Clinical trials: Physical Frailty
Spine Degeneration, Spine Fusion
Pre-operative Risk Assessment Combined With Targeted Intervention in the Chinese Elderly With Spine Surgery
With the extended life expectancy of the Chinese population and improvements in surgery and anesthesia techniques, the number of aged patients undergoing surgery has been increasing annually.
- Conditions
- Spine Degeneration, Spine Fusion, Frailty Syndrome
- Trial name
- PRACTICE (NCT06140797)
- Testing
- Multimodal prehabilitation combined with perioperative ERAS care（PREERAS）
- Where
- 3 sites in China
- Volunteers
- 164 people
- Sponsor
- Xuanwu Hospital, Beijing
Sarcopenia in Elderly
The Study, Conducted With 54 Individuals Over the Age of 65, Aimed to Reveal the Advantages and Disadvantages of a Combined Exercise Program Compared to Otago Exercise Alone.
Falls are a leading cause of morbidity and mortality in older adults. Approximately one-third of individuals over 65 years of age fall each year, and 10-15% of these falls result in serious injury.
- Trial name
- OPEP-SARCOBAL (NCT07689903)
- Testing
- Proprioception Exercise, Exercise Intervention
- Where
- Turkey (Türkiye)
- Volunteers
- 54 people, healthy volunteers welcome
- Sponsor
- Hacettepe University
Kidney Disease, End-Stage, Frailty
Virtual Home-based Physical Pre-habilitation in Kidney Transplant Candidates
The goal of this RCT is to address the feasibility of conducting a 12-week virtual pre-habilitation intervention, which includes exercise and education, in kidney transplant candidates.
- Conditions
- Kidney Disease, End-Stage, Frailty, Transplant;Failure,Kidney
- Trial name
- NCT06089473
- Testing
- Intervention Group: Exercise and education., Usual Care Only
- Where
- 2 sites in Canada
- Volunteers
- 30 people
- Sponsor
- McGill University Health Centre/Research Institute of the McGill University Health Centre
Frailty, Social Isolation in Older Adults
A Pilot Study to Explore the Feasibility of Navigator and Coach Support for Community Participation by Older People
Frailty is a multidimensional syndrome in which a person accumulates age-related deficits across life domains, increasingly including social components such as social isolation.
- Conditions
- Frailty, Social Isolation in Older Adults, Frailty in Older Adults
- Trial name
- ENGAGE (NCT07836465)
- Testing
- Navigation support, Coaching support
- Where
- Switzerland
- Volunteers
- 45 people, healthy volunteers welcome
- Sponsor
- Bastiaan Van Grootven
Frailty, Fall
Nicotinamide Supplementation Improves Physical Performance in Older Adults at Risk of Falls
Falls are unplanned events resulting in contact with a lower surface. They are common in older adults, affecting one in three individuals over 65 years old.
- Conditions
- Frailty, Fall, Frailty Syndrome, Falls
- Trial name
- NICE-FIT (NCT06465602)
- Testing
- Nicotinamide
- Where
- Chile
- Volunteers
- 60 people
- Sponsor
- University of Chile
Falls, Frailty Syndrome
Effectiveness of a Home-Based Multicomponent Exercise Program With Digital Support in Community-Dwelling Older Adults With Falls
This study evaluates the effectiveness of an 8-week multicomponent exercise program conducted at home with digital support through the VIVIFIL mobile application, compared to a traditional in-person hospital-based exercise…
- Conditions
- Falls, Frailty Syndrome, Gait Disorders, Mobility Limitation
- Trial name
- GAIT2CARE (NCT06936865)
- Testing
- VIVIFIL App Program, Hospital-Based Multicomponent Exercise
- Where
- Spain
- Volunteers
- 127 people
- Sponsor
- Spanish National Research Council
Frailty, Chronic Kidney Diseases
Comprehensive Geriatric Assessment for Frail Older People With Chronic Kidney Disease - The GOAL Trial
The GOAL trial addresses patient-prioritised research topics and outcomes and will be conducted, disseminated and implemented in partnership with patients and their caregivers.
- Trial name
- NCT04538157
- Testing
- Comprehensive Geriatric Assessment
- Where
- 15 sites in Australia
- Volunteers
- 240 people
- Sponsor
- The University of Queensland
Functional Status, Frailty
Protocol for Inpatient Nursing Frailty Assessment (INFA)
Background: Frailty confers greater risks of negative health outcomes in hospitalised older adults. To improve care for this vulnerable population, Comprehensive Geriatric Assessment (CGA) is recommended for frail older persons.
- Trial name
- NCT06469723
- Testing
- INFA Program
- Where
- Singapore
- Volunteers
- 300 people, healthy volunteers welcome
- Sponsor
- Tan Tock Seng Hospital
Frail Elderly Syndrome, Cognitive Impairment
Investigating My Active and Healthy Aging
This is a multicenter, multicultural, randomized control trial. Participants will be recruited from 10 centers located in Italy, Germany, Austria, Spain, United Kingdom, Belgium, Sweden, Japan, South Korea and Australia.
- Conditions
- Frail Elderly Syndrome, Cognitive Impairment, Physical Dependence
- Trial name
- my-AHA (NCT03342976)
- Testing
- My-AHA platform
- Where
- Italy
- Volunteers
- 201 people, healthy volunteers welcome
- Sponsor
- University of Turin, Italy
Postoperative Complications
POSSUM, P-POSSUM, Clinical Frailty Scale, Clinical Frailty Scale and Charlson's Comorbidity Index in Abdominal Surgery.
Abdominal surgery represents the most frequent activity in the surgical block. Advances in surgical techniques and improvements in postoperative care imply the need for greater control of the surgical outcomes obtained and the…
- Trial name
- NCT04774354
- Testing
- POSSUM
- Where
- Spain
- Volunteers
- 350 people
- Sponsor
- Ángel Becerra-Bolaños, MD PhD
Frailty, Frailty in Older Adults
Comparison of Preoperative Frailty Assessment Tools
Frailty is a significant risk factor for postoperative complications and functional decline. Preoperative assessment of frailty is therefore recommended in all older adults.
- Conditions
- Frailty, Frailty in Older Adults, Frailty/Sarcopenia
- Trial name
- PREFAS (NCT06889545)
- Testing
- Assessment of frailty using multiple tools
- Where
- Germany
- Volunteers
- 584 people
- Sponsor
- Universitätsklinikum Hamburg-Eppendorf
Frail Elderly, Malnutrition
Healthy Life for Frail Malnourished Seniors Performed Together With Trained Lay Buddies
Background: In elderly subjects frailty and malnutrition are very common and can lead to serious health hazards, increase mortality, morbidity, dependency, institutionalization and a reduced quality of life.
- Trial name
- NCT01991639
- Testing
- Nutritional and physical activity intervention
- Where
- Austria
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Medical University of Vienna
Head and Neck Cancers
Prospective Evaluation of Frailty in Patients With Head and Neck Tumors Before Curative Intended Therapy
In a prospective study the fragility of patients with head and neck tumors before the start of curative therapy will be assessed. Primary objective: Fragility is assessed using the G8 questionnaire.
- Trial name
- PRE-KOVERI (NCT06638216)
- Testing
- Geriatric Assessment
- Where
- Germany
- Volunteers
- 99 people
- Sponsor
- Charite University, Berlin, Germany
Frail Elderly Syndrome
Frailty Assessment and Treatment Strategies in the Elderly at Risk of Functional Decline in the Community
This study aims to design a patient -centered program to prevent or delay frailty , functional decline and adverse events, and evaluates the effectiveness of the program with a randomized clinical trial.
- Trial name
- NCT03591055
- Testing
- CGA, medication review, exercise and cognitive stimulation
- Where
- Spain
- Volunteers
- 300 people
- Sponsor
- Fundacio d'Investigacio en Atencio Primaria Jordi Gol i Gurina
Aging Problems, Frailty
Impact of Skills Acquired Through Judo Training on Risk Factors for Falling in Elderly Men and Women
Falls and injuries from falls are one of the greatest threats to public health. One of the risk factors for accidental falls is a low self-efficacy regarding the perceived capability to perform activities without the risk of…
- Conditions
- Aging Problems, Frailty, Fall Injury, Accidental Fall
- Trial name
- J4BE (NCT04061785)
- Testing
- Judo4Balance - 12 week judo inspired exercise program
- Where
- Sweden
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Dalarna University
Alzheimer Disease (AD), Cardio Vascular Disease
Arlington Longitudinal Optimal Healthy Aging Study (ALOHA)
The Arlington Longitudinal Optimal Healthy Aging (ALOHA) Study is a community-based research project led by the Marymount University Center for Optimal Aging (MCOA).
- Conditions
- Alzheimer Disease (AD), Cardio Vascular Disease, Mild Cognitive Impairment (MCI), Frailty Syndrome
- Trial name
- ALOHA (NCT07180147)
- Where
- United States
- Volunteers
- 500 people, healthy volunteers welcome
- Sponsor
- Marymount University
Lower Limb Fracture
Prognostic Value of Preoperative Frailty Assessment in Geriatric Lower Limb Orthopedic Surgery
This retrospective study evaluates the effectiveness of frailty assessment tools-specifically the Risk Analysis Index (RAI) and the 5-Item Modified Frailty Index (5-mFI)-in predicting postoperative outcomes for elderly patients…
- Trial name
- NCT07422025
- Testing
- Preoperative Frailty Scoring
- Where
- Egypt
- Volunteers
- 149 people
- Sponsor
- Benha University
Oral Frailty, Depression
Group Reading and Oral Exercise Program for Older Adults
Depression is common among older adults and is often associated with declines in physical and oral health. Non-pharmacological, community-based interventions are needed to support both mental and physical well-being.
- Conditions
- Oral Frailty, Depression, Sarcopenia, Physical Function Decline
- Trial name
- NCT07550335
- Testing
- Reading and Oral Exercise Program
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Mackay Memorial Hospital
One Hundred Patients Aged 65 and Older Who Underwent Emergency General Surgical Interventions, Clinical Utility of These Scoring Systems
A Comparative Study of CCI, EmSFI, and FTRST Scoring Systems
Frailty assessment tools and comorbidity indices play a crucial role, particularly in predicting outcomes for elderly patients undergoing emergency surgery.
- Conditions
- One Hundred Patients Aged 65 and Older Who Underwent Emergency General Surgical Interventions, Clinical Utility of These Scoring Systems, Gastrointestinal Neoplasms, Appendicitis Acute
- Trial name
- NCT06943924
- Testing
- Frailty assessment
- Where
- Turkey (Türkiye)
- Volunteers
- 100 people
- Sponsor
- Dr. Lutfi Kirdar Kartal Training and Research Hospital
Balance Impairment, Sarcopenia in Elderly
Multicomponent Exercise and Frailty in Nursing Home Residents
Frailty is common among older adults living in nursing homes and increases the risk of falls, disability, and loss of independence.
- Conditions
- Balance Impairment, Sarcopenia in Elderly, Frailty at Older Adults, Functional Decline
- Trial name
- BASE-Frail (NCT07686146)
- Testing
- Multicomponent Exercise Program (BASE), Usual Care
- Where
- Spain
- Volunteers
- 66 people
- Sponsor
- Escoles Universitaries Gimbernat