Clinical trials: Pigmented Skin
Peutz-Jeghers Syndrome, Neoplastic Processes
Study of Everolimus in the Treatment of Advanced Malignancies in Patients With Peutz-Jeghers Syndrome
In this pilot study the investigators will treat all patients known with Peutz-Jeghers syndrome (PJS) who are diagnosed with advanced malignancies with everolimus 10mg daily until disease progression.
- Conditions
- Peutz-Jeghers Syndrome, Neoplastic Processes, Neoplasm Metastasis
- Trial name
- EVAMP (NCT01178151)
- Testing
- Everolimus
- Where
- 2 sites in Netherlands
- Sponsor
- Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA)
Post-inflammatory Hyperpigmentation
Tolerance of Cyto-selective Difluoroethane-based Cryotherapy in the Treatment of Post-inflamamatory Hyperpigmentation (PIH).
CS5_2 study aims to evaluate the tolerance of 4 different conditions of cryotherapy treatments applied on dorsal post-inflammatory hyperpigmentation (PIH) spots.
- Trial name
- NCT05495503
- Testing
- Prototype (814A-v1), Prototype (814B-v1), Prototype (814C-v1)
- Where
- South Africa
- Volunteers
- 12 people
- Sponsor
- Cryonove Pharma
Vitiligo, Maintenance Therapy
Maintenance Therapy of 308-nm Excimer Laser Therapy in Patients With Vitiligo
Although vitiligo is difficult to cure, recurrences are frequent after treatment, and many patients suffer from concerns about recurrence as well as disease.
- Conditions
- Vitiligo, Maintenance Therapy, the 308-nm Excimer Laser, Recurrence
- Trial name
- NCT03384459
- Testing
- the 308-nm excimer laser
- Where
- South Korea
- Volunteers
- 100 people
- Sponsor
- The Catholic University of Korea
Alopecia Areata, Vitiligo
A Study of DR-01 in Subjects With Alopecia Areata and Vitiligo
This is a multi-center, parallel-group, open-label, randomized, Phase 1b study to explore the safety, clinical activity, pharmacokinetics and pharmacodynamics of DR-01 in adults with Alopecia Areata or Vitiligo.
- Trial name
- NCT06602232
- Testing
- DR-01
- Where
- 20 sites in United States, Australia and 1 more
- Volunteers
- 81 people
- Sponsor
- Dren Bio
Acanthosis Nigricans
Efficacy and Safety Of Fractional Carbon Dioxide Laser Plus Topical Metformin In Treatment Of Acanthosis Nigricans
evaluate and compare the clinical Efficacy \& Safety Of Fractional Carbon Dioxide (Co₂) Laser Plus Topical Metformin In Treatment Of Acanthosis Nigricans.
- Trial name
- NCT07760181
- Testing
- Topical metformin
- Volunteers
- 34 people, healthy volunteers welcome
- Sponsor
- Al-Azhar University
Melasma
Fractional co2 Laser Followed by Either Vitamin c or Tranexamic Acid in Treatment of Melasma.
The aim of the study: 1.To compare the efficacy and safety of fractional CO2 laser in combination with vitamin c and tranexamic acid in the treatment of melasma.
- Trial name
- NCT05911698
- Testing
- Fractional co2 laser
- Volunteers
- 25 people
- Sponsor
- Khadija Qenawi
Vitiligo
Interest of the Dermabrasion by Laser Erbium in the Treatment of the Vitiligo
The treatment of vitiligo remains disappointing especially in some localization such as bony prominences and extremities. The association of UVB and topical steroids has been proven to be synergistic but the results are still…
- Trial name
- NCT01087216
- Testing
- Group Laser = Arm A, Bras B : The group control
- Where
- France
- Volunteers
- 20 people
- Sponsor
- Centre Hospitalier Universitaire de Nice
Pigmentation
Evaluation of the Dermal Cooling System for the Enhanced Treatment of Benign Pigmented Lesions and Common Skin Conditions
The purpose of this study is to evaluate the Dermal Cooling System for lightening of benign pigmented lesions and to assess additional cosmetic benefits.
- Trial name
- NCT04493021
- Testing
- Dermal Cooling System
- Where
- United States
- Volunteers
- 137 people, healthy volunteers welcome
- Sponsor
- R2 Dermatology
Skin Diseases, Skin Disorder
OneDoc Picopulse™ for the Treatment of Melasma Among Malaysian Women
OneDoc Picopulse™ is a radiopulse technology beauty grade device invented for treating melasma.
- Conditions
- Skin Diseases, Skin Disorder, Melanoma (Skin)
- Trial name
- NCT04834167
- Testing
- OneDoc Picopulse
- Where
- Malaysia
- Volunteers
- 32 people
- Sponsor
- Universiti Tunku Abdul Rahman
Rosacea, Acne
Clinical Evaluation and Study of the Efficacy of a Centella Asiatica-Infused Facial Mask on Discosmetic Dermatosis
The purpose of this study was to investigate the efficacy and safety of repairing facial mask containing Asiaticum asiatica in treating disjunctive skin diseases.
- Conditions
- Rosacea, Acne, Centella, Melasma
- Trial name
- NCT06763367
- Testing
- Face mask containing Centella sinensis
- Where
- China
- Volunteers
- 30 people
- Sponsor
- Nanjing First Hospital, Nanjing Medical University
Aging Problems, Pigmentation
16-Week Randomized Split-Face Efficacy Study of Cosmetic Formulations in Photoaged Pigmented Skin Subjects
The objective of this study is to determine the efficacy of seven different formulations currently marketed and commercially available cosmetic products on skin tone evenness, post-inflammatory hyperpigmentation, and discrete…
- Trial name
- NCT05160103
- Testing
- Cosmetic Formulations
- Volunteers
- 84 people, healthy volunteers welcome
- Sponsor
- Avon Products, Inc.
Hyperpigmentation
Efficacy and Tolerability of the Tested Formula After 3 Months in Treatment of Facial Hyperpigmentation of 3 Origins
The objective of this study is to evaluate the efficacy, cosmetic acceptability and improvement of the stigmatization of the tested product (2039125 03) used bis in die (BID) for 3 months in adult patients suffering from mild to…
- Trial name
- NCT06268496
- Testing
- serum formula 2039125 03
- Where
- Brazil
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Cosmetique Active International
Vitiligo
HI-Light Pilot Trial for Vitiligo: Hand Held NB-UVB for Early or Focal Vitiligo at Home
This study is a small pilot randomised controlled trial (RCT) comparing hand-held NB-UVB light devices with placebo devices. These devices will be used by the participants to treat their vitiligo at home for a period of four…
- Trial name
- HI-Light (NCT01478945)
- Testing
- 311 nm NB-UVB light
- Where
- 2 sites in United Kingdom
- Volunteers
- 29 people
- Sponsor
- University of Nottingham
Vitiligo
Betamethasone Phonophoresis For Vitiligo
Vitiligo is a skin disorder that results in the formation of depigmented patches or hypopigmented macules due to selective destruction or reduction of melanocytes the cells that produce pigment in our skin.
- Trial name
- NCT07267273
- Testing
- Beclomethasone
- Where
- Egypt
- Volunteers
- 60 people
- Sponsor
- Cairo University
Pigmented Skin Lesion, Melanoma
fPAM for the in Vivo Depth Measurement of Pigmented Lesions and Melanoma Depth
The investigators propose the use of functional photoacoustic microscopy (fPAM) to evaluate both benign and malignant pigmented lesions for tumor depth.
- Trial name
- NCT02613325
- Testing
- Functional photoacoustic microscopy, Standard of care surgical excision, Single cell photoacoustic microscopy
- Where
- United States
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Washington University School of Medicine
Pigmented Skin Lesion of Uncertain Nature
Skin Imaging With Technologies in Development
The purpose of this research is to develop non-invasive imaging modalities for assessment of skin. This is a pilot study which will use multiple imaging modalities to collect information on normal and lesional skin.
- Trial name
- NCT00764920
- Testing
- non-invasive imaging modalities for assessment of skin
- Where
- United States
- Volunteers
- 750 people, healthy volunteers welcome
- Sponsor
- University of California, Irvine
Melasma
Efficacy and Safety of 30% Salicylic Acid and 10% Nicotinamide Combined Therapy in Melasma
This prospective, randomized, placebo-controlled study evaluated the synergistic effects of 30% salicylic acid (SA) chemical peels and topical 10% nicotinamide (NAM) in 56 patients with moderate-to-severe melasma.
- Trial name
- NCT07062120
- Testing
- Nicotinamide(NAM)(10%), Supramolecular salicylic acid(SSA) (30%), Supramolecular salicylic acid simulator
- Where
- China
- Volunteers
- 56 people
- Sponsor
- Second Affiliated Hospital of Xi'an Jiaotong University
Vitiligo
Assessing the Efficacy of Needling With or Without Corticosteroids in the Repigmentation of Vitiligo
Vitiligo is an autoimmune cutaneous disorder that destroys melanocytes leading to depigmented areas of skin. In the United States, vitiligo affects 1% of patients, causing not only changes in the color of skin, but also…
- Trial name
- NCT02191748
- Testing
- Needling, Triamcinolone
- Where
- United States
- Volunteers
- 22 people
- Sponsor
- Rutgers, The State University of New Jersey
Vitiligo, Generalized
Vitiligo, New Treatment and Serum s100B
vitiligo is an autoimmune depigmenting skin disorder characterized by milky white macules or patches, with 2% worldwide prevalence.
- Trial name
- NCT06768840
- Testing
- Baricitinib, oral mini pulse, Narrow Band UVB Treatment
- Where
- Egypt
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- South Valley University
Advanced Melanoma
Tebentafusp Regimen Versus Investigator's Choice in Previously Treated Advanced Melanoma (TEBE-AM)
The purpose of this study is to evaluate the efficacy and safety of tebentafusp-based regimens, including tebentafusp monotherapy and in combination with anti-PD1 vs investigator choice (including clinical trials of…
- Trial name
- NCT05549297
- Testing
- Tebentafusp, Tebentafusp with Pembrolizumab, Investigators Choice
- Where
- 82 sites in United States, Australia and 10 more
- Volunteers
- 540 people
- Sponsor
- Immunocore Ltd