Clinical trials: Physical Frailty
Sarcopenia, Frailty
Health Data from Well on My Legs Program
The percentage of people aged over 80 will double in 25 years, reaching 10% of the population. This means that care practices for older adults will have to be adapted.
- Conditions
- Sarcopenia, Frailty, Physical Inactivity, Fear
- Trial name
- DS-BSSJ (NCT06659484)
- Testing
- Assessment, Multicomponent exercise program, Follow-up at T3 + 6 months and T3 + 12 months
- Where
- France
- Volunteers
- 1,600 people, healthy volunteers welcome
- Sponsor
- Hospices Civils de Lyon
Tumor, Health Services Research
Care Pathways and Disparities in Care for Older Patients With Cancer: Typology, Determinants and Effect on Prognosis ( PASSAGE )
More than half of new cases of cancer in Europe in 2022 occurred in people aged over 70. In addition to cancer, the majority of older people have one or more illnesses that may interact with the treatment decision, cancer…
- Conditions
- Tumor, Health Services Research, Causality, Geriatric Assessment
- Trial name
- PASSAGE (NCT07092800)
- Where
- France
- Volunteers
- 75,000 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Falls, Old Age; Debility
Elastic Band Resistance Training on Physical Fitness and Risk of Falls in Elderly.
A lack of studies has applied elastic band resistance training exercises on hospitalized elderly, so the effect of elastic band resistance training exercises on physical fitness and risk of falls was unclear.
- Conditions
- Falls, Old Age; Debility, Hospitalisation, Resistance Training
- Trial name
- NCT05462015
- Testing
- elastic-band exercises, regular rehabilitation
- Sponsor
- Taipei Medical University
Heart Failure, Sarcopenia
Multivariate Biomarker Study for Sarcopenia in Heart Failure
In the United Kingdom, heart failure (HF) affects about 900,000 people with 60,000 new cases annually. Up to 60% of people living with HF also experience sarcopenia, known as loss of muscle mass and strength.
- Conditions
- Heart Failure, Sarcopenia, Muscle Weakness, Body Weight
- Trial name
- NCT06217640
- Testing
- Dual X Ray Absorptiometry
- Where
- United Kingdom
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- University of Liverpool
Fraility, Risk of Falling
Physical Activity Monitoring in Frailty and Falling
BioSensics has developed a Physical Activity Monitoring System (PAMSys) that consists of a single wearable motion sensor that is worn on the torso.
- Trial name
- NCT01880229
- Where
- 2 sites in United States
- Volunteers
- 180 people, healthy volunteers welcome
- Sponsor
- BioSensics
Frailty, Sarcopenia
Comprehensive Geriatric Assessment in Adults Aged 40 Years and Older Living With HIV
People living with HIV are experiencing longer life expectancy due to effective antiretroviral therapy; however, they may develop age-related conditions earlier than the general population.
- Trial name
- HIV-AGE40 (NCT07453303)
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Sehit Prof. Dr. Ilhan Varank Sancaktepe Training and Research Hospital
Chronic Kidney Disease Stage 5, Chronic Kidney Disease Stage 4B
Prognostic Value of a Multidimensional Assessment for Survival in Elderly Patients With CKD 4B/5
The aim of this study is to determine a multidimensional signature (integrating frailty and patient-reported outcomes measures (PROMs) at entry into stage 4B/5 CKD) to improve prediction of renal death (dialysis, transplantation…
- Trial name
- PROFILER (NCT06825234)
- Where
- 2 sites in France
- Volunteers
- 390 people
- Sponsor
- Centre Hospitalier Universitaire de Besancon
Frailty at Older Adults
Enhancing Physical Reserve to Promote Resilience in Physically Frail Older Adults
The goal of this clinical trial is to assess the efficacy of combined aerobic and resistance training in enhancing physical reserve in older adults with physical frailty.
- Trial name
- MRI exercise (NCT07513701)
- Testing
- Aerobic and resistance training, Usual Care
- Where
- Hong Kong
- Volunteers
- 224 people
- Sponsor
- The Hong Kong Polytechnic University
Cognitive Impairment, Alzheimer Disease
The SINgapore GERiatric Intervention Study to Reduce Cognitive Decline and Physical Frailty (SINGER) Study
A study in Finland found that a multidomain intervention of physical activity, nutritional guidance, cognitive training, social activities and management of vascular risk factors slowed cognitive decline in healthy older adults…
- Conditions
- Cognitive Impairment, Alzheimer Disease, Vascular Cognitive Impairment, Dementia
- Trial name
- SINGER (NCT05007353)
- Testing
- Structured Lifestyle Intervention, Self-Guided Intervention
- Where
- 3 sites in Singapore
- Volunteers
- 1,212 people, healthy volunteers welcome
- Sponsor
- National University of Singapore
Frailty, Older Adults
The Oral Symptom Assessment Scale in Older Patients With Frailty
Oral (or mouth) symptoms are common in older patients who live with frailty. It is known that frailty describes someone's overall resilience and how this relates to the chances of recovery following a health problem.
- Trial name
- NCT06286982
- Testing
- Oral Symptom Assessment Scale
- Where
- 2 sites in Ireland
- Volunteers
- 250 people
- Sponsor
- Our Lady's Hospice and Care Services
Aging, Sedentary Lifestyle
Nitrites, Skeletal Muscle Mitochondrial Bioenergetics, and Physical Activity in Old Age
This 2-site randomized double blinded controlled trial is to confirm and more definitively clarify the impact of a 12-week course of nitrite versus placebo on mitochondrial bioenergetics in older sedentary adults.
- Conditions
- Aging, Sedentary Lifestyle, Frailty
- Trial name
- Nitrite (NCT04405180)
- Testing
- 20mg sodium nitrite tid
- Where
- United States
- Volunteers
- 64 people
- Sponsor
- Gladwin, Mark, MD
Sedentary Time, Frailty
The Sedentary to Active Rising to Thrive (START) Trial
The goal of this behavioral clinical trial is to compare two different ways of becoming less sedentary and more active in 60 older adults at elevated risk of becoming frail.
- Trial name
- START (NCT06023680)
- Testing
- Continuous sedentary reduction intervention, Bouted sedentary reduction intervention
- Where
- 2 sites in United States
- Volunteers
- 61 people, healthy volunteers welcome
- Sponsor
- Johns Hopkins Bloomberg School of Public Health
HIV-1 Infection
PREPARE (A5361s) Ancillary Study of REPRIEVE (A5332)
Aging with HIV is associated with earlier development of frailty (weakness) or disability, including loss of physical and muscle strength, and walking speed.
- Trial name
- PREPARE (NCT03070223)
- Testing
- Pitavastatin
- Where
- 31 sites in United States, Puerto Rico
- Volunteers
- 602 people
- Sponsor
- Advancing Clinical Therapeutics Globally for HIV/AIDS and Other Infections
Self Care, Heart Failure
Self-care in Older Frail Persons With Heart Failure Intervention
The overall purpose of the randomized controlled study is to evaluate the effects of physical exercise, nutrition and symptom management on physical capacity in older, frail persons with heart failure.
- Conditions
- Self Care, Heart Failure, Frailty
- Trial name
- SOPHI (NCT05009706)
- Testing
- Self-care in Older frail Persons with Heart failure Intervention (SOPHI)
- Where
- Sweden
- Volunteers
- 212 people
- Sponsor
- Karolinska Institutet
Cirrhosis, Liver
Comparison of the Effect of Two Interventions on Liver Frailty Index in Pre-frail and Frail Cirrhotic Patients Enlisted for Liver Transplantation
The goal of this prospective, double blind randomized clinical trial is to compare the effectiveness of two interventions in improve frailty (measured by Liver Frailty Index) and quality of life (measured by Chronic Liver Disease…
- Trial name
- NCT06149026
- Testing
- Physical and nutritional therapy
- Where
- Chile
- Volunteers
- 80 people
- Sponsor
- Pontificia Universidad Catolica de Chile
Physical Activity, Elderly
Physical and Cognitive Exercises in Nursing Homes: Is Frailty Reversible?
Elderly in residential care spend 97% of their time sedentary. Moreover, exercise therapy often takes place in a poorly stimulating environment which is less motivational for the elderly to undertake regularly.
- Trial name
- NCT03526653
- Testing
- exercise without visual stimuli, excercise with National Geografics, Exercise with MemoRide
- Where
- Belgium
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- Hasselt University
Intellectual Frailty of Aging, Cardiovascular Diseases
Assessment of Frailty as a Risk Factor for Cardiac and Vascular Surgery
The purpose of this study is to assess the impact of frailty as a multidimensional risk factor on the outcomes of adult cardiac and vascular surgery.
- Conditions
- Intellectual Frailty of Aging, Cardiovascular Diseases, Myocardial Infarction, Vascular Diseases
- Trial name
- NCT02224222
- Where
- Hungary
- Volunteers
- 300 people
- Sponsor
- Semmelweis University Heart and Vascular Center
Hepatocellular Cancer
Assessment of Frailty in Patients With Advanced Hepatocellular Cancers
This study is looking at the feasibility of performing frailty assessments on patients with advanced hepatocellular cancer.
- Trial name
- FAC-L (NCT02482259)
- Where
- United Kingdom
- Volunteers
- 28 people
- Sponsor
- Newcastle-upon-Tyne Hospitals NHS Trust
Frailty, Aging
Community-Based Multicomponent Exercise and Recreational Programme for Older Adults
This quasi-experimental, non-randomized controlled evaluation examined whether participation in ELDERPLAY, a community-based programme combining Vivifrail-based multicomponent exercise with adapted traditional games, was…
- Conditions
- Frailty, Aging, Physical Functional Performance, Postural Balance
- Trial name
- ELDERPLAY (NCT07864831)
- Testing
- ELDERPLAY multicomponent exercise and recreational programme
- Where
- Spain
- Volunteers
- 184 people, healthy volunteers welcome
- Sponsor
- Universidad de Murcia
Frailty
Multifactorial Intervention on Frailty in Vulnerable Older Adults
Frailty is a highly prevalent, progressive condition in older adults that is characterized by multisystem physiologic impairments and vulnerability to stressful events, leading to increased risk of geriatric conditions…
- Trial name
- ASPRA-IS (NCT02554994)
- Testing
- Multifactorial intervention, Usual care
- Where
- 2 sites in South Korea
- Volunteers
- 187 people
- Sponsor
- Asan Medical Center