Clinical trials: Pigmentation
Skin Wrinkling
A Study to Validate Cosmetic Outcome Scales Used to Rate Uneven Skin Color and Wrinkling
Skin chronically exposed to the sun may become damaged and then develop wrinkles and/or uneven skin color. The purpose of this research study is to evaluate a newly developed scale (grading tool) that rates wrinkles and uneven…
- Trial name
- NCT00114673
- Where
- United States
- Volunteers
- 48 people, healthy volunteers welcome
- Sponsor
- Graceway Pharmaceuticals, LLC
Healthy
Safety of Serum for Post-Inflammatory on Hyperpigmentation Skin
This study aims to investigate the safety of serum product containing low dose of alpha hydroxy acid (AHA) i.e. 1% Glycolic acid and Lactic acid and Polyglutamate acid derivatives (PGA) for post-inflammatory hyperpigmentation…
- Trial name
- NCT05998200
- Testing
- Serum with low concentration AHA (1% Glycolic acid and Lactic acid) and PGA
- Where
- Malaysia
- Volunteers
- 34 people, healthy volunteers welcome
- Sponsor
- USMARI Research & Innovation Centre
Morbid Obesity, Acanthosis Nigricans
The Effect of Laparoscopic Sleeve Gastrectomy on Insulin Secretion Pattern in Morbidly Obese Patients With Acanthosis Nigricans
Acanthosis nigricans (AN) is increasing in its prevalence and is the most prevalent cutaneous manifestation in individuals with obesity.
- Conditions
- Morbid Obesity, Acanthosis Nigricans, Insulin Resistance, Insulin Sensitivity
- Trial name
- NCT05529563
- Testing
- LSG
- Where
- China
- Volunteers
- 138 people, healthy volunteers welcome
- Sponsor
- Shen Qu
Vitamin D Status
UVB Light and Sunscreen
Patients need vitamin D which is normally produced in the skin in response to ultraviolet light from the sun. Vitamin D is important for calcium absorption and good bone health.
- Trial name
- Sunscreen (NCT00818467)
- Testing
- Tanning spray, UVB
- Where
- United States
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Creighton University
Hyperpigmentation
Clinical Trial of 4% Niacinamide Versus 0.05% Desonide for the Treatment of Axillar Hyperpigmentation
Axillary hyperpigmentation is a frequent consultation in dark skin populations although its exact prevalency is unknown. Currently, there are not studies about physiopathology and treatment for this entity.
- Trial name
- NCT01542138
- Testing
- Desonide, Niacinamide
- Where
- Mexico
- Volunteers
- 28 people, healthy volunteers welcome
- Sponsor
- Universidad Autonoma de San Luis Potosí
Vitiligo
Thymic Stromal Lymphopoietin (TSLP) in Vitiligo
study \& verify the hypothesis of the involvement of TSLP in the pathogenesis of vitiligo in comparison to their levels in the healthy control persons.
- Trial name
- NCT03367273
- Testing
- skin biopsy
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Cairo University
Hyperpigmentation, Melasma
Evaluation of Efficacy and Tolerabilty of MelaB3 Serum in Combination of 35% Glycolic Acid Peeling Compared to 35% Glycolic Acid Peeling Alone in Various Hyperpigmentation Conditions
Randomized clinical trial to assess the effectiveness and tolerability of Mela B3 serum in combination with 35% glycolic acid peel vs.
- Conditions
- Hyperpigmentation, Melasma, Solar Lentigo, Peeling
- Trial name
- NCT07429786
- Testing
- Glycolic acid peel alone, MelaB3 serum
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Cosmetique Active International
Vitiligo
Comparative Effectiveness of Ruxolitinib Monotherapy Versus Its Combination With Tacrolimus and Corticosteroids in the Management of Vitiligo: A Randomized Controlled Trial
this randomized controlled trial aims to compare the effectiveness and safety of ruxolitinib monotherapy versus its combination with topical tacrolimus or topical corticosteroids in patients with non-segmental vitiligo involving…
- Trial name
- NCT07368673
- Testing
- ruxolitinib cream
- Where
- Pakistan
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- Dow University of Health Sciences
Pigmentation, Redness
Photoprotection Efficacy With Sunscreen Formulas Containing the Cyclic Merocyanine Long-UVA Absorber MCE Under Long-UVA Exposure
To evaluate the photo-protector effect of BC_3 (E212657) formulated in SPF compared to SPF alone on long-UVA induced pigmentation in healthy volunteers.
- Trial name
- NCT04865094
- Testing
- cyclic merocyanine
- Where
- Romania
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- L'Oreal
Wrinkle, Skin Pigmentation
Prospective Study of Topical Vitamin C (THDA) Versus Topical Vitamin C (THDA) With Acetyl Zingerone
The purpose of this study is to asses the impact of topically applying a form of vitamin C known as tetrahexyldecyl Ascorbate (THDA) along with a novel anti-aging ingredient, acetyl zingerone, compared against applying THDA alone.
- Trial name
- NCT05779280
- Testing
- THDA + Acetyl Zingerone Topical Product, THDA
- Where
- United States
- Volunteers
- 44 people, healthy volunteers welcome
- Sponsor
- Integrative Skin Science and Research
Melasma
Sylfirm X Radiofrequency Microneedling for the Treatment of Melasma
Microneedling radiofrequency technology has been shown in clinical studies to improve skin quality, tone, pigment, and to treat various skin conditions related to aging.
- Trial name
- NCT06415435
- Testing
- Radiofrequency Microneedling
- Where
- 3 sites in United States
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- Benev Company, Inc.
Retinal Pigment Epithelial Detachment Secondary to Age-related Macular Degeneration
Eylea to Treat Retinal Pigment Epithelial Detachment (RPED) Secondary to Wet Age-Related Macular Degeneration (wAMD)
Primary Objectives: To assess the efficacy of intravitreal administered Eylea in preventing visual loss in subjects with a retinal pigment epithelial detachment (PED) subtype of neovascular age-related macular degeneration (AMD)…
- Trial name
- NCT02142296
- Testing
- Eylea
- Where
- Canada
- Volunteers
- 37 people, healthy volunteers welcome
- Sponsor
- London Health Sciences Centre Research Institute OR Lawson Research Institute of St. Joseph's
Acne, Postinflammatory Hyperpigmentation
Efficacy of La Roche Posay Routine in the Management of Facial Post Inflammatory Hyperpigmentation (PIHP)
The goal of this clinical trial is to test and compare La Roche Posay routine --the studied product-- with a comparator product in participants with acne.
- Trial name
- PIHP (NCT06770127)
- Where
- Mauritius
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Cosmetique Active International
Muscle Oxygenation, Skin Pigmentation
Muscle Oxygenation and Skin Pigmentation
The investigators plan to enroll 500 consecutive Subjects at a major trauma center for this study. For each patient, the body mass index (BMI), age, sex, diastolic pressure and mean arterial pressure (MAP) at time of…
- Trial name
- NCT00747162
- Testing
- Measure of muscle oxygenation, Skin pigmentation determination
- Where
- United States
- Volunteers
- healthy volunteers welcome
- Sponsor
- Emory University
Metabolism and Clearance of Cyanidin 3 Glucoside
Tracing the Path of an Ingested Plant Pigment Through the Human Body
This study will trace the path of a natural plant pigment, (cyanidin-3-glucoside; C3G), through the human body after consumption.
- Trial name
- NCT01106729
- Testing
- Cyanidin 3 glucoside
- Where
- United Kingdom
- Volunteers
- 8 people, healthy volunteers welcome
- Sponsor
- University of East Anglia
Psoriasis
Levels of Pigment Epithelium-derived Factor in Patients With Psoriasis.
Psoriasis is an immune-mediated chronic inflammatory skin disease associated with increase interaction of inflammatory mediators like adipokines.
- Trial name
- NCT05252741
- Testing
- serum samples and punch skin biopsies
- Where
- Egypt
- Volunteers
- 52 people, healthy volunteers welcome
- Sponsor
- Sohag University
Aging Problems, Pigmentation
16-Week Randomized Split-Face Efficacy Study of Cosmetic Formulations in Photoaged Pigmented Skin Subjects
The objective of this study is to determine the efficacy of seven different formulations currently marketed and commercially available cosmetic products on skin tone evenness, post-inflammatory hyperpigmentation, and discrete…
- Trial name
- NCT05160103
- Testing
- Cosmetic Formulations
- Volunteers
- 84 people, healthy volunteers welcome
- Sponsor
- Avon Products, Inc.
Vitiligo
Evaluation of the Efficacy and the Cutaneous Acceptability of a Dermocosmetic Product in the Repigmentation of Vitiligo
Study in proof of concept; Double blind study; Comparative study, versus placebo in intra-individual Three parallel groups testing different dosages / combinations of treatments Randomized.
- Trial name
- NCT04171427
- Testing
- Lithium liposome
- Where
- Tunisia
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- Laboratoire Dermatologique ACM
Hyperpigmentation
Efficacy and Tolerability of the Tested Formula After 3 Months of Treatment of Facial Hyperpigmentation of 3 Origins
The objective of this study is to evaluate the efficacy, cosmetic acceptability and improvement of the stigmatization of the tested product (2039125 03) used bis in die (BID) for 3 months in adult patients suffering from mild to…
- Trial name
- NCT06234527
- Testing
- tested product
- Where
- Senegal
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Cosmetique Active International
Skin Pigmentation, Free Radicals
EPR (Electron Paramagnetic Resonance) as Method of Non-invasive Characterization of Melanin Content in Skins With Different Phototypes
The aim of this study is to assess the signal of melanin using Electron Paramagnetic resonance (EPR). Melanin is a paramagnetic pigment detectable by EPR.
- Conditions
- Skin Pigmentation, Free Radicals, Phototype, Magnetic Resonance
- Trial name
- NCT04270903
- Testing
- EPR measurement
- Where
- Belgium
- Volunteers
- 45 people, healthy volunteers welcome
- Sponsor
- Université Catholique de Louvain