Clinical trials: Physiopathology
Apathy
In Vivo Involvement of the Cholinergic and Dopaminergic Systems in the Pathophysiology of Apathy.
Apathy is a neurocognitive syndrome characterized by reduced goal-directed behaviors, contributing to decreased patient and caregiver quality of life.
- Trial name
- ADACHOL (NCT03998852)
- Testing
- Positron Emission Tomography (PET) with [18F]-FDOPA, Positron Emission Tomography (PET) with [18F]-FEOBV, Magnetic Resonnance Imaging (MRI)
- Where
- France
- Volunteers
- 30 people
- Sponsor
- University Hospital, Bordeaux
Hypertension, Aging
Effect of Heated Water-Based Versus Land-Based Exercise Training on Hemodynamic Variables, Functional Capacity and Quality of Life in Older Hypertensive
BACKGROUND: Physical exercise promotion is one of the main global goals of innumerous health and medical societies for preventing and managing noncommunicable chronic diseases (NCDs), being one of the main therapeutic for the…
- Conditions
- Hypertension, Aging, Exercise
- Trial name
- HExOLD (NCT07131748)
- Testing
- Physical Exercise Session in heated Swimming Pool - HEx, Physical Exercise Session in Land- LEx, Control Session Without Exercise- CON
- Where
- Brazil
- Volunteers
- 60 people
- Sponsor
- Universidade Estadual Paulista Júlio de Mesquita Filho
Ductal Breast Carcinoma in Situ, Breast Cancer, Stage I
Effect of Omega 3 on Atrophic Vaginitis in Breast Cancer Survivors
This randomized double-blind clinical trial studied the effect of oral omega-3 fatty acid on atrophic vaginitis in postmenopausal breast cancer survivors (N=52).
- Conditions
- Ductal Breast Carcinoma in Situ, Breast Cancer, Stage I, Breast Cancer, Stage II, Breast Cancer, Stage III
- Trial name
- NCT02150525
- Testing
- omega-3 fatty acid, Questionnaire administration
- Where
- United States
- Volunteers
- 52 people
- Sponsor
- Ohio State University Comprehensive Cancer Center
Hypertension, Pulmonary Artery, Ventricular Dysfunction, Left
Characterization of LV Strain Patterns in Mildly Elevated PCWP and PAH.
The purpose of this study is to determine if patients with pulmonary hypertension and mildly elevated heart pressure known as PCWP will exhibit different patterns on echocardiography and that these patterns will predict treatment…
- Trial name
- LV strain (NCT01800292)
- Testing
- sildenafil
- Where
- United States
- Volunteers
- 9 people
- Sponsor
- University of Arizona
Scoliosis, Spinal Deformity
Bilateral Bi-level Erector Spine Plane Block as a Component of General Anesthesia in Surgical Correction of Spinal Deformations
Improving the anesthesiology management for surgical correction of spinal deformations with introducing the diagnostic methods and treatment strategy of acute pain, preventing the evolution of chronic pain.
- Conditions
- Scoliosis, Spinal Deformity, Acute Pain, Chronic Pain
- Trial name
- BBESPB (NCT04697498)
- Testing
- Bilateral bi-level Erector spine plane block, General anaesthesia
- Where
- Ukraine
- Volunteers
- 150 people
- Sponsor
- Lviv National Medical University
Impotence
QEQ Treatment Responsiveness Evaluation Study
The Quality of Erection Questionnaire (QEQ) is a new questionnaire that was developed to assess erectile attributes in men with erectile dysfunction.
- Trial name
- NCT00151463
- Testing
- sildenafil citrate
- Where
- 9 sites in Australia
- Volunteers
- 100 people
- Sponsor
- Pfizer's Upjohn has merged with Mylan to form Viatris Inc.
Anomalous Aortic Origin of the Coronary Artery (AAOCA)
Anomalous Aortic Origin of Coronary Artery
This project has several objectives ranging from clinical data analysis to computational simulations as listed below: A) Clinical objectives: 1.
- Trial name
- AAOCA (NCT05692063)
- Where
- Italy
- Volunteers
- 130 people
- Sponsor
- IRCCS Policlinico S. Donato
Coronary Artery Disease, Chronic Kidney Disease
Clinical Feature and Outcome of Angiographic Coronary Artery Disease in Chronic Kidney Disease Patients
The prevalence and mortality rate of cardiovascular disease (CVD) in chronic kidney disease (CKD) patients is high. The prevalence of coronary artery disease (CAD) in CKD population ranges from 38 to 65%, with an average of 3.3…
- Trial name
- NCT00651521
- Where
- Taiwan
- Volunteers
- 1,000 people
- Sponsor
- Chang Gung Memorial Hospital
Erectile Dysfunction, Sexual Dysfunction
Concomitant Use of PriLigy in Men Treated for Erectile Dysfunction
The purpose of this study is to evaluate the efficacy and safety of dapoxetine compared to placebo in men with premature ejaculation and erectile dysfunction who are currently being treated with a phosphodiesterase-5 inhibitor…
- Trial name
- COUPLE (NCT01063855)
- Testing
- Dapoxetine, PDE5I (phosphodiesterase-5 inhibitor)
- Where
- 69 sites in United States, Argentina and 11 more
- Volunteers
- 495 people
- Sponsor
- Johnson & Johnson Pharmaceutical Research & Development, L.L.C.
Neuropsychiatric Post-Acute Sequelae of SARS-CoV-2 Infection
Neuropsychiatric Post-Acute Sequelae of SARS-CoV-2 (PASC) Using TSPO Positron Emission Tomography (PET) and MRI
The overarching goal of this study is to develop PET/MR techniques for the diagnosis of neuropsychiatric post-acute sequelae (PASC) of SARS-CoV-2.
- Trial name
- NCT05615415
- Testing
- PET Tracer, MRI Tracer, 3T PET/MRI
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- NYU Langone Health
Sacroiliac Dysfunction
Sacroiliac Joint Dysfunction Consequences and Its Reversal by Manipulation
Sacroiliac joint dysfunction (ASI) is an alteration in the normal biomechanics of the joint, which leads to hypomobility or hypermobility of that joint.
- Trial name
- LOUIS (NCT06710535)
- Testing
- Manual Manipulation
- Where
- Portugal
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- Aveiro University
Mild Cognitive Impairment, Poor Quality Sleep
Hypnosis for Sleep Quality for Individuals With Mild Cognitive Impairment
With the long-range goal to identify an efficacious and practical intervention to improve sleep for individuals with MCI, this pilot study will enroll 20 individuals with MCI into either a self-administered hypnosis for sleep…
- Trial name
- NCT05215717
- Testing
- Self-Administered Hypnosis, Self-Administered White Noise Hypnosis
- Where
- United States
- Volunteers
- 23 people
- Sponsor
- Baylor University
Mild Cognitive Impairment (MCI), Healthy Aging
Computerized Cognitive Training in Healthy Older Adults and Mild Cognitive Impairment
The overall objective of this study is to assess the effect of an adaptive computerized cognitive training program for executive functions (CogniFit platform) on improving these functions in older adults, both healthy and with…
- Trial name
- COGNI-AGE (NCT07598409)
- Testing
- Computerized Cognitive Training, Active Control Computerized Activities
- Where
- 2 sites in Spain
- Volunteers
- 156 people, healthy volunteers welcome
- Sponsor
- Universidad Antonio de Nebrija
Cerebral Small Vessel Diseases, Retinopathy
Cognitive Impairment, Retinopathy, and Cerebrovascular Lesions in the Elderly
The CIRCLE study is a single-center prospective observational study that enrolled individuals with cerebral small vessel disease (SVD), while free of known dementia or stroke (both cerebral infarction and hemorrhage).
- Conditions
- Cerebral Small Vessel Diseases, Retinopathy, Cognitive Dysfunction
- Trial name
- CIRCLE (NCT03542734)
- Testing
- multimodal magnetic resonance imaging
- Where
- China
- Volunteers
- 1,000 people, healthy volunteers welcome
- Sponsor
- Second Affiliated Hospital, Zhejiang University, School of Medicine
Autism Spectrum Disorder, Autism
Mitochondrial Dysfunction in Autism Spectrum Disorder
Researchers at Arkansas Children's Hospital Research Institute are conducting a study about mitochondrial function in children. The study involves up to 5 visits to Arkansas Children's Hospital with fasting blood draws…
- Conditions
- Autism Spectrum Disorder, Autism, Mitochondrial Disease, Developmental Delay
- Trial name
- Mito (NCT02000284)
- Where
- United States
- Volunteers
- 297 people, healthy volunteers welcome
- Sponsor
- University of Arkansas
Postoperative Cognitive Disorder, Glaucoma
Application of Innovative Non-Invasive Neuroprotective Technology in Cardiac Surgery and Ophthalmology
Postoperative cognitive dysfunction (POCD) and delirium (incidence up to 42 %) after cardiac surgery with cardiopulmonary bypass (CPB) are common postoperative complications that impair the patient's quality of life and increase…
- Trial name
- NCT04943458
- Testing
- Monitoring of cerebral autoregulation
- Where
- Lithuania
- Volunteers
- 270 people
- Sponsor
- Milda Svagzdiene
Frail Elderly Subjects
Omega-3 Fatty Acids and/or Multi-domain Intervention in the Prevention of Age-related Cognitive Decline
Epidemiological and fundamental research carried out in recent years has highlighted the role played by omega-3 fatty acids in the process of cognitive decline that accompanies advancing age and Alzheimer's disease.
- Trial name
- MAPT (NCT00672685)
- Testing
- omega-3, multi-domain intervention
- Where
- 13 sites in France, Monaco
- Volunteers
- 1,680 people
- Sponsor
- University Hospital, Toulouse
Dementia With Lewy Bodies, Alzheimer Disease
Optical Neuroimaging and Cognition
Dementia is associated with a variety of neurovascular and neurometabolic abnormalities. Traditional imaging techniques used to investigate such abnormalities, such as Positron Emission Tomography and functional Magnetic…
- Conditions
- Dementia With Lewy Bodies, Alzheimer Disease, Mild Cognitive Impairment
- Trial name
- ONAC (NCT05460143)
- Testing
- Near-infrared Spectroscopy scan, Magnetic Resonance Imaging scan
- Where
- United Kingdom
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- University of Cambridge
Erectile Dysfunction Following Radical Prostatectomy, Prostate Cancer
Multimodal Prehabilitation and Rehabilitation for Men Undergoing Robot-Assisted Radical Prostatectomy
Prostate cancer is the most common cancer in Australian men. Robot-assisted radical prostatectomy (RARP) - surgical removal of the prostate - is a standard treatment, but it frequently causes erectile dysfunction (ED) and urinary…
- Conditions
- Erectile Dysfunction Following Radical Prostatectomy, Prostate Cancer, Urinary Incontinence Following Surgical Procedure
- Trial name
- ROBOPREP (NCT07576335)
- Testing
- Tadalafil 5 mg, Pelvic Floor Muscle Training (PFMT), Aerobic Exercise Program
- Where
- 3 sites in Australia
- Volunteers
- 64 people
- Sponsor
- Surgical Outcomes Research Centre (SOuRCe)
Dementia, Mild Cognitive Impairment (MCI)
Predictors Of Cognitive Decline Using Digital Devices
The overall aim of this study is to find out if people with cognitive difficulties will wear and use different types of digital technology, and if they will allow data from that technology and their clinical profile to be…
- Conditions
- Dementia, Mild Cognitive Impairment (MCI), Subjective Cognitive Decline (SCD), Rapid Eye Movement Sleep Behavior Disorder
- Trial name
- CODEC-II (NCT07051408)
- Where
- United Kingdom
- Volunteers
- 135 people, healthy volunteers welcome
- Sponsor
- University College, London
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