynchroHealth LLC
Healthy, Older Adults
Group-Based Exercise Intervention to Prevent Cognitive and Motor Decline
The goal of this clinical trial is to evaluate the efficacy of the Ideomotor Program in healthy older adults living in the community.
- Trial name
- NCT07494149
- Testing
- Ideomotor, Control
- Where
- 2 sites in Italy
- Volunteers
- 158 people, healthy volunteers welcome
- Sponsor
- University of Bergamo
Coginitive Dysfunction
The Effects, Usability, Satisfaction, Barriers, and Benefits of a Remote, Multidomain Website-based Intervention to Prevent Cognitive Decline in Older Adults
Mexico exhibits a high prevalence of dementia, exceeding 8%, and it is estimated that by 2050 around 3.5 million older adults will be living with this condition.
- Trial name
- MeMoHealthCogR (NCT07668440)
- Testing
- Multi-domain intervention: Physical activity, cognitive training, and educational program through a website
- Where
- Mexico
- Volunteers
- 71 people
- Sponsor
- Instituto Mexicano del Seguro Social
Physical Performance Decline in Older Adults, Sarcopenia
Clinical Relevance of Ultrasound-based Intramuscular Fat Infiltration Assessment in Hospitalized Older Adults (FATUS-OLD)
Sarcopenia in older adults is associated not only with loss of muscle mass but also with deterioration of muscle quality, particularly intramuscular fat infiltration.
- Conditions
- Physical Performance Decline in Older Adults, Sarcopenia, Muscle Fat Infiltration
- Trial name
- FATUS-OLD (NCT07411547)
- Where
- France
- Volunteers
- 115 people
- Sponsor
- Nantes University Hospital
Cognitive Impairment, Mild, Cognitive Decline
Efficacy of a Multimodal Brain Health Intervention for Older African Americans
This study tests the feasibility, acceptability, and efficacy of a multimodal intervention (walking, social engagement, and reminiscence), including the use of wearable digital biomarkers, for cognitively healthy and mildly…
- Trial name
- SHARP (NCT04863378)
- Testing
- Walking conversational reminiscence
- Where
- United States
- Volunteers
- 13 people, healthy volunteers welcome
- Sponsor
- Oregon Health and Science University
Aging, Physical Activity
Effects of Regular Exercise on Cerebrovascular Reserve in Older Adults
While it is well established that physical inactivity is a modifiable risk factor for vascular disease and cognitive decline, the mechanism by which exercise exerts its protective effect on the cerebral circulation and cognition…
- Conditions
- Aging, Physical Activity, Cognitive Function
- Trial name
- BIM (NCT03158337)
- Testing
- Aerobic exercise
- Where
- Canada
- Volunteers
- 286 people, healthy volunteers welcome
- Sponsor
- University of Calgary
Aging, Mild Cognitive Impairment
Internet-based Conversational Engagement Clinical Trial
The study aims to randomize 320 (160 Caucasian, 160 African American) socially isolated adults 75+ years old (50:50 split between those with normal cognition and mild cognitive impairment (MCI)) recruited from the community to…
- Trial name
- I-CONECT (NCT02871921)
- Testing
- Conversational Engagement
- Where
- 2 sites in United States
- Volunteers
- 186 people, healthy volunteers welcome
- Sponsor
- Massachusetts General Hospital
Elderly, Alzheimer Disease
Effects of 3-Month Melatonin Treatment on Regional Cerebellar Structure and Blood Biomarkers in Alzheimer's Disease Spectrum
The goal of this clinical trial is to explore and verify the preventive effects of melatonin on the progression of Alzheimer's disease.
- Conditions
- Elderly, Alzheimer Disease, Melatonin, Cognitive Decline
- Trial name
- NCT06756828
- Testing
- Melatonin, Cognitive behavioral therapy group for insomnia
- Volunteers
- 40 people
- Sponsor
- Saint Vincent's Hospital, Korea
Cognitive Decline, Physical Activity
Virtual Reality-based Mindful Movement Therapy for Seniors
The current proposal aims to 1) develop a technical platform and implementation plan for the delivery of a virtual reality-based mindful movement therapy (VR-MMT) protocol for older adults; and 2) conduct a clinical trial to…
- Conditions
- Cognitive Decline, Physical Activity, Psychological Wellbeing
- Trial name
- NCT06334328
- Testing
- Virtual reality based mindful movement therapy
- Where
- United States
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- Drexel University
Obesity
Vibegron for ENergy Thinking and Resilience in Aging
This 12-week randomized, double-blind, placebo-controlled trial will test the hypothesis that Vibegron (brand name GEMTESA) can improve energy metabolism, cardiometabolic risk factors, and physical and cognitive function in…
- Trial name
- VENTURA (NCT06987383)
- Testing
- Vibegron
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- Wake Forest University Health Sciences
Frailty, Cognitive Decline
Precision Stratification for Frailty and Cognitive Decline
The Care4Senior mobile Application, Intensive Aerobic Resistance Training and Brain Health (CIRTAB) trial aim to test the effectiveness of an exercise, cognitive and lifestyle intervention amongst older adults over a 12-weeks…
- Trial name
- NCT07081282
- Testing
- Care4Senior mobile Application, Intensive Aerobic Resistance Training and Brain Health (CIRTAB), Centre-Based Exercise Health Session
- Where
- Singapore
- Volunteers
- 252 people, healthy volunteers welcome
- Sponsor
- National University of Singapore
Geriatric Depression
Community-based Rehabilitation Management for Patients With Remitted Geriatric Depression
This study intends to take patients with RGD as objects. Further construct a community-based rehabilitation management (CBRM) program with drug treatment, rehabilitation measures of education, psychology and exercise as its core…
- Trial name
- NCT05610917
- Testing
- CBRM (community-based rehabilitation management), TAR(treatment as routine)
- Where
- China
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- Duan Li