Clinical trials: Pilot Study
Kawasaki Disease, Pilot Study
Model-informed Dose Optimization for Rivaroxaban in Children With Giant Coronary Artery Aneurysm After Kawasaki Disease
Based on a population pharmacokinetic model-based dose optimization study, a 15 mg-equivalent, age-, and bodyweight-adjusted dosing regimen for Chinese children with giant coronary artery aneurysms after Kawasaki disease was…
- Conditions
- Kawasaki Disease, Pilot Study, Coronary Artery Aneurysm, Rivaroxaban
- Trial name
- NCT06978439
- Testing
- Rivaroxaban (Xarelto)
- Where
- China
- Volunteers
- 10 people
- Sponsor
- Children's Hospital of Fudan University
Postoperative Pulmonary Complications (PPCs), Feasibility Studies
PROtective Ventilation With FLOW-Controlled Ventilation
The investigators want to investigate in patients undergoing robot-assisted laparoscopic surgery (a minimally invasive procedure) how applicable flow-controlled ventilation is, and whether it might also be safer than the current…
- Conditions
- Postoperative Pulmonary Complications (PPCs), Feasibility Studies, Pilot Study
- Trial name
- PROFLOW (NCT06703814)
- Testing
- Intraoperative flow-controlled ventilation strategy, Intraoperative pressure-controlled ventilation strategy
- Where
- 3 sites in Austria, Germany and 1 more
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Cantonal Hospital of St. Gallen
Checkpoint Inhibitor, Pilot Study
Checkpoint Inhibitor Associated Diabetes Mellitus: Early Recognition and Treatment (CERT) Project: A Pilot Study
To find out if taking a drug called infliximab (the "study drug") is safe and effective in reversing insulin dependence in CIADM.
- Conditions
- Checkpoint Inhibitor, Pilot Study, Diabetes Melletus
- Trial name
- NCT07257068
- Testing
- Infliximab
- Where
- United States
- Volunteers
- 14 people
- Sponsor
- M.D. Anderson Cancer Center
Mental Health Care, Anxiety and Depression
Feasibility and Acceptability of Group Medical Visits for Anxiety and Depression
The goal of this clinical trial is to evaluate the feasibility and acceptability of the intervention, Group Medical Visits (GMVs), for patients with depression and anxiety.
- Conditions
- Mental Health Care, Anxiety and Depression, Pilot Study
- Trial name
- NCT06651801
- Testing
- Group Medical Visits
- Where
- Canada
- Volunteers
- 20 people
- Sponsor
- University of Manitoba
Cognition, Multiomics
Probiotic Research: Open-label Functional Intervention and Longitudinal Evaluation in Healthy Adults
This study is a pre-post, open-label cohort study designed to investigate how a food-grade probiotic supplement affects biological measurements and wellbeing in healthy adults.
- Conditions
- Cognition, Multiomics, Microbiome Analysis, Metabolome
- Trial name
- PROFILE (NCT07457242)
- Testing
- Probiotic Supplementation (Lactobacillus plantarum)
- Volunteers
- 180 people, healthy volunteers welcome
- Sponsor
- OneCarbon
Post Prandial Blood Glucose, Feasibility Pilot Study
Relaxing Virtual Reality Use and Blood Glucose Response to Food (ReViR) Study
This randomized cross-over pilot clinical trial aims to evaluate the feasibility and effect of a relaxing virtual reality (VR) experience on glucose response after white bread consumption, compared to a stress-inducing VR, a VR…
- Trial name
- NCT07541794
- Testing
- A relaxing VR environment, A stress-inducing VR game, A VR clinical room
- Where
- Canada
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- University of Manitoba
Pilot Study, PET/CT Imaging
A Pilot Study to Correlate 4-18F- Fluoro-1-naphthol 18F-4FN PET/CT Imaging With Graft Versus Host Disease Manifestations
To study the safety and possible side effects of using the imaging agent 4-[18F]Fluoro-1-Naphthol (also called [18F]4FN) in PET/CT scans for participants with chronic GVHD.
- Conditions
- Pilot Study, PET/CT Imaging, Host Disease Manifestation
- Trial name
- NCT07325253
- Testing
- [18F]-4FN, PET-CT
- Where
- United States
- Volunteers
- 16 people
- Sponsor
- M.D. Anderson Cancer Center
Continuous Glucose Monitoring, Diabetes, Gestational
Early Pregnancy Lifestyle and Glucose Patterns: A Substudy of TOFFFY
The goal of this clinical trial is to examine how daily behavioral patterns in early pregnancy, including sleep, physical activity, and meal timing, influence continuous glucose dynamics and subsequent risk of gestational…
- Conditions
- Continuous Glucose Monitoring, Diabetes, Gestational, Diet During Pregnancy, Meal Time
- Trial name
- NCT07534670
- Testing
- Continuous glucose monitor (CGM), Wrist actigraphy device, AI-based dietary and meal timing logging mobile application
- Where
- Singapore
- Volunteers
- 140 people, healthy volunteers welcome
- Sponsor
- KK Women's and Children's Hospital
Kidney Transplant, Urinary Tract Infection(UTI)
Antibiotics for Kidney Transplant Recipients
The goal of this clinical trial is to learn if a common antibiotic called trimethoprim-sulfamethoxazole (TMP-SMX) can help prevent urinary tract infections (UTIs) in children and young adults who recently had a kidney transplant.
- Conditions
- Kidney Transplant, Urinary Tract Infection(UTI), Antibiotic Prophylaxis, Remote Patient Monitoring
- Trial name
- TASK (NCT07106125)
- Testing
- Trimethoprim-Sulfamethoxazole (TMP-SMX), Usual Care
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- University of California, San Francisco
Pilot Study
How Differences in the Composition of Microorganisms in the Soil Affect the Microorganisms in the Human Gut, Through the Vegetables That Grow in it: a Process Pilot Study With Healthy Participants
There are two objectives for this clinical trial. The first is to test whether, with the current logistics and study setup it is possible to perform the study well and see where there might be bottlenecks we couldn't predict.
- Trial name
- HUMANITAS (NCT07742319)
- Testing
- Low diversity vegetable smoothie, High diversity vegetable smoothie
- Where
- Netherlands
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- Leiden University Medical Center
Coronary Artery Bypass Graft, Radial Artery Grafts
Different Anti-Spastic Therapy Strategies After CABG Using Radial Artery Grafts
The Pilot study will be a single-center, randomized, open-label, active-controlled trial. After CABG surgery using Radial Artery Grafts (RA-CABG) and signing the informed consent, all patients will be screened according to the…
- Conditions
- Coronary Artery Bypass Graft, Radial Artery Grafts, Antispastic Therapy, Pilot Study
- Trial name
- ASRAB-Pilot (NCT04310995)
- Testing
- Nicorandil 5mg tid, Diltiazem 180mg qd, Isosorbide Mononitrate 50mg qd
- Where
- China
- Volunteers
- 150 people
- Sponsor
- Ruijin Hospital
Orthopaedic Related Pain (Musculoskeletal Pain), Opioid
Two Post-Operative Pain Protocols at Discharge for Orthopaedic Patients
This is a single-center, pilot randomized controlled trial designed to evaluate the feasibility of a definitive trial comparing opioid-free discharge prescriptions to usual care (which includes opioids) in patients undergoing…
- Conditions
- Orthopaedic Related Pain (Musculoskeletal Pain), Opioid, Pain, Pilot Study
- Trial name
- NCT07265557
- Testing
- Discharge pain medication prescription
- Where
- United States
- Volunteers
- 100 people
- Sponsor
- Massachusetts General Hospital
Feasibility Pilot Study, Compliance
A Low-Insulinemic Dietary Intervention to Reduce Breast Cancer Risk in High-Risk Women
This clinical trial tests whether a new dietary pattern that consists of foods that lower the blood insulin response can reduce breast cancer risk in high-risk women.
- Trial name
- LIN-BRiCK (NCT06635005)
- Testing
- Biospecimen Collection, Dietary Intervention, Medical Device Usage and Evaluation
- Where
- United States
- Volunteers
- 34 people, healthy volunteers welcome
- Sponsor
- Ohio State University Comprehensive Cancer Center
RELAX Telehealth Intervention, Psychoeducational Waitlist Control
Regulating Emotions Like An eXpert Among Adolescents With ADHD
This study consists of a randomized controlled trial assessing the acceptability, feasibility, and efficacy of the RELAX (Regulating Emotions Like An eXpert) Intervention.
- Conditions
- RELAX Telehealth Intervention, Psychoeducational Waitlist Control, EMI Smartphone App Pilot
- Trial name
- RELAX (NCT06725186)
- Testing
- RELAX, Psychoeducational Materials
- Where
- United States
- Volunteers
- 60 people
- Sponsor
- Virginia Polytechnic Institute and State University
Feasibility Pilot Study
A Patient-Directed Computerized Intervention to Address Reproductive Coercion
The goal of this clinical trial is to evaluate the feasibility and acceptability of "BRIDGES" (Building Reproductive Decision-Making, Empowerment, \& Support), a new patient-directed educational website (bridges4support.org).
- Trial name
- NCT06764030
- Testing
- Educational web-based application
- Where
- United States
- Volunteers
- 156 people, healthy volunteers welcome
- Sponsor
- University of Michigan
Skin Temperature Change, Adverse Effects
Prolonged Cryocompression and Skin Temperature: a Safety and Feasibility Pilot
Guidelines for treatment duration for cold and compression therapy after knee surgery are typically based on the use of ice packs for 30 minutes.
- Conditions
- Skin Temperature Change, Adverse Effects, Safety of Intervention, Cryotherapy
- Trial name
- NCT06673277
- Testing
- Prolonged (2-hour) cryocompression therapy
- Where
- United Kingdom
- Volunteers
- 16 people, healthy volunteers welcome
- Sponsor
- University of Winchester
Family Engagement, Critical Care, Intensive Care
The Family Cares Trial
The goal of this pilot study is to learn if virtual peer support groups and strengths-based skills training can help family caregivers of ICU survivors providing ongoing support to ICU survivors after hospital discharge.
- Conditions
- Family Engagement, Critical Care, Intensive Care, Patient and Family Engagement, Health Care Delivery
- Trial name
- Family Cares (NCT06984770)
- Testing
- Virtual peer support group intervention, Caregiver Support intervention, Resources
- Where
- 2 sites in Canada
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Lady Davis Institute
Caregiver Subjective Burden, Caregiver Wellbeing
Feasibility & Preliminary Impacts of an Online Psychoeducational Program (iSupport-Malaysia) for Informal Dementia Caregivers
The general objective of this pilot feasibility study is to implement the pilot randomised controlled trial (RCT) and evaluate the feasibility of its methods and procedures for iSupport-Malaysia intervention.
- Conditions
- Caregiver Subjective Burden, Caregiver Wellbeing, Feasibility Pilot Study
- Trial name
- NCT06883708
- Testing
- iSupport-Malaysia Web-Based Intervention, iSupport-Malaysia eBook
- Where
- 4 sites in Malaysia
- Volunteers
- 70 people
- Sponsor
- Sunway University
Depression, Anxiety, Physical Activity
Promoting Active Therapy: Path to Wellness
This project will examine changes in depression and anxiety following a 10-week intervention promoting nature-based physical activity in mental health settings.
- Conditions
- Depression, Anxiety, Physical Activity, Time in Nature, Self-Efficacy
- Trial name
- NCT06858189
- Testing
- Walk-and-talk therapy
- Where
- United States
- Volunteers
- 60 people
- Sponsor
- Kansas State University
This is a Pilot Study Which Aims to Assess the Validity and Applicability of Lateral Flow Assays (LFAs) Which Can be Used as a Point of Care Test for COVID-19, Covid19
The LAVA (Lateral Flow Antigen Validation and Applicability) Study for COVID-19
This is a pilot study which aims to assess the validity and applicability of lateral flow assays (LFAs) which can be used as a point of care test for COVID-19.
- Trial name
- LAVA (NCT04629157)
- Testing
- Innova Lateral Flow Device
- Where
- 2 sites in United Kingdom
- Volunteers
- 400 people
- Sponsor
- Alder Hey Children's NHS Foundation Trust