Clinical trials: Placebo-Post
Mesopic Vision, Night Vision Loss
Safety and Efficacy of 0.75% Phentolamine Ophthalmic Solution in Subjects With Post-refractive Surgery Visual Disturbances
Safety and efficacy of 0.75% Phentolamine Ophthalmic Solution to improve mesopic low contrast visual acuity in subjects with post-refractive surgery visual disturbances.
- Trial name
- LYNX-2 (NCT06349759)
- Testing
- phentolamine ophthalmic solution 0.75%, a non-selective alpha-1 and alpha-2 adrenergic antagonist
- Where
- 25 sites in United States
- Volunteers
- 200 people
- Sponsor
- Opus Genetics, Inc
Healthy Volunteer
Safety and Tolerability Study of LBS-008 in Healthy Adult Subjects After Single and Multiple Doses
This is a single center, randomized, double-blind, placebo-controlled, Single Ascending Dose (SAD) and Multiple Ascending Dose (MAD) study is planned to assess safety, pharmacokinetics (PK), and pharmacodynamics of LBS-008 in…
- Trial name
- NCT03735810
- Testing
- LBS-008
- Where
- Australia
- Volunteers
- 71 people, healthy volunteers welcome
- Sponsor
- RBP4 Pty Ltd
Unresectable or Metastatic Hepatocellular Carcinoma, Child-Pugh A Hepatocellular Carcinoma
Visugromab, Nivolumab and Lenvatinib Compared to Double Placebo and Lenvatinib in Unresectable or Metastatic Hepatocellular Carcinoma Post Anti-PD-(L)1 Failure
This is a Phase 2b, randomized, blinded clinical trial investigating the efficacy and safety of visugromab in combination with nivolumab and Lenvatinib compared to double placebo and Lenvatinib in participants with unresectable…
- Conditions
- Unresectable or Metastatic Hepatocellular Carcinoma, Child-Pugh A Hepatocellular Carcinoma, Failure of First-Line Treatment That Included an Approved Anti PD-(L)1 Compound
- Trial name
- GDFATHERHCC01 (NCT07219459)
- Testing
- Visugromab RDE (recommended dose for expansion), Nivolumab, Lenvatinib
- Where
- 23 sites in United States, France and 4 more
- Volunteers
- 104 people
- Sponsor
- CatalYm GmbH
Acute Pain, Postoperative Pain Control
An Efficacy and Safety Study of LTG-001 Following Abdominoplasty
The goal of this clinical trial is to learn if LTG-001 works to treat post-operative / acute pain after an abdominoplasty procedure. It will also learn more information on the safety of LTG-001.
- Trial name
- NCT07102459
- Testing
- Experimental: LTG-001 High Dose, Experimental: LTG-001 Low Dose, Active Comparator: HB/APAP
- Where
- 5 sites in United States
- Volunteers
- 343 people
- Sponsor
- Latigo Biotherapeutics
Osteopenic Women
Pomegranate Extract Biomarker Study in Osteopenic Women
Treatment of post-menopausal subjects (with decreased bone mineral density) with pomegranate extract capsules will produce statistically significant changes in biomarkers for bone resorption and formation when compared to…
- Trial name
- NCT01219140
- Testing
- 2 POMx Capsules
- Where
- United States
- Volunteers
- 64 people
- Sponsor
- POM Wonderful LLC
Knee Replacement Arthroplasty
Effect of Adductor Canal Block vs. Placebo on Muscle Strength, Mobilisation and Pain After Total Knee Arthroplasty
The purpose of this study is to evaluate the effect of adductor canal block (ACB) vs. placebo on muscle strength, mobility and pain on the first postoperative day after total knee alloplastic (TKA).
- Trial name
- NCT02242591
- Testing
- Ropivacaine 7,5 mg/ml, Saline
- Where
- Denmark
- Volunteers
- 64 people
- Sponsor
- Ulrik Grevstad
Stroke, Chronic
Effects of Dualsite Anodic tDCS on Lower Limbs Function in Patients After Stroke: Randomized, Double-blind, Placebo-controlled, Crossover Trial
It is currently known that Transcranial Direct Current Stimulation (tDCS) can modulate cortical activity, being considered an important resource in the treatment of sequelae resulting from stroke.
- Trial name
- NCT04850963
- Testing
- Transcranial direct current stimulation (Anodal tDCS) + dual-task training, Transcranial direct current stimulation (tDCS dualsite) + dual-task traning
- Where
- Brazil
- Volunteers
- 40 people
- Sponsor
- Federal University of Paraíba
Acute Traumatic Spinal Cord Injury
NEUROwave - Extracorporeal Shock Wave Therapy (ESWT) in Acute Traumatic Complete (AIS A) and Incomplete (AIS B-D) Cross-sectional Lesions on Motor and Sensory Function Within Six Months After Injury
It has been hypothesized that there are two mechanisms of acute traumatic spinal cord injury (SCI): the primary mechanical damage and the secondary injury due to additional pathological processes initiated by the primary injury.
- Trial name
- NCT04474106
- Testing
- Shock waves, dummy head
- Where
- 15 sites in Austria
- Volunteers
- 246 people
- Sponsor
- AUVA
Antiplatelet Effect
Study to Investigate Safety and Tolerability of a Single Dose of AZD6482
AZD6482 is a new drug substance aiming to prevent blood clots which may arise in atherosclerotic blood vessels and cause myocardial infarction or stroke. This is the first study with AZD6482 in humans.
- Trial name
- NCT00688714
- Testing
- AZD6482
- Volunteers
- 49 people, healthy volunteers welcome
- Sponsor
- AstraZeneca
Allograft Rejection, Lung Transplantation
Vitamin D in Bronchiolitis Obliterans Syndrome
Vitamin D deficiency occurs in around 50% of our transplant population. Preventive treatment with Vitamin D (D-cure) can reduce the prevalence of Bronchiolitis Obliterans Syndrome after lung transplantation
- Conditions
- Allograft Rejection, Lung Transplantation, Bronchiolitis Obliterans
- Trial name
- VIT001 (NCT01212406)
- Testing
- Vitamin D
- Where
- Belgium
- Volunteers
- 100 people
- Sponsor
- Universitaire Ziekenhuizen KU Leuven
Asthma
A Study to Evaluate the Efficacy After Allergen Challenge, Safety and Tolerability of Inhaled CHF6001 DPI in Asthmatics
The study is designed to look at the safety, tolerability and efficacy of 2 different doses of the study drug (CHF6001, a PDE4 inhibitor) in asthmatics, when given by inhalation, once a day for 9 days.
- Trial name
- CHF6001_POC2 (NCT01689571)
- Testing
- CHF6001
- Where
- 3 sites in United Kingdom
- Volunteers
- 36 people
- Sponsor
- Chiesi Farmaceutici S.p.A.
Pain
Does Bupivacaine in Laparoscopic Portals Reduce Post Surgery Pain in Tubal Ligation by Electrocoagulation?
The use of bupivacaine , an anesthesic, in laparoscopic portals is recommended in some surgeries. In the ase of tubal ligation by electrocoagulation, where pain is reduced, there is no evidence of this benefit.
- Trial name
- DOPOL (NCT00810563)
- Testing
- Saline solution (laparoscopic tubal ligation), Bupivacaine
- Where
- Brazil
- Volunteers
- 46 people, healthy volunteers welcome
- Sponsor
- Hospital de Clinicas de Porto Alegre
Thoracic Surgery, Video-assisted, Postoperative Pain
RCT Comparing Analgesia Post-VATS With Epimorph VS Placebo
The purpose of the study is to determine if the administration of a mix of Sufentanil and Morphine in intrathecal is a better analgesia regimen than PCA alone in patient post-VATS.
- Conditions
- Thoracic Surgery, Video-assisted, Postoperative Pain, Rachianesthesia, Sufentanil
- Trial name
- NCT02152514
- Testing
- Intrathecal Morphine/Sufentanil, PCA
- Where
- Canada
- Volunteers
- 34 people
- Sponsor
- Université de Sherbrooke
Abortion, Septic
The Use of Antibiotics After Hospital Discharge in Septic Abortion
The use of antibiotics in post-partum infection has been abbreviated. After 48 hours of clinical improvement, the patient is discharged from the hospital without antibiotics. No trials has been found in cases of septic abortion.
- Trial name
- APA (NCT00353743)
- Testing
- doxycycline plus metronidazole
- Where
- Brazil
- Volunteers
- 56 people
- Sponsor
- Hospital de Clinicas de Porto Alegre
COVID-19
HH-120 Nasal Spray for Post-exposure Prevention of SARS-CoV-2
This study will assess the efficacy of HH-120 nasal spray in participants for the post-exposure prevention of SARS-CoV-2.
- Trial name
- NCT05787418
- Testing
- HH-120 Nasal Spray
- Where
- 2 sites in China
- Volunteers
- 918 people
- Sponsor
- Huahui Health
Dry Eye Syndrome
Phase I Study to Evaluate the Tolerability of Eye Drop DA-6034 in Healthy Volunteers
This is a double-blind, randomized, placebo-controlled, 4-period, cross-over clinical trial. The study is designed to evaluate the safety and local tolerability of DA-6034 upon single and repeated-dose topical application to the…
- Trial name
- NCT01162954
- Testing
- DA-6034
- Where
- South Korea
- Volunteers
- healthy volunteers welcome
- Sponsor
- Dong-A ST Co., Ltd.
Asthma
A Trial of HBM9378 in Healthy Chinese Subjects
The objective is to evaluate the safety, tolerability and pharmacokinetic profile of a single subcutaneous injection of HBM9378 (SKB378) at different doses in healthy Chinese subjects.
- Trial name
- NCT05790694
- Testing
- HBM9378 (SKB378) Injection
- Where
- China
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Harbour BioMed (Guangzhou) Co. Ltd.
Threatened Premature Labor
Vaginal PROgesterone as Maintenance Treatment After an epISode of prEterm Labor (PROMISE Study)
Eligible patients will be informed and asked to enroll in the study at hospital admission. A transvaginal ultrasound examination will be performed to determine cervical length.
- Trial name
- PROMISE (NCT00646802)
- Testing
- Progesterone
- Where
- 12 sites in Spain
- Volunteers
- 265 people
- Sponsor
- Hospital Clinic of Barcelona
Erectile Dysfunction
A Study of Tadalafil After Radical Prostatectomy
The study will include patients with localized prostate cancer who experience erectile dysfunction following bilateral nerve-sparing radical prostatectomy.
- Trial name
- REACTT (NCT01026818)
- Testing
- Tadalafil
- Where
- 52 sites in Belgium, Canada and 8 more
- Volunteers
- 583 people
- Sponsor
- Eli Lilly and Company
Normal Volunteers
Evaluation of Negative Symptoms and Cognitive Function After Administration of Antipsychotics in Healthy Volunteer
The aim of the study is to investigate the negative symptoms and cognitive function after administration of antipsychotics in healthy volunteer.
- Trial name
- NCT01185418
- Testing
- risperidone, aripiprazole, haloperidol
- Where
- South Korea
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Chonbuk National University Hospital
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