Clinical trials: Physiologic Changes
Fatigue
Fatigue and Kinematics During Isometric Activity of the Upper Limbs in Young and Older Adults
The aim of this study is to understand the relationship between perceived effort and physiological and kinematic variables caused by isometric activity of the upper limbs, as well as its relationship with socio-demographic…
- Trial name
- NCT04938791
- Testing
- Isometric activity
- Where
- Portugal
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Escola Superior de Saude da Cruz Vermelha Portuguesa - Lisboa
Sepsis, Severe Sepsis
Control of Fever in Septic Patients
The benefits of fever treatment in critically ill patients remains unclear. The aim of the prospective, randomized clinical trial was to verify the hypothesis that the administration of ibuprofen in order to decrease the fever in…
- Conditions
- Sepsis, Severe Sepsis, Septic Shock
- Trial name
- COVERSEP (NCT04227652)
- Testing
- Ibuprofen administration
- Where
- Czechia
- Volunteers
- 140 people
- Sponsor
- University Hospital Ostrava
Physiologic Changes
Creating an Artificial Night on Physiological Changes in Preterm Infants
Effects of creating an artificial night on physiological changes, weight and feeding tolerance in preterm infants. Introduction:Nowdays,with medical advances in intensive care increased chance of survival in premature infants.One…
- Trial name
- NCT01833091
- Testing
- artificial night
- Volunteers
- 38 people, healthy volunteers welcome
- Sponsor
- Mashhad University of Medical Sciences
Mucosal Congestion
Changes in Nasal Patency With Changes in Posture, Temperature, Humidity and Nasal Patency Seen by Acoustic Rhinometry
To study nasal physiologic responses to changes in posture, temperatures, humidity and nasal patency with acoustic rhinometry.
- Trial name
- NCT00147888
- Testing
- Acoustic rhinometry (procedure)
- Where
- United States
- Volunteers
- 15 people, healthy volunteers welcome
- Sponsor
- University of Chicago
Body Temperature Changes, Heat Stress
Consecutive Occupational Heat Exposure With and Without Overnight Cooling
Extreme heat events are becoming more frequent, intense, and prolonged, increasing the risk of heat-related illness among workers exposed to hot environments.
- Conditions
- Body Temperature Changes, Heat Stress, Heat Exposure, Heat Fatigue
- Trial name
- NCT07656519
- Testing
- Simulated occupational heat exposure with recovery at recommended indoor temperature limit, Simulated occupational heat exposure with recovery in an overheated indoor environment
- Where
- Canada
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- University of Ottawa
Erectile Dysfunctions, Endothelial Dysfunction
The Predictive Value of Modified EASIX Score for Determining Erectile Dysfunction Severity
This retrospective single-center case-control study evaluates whether the Modified EASIX score (LDH × CRP / Platelets), calculated from routine blood tests, predicts severity of erectile dysfunction (ED) as measured by the IIEF-5…
- Conditions
- Erectile Dysfunctions, Endothelial Dysfunction, Inflammation
- Trial name
- NCT07274982
- Testing
- IIEF-5, mEASIX
- Where
- Turkey (Türkiye)
- Volunteers
- 380 people
- Sponsor
- Ataturk University
Colonization, Asymptomatic, Colonization
Probiotic Delivered to the Small Intestine Changes Microbiota
This study will determine whether encapsulation of probiotic bacteria using natural plant protein can enhance bacterial colonisation.
- Trial name
- Probiotic (NCT07510282)
- Testing
- Probiotic containing L.rhamnosus R0011 strain, 200 ml yogurt drink
- Volunteers
- 25 people, healthy volunteers welcome
- Sponsor
- University College Dublin
Bipolar Disorder I, Bipolar Disorder II
PSYCHE (Personalised Monitoring SYstems for Care in Mental Health)
For the moment, the detection of a mood episode in Bipolar Disorder (BD) relies on the appearance of the first clinical signs that the clinician detect or that the patient becomes aware of and reports to the clinician.
- Conditions
- Bipolar Disorder I, Bipolar Disorder II, Rapid Cycling Bipolar Disorder(DSM-IV-TR)
- Trial name
- PSYCHE (NCT01879982)
- Where
- France
- Volunteers
- 8 people
- Sponsor
- University Hospital, Strasbourg, France
Skin Cancer
A Pilot Study to Evaluate Optical Spectroscopy of Pigmented Skin Lesions
The incidence of malignant melanoma has increased dramatically in recent decades. In 1930, the lifetime risk of an individual in the United States developing melanoma was 1 in 1,500.
- Trial name
- NCT00633516
- Testing
- Optical Spectroscopy
- Where
- 2 sites in United States
- Volunteers
- 37 people, healthy volunteers welcome
- Sponsor
- University of California, Irvine
Spinal Cord Injury, Spinal Cord Injuries
Testosterone Therapy With or Without Finasteride After Spinal Cord Injury: TRT-SCI Trial
Spinal cord injury (SCI) results in lower limb muscle loss, bone loss, and high fat mass that impede the recovery of physical function, increase bone fracture risk, and worsen health and quality of life.
- Conditions
- Spinal Cord Injury, Spinal Cord Injuries, Injuries, Spinal Cord, Spinal Cord Contusion
- Trial name
- TRT-SCI (NCT07742553)
- Testing
- testosterone cypionate, finasteride
- Where
- 4 sites in United States
- Volunteers
- 300 people
- Sponsor
- VA Office of Research and Development
Multiple Sclerosis
Ocrelizumab Effects on Physiological and Cognitive Changes in Multiple Sclerosis
This is a Phase IV, prospective, open-label, single-center, observational, longitudinal, single blinded study. The investigators will examine the effects of Ocrelizumab on cognitive, patient reported outcomes (PROs), quality of…
- Trial name
- NCT03025269
- Testing
- Ocrelizumab
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- University at Buffalo
The Effect of Head Massage Therapy on the Autonomic Nervous System
The Effect of Head Massage Therapy on the Regulation of the Autonomic Nervous System
The autonomic nervous system (ANS) unconsciously regulates the activities of vital organ systems such as the respiratory, circulatory, and urinary systems.
- Trial name
- NCT02215486
- Testing
- Head Massage Therapy, Simple relaxation (No Head Massage)
- Where
- Canada
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- Children's & Women's Health Centre of British Columbia
Depression, Schizophrenia
Repetitive Transcranial Magnetic Stimulation (rTMS) and P50 Evoked Potential Component
The repetitive transcranial magnetic stimulation (rTMS) is a recent technique that has demonstrated its efficiency in both depression and schizophrenia.
- Trial name
- rTMS-P50 (NCT01466439)
- Testing
- high-frequency of repetitive transcranial magnetic stimulation (rTMS), low frequency of repetitive transcranial magnetic stimulation (rTMS)
- Where
- France
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- University Hospital, Caen
Trauma Chest, Mechanical Ventilation
Ventilation dIstribution and effeCt of posTural Lateralization On Traumatic Lung injuRY: a Physiological Study
This is a single-center, prospective, physiological study. The study will enroll the traumatic lung injury patient who has at least 2 rib fractures requiring mechanical ventilation being on partially assisted breathing mode and…
- Trial name
- VICTORY (NCT06196125)
- Testing
- Four body positions
- Where
- Canada
- Volunteers
- 24 people
- Sponsor
- Unity Health Toronto
Weight Loss, Reflux
Mechanism of Weight Loss After Endoscopic and Laparoscopic Sleeve Procedures
The purpose of this research study is to understand the mechanism of weight loss for weight loss procedures: that is Laparoscopic sleeve gastrectomy and Endoscopic sleeve Gastroplasty.
- Trial name
- NCT04006002
- Testing
- Metabolic and Hormonal profile
- Where
- United States
- Volunteers
- 4 people, healthy volunteers welcome
- Sponsor
- Northwell Health
Type 1 Diabetes (T1D)
Clinical Trial for the Study of Stress and Exercise Impact on Glucose Levels and Additional Physiological Signals. Stress, Insulin and Exercise Study: a Trial in Argentina
The study lasted 28 days. During the study period, participants completed two structured aerobic exercise sessions (days 4 and 18), two structured resistance exercise sessions (days 11 and 25), and four structured stress tests…
- Trial name
- SIESTA (NCT07865923)
- Testing
- Structured Aerobic Exercise, Structured Resistance Exercise, Stress Test
- Where
- Argentina
- Volunteers
- 5 people
- Sponsor
- National Council of Scientific and Technical Research, Argentina
Vaccine Reaction
(VIII): The Eight Study and Immunologic Response Sub-study
The study's objective is to test the hypothesis that immune system activation and subsequent systemic inflammation can be detected through continuously tracking multiple bio signals including physiologic variables (ECG, skin…
- Trial name
- NCT05237024
- Where
- 2 sites in United States, Canada
- Volunteers
- 130 people, healthy volunteers welcome
- Sponsor
- physIQ, Inc.
Bradycardia
Effectiveness of Pacemaker With Closed Loop Stimulation Compared to Pacemakers With and Without Standard Rate Response
This is a randomized, prospective, single-blinded, multi-center study involving approximately 1500 patients at 100 centers. The purpose of this study is to demonstrate the effectiveness of Closed Loop Stimulation (CLS) rate…
- Trial name
- CLEAR (NCT00355797)
- Testing
- Closed Loop Stimulation (CLS), Standard Rate Adaptive (R) Technology, Non-rate adaptive (DDD) pacing
- Where
- 99 sites in United States
- Volunteers
- 1,491 people
- Sponsor
- Biotronik, Inc.
Retinal Vascular
Physiologic Changes of Posterior Ocular Segment During the Menstrual Cycle
Changes of luteinizing hormone (LH), estrogen and progesterone during the menstrual cycle influence the ocular physiology in both anterior and posterior segments.
- Trial name
- NCT04731207
- Testing
- Optovue®
- Where
- Thailand
- Volunteers
- 39 people, healthy volunteers welcome
- Sponsor
- Khon Kaen University
Impotence
Assessment Of Duration Of Action, Safety & Toleration Of UK369,003 and Cialis In Patients With Erectile Dysfunction
Assessment of duration of action, safety \& toleration of different formulations and doses of UK-369,003 and Cialis in patients with male erectile dysfunction.
- Trial name
- NCT00174486
- Testing
- UK0369,003, Cialis (Tadalafil)
- Volunteers
- 300 people
- Sponsor
- Pfizer