Clinical trials: Pituitary Disease
Pituitary Neoplasms, Prolactinoma
Interdisciplinary Pituitary Disorders Centre of Excellence: Assessment of Patient Education Tools
The purpose of this research study is to determine the utility of educational materials designed to inform patients of their pituitary condition, in an effort to assist the patients, families, and staff deal with pituitary…
- Conditions
- Pituitary Neoplasms, Prolactinoma, ACTH-Secreting Pituitary Adenoma, Gigantism
- Trial name
- NCT01775332
- Testing
- Educational Intervention
- Where
- Canada
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Unity Health Toronto
Acromegaly
Efficacy and Safety of C2L-OCT-01 PR in Acromegalic Patients
The purpose of this study is to assess the biological safety and efficacy of using the drug, C2L-OCT-01 PR, 30 mg to treat acromegalic patients.
- Trial name
- NCT00616551
- Testing
- C2L-OCT-01 PR, 30 mg, Octreotide acetate prolonged release, 30 mg
- Where
- 6 sites in Belarus, Hungary and 4 more
- Volunteers
- 65 people
- Sponsor
- Ambrilia Biopharma, Inc.
Acromegaly, Olfactory Disorder
Olfactory Function and Olfactory Bulb Volume in Acromegaly Patients
A prospective, controlled, single blinded study was planned. 20 patients with Acromegaly (Acromegaly Group) and 20 healthy subjects (Control Group) were planned to include in the study.
- Trial name
- NCT04138537
- Testing
- OB volume, CCCRC test
- Where
- Turkey (Türkiye)
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Bezmialem Vakif University
Endogenous Cushing's Syndrome
Treatment for Endogenous Cushing's Syndrome
The primary objectives of this study are to evaluate the clinical responder rate, defined as the proportion of subjects with normal UFC after 6 months of treatment with COR-003 in the Maintenance Phase without dose increase, and…
- Trial name
- SONICS (NCT01838551)
- Testing
- Levoketoconazole
- Where
- 42 sites in United States, Belgium and 13 more
- Volunteers
- 94 people
- Sponsor
- Cortendo AB
Acromegaly
Open Label Study of Octreotide Implant in Patients With Acromegaly
To evaluate the pharmacokinetic (PK) and pharmacodynamic (PD) response of a hydrated and non-hydrated 84 mg octreotide implant in patients with acromegaly in the first 6 weeks of treatment.
- Trial name
- NCT00913055
- Testing
- octreotide acetate
- Volunteers
- 34 people
- Sponsor
- Endo USA Inc., a Keenova Therapeutics Company
Healthy, Type 1 Diabetes
The Effect of Lixisenatide on the Effect of Pituitary Hormones
The current study has two aims: 1. to test the hypothesis that a single dose of lixisenatide can be used as a growth hormone stimulation test; 2.
- Trial name
- NCT05804513
- Testing
- Lixisenatide 10 micrograms (50 micrograms/ml in 3 ml) Pen Injector
- Where
- Estonia
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- University of Tartu
Acromegaly
Late Effects of Radiosurgery on Acromegaly Study
Transsphenoidal surgery is the first-line treatment of acromegaly. Adjunctive radiotherapy can be necessary when surgery is ineffective to avoid a prolonged medical treatment.
- Trial name
- LateRAc (NCT02296216)
- Testing
- Gamma Knife radiosurgery
- Where
- France
- Volunteers
- 66 people
- Sponsor
- Assistance Publique Hopitaux De Marseille
Osteopenia
Study of Adults With Low Growth Hormone Who Survived Childhood Cancer Where Treatment Caused Low Bone Density
The purpose of this project is to evaluate the hypothesis that bisphosphonate treatment given to growth hormone deficient patients (regardless of current growth hormone replacement therapy status and without changing that status)…
- Trial name
- NCT00145704
- Testing
- bisphosphonate therapy (risedronate), Vitamin D supplement, Calcium
- Where
- United States
- Volunteers
- 6 people
- Sponsor
- State University of New York - Upstate Medical University
Diabetes Mellitus, Type 2, Arterial Hypertension
Antidiuretic Function Before and During Treatment With SGLT2 Inhibitors
Subjects treated with Canagliflozin, Dapagliflozin and Empagliflozin obtained improvement on blood pressure values, body weight and cardiovascular mortality but pathophysiological explanations of these effects are not yet known.
- Conditions
- Diabetes Mellitus, Type 2, Arterial Hypertension, Body Weight Changes
- Trial name
- GliRACo1 (NCT03917758)
- Testing
- SGLT2 inhibitor
- Where
- Italy
- Volunteers
- 30 people
- Sponsor
- University of Turin, Italy
Cardiac Arrest, Out-Of-Hospital Cardiac Arrest
The Effect of Prehospital Combination of Epinephrine, Vasopressin, and Steroid in OHCA
This project is a randomized controlled clinical research design, The hypothesis P-I-C-O of the study is: For adult patients in the Taipei City and New Taipei City communities who have suffered sudden non-traumatic death and have…
- Conditions
- Cardiac Arrest, Out-Of-Hospital Cardiac Arrest, Emergency Medical Services
- Trial name
- REVIVES (NCT06203847)
- Testing
- Combination group, Standard group
- Where
- Taiwan
- Volunteers
- 1,344 people
- Sponsor
- National Taiwan University Hospital
Childhood Trauma, Major Depressive Disorder
HPA Axis Activity Due To Early Traumatic Stress and Metabolic Symptoms
This study evaluates the association between early trauma, depression and metabolic symptoms.
- Trial name
- Cort-Metab (NCT02398877)
- Testing
- stress
- Where
- Germany
- Volunteers
- 140 people, healthy volunteers welcome
- Sponsor
- Charite University, Berlin, Germany
Menopause
Cortisol Levels on Menopausal Symptoms - Ancillary (Addendum) Study to Protocol 16997
This is an ancillary study to Protocol 16997 to examine the stress hormone level in women with menopausal symptoms. This ancillary project will collect additional data from the 45 subjects enrolled in Protocol 16997 (no subjects…
- Trial name
- NCT00950781
- Testing
- ACTH
- Where
- United States
- Volunteers
- 45 people, healthy volunteers welcome
- Sponsor
- Cedars-Sinai Medical Center
Depression, Psychotic Disorders
Clinical and Biological Characteristics of Psychotic Depression
The primary objective of this study is to investigate the relationships among findings in structural and functional neuroimaging, cognitive testing and HPA (hypothalamic-pituitary-adrenal) axis dysregulation in psychotic…
- Conditions
- Depression, Psychotic Disorders, Depressive Disorder, Major
- Trial name
- NCT00576095
- Where
- United States
- Volunteers
- 73 people, healthy volunteers welcome
- Sponsor
- Stanford University
Growth Hormone Deficiency
The Effects of Growth Hormone (GH) on Lipid Depots
This study aims at investigating the effect of growth hormone on lipid-content of muscle and liver as well as visceral fat mass in relation to insulin sensitivity.
- Trial name
- NCT00491582
- Testing
- Growth hormone replacement therapy in growth hormone deficient patients only.
- Where
- Switzerland
- Volunteers
- 34 people, healthy volunteers welcome
- Sponsor
- Insel Gruppe AG, University Hospital Bern
Acromegaly
Reproducibility and Utility of OGTT in Acromegaly
Prospective study of reproducibility and utility of growth hormone inhibition by oral glucose tolerance test for the diagnosis of acromegaly, in acromegalic and non-acromegalic subjects, with a randomized double-blind crossover…
- Trial name
- ACROTEST (NCT04066569)
- Testing
- Performed 2 diagnostic tests (2 OGTT tests with 75g of Glucose)
- Where
- France
- Volunteers
- 109 people, healthy volunteers welcome
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Growth Hormone, Recombinant, Fatty Liver
The Effect of Growth Hormone Replacement on Liver Fat
We will examine a cohort of growth hormone deficient adults starting growth hormone (GH) replacement. The purpose of this study is to determine whether GH replacement reduces the fat content of the liver.
- Trial name
- NCT00774579
- Where
- United Kingdom
- Volunteers
- 30 people
- Sponsor
- Imperial College London
Hypotension, Poor Peripheral Perfusion
Effect of Vasopressin on Tissue Oxygen Saturation in Cardiac Surgery Patients During Cardiopulmonary Bypass
The objective of this research is to compare the effect of a low dose Vasopressin infusion or placebo during cardiopulmonary bypass on vasopressor requirements, hemodynamics and tissue oxygen saturation and its recovery using…
- Trial name
- NCT01532505
- Where
- Canada
- Volunteers
- 40 people
- Sponsor
- Mohamed Ismail
Growth Hormone Deficiency
Pegylated Somatropin (PEG Somatropin) in the Treatment of Children With Growth Hormone Deficiency
To Evaluate the safety and efficacy of PEG Somatropin in the treatment of children with growth hormone deficiency, as well as to study the dosage of PEG Somatropin.
- Trial name
- NCT03249480
- Testing
- PEG-somatropin
- Where
- 28 sites in China
- Volunteers
- 900 people
- Sponsor
- Changchun GeneScience Pharmaceutical Co., Ltd.
Acromegaly
Safety and Efficacy of Pasireotide Long Acting Release (LAR) vs. Octreotide LAR in Patients With Active Acromegaly
The patients received either Pasireotide LAR or Octreotide LAR for one year of treatment. The objective of this study was to compare the proportion of patients with a reduction of mean GH level to <2.5 µg/L and the normalization…
- Trial name
- NCT00600886
- Testing
- Pasireotide, Octreotide
- Where
- 95 sites in United States, Argentina and 25 more
- Volunteers
- 358 people
- Sponsor
- Novartis Pharmaceuticals
Healthy
A Study to Evaluate Suppression of the Pituitary-Ovarian Axis With Three Different Oral Contraceptive Regimens
This is a randomized, open-label study to evaluate pituitary ovarian suppression in healthy, reproductive-aged women using three different regimens of oral contraceptives (OCs).
- Trial name
- NCT00117273
- Testing
- Seasonale [levonorgestrel (LNG)/ethinyl estradiol (EE)], Seasonique (LNG/EE and EE), Portia (LNG/EE)
- Where
- United States
- Volunteers
- 36 people, healthy volunteers welcome
- Sponsor
- Duramed Research
The first 1,020 results can be paged through. Add a filter or change the sort order to reach the rest.