Clinical trials: Placebo-Pre
Infections, Rotavirus
To Assess Safety, Reactogenicity & Immunogenicity of 2 Doses of GSK's Oral Human Rotavirus Vaccine in Pre-Term Infants
This study is planned to evaluate the safety (in terms of occurrence of any serious adverse events), reactogenicity (any side effects) and immunogenicity (ability of the vaccine to develop antibodies that fight infection) of the…
- Trial name
- NCT00420745
- Testing
- Rotarix™
- Where
- 31 sites in France, Poland and 2 more
- Volunteers
- 1,009 people, healthy volunteers welcome
- Sponsor
- GlaxoSmithKline
Clinical High Risk for Psychosis
Randomized Controlled Trial of Aspirin vs Placebo in the Treatment of Pre-psychosis
The primary objective of this study is to determine whether aspirin is effective in alleviating symptoms of the clinical high risk (CHR) syndrome for psychosis.
- Trial name
- NCT02047539
- Testing
- Aspirin
- Where
- United States
- Volunteers
- 1 people, healthy volunteers welcome
- Sponsor
- Yale University
Elective Cesarean Section
Antibiotic Prophylaxis Before Surgery Versus After Cord Clamping in Elective Cesarean Delivery - a Double-blind, Prospective, Randomized Placebo-controlled Trial
In this prospective, randomized, placebo controlled trial the investigators were able to demonstrate the usefulness of prophylactic cefazolin in elective caesarean section versus placebo, irrespective of the timing of…
- Trial name
- NCT01248078
- Testing
- Keflex, saline solution
- Where
- Austria
- Volunteers
- 1,112 people, healthy volunteers welcome
- Sponsor
- Medical University of Vienna
Dietary Intervention
Probiotic, Prebiotic and Synbiotic Effect on Immunity
The aim of the study is to investigate the effect of dietary supplements such as probiotic, prebiotic and synbiotic on the immune response to influenza vaccination and faecal microbiota in adult healthy volunteers.
- Trial name
- NCT01084434
- Testing
- probiotic, prebiotic, Synbiotic
- Where
- United Kingdom
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- University of Reading
Preeclampsia
ToRsemide for pOstpartum HYpertension
Currently there is no intervention to prevent persistent postpartum hypertension in preeclamptic women. Physiologically, the use of a pharmacokinetically predictable loop-diuretic is a reasonable intervention to increase…
- Trial name
- TROPHY (NCT02813551)
- Testing
- Torsemide
- Where
- United States
- Volunteers
- 118 people, healthy volunteers welcome
- Sponsor
- The University of Texas Health Science Center, Houston
Renal Hemodynamics
Effect of Repeated Dosing of Naproxcinod on Renal Hemodynamic and on Sodium Balance in Healthy Volunteers Before and After a Single Dose of Furosemide
This phase 1 study is an 8-day treatment period, randomized, controlled, double-blind, 3 parallel-groups, monocentric study. The primary objective is to evaluate the effect of naproxcinod on the renal function when…
- Trial name
- NCT00909519
- Testing
- naproxcinod, Naproxen, furosemide
- Volunteers
- 31 people, healthy volunteers welcome
- Sponsor
- NicOx
Healthy
A Study to Evaluate the Single Vaccination of an Adenovirus Serotype 26 Pre-Fusion F (Ad26.preF) Based Respiratory Syncytial Virus (RSV) Vaccine in Japanese Adults Aged 60 Years and Older
The main purpose of this study is to assess the safety and reactogenicity of the Ad26.preF based RSV vaccine administered intramuscularly as a single injection versus placebo in Japanese adults aged greater than equal to 60 years.
- Trial name
- NCT04354480
- Testing
- RSV Vaccine
- Where
- Japan
- Volunteers
- 36 people, healthy volunteers welcome
- Sponsor
- Janssen Pharmaceutical K.K.
Depression
Effects of Light Treatment During Sleep on Young Men
This study will determine if green light exposure during sleep is effective in reducing mild depression symptoms in young men.
- Trial name
- NCT00796939
- Testing
- Green light mask, Red Light Mask
- Where
- United States
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- University of California, San Diego
Stress vs. Control, Estradiol vs. Placebo
Estradiol and Stress Reactivity in Women
Stress reactivity and prevalence of stress related diseases differ between pre- and postmenopausal women. Thus, hormonal fluctuations may present a general vulnerability factor for stress-related diseases.
- Trial name
- NCT06204016
- Testing
- Estradiol Valerate
- Where
- Germany
- Volunteers
- 74 people, healthy volunteers welcome
- Sponsor
- International Research Training Group 2804
Polycystic Ovary Syndrome
Metformin Treatment Before in Vitro Fertilization (IVF) in Women With Ultrasound Evidence of Polycystic Ovaries
The aim of study was to investigate whether pre-treatment with metformin before and during IVF increases the live birth rate compared to placebo in women with sonographic evidence of polycystic ovaries (PCO), but without any…
- Trial name
- NCT01046032
- Testing
- Metformin
- Where
- 3 sites in United Kingdom
- Volunteers
- 134 people, healthy volunteers welcome
- Sponsor
- University of Oxford
Respiratory Syncytial Virus-associated Lower Respiratory Tract Disease Prevention
A Study of Various Respiratory Syncytial Virus (RSV) Pre-Fusion (preF)-Based Vaccine Formulations in Adults Aged 60 Years and Older
The purpose of the study is to evaluate safety and immunogenicity of various respiratory syncytial virus (RSV) pre-Fusion (preF)-based vaccine components followed by expanded safety evaluation and durability/revaccination…
- Trial name
- NCT05327816
- Testing
- RSV preF-based Vaccine
- Where
- 11 sites in United States
- Volunteers
- 132 people, healthy volunteers welcome
- Sponsor
- Janssen Vaccines & Prevention B.V.
Metabolic Syndrome, Pre-diabetes
Effect of Pasteurized Akkermansia Muciniphila on Insulin Resistance in Otherwise Healthy Subjects With Dysglycaemia
The purpose of this study is to demonstrate the efficacy of pasteurized Akkermansia muciniphila (pAKK) in improving insulin sensitivity in hyperglycaemic, but otherwise healthy persons with metabolic syndrome.
- Conditions
- Metabolic Syndrome, Pre-diabetes, Overweight and Obesity
- Trial name
- NCT05114018
- Testing
- Pasteurized A. muciniphila
- Where
- 2 sites in Germany, Ireland
- Volunteers
- 143 people, healthy volunteers welcome
- Sponsor
- A-Mansia Biotech S.A.
Healthy
Training Study to Characterize Biomarkers to Chickenpox and Yellow Fever Vaccines
It is thought that vaccines trigger innate inflammatory responses to induce antigenspecific adaptive immunity (the desired effect), but excessive inflammation may lead to serious inflammatory complications or unwanted side…
- Trial name
- NCT01765413
- Testing
- Varicella-zoster virus, Yellow Fever Vaccine
- Where
- United Kingdom
- Volunteers
- 48 people, healthy volunteers welcome
- Sponsor
- University of Surrey
Sleep
Swallowable Cannabigerol Tablets for Sleep Quality In Veterans (Veterans Exploring Cannabigerol for Sleep)
New methods for the treatment and support of Veterans experiencing sleep issues is critically needed. LEVEL's unique, targeted effects-based cannabis products provide a unique opportunity to study the therapeutic safety and…
- Trial name
- ECS21 (NCT05088018)
- Testing
- Cannabigerol
- Where
- United States
- Volunteers
- 68 people, healthy volunteers welcome
- Sponsor
- Chris Emerson
HIV, HIV Pre-exposure Prophylaxis
Safety and Pharmacokinetic Study of Oral MK-8527 QM in Participants at Low-Risk for HIV-1 Infection (MK-8527-007)
This double-blind, placebo-controlled study was designed to assess the safety, tolerability, and pharmacokinetics of oral MK-8527 taken once monthly (QM) in participants at low risk for human immunodeficiency virus Type 1 (HIV-1)…
- Trial name
- NCT06045507
- Testing
- MK-8527
- Where
- 18 sites in United States, Israel and 1 more
- Volunteers
- 352 people, healthy volunteers welcome
- Sponsor
- Merck Sharp & Dohme LLC
Healthy Aging, Inflammaging
The Effects of Quercefit® and Ubiqsome™ in Mitigating Inflammation and Promoting Metabolic Health
The goal of this clinical trial is to learn if Quercefit® or Ubiqsome™ can improve markers of healthy aging, blood sugar control, and heart health in older adults. It will also learn about the safety of these supplements.
- Conditions
- Healthy Aging, Inflammaging, Metabolic Health, Quercetin
- Trial name
- NCT07760506
- Testing
- Quercetin (dietary supplement), Coenzyme Q10, Rice Flour
- Where
- United States
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Applied Science & Performance Institute
Preeclampsia
Anti-Hypertensive Treatment In Stable Pregnant Women With Severe Pre-Eclampsia (Metildopape)
Introduction: Hypertensive emergency in pregnant women with pre-eclampsia should be treated for preventing stroke and placental abruption.
- Trial name
- METILDOPAPE (NCT01361425)
- Testing
- methildopa
- Where
- 2 sites in Brazil
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Professor Fernando Figueira Integral Medicine Institute
Soft Tissue Healing
Laser-assisted Pontic Site Soft Tissue Healing Prior to Fixed Partial Denture Rehabilitation
This randomized placebo-controlled clinical trial aimed to evaluate the effect of laser-assisted therapy on soft tissue healing at the pontic site prior to fixed partial denture rehabilitation.
- Trial name
- NCT07415434
- Testing
- GRR laser, Nd:YAG laser
- Where
- Turkey (Türkiye)
- Volunteers
- 45 people, healthy volunteers welcome
- Sponsor
- University of Gaziantep
Vomiting, Postoperative, Postoperative Complications
The Effect of Intravenous Granisetron and Ondansetron in Patients Undergoing Cesarean Section
This study compared the effects of prophylactic intravenous (IV) infusion of ondansetron and granisetron before the spinal anesthesia on hemodynamic parameters in patients undergoing elective cesarean section.
- Conditions
- Vomiting, Postoperative, Postoperative Complications, Hypotension
- Trial name
- NCT04613726
- Testing
- ondansetron, Granisetron, Saline
- Where
- Turkey (Türkiye)
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- Ataturk University
Coronary Artery Disease
Topical Nitro or Placebo Pre-Cath
Phase 2, single-center, randomized, blinded clinical study to assess the safety and efficacy of topical nitroglycerin on ease of TRA during scheduled PCI.
- Trial name
- NCT06289946
- Testing
- NitroBid
- Volunteers
- 256 people, healthy volunteers welcome
- Sponsor
- Thomas Jefferson University