Clinical trials: Placenta
Ophthalmic Artery, Labor and Delivery
The Ophthalmic Artery Doppler Evaluation Prior to Labor Induction and Adverse Intrapartum Fetal Outcomes
The ophthalmic artery Doppler has been recently proposed as a potential "soft marker" for placental insufficiency in retrospective and observational studies, with similar clinical significance with respect to Uterine Artery (UA)…
- Conditions
- Ophthalmic Artery, Labor and Delivery, Induction of Labor, Intrapartum Fetal Distress
- Trial name
- OPHELIA (NCT07846137)
- Testing
- Ophthalmic Artery Doppler
- Where
- Italy
- Volunteers
- 1,477 people
- Sponsor
- Fondazione Policlinico Universitario Agostino Gemelli IRCCS
Pregnancy Complications, Obesity, Maternal
Innovations in Placental Metabolism and Association With Antioxidants and Nutrients in Diabetes and Gestational Obesity
This research project aims to investigate, in an innovative way, the molecular pathophysiology of gestational complications induced by maternal obesity and gestational diabetes mellitus (GDM).
- Conditions
- Pregnancy Complications, Obesity, Maternal, Diabetes Mel Gestational - in Pregnancy
- Trial name
- IMPACTING (NCT05174728)
- Where
- Brazil
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- Rio de Janeiro State University
Idiopathic Pulmonary Fibrosis (IPF)
Safety and Efficacy of Nebulized 3D-cultured Human Placental Mesenchymal Stem Cell-derived Extracellular Vesicles (hPMSC-EVs) for Idiopathic Pulmonary Fibrosis
This is a single-center, open-label, dose-escalation clinical study to evaluate the safety and efficacy of nebulized 3D-cultured human placental mesenchymal stem cell-derived extracellular vesicles (hPMSC-EVs) in patients with…
- Trial name
- NCT07515066
- Testing
- 3D-cultured human placental mesenchymal stem cell-derived extracellular vesicles
- Where
- China
- Volunteers
- 9 people
- Sponsor
- Huan Ye
Retained Placenta
Intravenous Nitroglycerin for Retained Placenta Extraction: a Multicenter Study
Primary objective The primary objective of this study is to see whether intravenous (IV) NTG 100-200 microgram can effectively help extract retained placenta as compared to placebo, in a randomized controlled multicenter study.
- Trial name
- NCT00707928
- Testing
- nitroglycerine, NSS
- Where
- Thailand
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Mahidol University
Placenta Accreta
Tranexamic Acid in Adherent Placenta (TAP)
The objective of this study is to investigate the effect of tranexamic acid (TXA) administration on the outcome of cesarean-hysterectomy in women with suspected Morbidly Adherent Placenta (MAP; placenta accreta, increta…
- Trial name
- NCT02329756
- Testing
- Tranexamic Acid (TXA), Sodium Chloride 0.9%
- Where
- United States
- Volunteers
- healthy volunteers welcome
- Sponsor
- Baylor College of Medicine
Stage 2 Pulmonary Sarcoidosis, Stage 3 Pulmonary Sarcoidosis
Safety of Intravenous Infusion of Human Placenta-Derived Cells (PDA001) for the Treatment of Adults With Stage II or III Pulmonary Sarcoidosis
The primary objective of the study is to assess the safety and tolerability of a single dose of PDA001 (given twice) in subjects with Stage II or III Pulmonary Sarcoidosis (PS) who are refractory to one or more of the following…
- Trial name
- NCT01440192
- Testing
- PDA001 (cenplacel-L)
- Where
- 4 sites in United States
- Volunteers
- 4 people
- Sponsor
- Celularity Incorporated
Preeclampsia
Prevention of Maternal and Perinatal Complications by Enoxaparin in Women With Previous Severe Preeclampsia
Preeclampsia (PE) complicates 2-8% of pregnancies. It is associated with an increased risk of adverse maternal (death, eclampsia, abruptio placenta, HELLP syndrome) and perinatal (perinatal death, growth restriction, prematurity)…
- Trial name
- HEPEPE (NCT00986765)
- Testing
- Lovenox® (enoxaparin), Aspegic ® (Aspirin)
- Where
- France
- Volunteers
- 257 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Preterm Birth
The Expression Heparanase in Term and Preterm Placentas
Heparanase is an endo-β-glucuronidase that cleaves heparin-sulfate (HS) side chains of heparan sulfate proteoglycans, an integral constituent of the extra cellular matrix (ECM).
- Trial name
- NCT03798964
- Testing
- Placental analysis
- Where
- Israel
- Volunteers
- 20 people
- Sponsor
- Hillel Yaffe Medical Center
Hematologic Malignancies
A Single-arm Safety Study of Transplantation Using Umbilical Cord Blood and Human Placental-derived Stem Cells From Partially Matched Related Donors in Persons With Certain Malignant Blood Diseases and Non-malignant Disorders
To investigate the safety of partially matched related human placental-derived stem cells (HPDSC) administered in conjunction with umbilical cord blood (UCB) stem cells from the same donor in subjects with various malignant or…
- Trial name
- HPDSC (NCT00596999)
- Testing
- UCB and HPDSC
- Where
- United States
- Volunteers
- 6 people
- Sponsor
- Celgene Corporation
IUGR
Viagra for the Treatment of IUGR
It has been suggested that Viagra (or other drugs that inhibit PDE-5, the enzyme that normally inhibits blood vessels' ability to expand) may have beneficial effects in hypertensive pregnancy and, possibly, preeclampsia.The…
- Trial name
- NCT00347867
- Testing
- Viagra administration in IUGR/PET pregnancies
- Where
- Israel
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Rambam Health Care Campus
Placenta Accreta
Conservative Surgical Novel Technique of Placenta Accreta in Menoufia University Hospital
Evaluation of maternal morbidity and mortality of our novel surgical procedure for conservative management of placenta accreta in our tertiary referral institute.
- Trial name
- NCT04161521
- Testing
- Novel Technique of Placenta Accreta in Menoufia University Hospital
- Where
- 2 sites in Egypt
- Volunteers
- 60 people
- Sponsor
- Menoufia Obstetrics and Gynecology Group
Diabetic Foot, DFU
Trial Assessing the Efficacy of Human Placental Membrane Products and Standard of Care Versus Standard of Care Alone in the Management of Nonhealing Diabetic Foot Ulcers and Venous Leg Ulcers
The purpose of this study is to evaluate the efficacy of human placental membrane products and standard of care versus standard of care alone in the management of nonhealing diabetic foot ulcers and venous leg ulcers.
- Conditions
- Diabetic Foot, DFU, Diabetic Foot Ulcer, Foot Ulcer, Diabetic
- Trial name
- BIOCAMP (NCT07089602)
- Testing
- Standard of Care DFU, Tri-Membrane Wrap™ DFU, Membrane Wrap™ DFU
- Where
- United States
- Volunteers
- 650 people
- Sponsor
- BioLab Holdings
Intrauterine Development
The Reus-Tarragona Birth Cohort Study of Early Development and Ageing.
The recent fall in birth and death rates has led to demographic changes such as low fertility and high life expectancy . The WHO reports the median age of the European population to be the highest in the world and predicts that…
- Trial name
- NCT01778205
- Testing
- Observational
- Where
- 2 sites in Spain
- Volunteers
- 831 people, healthy volunteers welcome
- Sponsor
- Institut Investigacio Sanitaria Pere Virgili
Hair Loss, Alopecia
Exosome Effect on Prevention of Hairloss
Many people suffer from alopecia, which is caused by hereditary factors, emotional stress, and psychiatric disorders. There are devastating physical and psychological consequences as a result.
- Trial name
- NCT05658094
- Testing
- Exosome
- Where
- Iran
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Isfahan University of Medical Sciences
Chronic Wounds, Diabetic Ulcers
Real-world Study of StimLabs Human Placental Membrane Tissue to Treat Hard-to-Heal Wounds
This is a retrospective, multi-center observational study to assess real-world outcomes of StimLabs human placental membrane tissue used in the treatment of hard-to-heal wounds, including chronic ulcers, diabetic foot ulcers…
- Trial name
- NCT07215741
- Where
- 3 sites in United States
- Volunteers
- 23 people
- Sponsor
- StimLabs
Preeclampsia
Marinobufagenin as a Target for DIGIBIND in Preeclampsia
Background: Preeclampsia is a combination of high blood pressure and other potentially life-threatening symptoms. Preeclampsia occurs in up to 10% of pregnancies and is a main cause of maternal and fetal death worldwide.
- Trial name
- NCT01328600
- Where
- 3 sites in Russia
- Volunteers
- 144 people
- Sponsor
- National Institute on Aging (NIA)
Placenta Previa
Vaginal Pessary Versus Expectant Management for Placenta Previa
The purpose of this study is to perform a large multi-center randomized trial comparing the role of vaginal pessary versus expectant management in women with placenta previa between 22w0d and 32w0d of gestation in prolonging…
- Trial name
- NCT01996345
- Testing
- Cervical Pessary Placement
- Where
- 10 sites in United States
- Volunteers
- 17 people
- Sponsor
- Pediatrix
Perianal Fistula in Patients With Crohn's Disease
Safety of Injection of Placental Mesenchymal Stem Cell Derived Exosomes for Treatment of Resistant Perianal Fistula in Crohn's Patients
Study aim: Safety of Human Placenta Mesenchymal Stem Cells Derived Exosomes for treatment of perianal fistula in patients with Crohn's disease 2.
- Trial name
- NCT05499156
- Testing
- placenal MSC derived exosomes
- Where
- Iran
- Volunteers
- 80 people
- Sponsor
- Tehran University of Medical Sciences
Pregnancy, Cesarean Delivery
Manual and Expressed Placental Removal at Cesarean Delivery and Its Effects on Various Cardiac Indices
The purpose of this study is to evaluate whether manual removal of the placenta during a cesarean delivery results in higher changes in the resistance of blood flow throughout the body, also called systemic vascular resistance…
- Trial name
- NCT00711451
- Testing
- Manual removal, Expressed removal
- Where
- United States
- Volunteers
- 19 people, healthy volunteers welcome
- Sponsor
- Corewell Health East
Placental Oxygenation
Could the Cerebral Oximetry be a Good Technology to Measure Placental Oxygenation?
To assess the potential of the cerebral oximeter to measure placental oxygenation
- Trial name
- NCT01834599
- Testing
- cerebral oximetry
- Where
- Canada
- Volunteers
- 20 people
- Sponsor
- Maisonneuve-Rosemont Hospital