Clinical trials: Physiopathology
Cervical Dysfunction
Palpatory and Ultrasound Assessment of Cervical Dysfunctions and the Effect of Cervical High Velocity Low Amplitude (HVLA) Technique
Osteopathic medicine is a distinct school of medicine. Osteopathic physicians evaluate the neuromusculoskeletal system and work to achieve normal body mechanics. They use palpation to identify somatic dysfunctions.
- Trial name
- NCT02249858
- Testing
- Cranial Vault Hold, Cervical HVLA
- Where
- United States
- Volunteers
- 51 people, healthy volunteers welcome
- Sponsor
- New York Institute of Technology
Presbycusis, Bilateral, Alzheimer Disease 2 Due to Apoe4 Isoform
Hearing Aid and Individuals With Cognitive Disorders
This is a pilot study with the aim of evaluating the feasibility of the procedures of a future clinical trial that will help determine the impacts of hearing aid interventions on older patients with Alzheimer's Disease and…
- Conditions
- Presbycusis, Bilateral, Alzheimer Disease 2 Due to Apoe4 Isoform, Mild Cognitive Impairment
- Trial name
- NCT04049643
- Testing
- Audiologist-based fitting, Service-only Fitting, Device-only fitting
- Where
- 2 sites in United States
- Volunteers
- 17 people
- Sponsor
- Yu-Hsiang Wu
Heart Failure, Left Ventricular Dysfunction
Resynchronization for Ambulatory Heart Failure Trial - LV Endocardial
This trial will compare two strategies for patients with Heart Failure, Left Ventricular systolic dysfunction, and intermediate QRS durations. The control group is conventional CRT. The experimental group is LVendo CRT
- Trial name
- RAFT-LVendo (NCT02757976)
- Testing
- Conventional CRT, LV endocardial CRT
- Where
- 11 sites in Canada
- Volunteers
- 8 people
- Sponsor
- London Health Sciences Centre Research Institute OR Lawson Research Institute of St. Joseph's
Heart Failure, Diastolic
Noninvasive Neuromodulation to Reserve Diastolic Dysfunction
This is a 2x2 cross over pilot study using low level transcutaneous vagus nerve stimulation (LLTS) to reverse diastolic dysfunction in patients with diastolic dysfunction.
- Trial name
- NERDD (NCT02983448)
- Testing
- transcutaneous vagus nerve stimulation
- Where
- United States
- Volunteers
- 24 people
- Sponsor
- University of Oklahoma
Ovarian Hyperstimulation Syndrome
Management of Ovarian Hyperstimulation Syndrome as a State of Defective Mineralocorticoid Response
lines of evidence that support nature of ovarian hyperstimulation syndrome (OHSS) as "defective mineralocorticoid response" are cited, our hypothesis is tested clinically in both prophylaxis against and treatment of OHSS.
- Trial name
- NCT04351126
- Testing
- Fludrocortisone 0.1 Milligrams (mg), Bromocriptine
- Where
- Egypt
- Volunteers
- 107 people
- Sponsor
- Ganin Fertility Center
Left Ventricular Dysfunction, Heart Failure, Systolic
Reprogramming to Prevent Progressive Pacemaker-induced Remodelling
The aim is to provide evidence of the long-term benefits of personalised pacemaker programming on heart function and battery longevity.
- Conditions
- Left Ventricular Dysfunction, Heart Failure, Systolic, Left Ventricular Failure, Pacemaker; Complication, Mechanical
- Trial name
- PPPR (NCT03627585)
- Testing
- Personalised programming
- Where
- 2 sites in United Kingdom
- Volunteers
- 91 people
- Sponsor
- University of Leeds
Myofascial Pain - Dysfunction Syndrome of TMJ
Dry Needling Vs Transcutaneous Electrical Nerve Stimulation in Management of Myofascial Pain Dysfunction Syndrome
Myofascial pain dysfunction syndrome (MPDS) is the most common form of temporomandibular disorders. Because of the multifactorial nature of the problem, its management is still not definite.
- Trial name
- NCT06583915
- Testing
- TENS, Dry Needle
- Volunteers
- 26 people
- Sponsor
- Cairo University
Coronary Vasospasm, Coronary Microvascular Dysfunction
The NetherLands Registry of Invasive Coronary Vasomotor Function Testing (NL-CFT)
The goal of this registry is to collect data on patients referred for clinically indicated coronary vasomotor function test (CFT) and answer different questions on prevalence, safety and outcomes. The registry is observational.
- Conditions
- Coronary Vasospasm, Coronary Microvascular Dysfunction, Non-Obstructive Coronary Atherosclerosis
- Trial name
- NL-CFT (NCT06083155)
- Testing
- Coronary Function Test, Patient questionnaires
- Where
- 15 sites in Netherlands
- Volunteers
- 2,000 people
- Sponsor
- Radboud University Medical Center
Cardiovascular Disease, Endothelial Dysfunction
Effect of Homocysteine-lowering Therapy With Folic Acid, Vitamin B12, and Vitamin B6 on Endothelium-dependent Vasodilatation of Forearm Resistance Vessels in Patients With Coronary Heart Disease
Endothelial dysfunction is an early marker of atherosclerosis and is found in patients (pts) with coronary (CAD) and peripheral artery disease (PAD).
- Trial name
- NCT00693589
- Testing
- folic acid, vitamin B12 and B6 and rosuvastatin
- Volunteers
- 36 people
- Sponsor
- Insel Gruppe AG, University Hospital Bern
Erectile Dysfunction
Efficacy of Intracavernosal Xeomin With Tadalafil for Mild-Moderate Erectile Dysfunction
Erectile dysfunction (ED) affects approximately 30 million men in the United States and is associated with factors such as aging, smoking, diabetes, hypertension, obesity, and sedentary lifestyle.
- Trial name
- NCT07537855
- Testing
- IncobotulinumtoxinA (100 Units), Tadalafil 20 MG
- Volunteers
- 30 people
- Sponsor
- Northwestern University
Symphysis Pubis Dysfunction, Pregnancy
Effects of Pelvic Floor Muscle Training and a Modified Lumbopelvic Belt on Pain, Kinesiophobia, and Functional Status in Pregnant Women With Symphysis Pubis Pain
The aim of this study is to investigate the effects of pelvic floor muscle training and a modified lumbopelvic belt on pain, kinesiophobia, and functional status in pregnant women with symphysis pubis pain.Although the power…
- Conditions
- Symphysis Pubis Dysfunction, Pregnancy, Pregnancy Complication
- Trial name
- Pubic Pain (NCT07919548)
- Testing
- educational program, modified lumbopelvic belt
- Where
- Turkey (Türkiye)
- Volunteers
- 15 people
- Sponsor
- Kahramanmaras Sutcu Imam University
Alzheimer Disease, Cognitive Impairment, Mild
Comparing Smartphone Technology and a Memory Strategy on Improving Prospective Memory in Alzheimer's Disease
Alzheimer's disease is a debilitating condition for patients and their caregivers marked by hallmark cognitive symptoms (e.g., memory loss) as well as an impact on quality of life.
- Conditions
- Alzheimer Disease, Cognitive Impairment, Mild, Dementia, Mild
- Trial name
- NCT03384043
- Testing
- Smartphone Personal Assistant, Implementation Intention
- Where
- United States
- Volunteers
- 52 people
- Sponsor
- Baylor University
Coronary Artery Disease, Left Ventricular Systolic Dysfunction
Preoperative Gastric Ultrasound and Left Ventricular Function in Coronary Artery Bypass Surgery
This study aims to investigate whether reduced heart function is associated with differences in stomach contents before elective coronary artery bypass graft (CABG) surgery.
- Conditions
- Coronary Artery Disease, Left Ventricular Systolic Dysfunction, Gastric Contents
- Trial name
- NCT07898215
- Testing
- Gastric Ultrasonography
- Where
- Turkey (Türkiye)
- Volunteers
- 50 people
- Sponsor
- Adiyaman University
Congenital Heart Defects
Using Tissue Doppler/Synchronization to Determine Heart Function in Children With Congenital Heart Disease
There are many children that have heart dysfunction because they are either born with Congenital Heart Disease (CHD) or developed poor heart function because their hearts are ill.
- Trial name
- NCT00208676
- Where
- United States
- Volunteers
- 200 people
- Sponsor
- Emory University
Right Ventricular Outflow Tract Dysfunction
Observational Study of Venus P-Valve
Real-world evidence, retrospective and prospective, non-randomized, multicenter observational study of VenusP-ValveTM System in treating moderate or greater pulmonary regurgitation with/without pulmonary stenosis in patients with…
- Trial name
- Registry (NCT05835349)
- Testing
- transcatheter pulmonary valve implantation (TPVI)
- Where
- 10 sites in France, Germany and 2 more
- Volunteers
- 200 people
- Sponsor
- Venus MedTech (HangZhou) Inc.
COVID-19, Post COVID-19 Condition
Safety and Efficacy of Hyperbaric Oxygen Therapy for Long COVID Syndrome
Long COVID Syndrome (Long COVID), Post Acute COVID-19 Syndrome (PACS) or Post COVID-19 Syndrome (PCS) is defined as 'signs and symptoms that develop during or following an infection consistent with COVID-19, continue for more…
- Conditions
- COVID-19, Post COVID-19 Condition, Post COVID-19 Condition, Unspecified, Post COVID Condition
- Trial name
- HOT-LoCO (NCT04842448)
- Testing
- Hyperbaric oxygen
- Where
- Sweden
- Volunteers
- 80 people
- Sponsor
- Karolinska University Hospital
Left Ventricular Diastolic Dysfunction
Human Brain Natriuretic Peptide (BNP) (or Nesiritide) to Help Heart, Kidney and Humoral Function.
The purpose of this research study is to evaluate the effects of cardiac hormone replacement with SQ (subcutaneous or under the skin) injection of BNP (brain natriuretic peptide, a hormone produced by the heart) on the pumping…
- Trial name
- NCT00405548
- Testing
- BNP (nesiritide)
- Where
- United States
- Volunteers
- 41 people
- Sponsor
- Mayo Clinic
Eustachian Tube Dysfunction, Middle Ear Disease
Ph.D.-Project: Eustachian Tube Dysfunction: Causes, Diagnosis, Treatment, and Prognosis
Background: The Eustachian Tube (ET) is a mucosa-lined connection between the nasopharynx and the middle ear cavity. It is believed to have three functions: 1) ventilation of and pressure equalization in the middle ear cavity, 2)…
- Conditions
- Eustachian Tube Dysfunction, Middle Ear Disease, Hearing Loss, Conductive, Middle Ear Problem
- Trial name
- NCT05055115
- Testing
- Balloon Eustachian Tuboplasty
- Where
- Denmark
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Regional Hospital West Jutland
Insomnia
Sleep Restriction Therapy for Insomnia in Primary Health Care
The recommended treatment for insomnia, cognitive behavioral therapy for insomnia (CBT-I), is effective. However, its long, multi-component nature makes it challenging to implement in ordinary primary care, where most people are…
- Trial name
- NCT04975776
- Testing
- Sleep restriction therapy, Sleep hygiene
- Where
- Sweden
- Volunteers
- 104 people
- Sponsor
- Region Stockholm
Facial Palsy
Relationship Between Facial Palsy and Psychological Distress
The goal of this observational cross-sectional study is to investigate whether the severity of facial dysfunction is associated with psychological distress in patients with unilateral facial palsy.
- Trial name
- FNP-Psy (NCT07511140)
- Where
- Egypt
- Volunteers
- 85 people
- Sponsor
- Cairo University
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