Clinical trials: Pituitary Adenoma
Pituitary Adenoma
Proton Radiation Therapy for Pituitary Adenoma
The purpose of this study is to collect information from medical records to see what effects proton beam radiation has on pituitary tumors and analyze possible side effects.
- Trial name
- PI01 (NCT00798057)
- Where
- United States
- Volunteers
- 16 people
- Sponsor
- University of Florida
Prolactinoma, Insulin Resistance
Insulin Resistance in Women With Prolactinoma
Prolactin is suggested to influence insulin resistance, but scarce data is available on the metabolic profile of patients with prolactinoma.
- Conditions
- Prolactinoma, Insulin Resistance, Hyperlipidemia
- Trial name
- NCT00481299
- Where
- Brazil
- Volunteers
- 2,004 people, healthy volunteers welcome
- Sponsor
- Universidade Federal do Rio de Janeiro
Pituitary Adenomas
The Effect of Chemoradiotherapy in Patients With Refractory Pituitary Adenomas
The purpose of this study was to determine whether radiotherapy combined with Temozolomide is more effective than radiotherapy alone in the treatment of patients with refractory pituitary adenomas.
- Trial name
- NCT04244708
- Testing
- Radiotherapy plus temozolomide
- Volunteers
- 150 people
- Sponsor
- Peking Union Medical College Hospital
Acromegaly
Pasireotide in Patients With Acromegaly Inadequately Controlled With First Generation Somatostatin Analogues
This is a phase IIIb multicenter, open-label; single arm study to evaluate the efficacy and safety of pasireotide LAR 40 mg and 60 mg in patients with inadequately controlled acromegaly with maximal approved doses of first…
- Trial name
- NCT02354508
- Testing
- Pasireotide LAR
- Where
- 50 sites in Argentina, Belgium and 13 more
- Volunteers
- 123 people
- Sponsor
- Novartis Pharmaceuticals
Cushing Disease, ACTH-producing Pituitary Tumour
Evaluation of Positron Emission Tomography (PET) With [18F]FET for the Detection of ACTH-Secreting Corticotroph Pituitary Neuroendocrine Tumors.
Cushing's disease results from adrenocorticotropic hormone (ACTH) secretion by corticotroph pituitary neuroendocrine tumors (PitNETs).
- Trial name
- PiTFET (NCT07463625)
- Testing
- Data-only evaluation of [18F]FET PET, pituitary MRI, and biomarkers
- Where
- France
- Volunteers
- 20 people
- Sponsor
- Hospices Civils de Lyon
Non-functioning Pituitary Adenoma
Individualized Physical Activity or Patients With Non Functioning Pituitary Adenoma
The goal of this clinical trial is to learn about physical activity's effect on health in people who have had surgery of a non-functioning pituitary adenoma.
- Trial name
- NCT06163261
- Testing
- Physical activity
- Where
- Sweden
- Volunteers
- 120 people
- Sponsor
- Vastra Gotaland Region
Pituitary Adenoma
Long-term Follow up for Retinal Vascular Changes After Endoscopic Endonasal Pituitary Surgery.
This study investigates the retinal vascular features, using optical coherence tomography angiography, in patients during one year's follow up after the endoscopic endonasal surgery to remove an intra-suprasellar pituitary…
- Trial name
- NCT04546386
- Testing
- Endoscopic endonasal pituitary surgery
- Where
- Italy
- Volunteers
- 14 people
- Sponsor
- Federico II University
Craniopharyngioma, Obesity
Multicenter Registry for Patients With Childhood.Onset Craniopharyngioma, Xanthogranuloma, Cysts of Rathke's Pouch, Meningioma, Pituitary Adenoma, Arachnoid Cysts
KRANIOPHARYNGEOM Registry 2019 will prospectively collect and descriptively analyse data on diagnostics, treatment, and follow-up of patients with craniopharyngioma.
- Trial name
- NCT04158284
- Where
- Germany
- Volunteers
- 90 people
- Sponsor
- Klinikum Oldenburg gGmbH
Childhood Atypical Teratoid/Rhabdoid Tumor, Childhood Central Nervous System Choriocarcinoma
Gamma-Secretase Inhibitor RO4929097 in Treating Young Patients With Relapsed or Refractory Solid Tumors, CNS Tumors, Lymphoma, or T-Cell Leukemia
This phase I/II clinical trial is studying the side effects and best dose of gamma-secretase inhibitor RO4929097 and to see how well it works in treating young patients with relapsed or refractory solid tumors, CNS tumors…
- Conditions
- Childhood Atypical Teratoid/Rhabdoid Tumor, Childhood Central Nervous System Choriocarcinoma, Childhood Central Nervous System Germinoma, Childhood Central Nervous System Mixed Germ Cell Tumor
- Trial name
- NCT01088763
- Testing
- gamma-secretase/Notch signalling pathway inhibitor RO4929097, diagnostic laboratory biomarker analysis, pharmacological study
- Where
- 12 sites in United States, Canada
- Volunteers
- 129 people
- Sponsor
- National Cancer Institute (NCI)
Pituitary Adenoma
Detection of Functioning Pituitary Microadenoma: PET/MRI Versus PET/CT
This is a prospective case-control study to compare the usefulness of 18F-FDG PET/MRI with that of 18F-FDG PET/CT in detection of functioning pituitary microadenomas.A single dose of 370 Mega-Becquerel (MBq) 18F-FDG will be…
- Trial name
- NCT03404414
- Testing
- 18F-FDG
- Where
- China
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Peking Union Medical College Hospital
Cushing's Disease
Effect of Vorinostat on ACTH Producing Pituitary Adenomas in Cushing s Disease
Background: Cushing s disease is caused by excess ACTH hormone release by a benign tumor of the pituitary gland. It can lead to decreased quality of life and early death.
- Trial name
- NCT04339751
- Testing
- Vorinostat
- Where
- United States
- Sponsor
- National Institute of Neurological Disorders and Stroke (NINDS)
Pituitary Adenoma 1, Acth-Secreting
Pituitary Adenoma and Serum Lipid
Pituitary adenomas are usually benign monoclonal neoplasms caused by a mixture of pituicyte alterations together with a changed endocrine and paracrine regulatory milieu.
- Trial name
- NCT04021212
- Where
- China
- Volunteers
- 1,000 people
- Sponsor
- Shandong Provincial Hospital
Pituitary Adenoma, Pituitary Tumor
Setting Benchmarks for Transsphenoidal Resection of Pituitary Adenomas
To conduct a retrospective multicenter cohort study to define benchmark values for best achievable outcomes following transsphenoidal resection of pituitary adenomas.
- Conditions
- Pituitary Adenoma, Pituitary Tumor, Pituitary Diseases
- Trial name
- NCT04951557
- Testing
- Transsphenoidal resection
- Where
- Germany
- Volunteers
- 5,000 people
- Sponsor
- Universitätsklinikum Hamburg-Eppendorf
Surgery, Pituitary Adenoma
Comparative Effectiveness of Different Surgical Approaches for Giant Pituitary Adenomas
The surgical treatment strategy for giant invasive pituitary adenoma is one of the current hot spots in the field of clinical research on pituitary adenoma.
- Trial name
- NCT05448690
- Testing
- Two different approaches, Non-combined approach
- Where
- 13 sites in China
- Volunteers
- 600 people
- Sponsor
- Huashan Hospital
Acromegaly
A Pilot Study of Pre- and Post-operative Use of Somatuline Depot.
If someone is diagnosed with a pituitary tumor that causes acromegaly (too much growth hormone) the treatment is to have it surgically removed. This study has two phases.
- Trial name
- NCT01861717
- Testing
- lanreotide
- Where
- United States
- Volunteers
- 4 people
- Sponsor
- Saint John's Cancer Institute
Pituitary Adenoma, Surgery
Pain Management After Transnasal Transsphenoidal Surgery for Pituitary Adenomas
We hypothesize that the effects of non-steroidal anti-inflammatory drugs (NSAIDS) for pain relief among patients with pituitary adenomas undergoing transnasal transsphenoidal surgeries are non-inferior to tramadol.
- Conditions
- Pituitary Adenoma, Surgery, Pain
- Trial name
- NCT04611685
- Testing
- NSAID, Tramadol
- Where
- China
- Volunteers
- 202 people
- Sponsor
- Peking Union Medical College Hospital
Prolactinoma
Exercise Capacity and Physical Activity Level in Prolactinoma Patients
Prolactinoma, one of the most common pituitary adenomas, is an adenoma that causes excessive prolactin (PRL) secretion. An increase in prolactin level can cause weakness, decrease in muscle mass and fatigue.
- Trial name
- NCT05236829
- Where
- Turkey (Türkiye)
- Volunteers
- 38 people, healthy volunteers welcome
- Sponsor
- Hacettepe University
Cushing's Syndrome
A Study to Confirm Recurrent or Persistent Cushing's Syndrome in Patients With Signs or Symptoms of Hypercortisolemia
This is an observational study to confirm the presence of recurrent or persistent endogenous Cushing's syndrome in patients who have had primary surgical and/or radiation therapy for Cushing's disease and continue to manifest…
- Trial name
- NCT00796783
- Testing
- Cushing's syndrome confirmation
- Where
- 3 sites in United States
- Volunteers
- 2 people
- Sponsor
- Corcept Therapeutics
Pituitary Adenoma
Application of Radiomics in the Diagnosis and Treatment Prediction of Pituitary Adenoma
The images of patients with Pituitary adenoma were collected and analyzed based on the methods of radiomics.
- Trial name
- RIPA (NCT06234553)
- Testing
- surgery of pituitary adenomas
- Where
- China
- Volunteers
- 200 people
- Sponsor
- Beijing Tiantan Hospital
Pituitary Adenoma
Outcome Analysis of Endoscopic Resection of Pituitary Adenomas
The goal of this prospective study is to learn about the operative outcomes in patients with pituitary adenoma who receive endoscopic resection.
- Trial name
- NCT06156020
- Testing
- Endoscopic endonasal surgery
- Where
- Taiwan
- Volunteers
- 500 people
- Sponsor
- National Cheng-Kung University Hospital