Clinical trials: Physical Frailty
Frailty, Cognitive Decline
Precision Stratification for Frailty and Cognitive Decline
The Care4Senior mobile Application, Intensive Aerobic Resistance Training and Brain Health (CIRTAB) trial aim to test the effectiveness of an exercise, cognitive and lifestyle intervention amongst older adults over a 12-weeks…
- Trial name
- NCT07081282
- Testing
- Care4Senior mobile Application, Intensive Aerobic Resistance Training and Brain Health (CIRTAB), Centre-Based Exercise Health Session
- Where
- Singapore
- Volunteers
- 252 people, healthy volunteers welcome
- Sponsor
- National University of Singapore
Balance Disorders, Accidental Falls
Population Cohort Set-up for the Epidemiological Assessment of Balance Disorders in Elderly People
As people age, it becomes more common to experience balance problems. These issues can increase the risk of falling, which may lead to serious health consequences and loss of independence.
- Conditions
- Balance Disorders, Accidental Falls, Frailty, Aging
- Trial name
- EPIBAS (NCT06965660)
- Where
- Spain
- Volunteers
- 1,300 people, healthy volunteers welcome
- Sponsor
- Fundacio d'Investigacio en Atencio Primaria Jordi Gol i Gurina
Physical Frailty, Mild Cognitive Impairment (MCI)
Effects of Music-with-Movement on Cognitive and Physical Performance of People With Potentially Reversible Cognitive Frailty: a Randomised Controlled Trial
This study aims to evaluate the effects of Music-with-Movement Simultaneous Cognitive-Motor Dual-Task Training (MM-SDTT) on cognitive and physical performance in older adults with cognitive frailty coexisting with mild cognitive…
- Conditions
- Physical Frailty, Mild Cognitive Impairment (MCI), Cognitive Frailty
- Trial name
- NCT06791720
- Testing
- music-based cognitive-motor dual-task training/exercise, Social Gatherings
- Where
- Hong Kong
- Volunteers
- 113 people
- Sponsor
- The Hong Kong Polytechnic University
Frailty
Effects of Exercise Interventions in Frail Middle-aged and Older Adults
This study aimed to determine the ideal parameters of exercise program for frail middle-aged and older adults on physical and mental functions.
- Trial name
- NCT05279625
- Testing
- exercise training
- Where
- Taiwan
- Volunteers
- 200 people
- Sponsor
- Taipei Veterans General Hospital, Taiwan
Effects of Chemotherapy, Aging
Aging and Frailty Study
The purpose of this research study is to compare methods to help personalize the prediction of chemotherapy side effects for older adults and to evaluate whether chemotherapy causes changes in the body that are associated with…
- Conditions
- Effects of Chemotherapy, Aging, Frailty
- Trial name
- NCT05268991
- Testing
- Geriatric Assessments and Frailty Indices
- Where
- United States
- Volunteers
- 25 people
- Sponsor
- Wake Forest University Health Sciences
Gynecologic Cancer, Frailty
Frailty Assessments for Risk Assessment in Gynecologic Oncology Patients
FARGO is a prospective cohort study that aims to determine the performance of preoperative frailty assessment based on the Frailty Phenotype (FP), compared to a perioperative cardiovascular risk assessment based on the…
- Conditions
- Gynecologic Cancer, Frailty, Oncology
- Trial name
- FARGO (NCT05738252)
- Testing
- Clinical Frailty Scale, Frailty Phenotype
- Where
- 4 sites in Canada
- Volunteers
- 280 people
- Sponsor
- Population Health Research Institute
Frailty
Inter-rater Reliability of the Clinical Frailty Scale in a Swedish Emergency Department Setting
Frailty is a common clinical syndrome in older adults, which may be assessed through various assessment tools. One frequently used tool is the Clinical Frailty Scale (CFS) which potentially can be adopted for daily use in the…
- Trial name
- NCT04869878
- Where
- Sweden
- Volunteers
- 100 people
- Sponsor
- University Hospital, Linkoeping
Frail Elderly Subjects
Omega-3 Fatty Acids and/or Multi-domain Intervention in the Prevention of Age-related Cognitive Decline
Epidemiological and fundamental research carried out in recent years has highlighted the role played by omega-3 fatty acids in the process of cognitive decline that accompanies advancing age and Alzheimer's disease.
- Trial name
- MAPT (NCT00672685)
- Testing
- omega-3, multi-domain intervention
- Where
- 13 sites in France, Monaco
- Volunteers
- 1,680 people
- Sponsor
- University Hospital, Toulouse
Dementia
Adherence by Music to Exercise in Dementia: Group Therapy
The aim of this study is to asses the effect of a music and video-based group exercise therapy on motivation, physical functioning, cognition and well-being in older adults with moderate dementia.
- Trial name
- AMUSED (NCT05603533)
- Testing
- Music and video-based group exercise therapy
- Where
- 4 sites in Belgium
- Volunteers
- 75 people
- Sponsor
- Hasselt University
Frailty, Nursing Home Residents
The Effect on Function of Increasing Activity for Nursing Home Residents
As designs of existing outcome studies are disparate and do not always relate well to a Swedish context, the need for further studies is obvious.
- Trial name
- NCT00218842
- Testing
- Individualized exercise
- Where
- Norway
- Volunteers
- 125 people
- Sponsor
- Norwegian University of Science and Technology
Colorectal Neoplasms, Frailty
Effect of CGA for Frail Elderly Patients Operated for Colorectal Cancer - The CRC Frailty-study
This multicentre randomized controlled trial aims to investigate whether an individualized comprehensive geriatric assessment (CGA) and care will improve postoperative results in frail elderly patients undergoing surgery for…
- Conditions
- Colorectal Neoplasms, Frailty, CGA
- Trial name
- NCT04358328
- Testing
- Comprehensive geriatric assessment (CGA) and care, Standard care
- Where
- 2 sites in Sweden
- Volunteers
- 340 people
- Sponsor
- Sahlgrenska University Hospital
Home Care Services, Hospital-Based, Frailty
Rockwood Frailty Index and Survival in Hospital-at-Home Patients
Frailty is a key determinant of prognosis in older adults with complex chronic conditions and in palliative care settings. The Rockwood Frailty Index (RFI), based on the accumulation of health deficits, has demonstrated…
- Conditions
- Home Care Services, Hospital-Based, Frailty, Mortality, Palliative Care
- Trial name
- DOMMOR (NCT07529470)
- Testing
- Patients identified and followed in this cohort received scheduled supportive telephone calls every two weeks if classified in the oncologic palliative care group, and once monthly in the case of comp
- Where
- Spain
- Volunteers
- 2,610 people
- Sponsor
- Instituto de Investigacion Sanitaria La Fe
Frailty, Frailty Syndrome
Smart Home Technologies for Assessing and Monitoring Frailty in Older Adults
This project aims to address the impact of frailty on older adults, particularly its connection to cognitive impairments such as dementia.
- Conditions
- Frailty, Frailty Syndrome, Frail Elderly Syndrome, Pre-Frailty
- Trial name
- NCT05961319
- Testing
- Smart-Home Monitoring
- Where
- 2 sites in Canada
- Volunteers
- 21 people, healthy volunteers welcome
- Sponsor
- University of Alberta
Diabetes Mellitus
Effect of Thera-Band Elastic Band-Assisted Progressive Resistance Training on Physical Health in Diabetes Patients with Frailty Syndrome
Goal: The goal of this clinical trial is to evaluate the effectiveness of Thera-Band elastic band-assisted progressive resistance training (PRT) in improving physical health and reducing frailty in older adults with diabetes…
- Trial name
- NCT06658106
- Testing
- Thera-Band Elastic Band-Assisted Progressive Resistance Training, Conventional Diabetes Management
- Where
- China
- Volunteers
- 96 people
- Sponsor
- Zhejiang Rongjun Hospital
Frailty Syndrome, Respiratory Muscle Weakness
Longitudinal Ultrasound Assessment of Diaphragmatic and Respiratory Muscle Function Following Respiratory Muscle Training in Frail Older Adults
This study aims to evaluate the effects of an 8-week inspiratory muscle training program on diaphragmatic and respiratory muscle function in frail older adults aged 80 years and above.
- Conditions
- Frailty Syndrome, Respiratory Muscle Weakness, Age-Related Frailty, Geriatric Health
- Trial name
- IMT-1 (NCT07258615)
- Testing
- Inspiratory Muscle Training
- Where
- Spain
- Volunteers
- 30 people
- Sponsor
- Universidad Francisco de Vitoria
Frailty, Sarcopenia
Frailty and Muscle Strength Tests in Older Adults Undergoing Major Surgery
The goal of this observational study is to learn if simple tests for frailty and muscle strength can help predict which older adults (age 65 and older) are at higher risk for problems after major abdominal surgery.
- Conditions
- Frailty, Sarcopenia, Sarcopenia in Elderly, Muscle Strength
- Trial name
- NCT06988176
- Testing
- Frailty assessment, nutrition assessment, cognition assessment, muscle strength testing
- Where
- United States
- Volunteers
- 100 people
- Sponsor
- University of North Carolina, Chapel Hill
ESRD, Cardiovascular Diseases
The Impact of Statin Holiday in Dialysis Patients Over 70 Years Old on Mental Function, Physical Function and Frailty
Patients who are on chronic dialysis and 70 and older are frequently on multiple medications including statins. However, the benefit of statins in dialysis patient population is uncertain.
- Trial name
- NCT03663049
- Testing
- discontinue statin
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- Loyola University
HIV-1-infection, Frailty
Tesamorelin as an Adjunct to Exercise for Improving Physical Function in HIV
People with HIV experience earlier impairments in physical function compared to people in the general population. They also exhibit an earlier presentation and more rapid development of frailty, a multisystemic syndrome of aging…
- Conditions
- HIV-1-infection, Frailty, Impaired Physical Function, Abdominal Obesity
- Trial name
- TRIUMPH (NCT06554717)
- Testing
- Tesamorelin, Exercise
- Where
- 2 sites in United States
- Volunteers
- 100 people
- Sponsor
- Massachusetts General Hospital
Cancer
Frailty Study of Older Adults Getting Chemotherapy and Radiation Therapy
The investigators hypothesize that frailty assessment prior to concurrent chemotherapy and radiation therapy in the elderly will predict treatment-related toxicity and morbidity and that such assessment at serial time points will…
- Trial name
- NCT01808833
- Where
- United States
- Volunteers
- 4 people
- Sponsor
- The University of Texas Health Science Center at San Antonio
Frailty, Comprehensive Geriatric Assessment
The Impact of Domiciliary Versus 'Hub' Based Comprehensive Geriatric Assessment on Clinical and Process Outcomes Among Older Adults Attending Community Specialist Teams: a Randomised Controlled Trial.
The investigators plan to implement a randomised controlled trial to examine the impact of domiciliary (home based) versus 'hub-based' Comprehensive Geriatric Assessment (CGA) on clinical and process outcomes among older adults…
- Conditions
- Frailty, Comprehensive Geriatric Assessment, Older Adults, Domiciliary Care
- Trial name
- NCT06205238
- Testing
- CGA
- Where
- Ireland
- Volunteers
- 106 people
- Sponsor
- University of Limerick