Clinical trials: Physiopathology
Postoperative Ileus, Gastrointestinal Dysfunction
Low Pressure Pneumoperitoneum and Postoperative Ileus
The investigators are testing the hypothesis that lower pressure pneumoperitoneum during laparoscopic large bowel surgery protects the bowel from postoperative ileus and bowel dysfunction leading to faster recovery and discharge…
- Trial name
- NCT05344417
- Testing
- Pneumoperitoneum Pressure, Neuromuscular blockade, Pneumoperitoneum insufflation device
- Where
- 2 sites in United States
- Volunteers
- 125 people
- Sponsor
- Ohio State University
Congestive Heart Failure (CHF), Systolic Dysfunction
Improving Heart Failure Care in Minority Communities
For congestive heart failure (CHF) patients with systolic dysfunction, a randomized controlled trial compared nurse-based disease management to address problems in patient and clinician management with usual care for effects on…
- Trial name
- NCT00211874
- Testing
- Nurse-management
- Where
- 4 sites in United States
- Volunteers
- 406 people
- Sponsor
- Icahn School of Medicine at Mount Sinai
Cognitive Decline, Cancer
Combined Model of Online Remote Interventions for Cancer-Related Cognitive Impairment
Cancer survival rates have increased dramatically in recent years. However, many survivors report cognitive decline following treatment, which significantly impairs their quality of life.
- Trial name
- CRCI (NCT04210778)
- Testing
- Cognitive orientation to daily occupational performance (CO-OP), Computerized Cognitive Training (BrainHQ, posit science)
- Where
- Israel
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- Hadassah Medical Organization
Mild Cognitive Impairment
BestBrain Evaluation of Cognitive Memory & Executive-Function
This study is intended 1. To quantify the effects of the iRemember personalized EEG-NFB therapy on working memory and executive functions in subjects with MCI by calculating the percentage of change in the Neurotrax tests…
- Trial name
- BECOME (NCT03954340)
- Testing
- iRemember Neurofeedback (NFB)
- Where
- Israel
- Volunteers
- 140 people
- Sponsor
- BestBrain Ltd.
Epilepsy, Seizures
Pharmacological Modulation of Brain Oscillations in Memory Processing
The goal of this study is to learn about the effects of scopolamine (an anticholinergic drug) on areas of the brain involved in memory, and changes it may have on brain activity.
- Conditions
- Epilepsy, Seizures, Cognitive Impairment, Mild, Memory Disorders
- Trial name
- NCT05594017
- Testing
- Scopolamine (0.4mg)
- Where
- United States
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- University of Texas Southwestern Medical Center
Obesity & Overweight, Inflammation
Assessment of Respiratory Dysfunction in Obesity and the Use of IMT.
The aim of the project will be to assess the functional condition of the respiratory tract and inflammation resulting from obesity, as well as the possibility of using inspiratory muscle training as a factor reducing the…
- Conditions
- Obesity & Overweight, Inflammation, Ventilation Disorders
- Trial name
- IMT (NCT07307417)
- Testing
- inspiratory muscle training
- Where
- Poland
- Volunteers
- 40 people
- Sponsor
- Wroclaw University of Health and Sport Sciences
Major Depressive Disorders, Cognitive Dysfunction
Effects of Electroacupuncture on Cognitive Symptoms in Major Depressive Disorder
The goal of this pilot Study and Randomized Controlled Trial is to investigate the impact of electroacupuncture on cognitive function, quality of life (QoL), and depression severity in patients with major depressive disorder…
- Trial name
- ELECACU-COG-Pi (NCT06239740)
- Testing
- Electroacupuncture group
- Where
- Thailand
- Volunteers
- 60 people
- Sponsor
- Thammasat University
Erectile Dysfunction
Safety of Autologous Bone Marrow Derived Mesenchymal Stem Cells in Erectile Dysfunction
This phase I clinical trial is designed to evaluate the safety of autologous Mesenchymal Stem Cells (MSC) injected intracavernously.
- Trial name
- NCT02344849
- Testing
- mesenchymal stem cell
- Where
- South Korea
- Volunteers
- 10 people
- Sponsor
- Pharmicell Co., Ltd.
Erectile Dysfunction
Penile Lengthening Pre-Penile Prosthesis Implantation
This study is intended to utilize a novel, class I (ie. lowest risk, clinical studies not required) medical device to determine whether penile length can be increased in men prior to undergoing a penile prosthesis implantation…
- Trial name
- NCT03500406
- Testing
- RestoreX, Control
- Where
- 2 sites in United States
- Volunteers
- 24 people
- Sponsor
- Mayo Clinic
POCD - Postoperative Cognitive Dysfunction, Mechanical Bowel Preparation
Investigation of the Effect of Preoperative Bowel Cleansing on Postoperative Cognitive Impairment
Cognitive impairment has been reported up to 54 % after colorectal surgeries. Mechanical bowel cleansing means that a system called the second brain in the body, which includes a wide variety of genetic and neuronal structures…
- Trial name
- NCT05942404
- Testing
- mechanical bowel preparation
- Where
- Turkey (Türkiye)
- Volunteers
- 84 people
- Sponsor
- TC Erciyes University
Obsessive-Compulsive Disorder
Effect of Cognitive Behavioral Therapy in OCD Highlighted by Neuropsychological Tests and MRI: Pathophysiology and Treatment Outcome Predictors
OCD patients are assessed before and after treatment using diagnostic tools, rating scales neuropsychological assessment and functional and structural MR-scans.
- Trial name
- NCT00792038
- Where
- Denmark
- Volunteers
- 88 people, healthy volunteers welcome
- Sponsor
- University of Aarhus
Acute Coronary Syndrome
Effect of Pentoxifylline on Endothelial Dysfunction in Patients With Acute Coronary Syndrome
This study aims to investigate the effect of pentoxifylline administration on the status of endothelial function and oxidative stress biomarkers in patients with Acute Coronary Syndrome (ACS).
- Trial name
- NCT04367935
- Testing
- Pentoxifylline
- Where
- Egypt
- Volunteers
- 43 people
- Sponsor
- Ain Shams University
Bipolar Disorder (BD), Cognitive Impairment
TMS for Improving Cognitive Function in Bipolar Disorder
Bipolar disorder is a highly disabling psychiatric illness, and cognitive impairment is common in patients with bipolar depression as well as during remission, contributing substantially to functional disability and poorer…
- Trial name
- NCT07414147
- Testing
- Active Intermittent Theta Burst Stimulation, Online Cognitive Training
- Where
- China
- Volunteers
- 88 people
- Sponsor
- First Affiliated Hospital of Zhejiang University
Reminder Systems, Text Messaging
Feasibility of Text4US Program
Pediatric Lower Urinary Tract Symptoms (pLUTS) is common in school-age children and can negatively impact the quality of their life.
- Conditions
- Reminder Systems, Text Messaging, Urinary Dysfunction, Urinary Bladder
- Trial name
- Text4US (NCT05509738)
- Testing
- SMS Text Messaging
- Where
- United States
- Volunteers
- 2 people, healthy volunteers welcome
- Sponsor
- Stanford University
Erectile Dysfunction
Platelet-Rich Plasma With or Without Tadalafil for Erectile Dysfunction
Platelet-rich plasma is being studied as a regenerative treatment option for erectile dysfunction, but it is unclear whether adding daily tadalafil gives additional benefit over platelet-rich plasma alone.
- Trial name
- NCT07602608
- Testing
- Tadalafil, Intracavernosal Platelet-Rich Plasma Injection
- Where
- Egypt
- Volunteers
- 160 people
- Sponsor
- Benha University
Coronary Microvascular Dysfunction
Coronary Microvascular Disease (CMD) Registry
The purpose of this project is to provide appropriate administrative and technical supports for the warehousing and use of a database of patients with coronary microvascular disease (CMD).
- Trial name
- NCT05960474
- Testing
- Outcomes for Patients with CMD
- Where
- 3 sites in United States
- Volunteers
- 1,000 people
- Sponsor
- Medstar Health Research Institute
Voiding Disorders
Prevalence of Detrusor Underactivity and Bladder Outlet Obstruction in Female Without Cystocele
Women with symptoms of voiding dysfunction may be associated with detrusor underactivity (DU) or bladder outlet obstruction (BOO). The treatment strategies are different between DU and BOO.
- Trial name
- NCT04184752
- Testing
- Urodynamic study
- Where
- Taiwan
- Volunteers
- 602 people
- Sponsor
- National Taiwan University Hospital
Hypogonadism, Metabolic Syndrome
Testosterone Replacement in Metabolic Syndrome and Inflammation
Hypogonadism (HG) frequently complicates the Metabolic Syndrome (MetS), whether testosterone replacement (TRT) is beneficial has not been clearly ascertained.
- Conditions
- Hypogonadism, Metabolic Syndrome, Obesity, Erectile Dysfunction
- Trial name
- TERMSINFAT (NCT01123278)
- Testing
- Testosterone
- Where
- 2 sites in Italy
- Volunteers
- 82 people
- Sponsor
- University of Roma La Sapienza
Heart Failure, Pulmonary Hypertension
Mechanisms of Pulmonary Vascular Dysfunction in Heart Failure
Heart failure (HF) patients often develop pulmonary hypertension (PH) that leads to transition into a biventricular HF with poor prognosis.
- Conditions
- Heart Failure, Pulmonary Hypertension, Pulmonary Vascular Resistance Abnormality
- Trial name
- LUNG-HF (NCT06331208)
- Testing
- non-contrast chest CT, spirometry with diffusing lung capacity for carbon monoxide (DLCO) analysis, Omics analysis of blood plasma obtained from pulmonary artery or peripheral blood
- Where
- Czechia
- Volunteers
- 230 people
- Sponsor
- Institute for Clinical and Experimental Medicine
Hepatic Complications, Malignant Neoplasm
Bortezomib in Treating Patients With Advanced Cancer and Liver Dysfunction
Bortezomib may stop the growth of cancer cells by blocking the enzymes necessary for their growth. This phase I trial is studying the side effects and best dose of bortezomib in treating patients with advanced cancer and liver…
- Trial name
- NCT00091117
- Testing
- bortezomib, pharmacological study
- Where
- 3 sites in United States
- Volunteers
- 80 people
- Sponsor
- National Cancer Institute (NCI)
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