Clinical trials: Placenta
Third Stage of Delivery
Maternal Outcomes Following Manual Lysis of the Placenta.
Comparison of maternal outcomes following manual lysis of placenta 15 vs 30 minutes after delivery. A primary outcome of the drop in hemoglobin will be compared between the two groups.
- Trial name
- NCT03626844
- Testing
- Manual Lysis of Placenta after 15 minutes (Intervention), Manual Lysis of Placenta after 30 minutes (Control)
- Where
- Israel
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Holy Family Hospital, Nazareth, Israel
First Trimester Pregnancy, Fetal Heart Activity Absent
Markers of Oxidative Stress in a Early Week Miscarriage: Ischemia of Modified Albumin
The finding that ischemia-modified albumin (IMA) is increased in pre-eclamptic pregnancy suggests a role for IMA as a potential biomarker for abnormal placental development related to miscarriage.This study was undertaken to…
- Conditions
- First Trimester Pregnancy, Fetal Heart Activity Absent, Absence of Fetal Pole on Ultrasonographic Examination.
- Trial name
- IMA (NCT01988740)
- Where
- Turkey (Türkiye)
- Volunteers
- 180 people
- Sponsor
- Bakirkoy Dr. Sadi Konuk Research and Training Hospital
Placenta Accreta
Conservative Management for PAS Pilot
Conservative in situ management is a promising alternative treatment to hysterectomy for patients with placenta accreta spectrum and may be safer and preferable for some patients.
- Trial name
- NCT05139498
- Testing
- Conservative management for placenta accreta spectrum (PAS), Cesarean hysterectomy for placenta accreta spectrum (PAS)
- Where
- United States
- Volunteers
- 4 people
- Sponsor
- University of Utah
Neoplasm, Trophoblastic, Gestational Trophoblastic Disease
The French National Reference Centre of GTD
The French Gestational Trophoblastic Disease (GTD) centre has been set up and active by registering, monitoring and treating women with GTD since november 1999.
- Conditions
- Neoplasm, Trophoblastic, Gestational Trophoblastic Disease, Hydatidiform Mole, Hydatidiform Mole, Invasive
- Trial name
- French GTDC (NCT02892877)
- Where
- France
- Volunteers
- 25,500 people
- Sponsor
- Hospices Civils de Lyon
Frailty
Safety of Cultured Allogeneic Adult Umbilical Cord or Placental Derived Mesenchymal Stem Cell Intravenous Infusion for Aging Frailty
This trial will study the safety and efficacy of intravenous infusion of cultured allogeneic adult umbilical cord or placental derived mesenchymal stem cells for the treatment of Aging Frailty
- Trial name
- NCT05018767
- Testing
- cultured allogeneic adult umbilical cord or placental derived mesenchymal stem cells
- Where
- 2 sites in United States, Greece
- Volunteers
- 86 people
- Sponsor
- The Foundation for Orthopaedics and Regenerative Medicine
PreTerm Birth
The Effect of Zinc, β-carotene, and Vitamin D3 in Preterm Delivery Through Placental MyD88, TRIF, NFkB, and IL-1β
This study is a controlled trial which compares the effect of zinc, beta-carotene, and Vitamin D3 supplementation in pregnant women which has preterm birth.
- Trial name
- NCT03005496
- Testing
- Zinc, Nifedipine, Beta Carotene
- Volunteers
- 56 people, healthy volunteers welcome
- Sponsor
- Universitas Indonesia
Preterm Birth
Placental Inflammation in Prenatal Care
Objective of study is to explore expression of stress-related genes and inflammation in placentas and umbilical cord blood for women participating in group prenatal care compared with women receiving individual prenatal care.
- Trial name
- PINC (NCT02476656)
- Volunteers
- 40 people
- Sponsor
- Prisma Health-Upstate
High Risk Pregnancy
Placenta Imaging Project
The purpose of this study is to test the application of newly generated magnetic resonance imaging (MRI) protocols for the assessment of placental perfusion in human subjects.
- Trial name
- PIP (NCT02749851)
- Testing
- MRI, MRI - IUGR
- Where
- 2 sites in United States
- Volunteers
- 379 people, healthy volunteers welcome
- Sponsor
- Oregon Health and Science University
Parkinson Disease
Safety of Cultured Allogeneic Adult Umbilical Cord or Placental Derived Mesenchymal Stem Cell Exosomes for Parkinson's Disease
This trial will study the safety and efficacy of intranasal instillation of cultured allogeneic adult umbilical cord or placental derived mesenchymal stem cell exosomes for the treatment of Parkinson's Disease
- Trial name
- NCT05152394
- Testing
- cultured allogeneic adult umbilical cord or placental derived mesenchymal stem cell exosomes
- Where
- 2 sites in United States, Greece
- Volunteers
- 20 people
- Sponsor
- The Foundation for Orthopaedics and Regenerative Medicine
GVHD
Effect of PMSCs and Their Secretome for the Treatment of GvHD
In this clinical trial study, 60 patients with GvHD referred to Shahid Qazi Hospital in Tabriz, were randomly divided into 2 intervention and control groups (n= 30 in each) that received secretome and distilled water by…
- Trial name
- GvHD (NCT06469411)
- Testing
- Secretome (set of substances released from the cell to its surroundings) of mesenchymal stem cells retrieved from the placenta (containing 400 microgram protein/ milliliter), 4 cc distilled water dissolved in albumin 20%
- Where
- Iran
- Volunteers
- 60 people
- Sponsor
- Tabriz University of Medical Sciences
Placental Insufficiency
Reference Ranges for Placental Perfusion Using Magnetic Resonance Imaging (MRI)PLACENTIMAGE
To evaluate the feasibility of functional MRI method developed in an animal model and to construct normal reference ranges for in vivo placental perfusion using functional MRI.
- Trial name
- NCT01092949
- Testing
- MRI
- Where
- France
- Volunteers
- 135 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Placenta Previa
The Placenta Previa and Fetal Weight
Placenta previa is a placenta that implants at lower uterine segment, it occurs in about 0.3-0.5% of pregnancies at term. It is a significant risk for development of maternal morbidity, as well as maternal mortality secondary to…
- Trial name
- NCT03321435
- Testing
- placenta previa patient, normal women
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Assiut University
Hemorrhagic Cystitis
A Pilot Study Using Placenta Derived Decidual Stromal Cells for Hemorrhagic Cystitis
The purpose of this study is to evaluate the safety and efficacy using placenta derived decidual stromal cell therapy for hemorrhagic cystitis after allogeneic hematopoietic cell transplantation.
- Trial name
- NCT02172963
- Testing
- Decidual Stromal Cell therapy
- Where
- Sweden
- Volunteers
- 12 people
- Sponsor
- Karolinska Institutet
Pregnancy
Intrauterine Cleaning After Placental Delivery at Cesarean Section: RCT
PURPOSE: To test the hypothesis that omission of intrauterine cleaning during cesarean deliveries does not increase intraoperative and postoperative complications.
- Trial name
- NCT02152735
- Testing
- Cleaning the uterine cavity
- Where
- United States
- Volunteers
- 206 people, healthy volunteers welcome
- Sponsor
- Michigan State University
Intraoperative Blood Loss
Comparative Study Between Oxytocin Infusion Before and After Placental Delivery on Blood Loss During and After Cesarean Delivery .
Participants were randomized using computer-generated random numbers into 2 groups. Group I included 32 women who received oxytocin infusion before placental delivery just after cord clamping and group II included 32 women who…
- Trial name
- NCT06889155
- Testing
- Oxytocin
- Where
- Egypt
- Volunteers
- 64 people
- Sponsor
- Cairo University
Pregnancy
Serum Concentrations of Pregnancy-associated Proteins for Assessment of Gestational Age Before Abortion
This will be a case-series multicenter study enrolling 800 pregnant people. Serum will be collected from people seeking abortion and assayed at a qualified laboratory.
- Trial name
- NCT04232189
- Testing
- no intervention
- Where
- 3 sites in United States
- Volunteers
- 275 people
- Sponsor
- Gynuity Health Projects
Placenta Previa Complete Centralis
Accuracy of Rail Sign at Detection of PAS
Accuracy OF Rail Sign at Detection Of Placenta Accreta At The second And the Third Trimester Of Pregnancy By Ultrasound Scanning
- Trial name
- NCT07159997
- Testing
- Accuracy of rail sign by ultrasound st diagnosis placent previa
- Where
- Egypt
- Volunteers
- 90 people
- Sponsor
- Sohag University
Premature, Placental Transfusion
Evaluation of Placental Transfusion Techniques in Prevention of Prematurity Related Complications and Effect on Their Hematological Profile
The objective of this study is to evaluate the general course and prognosis associated with different methods of placental transfusion (Intact umbilical cord milking, cut- umbilical cord milking and delayed cord clamping) in…
- Trial name
- NCT06812507
- Testing
- intact umbilical milking, cut umbilical milking, Delayed cord clamping
- Where
- Egypt
- Volunteers
- 160 people, healthy volunteers welcome
- Sponsor
- Alexandria University
Preterm Birth
The Australian Placental Transfusion Study (APTS): Should Very Pre Term Babies Receive a Placental Blood Transfusion at Birth Via Deferring Cord Clamping Versus Standard Cord Clamping Procedures?
To establish if placental transfusion, using deferred cord clamping for 60 seconds or more while holding the baby at or below the level of the placenta, will improve survival without disability compared with standard early cord…
- Trial name
- APTS (NCT02606058)
- Testing
- Deferred cord clamping
- Where
- 26 sites in United States, Australia and 5 more
- Volunteers
- 1,637 people
- Sponsor
- University of Sydney
Placenta Previa
Management Of Placenta Previa Cases And Determination Of Hospitalization Criteria
Placenta previa cases are one of the difficult groups of patients to manage in modern obstetrics. When the literature is evaluated extensively, no clear information can be seen especially in terms of hospitalization time.
- Trial name
- NCT04264234
- Testing
- Vaginal Ultrasonography, Magnetic Resonance Imaging
- Where
- Turkey (Türkiye)
- Volunteers
- 98 people, healthy volunteers welcome
- Sponsor
- Ege University