Clinical trials: Pigmentation
Vitiligo, Generalized
Gasdermin D Expression in Generalized Vitiligo Patients After Narrow-band Ultraviolet B Therapy
The aim of this study is to: 1. Evaluate the role of tissue Gasdermin D expression using immunehistochemstry techniques in patients with generalized vitiligo and compare it with healthy controls. 2.
- Trial name
- NCT06546059
- Testing
- narrow band ultraviolet-B
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- South Valley University
Hyperpigmentation, Photodamaged Skin
A Multi-Center, Open-label Study Evaluate the Efficacy and Tolerability of a Dual Skincare Regimen Treatment for Facial Hyperpigmentation and Photodamaged Skin in Patients Exposed to Extrinsic Factors of Aging
This open-label, multi-center clinical trial was conducted to evaluate the dual skincare regimen of vitamin C serum and moisturizing sunscreen SPF 45 to improve facial hyperpigmentation and photodamage after 12 weeks of twice…
- Conditions
- Hyperpigmentation, Photodamaged Skin, Wrinkle, Fine Lines
- Trial name
- NCT05423873
- Testing
- Gentle Cleansing Lotion, Revision Skincare
- Where
- 3 sites in United States
- Volunteers
- 33 people, healthy volunteers welcome
- Sponsor
- Revision Skincare
Melasma
Effectiveness and Safety of Intradermal Tranexamic Acid Injection as An Adjunctive Treatment for Melasma in Skin Type IV - V
A double-blind, randomized, split-face controlled trial of 34 female patients with melasma was conducted. All subject were randomized to receive either intradermal tranexamic acid or placebo injection on the right or the left…
- Trial name
- NCT05236569
- Testing
- Tranexamic acid injection, Injection Water
- Where
- Indonesia
- Volunteers
- 34 people, healthy volunteers welcome
- Sponsor
- Universitas Indonesia
Solar Lentigines
A Fixed Triple Combination Cream for Solar Lentigines Associated to Cryotherapy
To evaluate safety and efficacy of Tri-Luma® cream as an adjunctive treatment to cryotherapy when used in the pre- and post-procedure phases for the treatment of solar lentigines on the back of the hands and in the prevention of…
- Trial name
- NCT01778179
- Testing
- Tri-luma, Cryotherapy (CRY-AC3® device)
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Hexsel Dermatology Clinic
Skin Pigmentation
Evaluation of a Tranexamoc Acid Treatment on Post-inflammatory Pigmentation in the Suction Blister Model
Post-inflammatory hyperpigmentation (PIH) is a common sequela of inflammatory dermatoses. PIH results from the overproduction of melanin or irregular pigment dispersion after skin inflammation.
- Trial name
- TRANEX (NCT05311033)
- Testing
- Exacyl
- Where
- France
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- Centre Hospitalier Universitaire de Nice
Vitiligo
Prostaglandin F2-alpha (PGF2α) in Vitiligo
study the cutaneous expression of PGF2α in vitiligo patients and compare it with normal control subjects.
- Trial name
- NCT03755830
- Testing
- Skin biopsy
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Cairo University
Photodamage
Single Band vs. Dual Band Pulsed Light Technology for the Treatment of Photodamage - A Split Face Comparison Study
Both the Dye - VL 500 - 600 nm and the Dual band will improve significantly the appearance of Photo Damage with high efficacy including; safety, minimal discomfort and downtime.
- Trial name
- NCT04519736
- Testing
- Single Band vs. Dual Band Pulsed Light Technology for the Treatment of Photodamage
- Where
- United States
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Alma Lasers Inc.
Hyperpigmentation, Skin Aging
Identification of Gene Biomarkers in Aging Skin
This study is a blinded, prospective, single-center, clinical study conducted in Japanese female subjects between the ages of 20-75 years.
- Trial name
- NCT00884936
- Where
- Japan
- Volunteers
- 121 people, healthy volunteers welcome
- Sponsor
- Interleukin Genetics, Inc.
Post-inflammatory Hyperpigmentation, Melasma
A Clinical Study to Evaluate the Efficacy in Improving Dark Spots After 8 Weeks of Use of Facial Sunscreens in Adult Participants
The study aims to evaluate the efficacy of a facial sunscreen under two experimental conditions-untinted and tinted-in improving facial spots (melasma and solar lentigines/post-inflammatory hyperpigmentation) after 8 weeks of…
- Conditions
- Post-inflammatory Hyperpigmentation, Melasma, Solar Lentigo
- Trial name
- El Porto Ex-US (NCT07679945)
- Testing
- Sunscreen untinted, Sunscreen tinted
- Where
- Brazil
- Volunteers
- 152 people, healthy volunteers welcome
- Sponsor
- Kenvue Brands LLC
Age-related Macular Degeneration
Consumption of Eggs Rich in Lutein and Omega-3 Fatty Acids on the Macular Pigment
This study is to determine the impact of the consumption of eggs rich in lutein/zeaxanthin from lucerne protein concentrate and DHA from microalgae on the plasma levels of these compounds but also on the macular pigment optical…
- Trial name
- ALGOVUE (NCT01480700)
- Testing
- Nutritional study
- Where
- France
- Volunteers
- 99 people, healthy volunteers welcome
- Sponsor
- Institut Pasteur de Lille
Study the Potency of Sunscreen to Protect Against the Pigmentation Induced by Visible Light Exposure on Healthy Back Skin
Evaluate the Photoprotection Efficiency of Sunscreen Formulas Under Visible Light Exposure
To evaluate the protective effect of three sunscreens on the pigmentation caused by visible light in comparison to an untreated control zone in healthy volunteers.
- Trial name
- NCT06796088
- Testing
- Treated zones exposed to Visible Light source, Untreated zone exposed to Visible Light source
- Where
- France
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Cosmetique Active International
Sunscreening Agents
18612 - Sun Protection Factor Assay
To evaluate the Sun Protection Factor efficacy on human skin.
- Trial name
- NCT02760576
- Testing
- BAY 987521
- Where
- United States
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- Bayer
Sunscreening Agents
Sun Protection Factor Assay (SPF Assay 202/2016)
To evaluate the Sun Protection Factor efficacy on human skin.
- Trial name
- NCT02930785
- Testing
- BAY987517
- Where
- United States
- Volunteers
- 5 people, healthy volunteers welcome
- Sponsor
- Bayer
Sunscreening Agents
Sun Protection Factor Assay (SPF Assay 104/2016)
To evaluate the Sun Protection Factor efficacy on human skin.
- Trial name
- NCT02891057
- Testing
- BAY987517
- Where
- United States
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- Bayer
Sunscreen
A Study to Evaluate the Whitening Effect of Mineral Sunscreens in Multi-Cultural Skin Tones
The purpose of this study is to evaluate the whitening potential effect of different mineral sunscreens across multi-cultural skin tones through instrumentation, imaging, and self-assessment and also evaluate the relationship…
- Trial name
- NCT05565625
- Testing
- Sunscreen A, Sunscreen B, Sunscreen C
- Where
- United States
- Volunteers
- 97 people, healthy volunteers welcome
- Sponsor
- Johnson & Johnson Consumer Inc. (J&JCI)
Vitiligo, Skin Abnormalities
How Does Skin Tone Affect Quantitative Photoacoustic Imaging
Photoacoustic imaging (PAI) is an emerging method which combines light and ultrasound to assess the blood content and oxygenation of the body.
- Trial name
- PAISKINTONE (NCT05554523)
- Testing
- Photoacoustic imaging
- Volunteers
- 42 people, healthy volunteers welcome
- Sponsor
- University of Cambridge
Sunscreening Agent
18616 - Sun Protection Factor Assay
To evaluate the Sun Protection Factor efficacy on human skin.
- Trial name
- SPF Assay (NCT02788162)
- Testing
- Coppertone (BAY 987517)
- Where
- United States
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- Bayer
Sunscreening Agents
Sun Protection Factor Assay (SPF Assay 200/2016)
To evaluate the Sun Protection Factor efficacy on human skin.
- Trial name
- NCT02930759
- Testing
- BAY987516
- Where
- United States
- Volunteers
- 3 people, healthy volunteers welcome
- Sponsor
- Bayer
Sunscreening Agent
Sun Protection Factor Assay
To evaluate the Sun Protection Factor efficacy on human skin.
- Trial name
- SPF Assay (NCT02822300)
- Testing
- Coppertone (BAY987517)
- Where
- United States
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- Bayer
Melasma
Stem Cell Derived Exosomes in the Treatment of Melasma and Its Percutaneous Penetration
Melasma is a refractory skin disease due to its complex pathogenesis and difficult treatment. Studies have found that human umbilical cord mesenchymal stem cell-derived exosomes (hUCMSC-Exos) could serve as a novel cell-free…
- Trial name
- NCT06221787
- Testing
- 1565 nm non-ablative fractional laser combined with normal saline, microneedles combined with hUCMSC-Exos, 1565 nm non-ablative fractional laser combined with hUCMSC-Exos
- Where
- China
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Fujian Medical University Union Hospital