Clinical trials: Physical Frailty
Frailty Syndrome, Geriatric Health
Longitudinal Assessment of Lung Function and Respiratory Muscle Strength Following Training of the Inspiratory Muscles in Frail Older Adults (IMT-3)
This study aims to evaluate the effects of an 8-week inspiratory muscle training program on lung function and respiratory muscle strength in frail older adults aged 80 years and above.
- Conditions
- Frailty Syndrome, Geriatric Health, Respiratory Muscle Weakness, Age-Related Frailty
- Trial name
- NCT07556445
- Testing
- Inspiratory Muscle Training
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Universidad Francisco de Vitoria
Oral Health of Older Men
Talking Pen Audio-Interactive Program for Oral Frailty Delay in Community-Dwelling Elderly
This study aims to develop and evaluate the effectiveness of a talking pen audio-interactive technology integrated with an oral frailty delay care program for community-dwelling older adults in rural agricultural regions of…
- Trial name
- NCT07191600
- Testing
- Talking Pen Audio-Interactive Oral Frailty Care Program
- Where
- Taiwan
- Volunteers
- 88 people, healthy volunteers welcome
- Sponsor
- Chang Gung University of Science and Technology
Virtual Reality, Physical Fitness
Effects of Physical Fitness Using a Kinect Interventional System
The Kinect intervention system combined with aerobic exercise training can improve the quality of life of older adults in the community, standardize behavior regulation in exercise and improve fitness enthusiasm.
- Trial name
- NCT06216236
- Testing
- Kinect intervention system combined with aerobic exercise training, aerobic dance training
- Where
- 2 sites in Taiwan
- Volunteers
- 64 people
- Sponsor
- Wan-Yun Huang
Cognitive Decline Prevention in Robust Older Adults, Cognitive Decline Prevention in Pre-frail Older Adults
The StayFitLonger Study: an Innovative Computerized Home-based Training to Foster Independent Life at Home
Multimodal training, including physical and cognitive activities, has been associated with a reduction in age-related physical and cognitive decline.
- Conditions
- Cognitive Decline Prevention in Robust Older Adults, Cognitive Decline Prevention in Pre-frail Older Adults, Physical Decline Prevention in Robust Older Adults, Physical Decline Prevention in Pre-frail Older Adults
- Trial name
- SFL (NCT04237519)
- Testing
- SFL training, Active controlled training
- Where
- 4 sites in Belgium, Canada and 1 more
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- University of Lausanne Hospitals
Frailty Syndrome, Aging
Optimizing Prevention of Hospital-Acquired Disability Through Multidomain Interventions
The aim of this study is to assess whether a multidomain, multidisciplinary intervention (MDI), enhanced by technological solutions, effectively improves the functional and cognitive status of older hospitalized patients at risk…
- Trial name
- OPTIMAge-IT (NCT06611228)
- Testing
- Multidomain Interventions
- Where
- Italy
- Volunteers
- 288 people
- Sponsor
- University of Milano Bicocca
HIV, Frailty
Improving Physical Ability and Cellular Senescence Elimination in HIV
This clinical trial is a Phase II study designed to test the safety and effectiveness of a combination of dasatinib and quercetin (D+Q) in improving physical function for people with HIV who are frail or prefrail.
- Conditions
- HIV, Frailty, Prefrail, Aging Problems
- Trial name
- IPACE-HIV (NCT07144293)
- Testing
- Dasatinib, Quercetin
- Where
- 24 sites in United States
- Volunteers
- 82 people
- Sponsor
- National Institute of Allergy and Infectious Diseases (NIAID)
Frail Elderly Syndrome, Patient Admission
Geriatric Assessment and Intervention for Older Patients With Frailty in the Emergency Department
Comprehensive Geriatric Assessment (CGA) is an established approach for better detection of frailty-related problems and includes individualized treatment plan with multi-discipline supportive and treating measures for the older…
- Conditions
- Frail Elderly Syndrome, Patient Admission, Hospital Readmission, Length of Stay
- Trial name
- GAOPS (NCT03751319)
- Testing
- CGA
- Where
- Finland
- Volunteers
- 432 people
- Sponsor
- Helsinki University Central Hospital
Sarcopenia, Frailty
BandPass: A Remote Monitoring System for Sarcopenia and Functional Decline Phase II Aim 4
This study evaluates a home-based strengthening program supported by the BandPass system, which includes a Bluetooth-enabled resistance exercise band, a mobile app that provides real-time feedback, and a clinician dashboard for…
- Trial name
- NCT07421648
- Testing
- BandPass System
- Where
- 2 sites in United States
- Volunteers
- 39 people
- Sponsor
- SynchroHealth LLC
Gastric Cancer
Frailty Assessment and Intervention in Elderly Patients with Gastric Cancer Receiving Gastrectomy and Adjuvant Chemotherapy
Gastric cancer ranks among the top ten leading causes of death in Taiwan. Radical surgery is the sole curative method for gastric cancer.
- Trial name
- NCT06055387
- Testing
- Frailty intervention measures
- Where
- Taiwan
- Volunteers
- 300 people
- Sponsor
- Chang Gung Memorial Hospital
Frail Elderly
Effectiveness of a Program Using Video Games Associated With Conventional Physiotherapy in Physical Functioning in Frail Elderly Compared to Conventional Physiotherapy
Frailty is a highly prevalent condition, reaching approximately 7% to 30% of older adults aged from 65 up to 80 years [2]. Although exercises seemed to be beneficial for the frail elders, there is still insufficient evidence to…
- Trial name
- NCT02333214
- Testing
- Exergames and conventional physiotherapy, Conventional physiotherapy
- Where
- Brazil
- Volunteers
- 82 people
- Sponsor
- Universidade Cidade de Sao Paulo
Frailty, Frail Elderly Syndrome
Protocol for Multi-site Evaluation of New Community-based Frailty Programme
Background: Frailty is increasing in prevalence internationally with population ageing. Frailty can be managed or even reversed through community-based interventions delivered by a multi-disciplinary team of professionals, but to…
- Conditions
- Frailty, Frail Elderly Syndrome, Frailty Syndrome
- Trial name
- NCT04866316
- Testing
- There is no active intervention as this is a service evaluation
- Where
- Singapore
- Volunteers
- 335 people, healthy volunteers welcome
- Sponsor
- Geriatric Education and Research Institute
COVID, Social Isolation
First Level Socio-geriatric Evaluation: ESOGER Databank
Coronavirus disease 2019 (COVID-19) is an infectious disease. Physical distancing is one of the most effective ways to reduce the spread of COVID-19, but this key prevention intervention may have adverse consequences on older…
- Conditions
- COVID, Social Isolation, Anxiety, Frailty
- Trial name
- NCT04393649
- Testing
- ESOGER
- Where
- Canada
- Volunteers
- 20,000 people
- Sponsor
- Jewish General Hospital
Chronic Liver Disease and Cirrhosis
Effectiveness of Nurse-led Physical Therapy in Terms of Patient Competency, Patient Engagement and Physical Performance.
Due to Prolonged diseased Condition, Patients are not able to care for themselves and even avoid movement their range of motion is limited which may develop frailty among Liver disease Patients.
- Trial name
- NCT05376826
- Testing
- Nurse Led Physical Therapy
- Where
- India
- Volunteers
- 80 people
- Sponsor
- Institute of Liver and Biliary Sciences, India
Cardiovascular Diseases, Frailty
Managing Frailty Through Mobilization in Males and Female Inpatients With Cardiovascular Disease
Frailty describes the overall health of a person. Inpatients with cardiovascular problems have a higher risk for frailty - or the sick are more likely to get sicker - causing longer hospital stays, hospital readmission, and…
- Trial name
- NCT06810661
- Testing
- Mobility promotion
- Where
- Canada
- Volunteers
- 60 people
- Sponsor
- Université de Sherbrooke
Frailty, Sedentary Behavior
Stand if You Can: A Standing Intervention in Long Term Care
It is currently unknown if reducing sitting time, an activity that is highly prevalent in frail older adults living in long term care (LTC) facilities, is associated with an improvement in physical capacity such as walking speed.
- Conditions
- Frailty, Sedentary Behavior, Physical Disability
- Trial name
- NCT03796039
- Testing
- Standing
- Where
- Canada
- Volunteers
- 97 people, healthy volunteers welcome
- Sponsor
- University of New Brunswick
Frailty at Older Adults
Preventing Frailty in Hospital Through Mobilizing
Frailty describes the variability in aging and explains why two people of the same chronological age may look very different. Higher frailty leads to poor quality of life, disability, and death.
- Trial name
- NCT06802289
- Testing
- Mobility promotion
- Where
- Canada
- Volunteers
- 80 people
- Sponsor
- Université de Sherbrooke
Ovarian Cancer, Frailty
FRAGINOC Study: Screening and Geriatric Assessment and Intervention in Older Patients With Epithelial Ovarian Cancer
Ovarian cancer (OC) is the fifth most common cause of cancer death. More than 40% are older than 70 years. The standard treatment is radical surgery combined with chemotherapy.
- Trial name
- FRAGINOC (NCT05810701)
- Testing
- Comprehensive geriatric assessment and individualised physical training
- Where
- 5 sites in Denmark
- Volunteers
- 300 people
- Sponsor
- Odense University Hospital
Functionality, Fragility
IMPACT OF A MULTICOMPONENT PHYSICAL EXERCISE PROGRAM ON THE FUNCTIONAL CAPACITY OF PATIENTS ADMITTED TO AN INTERMEDIATE CARE HOSPITAL. VIVIFRAIL FOR A BETTER VIG-FRAIL.
INTRODUCTION Physical exercise in frail individuals has demonstrated benefits in variables such as reduced mortality risk and improved frailty and quality of life.
- Trial name
- NCT07637383
- Testing
- vivifrail
- Where
- Spain
- Volunteers
- 120 people
- Sponsor
- Fundacio d'Investigacio en Atencio Primaria Jordi Gol i Gurina
Frail Elderly, Fall Risk
Functional Changes and Fall Risk in Older Adults Participating in a Frailty Program
This prospective observational study aims to describe changes in physical function and fall risk in adults aged 70 years and older participating in a routine multicomponent frailty and falls prevention program in primary care.
- Trial name
- FRAIL-ALAMA (NCT07572851)
- Testing
- Multicomponent Exercise Program- 1 times per week., Multicomponent Exercise Program- 2 times per week.
- Where
- Spain
- Volunteers
- 56 people
- Sponsor
- University of Vigo
Sarcopenia, Acute Lymphoblastic Leukemia
Physical Activity and Exercise During Early Treatment Phases for Childhood Acute Lymphoblastic Leukaemia to Protect Against Muscle Loss and Improve Frailty Outcomes
This is a small trial testing out a new approach before doing a bigger study. Researchers are observing a group of children/adolescents (ages 5-17) with acute lymphoblastic leukemia (ALL) and testing a physical activity and…
- Trial name
- PROTECT (NCT07325305)
- Testing
- Exercise
- Where
- Australia
- Volunteers
- 60 people
- Sponsor
- Murdoch Childrens Research Institute