Clinical trials: Placebo Response
Healthy, Respiratory Quotient Measurement
Effect of Molecular Hydrogen Inhalation on Metabolic Response During Low-intensity Exercise on a Bicycle Ergometer
This trial evaluates the effect of molecular hydrogen inhalation on metabolic response, heart rate, and rating of perceived exertion in healthy females during 30 minutes of exercise on a bicycle ergometer.
- Trial name
- NCT06951789
- Testing
- Molecular hydrogen
- Where
- Czechia
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Palacky University
Rheumatoid Arthritis
A Study to Evaluate Efficacy and Safety of ASP015K in Patients With Rheumatoid Arthritis (RA) Who Had an Inadequate Response to Methotrexate (MTX) Treatment
The objective of this study was to verify the efficacy of ASP015K versus placebo administrated in combination with methotrexate (MTX) over placebo in terms of efficacy in participants with rheumatoid arthritis (RA) who had an…
- Trial name
- NCT02305849
- Testing
- Peficitinib, Methotrexate
- Where
- 146 sites in Japan
- Volunteers
- 519 people
- Sponsor
- Astellas Pharma Inc
Breast Cancer, Chemotherapy Effect
Simvastatin Effect in Combination With Neoadjuvant Chemotherapy to Clinical Response and Tumor-Free Margin in Locally Advanced Breast Cancer
Introduction: Neoadjuvant chemotherapy (NACT) has been the standard therapy for treating patients with locally advanced breast cancer (LABC). Doxorubicin-based regimen showed a clinical response for 70-80%.
- Trial name
- NCT04418089
- Testing
- Simvastatin 40mg
- Where
- Indonesia
- Volunteers
- 60 people
- Sponsor
- Universitas Indonesia
Gastroparesis
Dose Response of 28 Days of Dosing of GSK962040 in Type I and II Diabetic Male and Female Subjects With Gastroparesis
GSK962040 is a novel small molecule motilin agonist. The Phase I studies (MOT107043 and MOT109681) demonstrated that single doses of GSK962040 up to 150 mg and repeat dosing of up to 125 mg/day for 14 days were well tolerated…
- Trial name
- NCT01262898
- Testing
- GSK962040 (5 mg tablet), GSK962040 (25 mg tablet), GSK962040 (125 mg tablet)
- Where
- 22 sites in United States, Australia and 4 more
- Volunteers
- 79 people
- Sponsor
- GlaxoSmithKline
Asthma
Inhalation of Corticosteroids in Smoking and Non-smoking Asthmatics.
People with asthma suffer from breathlessness because the small tubes (bronchioles) that carry air in and out of the lungs become inflamed and narrow.
- Trial name
- NCT01400906
- Testing
- 100 micrograms Fluticasone propionate, 500 micrograms Fluticasone propionate, lactose powder
- Where
- 2 sites in Belgium, United Kingdom
- Volunteers
- 36 people
- Sponsor
- GlaxoSmithKline
Depressive Disorder, Major, Inflammation
Antidepressant Trial With P2X7 Antagonist JNJ-54175446
Depression is one of the most important causes of disability in the world today, with major personal, social and economic costs.
- Trial name
- ATP (NCT04116606)
- Testing
- Active JNJ-54175446
- Where
- 5 sites in United Kingdom
- Volunteers
- 142 people
- Sponsor
- CCTU-Core
Inflammation, Inflammatory Response
A Study to Evaluate the Effects of a Marine Lipid Oil Concentrate Formulation on Inflammation
To assess the efficacy and safety of a Marine Lipid Oil Concentrate formulation on inflammatory biomarkers and overall well-being in male and female subjects who are overweight to mildly obese, but otherwise generally healthy.
- Trial name
- NCT04269876
- Testing
- Marine Lipid Oil Concentrate, Dietary Supplement
- Where
- United States
- Volunteers
- 8 people, healthy volunteers welcome
- Sponsor
- Supplement Formulators, Inc.
Open-Angle Glaucoma, Ocular Hypertension
Safety and Efficacy Study of DE-104 Ophthalmic Solution to Treat Open-angle Glaucoma or Ocular Hypertension
To investigate the dose-response relationship of DE-104 ophthalmic solution in lowering intraocular pressure (IOP) in subjects with Primary Open-Angle Glaucoma or Ocular Hypertension
- Trial name
- NCT00650338
- Testing
- DE-104 ophthalmic solution, low concentration, DE-104 ophthalmic solution, medium concentration, DE-104 ophthalmic solution, high concentration
- Where
- 14 sites in United States
- Volunteers
- 165 people
- Sponsor
- Santen Inc.
Cognitive Impairment Associated With Schizophrenia
Evoked Responses as Pharmacodynamic Biomarkers in Healthy and Schizophrenic Participants (MK-4334-007)
The primary purpose of this randomized, double-blind, placebo-controlled cross-over study was to record and measure 40 Hz-auditory steady-state response (ASSR) in healthy controls (HC) and participants with mild-to-moderate…
- Trial name
- NCT05136690
- Testing
- Nicotine patch, MK-4334
- Where
- 2 sites in United States
- Volunteers
- 38 people, healthy volunteers welcome
- Sponsor
- Merck Sharp & Dohme LLC
Cardiovascular Diseases
Resveratrol-enriched Grape Extract (Stilvid) in Primary and Secondary Prevention of Cardiovascular Disease
Resveratrol can exhibit benefits against cardiovascular diseases (CVDs) although the cardioprotective role of resveratrol as part of the human diet is not yet clear.
- Trial name
- FUNGRAPE (NCT01449110)
- Testing
- Grape extract in primary prevention (PP), Grape extract in SP, Resveratrol-enriched grape extract in PP
- Where
- Spain
- Volunteers
- 150 people
- Sponsor
- National Research Council, Spain
Schizophrenia
Efficacy and Safety of a Long Acting Anti-Psychotic Versus Placebo in Patients With Schizophrenia
The purpose of this study is to determine the efficacy (how well the drug works), safety, and side effects of paliperidone palmitate compared to placebo in the treatment of the symptoms of schizophrenia in adults.
- Trial name
- NCT00101634
- Testing
- Paliperidone palmitate
- Volunteers
- 518 people
- Sponsor
- Johnson & Johnson Pharmaceutical Research & Development, L.L.C.
Pain
The Warmth, Anticipation, Sensation, Aversion, and Body-part Imaging Study
This functional magnetic-resonance imaging study of the brain will feature a within-subject crossover design to investigate the effects of a placebo cream on painful thermal stimulation rendered upon eight body sites.
- Trial name
- WASABI (NCT04653064)
- Testing
- Control Cream
- Where
- United States
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- Trustees of Dartmouth College
Prematurity
Are Newborns Conscious of the Placebo Effect? Result From an RCT in Osteopathy
Results from previous studies suggest the association between Osteopathic Manipulative Treatment (OMT) and length of stay (LOS) reduction in a population of preterm infants.
- Trial name
- NCT01852500
- Testing
- Standard care
- Where
- Italy
- Volunteers
- 250 people, healthy volunteers welcome
- Sponsor
- European Institute for Evidence Based Osteopathic Medicine
Staphylococcus Aureus
A Study to Evaluate AZD7760 Safety and Pharmacokinetics in Healthy Adults (Phase I) and Adults With End-stage Kidney Disease on Hemodialysis With a Central Venous Catheter (Phase IIa)
The purpose of this study is to evaluate the safety and pharmacokinetics (PK) of AZD7760 when given as an intravenous infusion to healthy participants (Phase I) or participants with end-stage kidney disease receiving hemodialysis…
- Trial name
- PEAK (NCT06749457)
- Testing
- AZD7760
- Where
- 40 sites in United States
- Volunteers
- 242 people, healthy volunteers welcome
- Sponsor
- AstraZeneca
General Practitioners
Placebo Interventions in General Practice
Physicians often have an ambivalent relationship to placebo interventions. On the one hand they know of the intriguing effect of sugar pills or saline infusions but on the other hand they mostly feel constrained to adopt…
- Trial name
- NCT00603928
- Where
- Switzerland
- Volunteers
- 600 people, healthy volunteers welcome
- Sponsor
- University of Zurich
Lupus Nephritis
Aurinia Renal Response in Active Lupus With Voclosporin
The purpose of this study is to assess the efficacy of voclosporin compared with placebo in achieving renal response after 52 weeks of therapy in subjects with active lupus nephritis.
- Trial name
- AURORA (NCT03021499)
- Testing
- Voclosporin
- Where
- 185 sites in United States, Argentina and 29 more
- Volunteers
- 358 people
- Sponsor
- Aurinia Pharmaceuticals Inc.
Painful Osteoarthritis of the Knee
A Study of the Efficacy and Safety of MEDI7352 in Participants With Painful Osteoarthritis of the Knee
This is a Phase IIb randomised, double-blind, placebo-controlled, dose-response study in participants with painful osteoarthritis (OA) of the knee.
- Trial name
- BESPOKE (NCT04675034)
- Testing
- MEDI7352
- Where
- 41 sites in Denmark, Estonia and 4 more
- Volunteers
- 345 people
- Sponsor
- AstraZeneca
Locally Advanced Malignant Neoplasm
Metformin Plus Neoadjuvant Chemotherapy in Breast Cancer
Background Obesity and overweight are well known risk factors for breast cancer and also are associated with higher recurrence and mortality rates.
- Trial name
- NCT01566799
- Testing
- Metformin
- Where
- Mexico
- Volunteers
- 60 people
- Sponsor
- Instituto Nacional de Cancerologia de Mexico
Covid19, SARS-CoV Infection
COVID-FIS: Pilot in COVID-19 (SARS-CoV-2) of Fisetin in Older Adults in Nursing Homes
The purpose of this study is to test whether Fisetin, a senolytic drug, can assist in preventing an increase in the disease's progression and alleviate complications of coronavirus due to an excessive inflammatory reaction.
- Trial name
- COVID-FIS (NCT04537299)
- Testing
- Fisetin
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- Mayo Clinic
Gastrointestinal Digestion, Healthy
Clinical Trial on Digestive Enzymes: Effects on Post-Meal Response to High-Macronutrient Meals
This study aims to show how digestive enzyme supplements help the body break down fats, proteins, and carbohydrates, especially after eating a high-macronutrient meal.
- Conditions
- Gastrointestinal Digestion, Healthy, Gastrointestinal Wellbeing, Gastrointestinal Supplements
- Trial name
- NCT06949735
- Testing
- Digestive Enzyme Blend
- Where
- Canada
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Pancap Pharma Inc.
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