Clinical trials: Physiopathology
Ejaculation Delayed
A Clinical Investigation to Assess the Effectiveness of Benzocaine Condoms in Healthy Adult Men
This investigation is designed to evaluate the effectiveness of two NRL condoms with Benzocaine paste compared with a standard NRL control.
- Trial name
- NCT05255770
- Testing
- Test condom A (NRL condom with 5% benzocaine paste), Test condom B (NRL condom with 3% benzocaine paste), Control NRL condom
- Volunteers
- healthy volunteers welcome
- Sponsor
- Reckitt Benckiser Healthcare (UK) Limited
Contraception, Female Sexual Function
The Effect of Sexual Education-Counseling According to PLISSIT in Solving Sexual Problems in Women Using Contraceptive Methods: One Year Follow-up Results
Sexuality is a universal part of human life and is a process in which two people share their emotions, body, soul and pleasures. Although it is a natural part of life, sexuality can be affected by many factors.
- Conditions
- Contraception, Female Sexual Function, Sexual Dysfunction, PLISSIT
- Trial name
- NCT06772883
- Testing
- sexual education and counseling, control group
- Where
- Turkey (Türkiye)
- Volunteers
- 352 people, healthy volunteers welcome
- Sponsor
- Izmir Katip Celebi University
Cognitive Impairment, Hereditary Spastic Paraplegia
Studying Cognition in SPG4
Comparing the cognitive levels of patients with SPG4 mutations to healthy controls.
- Trial name
- NCT03104088
- Testing
- CANTAB, MOCA
- Where
- Germany
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- University Hospital Tuebingen
Post-Acute COVID-19, Post Acute COVID-19 Syndrome
Safety and Dosage of a Computerized Cognitive Training Program for Cognitive Dysfunction After COVID-19
The goal of this Phase I/II clinical trial is to assess the safety and maximum tolerated training time of a self-administered computerized cognitive training (CCT) in individuals with cognitive dysfunction as a consequence of…
- Conditions
- Post-Acute COVID-19, Post Acute COVID-19 Syndrome, Cognitive Dysfunction, Cognitive Impairment
- Trial name
- CCTLongCOVID (NCT05582603)
- Testing
- CCT Long COVID
- Where
- Spain
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Universidad Antonio de Nebrija
Sepsis
The Effect of Rhubarb on Sepsis and Post-traumatic Gastrointestinal Function Failure
Random grouping by computer, divided into two groups, a group of rhubarb treatment group, another group for the placebo group.
- Trial name
- NCT03048903
- Testing
- Rheum Palmatum Root, Starch Corn
- Where
- China
- Volunteers
- 400 people
- Sponsor
- CHEN De-chang
Acute Renal Failure, Gastroenteritis
Cystatin C as a Marker for Detecting Early Renal Dysfunction in a Pediatric Emergency Department
Acute renal failure (ARF) is a rare but serious complication of gastroenteritis and dehydration, the most common reason for pediatric emergency visits. Renal function is determined by the glomerular filtration rate (GFR).
- Conditions
- Acute Renal Failure, Gastroenteritis, Dehydration
- Trial name
- CARING (NCT00462527)
- Where
- Canada
- Volunteers
- 464 people, healthy volunteers welcome
- Sponsor
- Children's Hospital of Eastern Ontario
Abdominal Hypertension, Abdominal Compartment Syndrome
Updated Abdominal Compartment Society Consensus Definitions
An international team of experts is working on a project called updated WSACS consensus definitions. The goals of this study are to: 1. To generate expert consensus on the definitions and classification of IAH and ACS. 2.
- Trial name
- WSACS (NCT07563842)
- Testing
- Delphi study
- Where
- Poland
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Medical University of Lublin
Cognitive Decline, Mild
Predict Early Cognitive Changes in a Healthy Elderly Population by Passively Recording Sensor Data From Mobile Devices
The study will recruit 100 participants aged 65+ residing in assisted living facilities. Eligible participants will undergo an initial cognitive assessment to document their baseline cognitive status using cognitive tests…
- Trial name
- 0150-24 SOR (NCT07596186)
- Where
- Israel
- Volunteers
- 98 people, healthy volunteers welcome
- Sponsor
- Soroka University Medical Center
Sleep Initiation and Maintenance Disorders
Efficacy of Ramelteon in Subjects With Chronic Insomnia
The purpose of this study is to determine the long-term safety of Ramelteon, once daily (QD), in subjects with chronic insomnia.
- Trial name
- NCT00671086
- Testing
- Ramelteon
- Where
- 122 sites in United States
- Volunteers
- 1,213 people
- Sponsor
- Takeda
Eustachian Tube Dysfunction
Correlation Analysis Between ETF and Prognosis of Tympanoplasty
The regular opening of the eustachian tube plays an important role in maintaining normal pressure in middle ear cavity, hearing function and preventing the occurrence of middle ear inflammation.
- Trial name
- NCT03424369
- Testing
- Tympanoplasty
- Where
- China
- Volunteers
- 1,000 people, healthy volunteers welcome
- Sponsor
- Eye & ENT Hospital of Fudan University
Measurement Properties of 5iTUG, Physical Disability
Evaluation of the Measurement Properties of a 5 Time Repeated Instrumented Timed Up and Go (5iTUG)
In order to tailor interventions, objective assessments of physical function is needed. A limitation of several of today's clinical assessments is that they require too much time and/or space.
- Conditions
- Measurement Properties of 5iTUG, Physical Disability, Balance, Cognitive Impairment
- Trial name
- 5iTUG (NCT03769220)
- Where
- Germany
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Robert Bosch Gesellschaft für Medizinische Forschung mbH (RBMF)
Cancer Therapy-Related Cardiac Dysfunction, Heart Failure
Risk Stratification of Cancer Therapy-Related Cardiac Dysfunction Using AI-Enhanced Electrocardiography
This study investigates the use of AI-enhanced electrocardiogram (ECG) for risk stratification of cancer therapy-related cardiac dysfunction (CTRCD) before the initiation of cancer therapy.
- Conditions
- Cancer Therapy-Related Cardiac Dysfunction, Heart Failure, Left Ventricular Dysfunction
- Trial name
- NCT07515859
- Testing
- No intervention (retrospective observational study)
- Where
- South Korea
- Volunteers
- 31,486 people
- Sponsor
- Yonsei University
Endothelial Dysfunction
Effects of Incorporating Sprouted and Non-sprouted Chickpea Flour in Pasta Products Analyzed in Vivo Flow-mediated Dilation
The investigators examined the effects on post-digestion brachial artery flow mediated dilation (FMD) and in vitro antioxidant capacity of 40% semolina flour replacement with sprouted chickpea flour.
- Trial name
- NCT03801486
- Testing
- Experimental: Sprouted Chickpea Flour, Control: Semolina Flour
- Volunteers
- 34 people, healthy volunteers welcome
- Sponsor
- Montclair State University
Fecal Incontinence, Outlet Dysfunction Constipation
Treatment of Fecal Incontinence and Functional Evacuation Disorders Using Non-instrumental Biofeedback
Background. Rehabilitation and re-education using instrumental anorectal biofeedback are the main treatment of anorectal functional disorders producing incontinence and outlet obstructed defecation.
- Trial name
- NCT06273046
- Testing
- Biofeedback
- Where
- Spain
- Volunteers
- 96 people
- Sponsor
- Hospital Universitari Vall d'Hebron Research Institute
Hidradenitis Suppurativa (HS)
MAIT Cells in Hidradenitis Suppurativa
Hidradenitis Suppurativa (HS) is a chronic, debilitating inflammatory skin disease characterized by painful, purulent lesions primarily in skin folds. Its pathogenesis remains poorly understood.
- Trial name
- HS-MAIT (NCT07388446)
- Testing
- Collect lesional biopsies, Collect score from Bristol stool scale
- Where
- France
- Volunteers
- 45 people
- Sponsor
- Hospices Civils de Lyon
Lumbar Spinal Stenosis
Role of Spinal Load in the Pathophysiology of Lumbar Spinal Stenosis
This study is to improve the understanding of the role of postural and ambulatory biomechanics for symptoms in patients with sLSS and to correlate patient-reported outcome measures (PROMs) with dynamic compensation (difference…
- Trial name
- RoLSSroice (NCT05523388)
- Testing
- Collection of health-related data
- Where
- Switzerland
- Volunteers
- 122 people
- Sponsor
- University Hospital, Basel, Switzerland
COVID-19, Endothelial Function
Diagnostics of Coronavirus Disease 2019 Cardiovascular Complications
Aim of this prospective, observational, multi-centered, randomized study is to detect cardiovascular complications in patients after coronavirus infection.
- Conditions
- COVID-19, Endothelial Function, Diastolic Dysfunction, Oxygen Consumption
- Trial name
- NCT05608603
- Testing
- Portable cardiac monitor "CardioQvark", Cardiorespiratory stress test, Analysis of exhaled air using the Compact PTR-MS proton mass spectrometer
- Where
- Russia
- Volunteers
- 100 people
- Sponsor
- I.M. Sechenov First Moscow State Medical University
Arthralgia, Breast Cancer
Testosterone in Treating Postmenopausal Patients With Arthralgia Caused by Adjuvant Aromatase Inhibitor Treatment
This randomized phase III trial studies testosterone to see how well it works compared to placebo in treating postmenopausal patients with arthralgia (joint pain) caused by anastrozole or letrozole.
- Conditions
- Arthralgia, Breast Cancer, Hot Flashes, Musculoskeletal Complications
- Trial name
- NCT01573442
- Testing
- testosterone
- Where
- 529 sites in United States, Puerto Rico
- Volunteers
- 227 people
- Sponsor
- Alliance for Clinical Trials in Oncology
Cognitive Impairment, Frail Older Adults
Cognitive Fraility and Biomarkers in Older Patients
this study aimed to investigate the association between cognitive fraility and selected plasma and cerebrospinal fluid biomarkers related to neurodegenetaion and neuroinflammation in older adult patients undergoing elective…
- Conditions
- Cognitive Impairment, Frail Older Adults, Orthopaedic Surgery
- Trial name
- NCT07184073
- Testing
- assessment Mini mental state examination, assessment FRAIL scale, collecting cerebrospinal fluid during regional anesthesia
- Where
- Turkey (Türkiye)
- Volunteers
- 129 people
- Sponsor
- Baskent University
Covid19, Hypoxemic Respiratory Failure
Endothelial Dysfunction in Covid-19
SARS-CoV-2 targets endothelial cells via the angiotensin-converting enzyme 2 receptor. The specific impact of the resulting endothelial injury is currently unknown but may contribute to the pro-coagulant state classically…
- Trial name
- ENDOCOVID (NCT04830683)
- Where
- Belgium
- Volunteers
- 85 people
- Sponsor
- Cliniques universitaires Saint-Luc- Université Catholique de Louvain
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