Clinical trials: Physical Dependence
Schizophrenia
A Clinical Study to Learn if SEP-363856 Has Physical Dependence in Adults With Schizophrenia
A Clinical Study to learn if SEP-363856 has physical dependence in adults with schizophrenia. This study will be held in approximately 6 study sites in the United States.
- Trial name
- NCT05848700
- Testing
- SEP-363856
- Where
- 7 sites in United States
- Volunteers
- 60 people
- Sponsor
- Otsuka Pharmaceutical Development & Commercialization, Inc.
Smoking Behaviors, Physical Inactivity
Impact of Smoking on Physical Activity Level in Young Adults
This study will aim to examine the relationship between the daily physical activity level and nicotine dependence severity in university students.
- Trial name
- NCT07043920
- Testing
- Behavioral Assessment (No therapeutic intervention will be administered)
- Where
- Turkey (Türkiye)
- Volunteers
- 164 people
- Sponsor
- Saglik Bilimleri Universitesi
Nicotine Dependence
Examination of Sleep, Smoking Cessation, and Cardiovascular Health
Most treatment-seeking smokers will fail in their attempts to quit smoking in the early days and weeks of quitting. Poor sleep (e.g., short duration) is an overlooked, but important nicotine withdrawal symptom that can affect up…
- Trial name
- NCT02941718
- Testing
- Sleep Advancement Counseling, General Health Information
- Where
- United States
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- University of Delaware
Frailty, Disability Physical
Viability of an Educational Program for Lifestyle Changes and an Algorithm for the Derivation of Exercise Programs in Older People at Risk of Dependency at Primary Care.
According to the INE in 2021, more than 9 million people are currently over 65 years of age. This means that more than 1 million are frail and almost 4 million are pre-fragile only in Spain.
- Conditions
- Frailty, Disability Physical, Old Age; Atrophy
- Trial name
- PRICA-POWFRAIL (NCT05772910)
- Testing
- EDUcation, EXERcise, EDU-EXER
- Volunteers
- 110 people
- Sponsor
- University of Cadiz
Opioid-use Disorder, Opioid-related Disorders
An Observational Study of Environmental and SocioEconomic Factors in Opioid Recovery
The RECOVER Study will examine clinical, environmental and socioeconomic factors in recovery from opioid use disorder (OUD) over a 24-month period following exit from a Phase III clinical program for a buprenorphine…
- Trial name
- RECOVER® (NCT03604861)
- Testing
- Not applicable - no defined intervention
- Where
- 35 sites in United States
- Volunteers
- 534 people
- Sponsor
- Indivior Inc.
Depression, Anxiety
More Individualized Care: Assessment and Recovery Through Engagement
The MI-CARE trial tests 12 months of telephone-based nurse care management for patients with depressive symptoms who take or have taken opioids at some time.
- Conditions
- Depression, Anxiety, Opioid-Related Disorders, Pain, Chronic
- Trial name
- MI-CARE (NCT05122676)
- Testing
- More Individualized Care: Assessment and Recovery through Engagement (MI-CARE)
- Where
- 2 sites in United States
- Volunteers
- 805 people
- Sponsor
- Kaiser Permanente
Substance Withdrawal Syndrome
Validation of a Pediatric-Specific Abstinence Syndrome Assessment Tool
The purpose of this study is to assess the validity and reliability of an abstinence syndrome assessment tool used in pediatric patients with iatrogenic opioid dependence.
- Trial name
- NCT00792415
- Where
- United States
- Sponsor
- Banner Health
Cardiac Surgery With Extracorporeal Circulation
Preload Dependency by Impedance Cardiography After Cardiac Surgery
The primary purpose of this study is to investigate wether the measure of stroke volume (SV) variations by impedance cardiography during passive leg raising (PLR) can reliably predict preload dependency after cardiac surgery, in…
- Trial name
- NCT02132871
- Testing
- Impedance cardiography Physioflow ®
- Where
- France
- Volunteers
- 65 people
- Sponsor
- University Hospital, Strasbourg, France
Alcohol Dependence
A Study of Brain Receptor Occupancy in Healthy Subjects
To measure the occupancy of brain kappa opioid receptors after single oral doses of LY2456302.
- Trial name
- NCT01232439
- Testing
- opioid receptor kappa antagonist
- Where
- United States
- Volunteers
- 13 people, healthy volunteers welcome
- Sponsor
- Eli Lilly and Company
Alcoholism, Alcohol Dependence
Alcoholism Assessment and Treatment
The purpose of this study is to gather information about people s drinking histories and to evaluate them for other research studies being conducted at the National Institute on Alcohol Abuse and Alcoholism (NIAAA).
- Conditions
- Alcoholism, Alcohol Dependence, Alcohol Drinking Related Problems
- Trial name
- NCT00106093
- Where
- United States
- Volunteers
- 1,192 people
- Sponsor
- National Institute on Alcohol Abuse and Alcoholism (NIAAA)
Critical Illness, Muscle Weakness
Relationship Between Muscle Strength and Physical Function in ICU
This observational study aims to assess the relationship between muscle strength and physical function in critical ill patients. Grip and quadriceps strengths are measured using a standardized protocol of dynamometry.
- Conditions
- Critical Illness, Muscle Weakness, Physical Disability, Physical Dependence
- Trial name
- NCT04284475
- Testing
- Quadriceps strength, Grip strength, ICU mobility scale
- Where
- Belgium
- Volunteers
- 93 people
- Sponsor
- University of Liege
Tobacco Dependence, Cardiovascular Diseases
Physical Activity as an Aid for Smoking Cessation
Including a tailored moderate-intensity physical activity intervention in a standard smoking cessation treatment program (pharmaceutical treatment and counseling) increases the chances of quitting and reduces nicotine withdrawal…
- Conditions
- Tobacco Dependence, Cardiovascular Diseases, Physical Activity
- Trial name
- PHASMO (NCT00521391)
- Testing
- Allez Hop
- Volunteers
- 600 people, healthy volunteers welcome
- Sponsor
- University of Lausanne Hospitals
Substance Use Disorders, Substance Dependence
Correlation of Genetic Variations With Clinical Response in Substance Use Disorder
This research outcomes can be summarized as follows: 1. Pharmacogenomic analysis of Substance Use Disorder (SUD) and medications used for the treatment of SUD. 2.
- Trial name
- NCT05833399
- Testing
- Quetiapine, olanzapine, mirtazapine, carbamazepine, sertraline, amitriptyline, chlorpromazine and risperidone
- Where
- Egypt
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Alexandria University
Alcohol Dependence, Alcohol Withdrawal Syndrome
Assessment of Valproate on Ethanol Withdrawal
Alcohol use disorder, or heavy drinking, is commonly seen in patients who present to trauma centers. These patients are at risk for Alcohol Withdrawal Syndrome (AWS), which is collection of symptoms that can range from anxiety…
- Conditions
- Alcohol Dependence, Alcohol Withdrawal Syndrome, Trauma, Heavy Drinking
- Trial name
- PAVE (NCT03235531)
- Testing
- Valproate, Lorazepam
- Where
- 2 sites in United States
- Volunteers
- 3 people
- Sponsor
- CAMC Health System
Opioid-use Disorder, Substance Use Disorders
Physical Activity as Adjunct Treatment for Opioid Substitution Therapy
In terms of research, it is documented that exercise has a positive effect on mental disorders. Studies have shown positive correlations between physical and mental health, also among substance users.
- Conditions
- Opioid-use Disorder, Substance Use Disorders, Opioid Dependence
- Trial name
- NCT04496934
- Testing
- Exercise
- Where
- Norway
- Volunteers
- 17 people
- Sponsor
- Haukeland University Hospital
Chronic Pain, Pain
A Study of Cebranopadol for Opioid Withdrawal Symptoms in Adults With Chronic Pain
This Phase 2 study will evaluate whether multiple doses of cebranopadol suppress opioid withdrawal signs and symptoms compared with placebo in adults with chronic pain who are physically dependent on prescribed opioids.
- Conditions
- Chronic Pain, Pain, Opioid Withdrawal (Disorder), Opioid Use Disorder
- Trial name
- NCT07874620
- Testing
- Cebranopadol
- Where
- 2 sites in United States
- Volunteers
- 45 people
- Sponsor
- Adneuris Therapeutics, Inc.
Tobacco Dependence
UW Withdraw From Tobacco Study
It is of considerable scientific and clinical importance to assess tobacco withdrawal accurately since withdrawal severity is highly determinant of smoking cessation success.
- Trial name
- NCT04969198
- Testing
- Combination nicotine replacement therapy (Nicotine patch + nicotine mini-lozenge)
- Where
- United States
- Volunteers
- 232 people, healthy volunteers welcome
- Sponsor
- University of Wisconsin, Madison
Cocaine-Related Disorders
Assessment of Potential Interactions Between GBR 12909 and Cocaine - 1
The purpose of this study is to assess potential interactions between intravenous (IV) cocaine and 3 doses of GBR 12909.
- Trial name
- NCT00100113
- Testing
- GBR 12909
- Where
- United States
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- National Institute on Drug Abuse (NIDA)
MDS, MDS/MPN
Study Investigating Patient-Reported Outcomes in Lower-risk MDS Patients
PRO-RED is a prospective, longitudinal, and multicenter observational study. Enrolled patients will be followed for 6 months in at least monthly intervals in terms of their received red blood cell transfusions and routine…
- Trial name
- PRO-RED (NCT05582902)
- Where
- 11 sites in Austria, Germany
- Volunteers
- 60 people
- Sponsor
- University of Leipzig
Fragility, Physical Disability
Exercise Intervention in Institutionalized Elderly People
Questions: Does an evidence-based exercise program increase activities of daily living and physical fitness in institutionalized older adults? Does this program decrease the care dependency of institutionalized older adults?…
- Trial name
- BENENFIT (NCT01646632)
- Testing
- Physical exercise intervention, Lifestyle counseling
- Where
- Netherlands
- Volunteers
- 164 people, healthy volunteers welcome
- Sponsor
- Hanze University of Applied Sciences Groningen