Clinical trials: Pituitary Tumour
Pituitary Adenoma, Pituitary Diseases
Peri-Operative Steroid Management in Patients
During transsphenoidal resection of pituitary tumors and cysts, surgery is performed by a neurosurgeon and ear nose and throat surgeon.
- Trial name
- Steroid (NCT02084134)
- Testing
- hydrocortisone, dexamethasone
- Where
- United States
- Volunteers
- 43 people
- Sponsor
- Washington University School of Medicine
Cognition, Brain Tumor
Neurocognition After Radiotherapy in CNS- and Skull-base Tumors
The goal of this multicenter prospective longitudinal study is to study the long-term impact of multimodal treatment (chemotherapy, radiotherapy and surgery) in adult brain and base of skull tumors on neurocognitive functioning.
- Conditions
- Cognition, Brain Tumor, Magnetic Resonance Imaging, Meningioma
- Trial name
- NARCiS (NCT05727605)
- Testing
- Neurocognitive tests: WAIS digit span, HVLT-R, COWAT, MOCA, WAIS digit symbol substitution, TMT A&B, Stroop Color Word Test, MRI, Questionnaires: EORTC QLQ C30 & BN20, STAI, CFQ, BDI-II, BRIEF-A, FACIT-F, PSQI
- Where
- 3 sites in Belgium
- Volunteers
- 120 people
- Sponsor
- Universitaire Ziekenhuizen KU Leuven
Prolactinoma
Dopamine D2 Receptors(D2R) Imaging in Prolactinomas
To study the in vivo expression of dopamine D2 receptors in prolactinoma and the predictive role of dopamine D2 receptors PET-MR imaging in the therapeutic effect of dopamine agonists.
- Trial name
- NCT03717454
- Testing
- Surgery, Drug treatment
- Volunteers
- 50 people
- Sponsor
- Zhebao Wu
Surgery
Mode of Ventilation and Bleeding During Transsphenoidal Surgery
The risk of bleeding is important during transsphenoidal surgery. This study aims to find if the ventilation mode, controlled pressure and controlled volume, modifies the risk of bleeding.
- Trial name
- Vent-Hyp (NCT01891838)
- Testing
- Volume controlled ventilation, Pressure-controlled ventilation
- Where
- France
- Volunteers
- 101 people
- Sponsor
- Hopital Foch
Radiation of Neurocranial Region
Enhancement of Neurocognitive Functions by Hippocampal Sparing Radiotherapy
This randomized trial examines possible enhancements in live quality and neurocognitive functions in patients after radiotherapy of the neurocranial area with hippocampal sparing.
- Trial name
- HIPPO-SPARE 01 (NCT01849484)
- Testing
- Radiation according to indication with hippocampal sparing, Radiation according to indication without hippocampal protection
- Where
- Germany
- Volunteers
- 150 people
- Sponsor
- University of Erlangen-Nürnberg Medical School
Pituitary Adenoma
Heart Rate Variability (HRV) in Pituitary Adenoma
Several studies have been reported that heart rate is known to be associated with prognosis in chronic diseases and acute diseases.
- Trial name
- NCT03164148
- Testing
- T-REX TRI00A
- Where
- South Korea
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Seoul St. Mary's Hospital
Pituitary Adenoma
Comparison of The Effects of Sevoflurane, Desflurane and Total Intravenous Anaesthesia on Pulmonary Function Tests
This study will compare the effects of sevoflurane, desflurane and total intravenous anaesthesia on pulmonary function tests in patients undergoing endoscopic endonasal transsphenoidal surgery of pituitary gland.
- Trial name
- NCT02709863
- Testing
- Sevoflurane, Desflurane, Propofol
- Where
- Turkey (Türkiye)
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- Istanbul University
Solid Tumors With PTCH1 Loss-of-function Mutations
A Study Evaluating the Safety and Efficacy of ENV-101 (Taladegib) in Patients With Advanced Solid Tumors Harboring PTCH1 Loss of Function Mutations
This study employs a 2-stage design that aims to evaluate the efficacy and safety of ENV- 101, a potent Hedgehog (Hh) pathway inhibitor, in patients with refractory advanced solid tumors characterized by loss of function (LOF)…
- Trial name
- NCT05199584
- Testing
- ENV-101 (taladegib)
- Where
- 16 sites in United States
- Volunteers
- 20 people
- Sponsor
- Endeavor Biomedicines, Inc.
Hyponatremia, Syndrome of Inappropriate ADH (SIADH) Secretion
An Observational Study Measuring Outcomes in Cancer Patients Treated for Moderate to Severe Hyponatremia in Italy
This observational, prospective, non-interventional study will include cancer patients who need a treatment for hyponatraemia secondary to SIADH.
- Conditions
- Hyponatremia, Syndrome of Inappropriate ADH (SIADH) Secretion, Cancer
- Trial name
- ASSERT (NCT02573077)
- Where
- 20 sites in Italy
- Volunteers
- 69 people
- Sponsor
- Otsuka Pharmaceutical Europe Ltd
Pituitary Tumor, Blood Loss
Tranexamic Acid for Blood Loss Minimization in Endoscopic Pituitary Surgery
This trial is to determine the effect of Tranexamic Acid (TXA) on blood loss during endoscopic pituitary surgery. The hypothesis of this study is that TXA will reduce blood loss during surgery compared to a placebo.
- Conditions
- Pituitary Tumor, Blood Loss, Surgery
- Trial name
- NCT04863339
- Testing
- Tranexamic acid
- Volunteers
- healthy volunteers welcome
- Sponsor
- University of North Carolina, Chapel Hill
Pituitary Adenoma
Glycemic Fluctuations in Newly Diagnosed Growth Hormone-Secreting Pituitary Adenoma and Cushing Syndrome Subjects
Glucose fluctuations present not only in patients with diabetes mellitus but also in subjects with normal glucose tolerance or impaired glucose regulation.
- Trial name
- NCT02574793
- Testing
- continuous glucose monitoring
- Where
- China
- Volunteers
- 60 people
- Sponsor
- Huashan Hospital
Osteopenia
Study of Adults With Low Growth Hormone Who Survived Childhood Cancer Where Treatment Caused Low Bone Density
The purpose of this project is to evaluate the hypothesis that bisphosphonate treatment given to growth hormone deficient patients (regardless of current growth hormone replacement therapy status and without changing that status)…
- Trial name
- NCT00145704
- Testing
- bisphosphonate therapy (risedronate), Vitamin D supplement, Calcium
- Where
- United States
- Volunteers
- 6 people
- Sponsor
- State University of New York - Upstate Medical University
Neoplasms, Pituitary Neoplasms
Intraoperative Imaging of Pituitary Adenomas by OTL
The primary end-point of the study is to determine the specificity and sensitivity of OTL38 in identifying pituitary adenomas when excited by an imaging probe. The investigators intend to enroll 50 patients in this study.
- Trial name
- NCT02629549
- Testing
- OTL38
- Where
- United States
- Volunteers
- 33 people
- Sponsor
- University of Pennsylvania
Pituitary Tumor, Optic Chiasm Disorder
Visual Outcome After Transsphenoidal Surgery for Pituitary Macroadenoma
Endoscopic endonasal transsphenoidal surgery is a procedure for the treatment of pituitary macroadenomas that cause visual impairment through optic chiasm compression.
- Trial name
- RetroADEN (NCT03363126)
- Testing
- Endonasal transsphenoidal pituitary tumor removal
- Volunteers
- 88 people
- Sponsor
- Fondation Ophtalmologique Adolphe de Rothschild
Acromegaly
Lanreotide Autogel-120 mg as First-Line Treatment of Acromegaly
Recently, a new formulation of lanreotide, lanreotide Autogel (ATG) 60 mg, 90 mg and 120 mg was developed in order to further extend the duration of the release of the active ingredient.
- Trial name
- ATG1line (NCT00627796)
- Testing
- Lanreotide-Autogel 120 mg
- Where
- Italy
- Volunteers
- 27 people
- Sponsor
- Federico II University
Adenoma Pituitary, CSF Leakage
Bed Rest on the Effect of CSF Leakage Repair After Transsphenoidal Pituitary Surgery
Postoperative cerebrospinal fluid (CSF) leakage is a well-known complication that might occur after transnasal transsphenoidal adenomectomy at an incidence of 0.5-15% according to different literature reports.
- Trial name
- NCT05682391
- Testing
- Bed rest
- Where
- Taiwan
- Volunteers
- 180 people
- Sponsor
- National Taiwan University Hospital
Pituitary Neoplasms, Pituitary Adenoma
Hypofractionated Radiosurgery to Treat Residual/Recurrent Non Secreting Pituitary Adenoma (HYPOADENO)
Single session stereotactic radiosurgery (SRS) is commonly used for patients with non-functioning adenomas. However the SRS can be limited by the proximity of the tumor with the surrounding critical structures (i.e., the optic…
- Trial name
- HYPOADENO (NCT06826170)
- Testing
- hypofractionated radiosurgery
- Where
- Italy
- Volunteers
- 25 people
- Sponsor
- Fondazione I.R.C.C.S. Istituto Neurologico Carlo Besta
Headache, Pituitary Adenoma
Prediction Model for Postoperative Headache After Transsphenoidal Pituitary Surgery
Primary Objective: This observational study aims to construct a predictive model for short-term headache following endonasal pituitary adenoma surgery and to identify risk factors associated with postoperative headache after…
- Conditions
- Headache, Pituitary Adenoma, Endonasal Surgery, Predictive Model
- Trial name
- NCT07446036
- Testing
- Transsphenoidal Pituitary Surgery
- Where
- China
- Volunteers
- 500 people
- Sponsor
- Beijing Tiantan Hospital
Adrenal Insufficiency, Leukemia, Lymphoblastic, Acute, Pediatric
A Swiss Assessment of Hypothalamic-pituitary-adrenal Axis Suppression After Glucocorticoid Therapy for Leukemia and Lymphoblastic Lymphoma in Children
Plain Language Summary: Background Glucocorticoids are stress hormones produced by the human body to control inflammation and regulate the immune system. Cortisol is the most well-known example of a glucocorticoid.
- Conditions
- Adrenal Insufficiency, Leukemia, Lymphoblastic, Acute, Pediatric, Lymphoma, Lymphoblastic
- Trial name
- LeukemiaCort (NCT06861530)
- Where
- 2 sites in Switzerland
- Volunteers
- 40 people
- Sponsor
- University Children's Hospital Basel
Pituitary Adenoma
Comparison of Extent of Resection of Pituitary Adenoma Via Transnasal Transsphenoidal Approach Using Endoscope Versus Microscope
This randomized controlled trial, titled "Comparison of Extent of Resection of Pituitary Adenoma via Transnasal Transsphenoidal Approach Using Endoscope Versus Microscope," was conducted in the Department of Neurosurgery, Sir…
- Trial name
- GTR MRI (NCT07886242)
- Testing
- Endoscopic surgery, Microscopic surgery
- Where
- Pakistan
- Volunteers
- 38 people
- Sponsor
- Sir Ganga Ram Hospital