Clinical trials: Placenta
Malaria, Placental Malaria
Malaria Rapid Diagnostic Tests (RDTs) in Pregnancy: Detection of Placental Malaria
This study seeks to determine whether screening pregnant women for malaria with malaria rapid diagnostic tests (RDTs) may detect placental infection and predict risk of poor birth outcomes due to malaria in areas of varied…
- Conditions
- Malaria, Placental Malaria, Malaria in Pregnancy
- Trial name
- NCT01555255
- Where
- 2 sites in Burkina Faso, Uganda
- Volunteers
- 1,205 people
- Sponsor
- Foundation for Innovative New Diagnostics, Switzerland
Diabetic Foot Ulcer (DFU), Venous Leg Ulcer (VLU)
A Non-Randomized Open Label Clinical Trial Evaluating DermaBind TL
The purpose of this clinical evaluation is to collect patient outcome data and evaluate the efficacy, safety and tolerability of HealthTech DermaBind TL™ in patients with chronic non-healing wounds in patients with chronic…
- Trial name
- NCT07172893
- Testing
- DermaBind TL
- Where
- 10 sites in United States
- Volunteers
- 150 people
- Sponsor
- HealthTech Wound Care
Pregnancy Complication
Effect of Sildenafil Citrate on Uteri- Placental Perfusion, Doppler Indices in Growth Restricted Fetuses
To detect the effect of sildenafil citrate on Doppler parameters in fetuses suffering from growth restriction to support its use later as prolonged therapy in those pregnancies at higher risk for such complication.
- Trial name
- NCT02362399
- Testing
- sildenafil citrate
- Where
- Egypt
- Volunteers
- 54 people
- Sponsor
- Al Hayat National Hospital
Pregnancy, Venous Thrombosis
Free DNA and Nucleosome Concentrations in Pathological Pregnancies
The primary objective of this study is to demonstrate that plasma concentrations of nucleosomes and free DNA differ between three groups: 1.
- Conditions
- Pregnancy, Venous Thrombosis, Pulmonary Embolism, Hypertension, Pregnancy-Induced
- Trial name
- NCT01736826
- Testing
- Bloodwork, baseline, Blood work, Months 1 & 2, Bloodwork, Months -1 to -6
- Where
- France
- Volunteers
- 137 people, healthy volunteers welcome
- Sponsor
- Centre Hospitalier Universitaire de Nīmes
Placenta Accreta, Postpartum Hemorrhage
Perioperative Administration of Tranexamic Acid for Placenta Previa and Accreta Study
The purpose of this pilot study is to determine if intravenous tranexamic acid (TXA) is effective for reducing blood loss during high risk surgical procedures related to placenta previa and placenta accreta.
- Conditions
- Placenta Accreta, Postpartum Hemorrhage, Cesarean Section, Tranexamic Acid
- Trial name
- TAPPAS (NCT02806024)
- Testing
- Tranexamic Acid
- Where
- United States
- Volunteers
- 14 people
- Sponsor
- University of California, San Francisco
Postpartum Hemorrhage
Prophylactic Oxytocin Before Versus After Placental Delivery to Reduce Blood Loss in Vaginal Delivery
Randomized controlled study to assess the efficacy and safety of the timing of administration of prophylactic oxytocin via intramuscular route (before compared to after placental delivery) on blood loss in vaginal delivery.
- Trial name
- NCT03006380
- Testing
- oxytocin
- Where
- Egypt
- Volunteers
- 400 people, healthy volunteers welcome
- Sponsor
- Ain Shams Maternity Hospital
Obstetric Complication
Placental Vasculature for Prediction of Recurrent Fetal Growth Restriction
: In this Prospective longitudinal observational study, two hundred pregnant women with singleton pregnancy from 11 up to 13 weeks with history of intrauterine growth restriction in a previous pregnancy underwent ultrasound…
- Trial name
- NCT04399174
- Testing
- US
- Volunteers
- 200 people
- Sponsor
- Benha University
Labor, Premature, Preterm Premature Rupture of the Membranes
N-acetylcysteine in Intra-amniotic Infection/Inflammation
The aim of the study is to determine if N-acetylcysteine (a potent free radical scavenger) prevents the occurrence of adverse neonatal outcomes in preterm deliveries complicated by infection associated with preterm labor or…
- Conditions
- Labor, Premature, Preterm Premature Rupture of the Membranes, Infection, Inflammation
- Trial name
- NCT00397735
- Testing
- amniocentesis
- Where
- 2 sites in United States
- Volunteers
- 68 people
- Sponsor
- Ohio State University
Pregnancy Related, Diabetes
Transport of Artificial Sweeteners During Pregnancy
With obesity on the rise worldwide more and more young women are also affected, leading to a higher prevalence of obese pregnant women and pregnant women with diabetes.
- Conditions
- Pregnancy Related, Diabetes, IUGR
- Trial name
- NCT03954418
- Testing
- Acesulfame K, cyclamate, saccharine, aspartame
- Where
- Denmark
- Volunteers
- 35 people, healthy volunteers welcome
- Sponsor
- University of Aarhus
Fetal Growth Retardation
Placental Lesions in Fetal Growth Restrictions
The purpose of this research study is to develop imaging methods to diagnose placental injury in pregnancies diagnosed with fetal growth restriction (FGR).
- Trial name
- NCT04839185
- Testing
- Ferumoxytol infusion, MRI scan
- Where
- United States
- Volunteers
- 3 people
- Sponsor
- University of Wisconsin, Madison
Hif-1α Covid-19
Effect of Post Covid-19 Hypoxia on Placenta of Normal Pregnant Women: A Possible Role of Hypoxia Inducible Factor-1α.
To study the risk of hypoxia in placenta of normal pregnant women infected with covid-19 during third trimester of pregnancy.
- Trial name
- NCT05158868
- Testing
- HiF-1 alpha measurement
- Volunteers
- 50 people
- Sponsor
- Assiut University
Placenta Accreta Spectrum
Comparison Between Cervical Tourniquet and Uterine Artery Ligation Prior to Segmental Resection Approach
The study will compare a modified surgical approach for preserving fertility and minimizing hemorrhage in morbidly adherent placenta during cesarean section with a cervical tourniquet against uterine artery ligation.
- Trial name
- NCT06483724
- Testing
- cervical tourniquet, uterine artery ligation
- Volunteers
- 82 people
- Sponsor
- Minia University
Diabetic Foot Ulcer
Nonhealing Diabetic Foot Ulcers Treated With Standard of Care (SOC) Alone or Standard of Care and Amnion-Intermediate-Chorion (AIC)
The purpose of this study is to determine how well our dHPT (Dehydrated Human Placental Tissue) Product and Standard of Care work when compared to Standard of Care alone in achieving complete closure of diabetic foot.
- Trial name
- ELITE (NCT07014176)
- Testing
- Amnion-Intermediate-Chorion, Standard of Care (SOC)
- Where
- 8 sites in United States
- Volunteers
- 84 people
- Sponsor
- Cellution Biologics
Diabetic Foot Ulcer (DFU), Venous Leg Ulcer (VLU)
Evaluation of the Safety and Efficacy of Dehydrated Human Placenta Tissue (dHPT) for Wound Healing
The retrospective trial is observational, intended to stand alone, complement and integrate data collected in ongoing clinical studies to aid in establishing payor coverage in the United States (U.S.) for Cellution Biologics…
- Conditions
- Diabetic Foot Ulcer (DFU), Venous Leg Ulcer (VLU), Pressure Ulcer (PU)
- Trial name
- RETRO-PLAST (NCT07375160)
- Testing
- dHPT, AIC
- Where
- United States
- Volunteers
- 300 people
- Sponsor
- Cellution Biologics
Placenta Accreta Spectrum, Placenta Previa
Maternal Serum Adropin in Placenta Accreta Spectrum
Aim: To compare maternal serum adropin levels in pregnancies complicated by placenta previa and/or placenta accreta spectrum (PAS) with those of healthy pregnant women and to evaluate the diagnostic value of adropin for…
- Trial name
- Adropin (NCT07421180)
- Where
- Turkey (Türkiye)
- Volunteers
- 84 people, healthy volunteers welcome
- Sponsor
- Adana City Training and Research Hospital
Cesarean Section, Infant Conditions
Intact-cord Stabilisation and Physiology-based Cord Clamping in Caesarean Sections
This is a feasibility study with historical control designed to evaluate whether delivery of the placenta prior to umbilical cord clamping at caesarean sections is a feasible, safe and acceptable way of facilitating intact-cord…
- Trial name
- INTACT (NCT05461950)
- Testing
- Extrauterine placental transfusion and physiology-based umbilical cord clamping, Extrauterine placental transfusion, intact cord stabilisation and physiology-based umbilical cord clamping, Delayed umbilical cord clamping
- Where
- Norway
- Volunteers
- 263 people
- Sponsor
- Helse Møre og Romsdal HF
Wounds
Study of Donated Amnion, Fetal Placental Membrane, as Skin Substitute for Burn Patients
Is the use of fetal membrane (human amnion) as a transient wound coverage in wound repair safe and efficacious. Will the incorporation of liposomal gene constructs to amnion enhance the functionality of human amnion and improve…
- Trial name
- Amnion (NCT00592189)
- Testing
- blood draw
- Where
- United States
- Volunteers
- 1,164 people, healthy volunteers welcome
- Sponsor
- The University of Texas Medical Branch, Galveston
Chorioamnionitis, Intrapartum Fever
Intrapartum Fever: Antibiotics Versus no Treatment
The purpose of this study is to determine whether antibiotics can be safely avoided in women who develop a fever during labor. Because investigators have no accurate tests to determine whether women who develop fever during labor…
- Conditions
- Chorioamnionitis, Intrapartum Fever, Intra-amniotic Infection
- Trial name
- NCT03168178
- Testing
- Standard Antibiotic Treatment, No Antibiotic Treatment
- Where
- United States
- Sponsor
- University of Utah
Pre-Eclampsia, Fetal Growth Retardation
Antepartum Chronic Epidural Therapy (ACET) to Improve Blood Flow to the Uterus, Placenta and Baby in Pre-Eclampsia and Intrauterine Growth Restriction
Pre-eclampsia (PE) and intrauterine growth restriction (IUGR) are common and important disorders of pregnancy. Both disorders are associated with an impairment of uteroplacental blood flow (UPBF).
- Trial name
- NCT00197340
- Testing
- Epidural ropivacaine
- Where
- Israel
- Volunteers
- 20 people
- Sponsor
- Hadassah Medical Organization
Placenta Previa
Management Of Placenta Previa Cases And Determination Of Hospitalization Criteria
Placenta previa cases are one of the difficult groups of patients to manage in modern obstetrics. When the literature is evaluated extensively, no clear information can be seen especially in terms of hospitalization time.
- Trial name
- NCT04264234
- Testing
- Vaginal Ultrasonography, Magnetic Resonance Imaging
- Where
- Turkey (Türkiye)
- Volunteers
- 98 people, healthy volunteers welcome
- Sponsor
- Ege University