Clinical trials: Placenta
Obstetric Complication
Caesarean Hysterectomy Versus Conservative Management of Placenta Accreta: A Comparative Study
Placenta accreta rates are rising alongside the rising rates of caesarean deliveries. This has lead to a vast number of studies negotiating the histopathological nature, risk factors and outcomes of pregnancies complicated with…
- Trial name
- NCT06861972
- Testing
- Caesarean Hysterectomy, Conservative management
- Where
- Egypt
- Volunteers
- 36 people
- Sponsor
- Cairo University
Placenta Accreta
Bilateral Uterine Artery Ligation in PPC Technique for Management of PAS
Aim of the study Primary outcomes: 1. The effect of bilateral uterine artery ligation in reducing intraoperative bleeding in women underwent PPC as a conservative surgical technique. 2. Decrease surgical time.
- Trial name
- NCT05314595
- Testing
- bilateral uterine artery ligation
- Where
- Egypt
- Volunteers
- 130 people
- Sponsor
- Assiut University
Placenta Previa
Progesterone in Patients With Placenta Previa
This study evaluates the efficacy of prophylactic vaginal progesterone administration in reducing of the episodes of antepartum hemorrhage and subsequent prevention of preterm delivery in women with placenta previa.
- Trial name
- NCT03633175
- Testing
- Vaginal progesterone
- Where
- Egypt
- Volunteers
- 74 people
- Sponsor
- Ain Shams University
Placenta Accreta
Feasibility of HIFU for Management of Placenta Accreta (HIFU-ACCRETA)
Placental accretion during pregnancy refers to an abnormally deep insertion of the placenta into the uterus, leading to the impossibility of removing the placenta without inducting uterine or surrounding organs lesions.
- Trial name
- HIFU-ACCRETA (NCT04003428)
- Testing
- High Intensity Focused Ultrasound
- Sponsor
- Hospices Civils de Lyon
Placental Malaria Infection, HIV Infections
Intermittent Preventive Treatment of Malaria in HIV-Seropositive Pregnant Women in Zambia
Prevention of malaria in pregnancy is critical given the high incidence of malaria in Zambia and its serious impact on both maternal and infant survival.
- Conditions
- Placental Malaria Infection, HIV Infections, Stillbirth, Prematurity
- Trial name
- NCT00270530
- Testing
- Sulfadoxine-pyrimethamine (Fansidar)
- Where
- Zambia
- Volunteers
- 454 people
- Sponsor
- Center for International Health and Development
Placenta Accreta, Third Trimester
Relationship Between Maternal Soluble Trigger Receptor Expressed on Myeloid Cells-1 (sTREM-1) and Placenta Accreta Spectrum
We planed to evaluate soluble the triggering receptors expressed on myeloid cell-1 (s TREM-1) levels in serum of pregnant women diagnosed with placenta accreta spectrum and compare it with healthy pregnant women's s TREM-1 serum…
- Trial name
- NCT05376410
- Where
- Turkey (Türkiye)
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- Necmettin Erbakan University
Postpartum Haemorrhage, Retained Placenta
Two Different Regimens of Misoprostol in Retained Placenta
This study evaluates intra umbilical vein injection of 800 µg versus 400 µg misoprostol for the treatment of retained placenta to reduce the need of manual removal of placenta under general anaesthesia
- Trial name
- NCT02704780
- Testing
- Misoprostol
- Where
- Iraq
- Volunteers
- 509 people, healthy volunteers welcome
- Sponsor
- Hawler Medical University
Placenta Accreta
Internal Iliac Artery Ligation During Management of Placenta Accreta Spectrum
Vessels ligation have been used as a part of conservative management in treatment of placenta accrete spectrum to decrease blood loss as uterine artery ligation and internal iliac artery ligation.
- Trial name
- NCT04593303
- Testing
- Internal iliac artery ligation with cervicoisthmic compression suture, Cervicoisthmic compression suture without Internal iliac artery ligation
- Where
- Egypt
- Volunteers
- 42 people
- Sponsor
- Mansoura University Hospital
Pre-eclampsia, Oocyte Donation
PRIOR Study (Pre-eclampsia Risk In Oocyte Recipients)
The aim of this prospective observational cohort study is to investigate the pathophysiological mechanisms behind and risk of pre-eclampsia in women pregnant after fertility treatment with oocyte donation.
- Conditions
- Pre-eclampsia, Oocyte Donation, Pre-Eclampsia; Complicating Pregnancy, Pre-Eclampsia; Mild
- Trial name
- PRIOR (NCT07263490)
- Where
- 6 sites in Denmark
- Volunteers
- 462 people
- Sponsor
- Copenhagen University Hospital, Hvidovre
Bacterial Vaginosis, Fetal Membranes, Premature Rupture
Perinatal Infections in Pakistan
There are large differences in health outcomes related to pregnancy and birth between developed and developing countries. This study will investigate how infections, medical history, health care behavior and psychosocial issues…
- Conditions
- Bacterial Vaginosis, Fetal Membranes, Premature Rupture, Chorioamnionitis, Pregnancy
- Trial name
- NCT00070746
- Where
- Pakistan
- Volunteers
- 1,500 people, healthy volunteers welcome
- Sponsor
- NICHD Global Network for Women's and Children's Health
Postpartum Haemorrage Sever Bleeding After Delivery
Efficacy of Tranexamic Acid In Reducing Blood Loss During Cesarean Section Because Of Placenta Previa
This study evaluate role of tranexamic acid in reducing blood loss among pregnant women undergoing cesarean section because of placenta previa .Half of participants will receive tranexamia acid drug While the other half will…
- Trial name
- NCT02688127
- Testing
- Tranexamic Acid
- Volunteers
- 52 people
- Sponsor
- Medical Research Council
Placenta Diseases, IVF
Ultrasound Diagnosis of Placental and Umbilical Cord Anomalies in Singleton Pregnancies Resulting From In-vitro Fertilization
Objectives: to identify which type of placental and umbilical cord abnormalities are more common in IVF singleton pregnancies; to investigate if heterologous fertilization is an additional risk factor for the development of these…
- Trial name
- PLACENTA (NCT05172674)
- Testing
- ultrasound according routine antenatal care
- Where
- Italy
- Volunteers
- 587 people, healthy volunteers welcome
- Sponsor
- IRCCS Azienda Ospedaliero-Universitaria di Bologna
Placenta Previa Bleeding
High Versus Low Dose of Magnesium Sulfate as Initial Tocolytic Agent for Preterm Labour in Symptomatic Placenta Previa.
To assess the efficacy and safety of alternative magnesium sulfate regimens when used as single agent tocolytic therapy for prevention of preterm labour in patients with symptomatic placenta previa and subsequent changes in the…
- Trial name
- NCT04599868
- Testing
- Magnesium sulfate
- Where
- Egypt
- Volunteers
- 130 people
- Sponsor
- Assiut University
Placenta Accreta, Third Trimester
A Serum Galectin-3 Levels in Placenta Accreta Spectrum Pregnancies
Placenta Accreta Spectrum (PAS) represents a significant cause of maternal morbidity and mortality, causing complications that surpass those posed by most routine obstetric issues.
- Trial name
- NCT05945446
- Testing
- Galectin 3
- Where
- Turkey (Türkiye)
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Necmettin Erbakan University
Retained Placenta
Management of Third-stage of Labor After Second Trimester Medical Pregnancy Termination
Prospective randomized trail which compare 2 regimens for third-stage management after second trimester medical pregnancy termination : 10UI intra venous oxytocin or no additional medication after fetal expulsion.
- Trial name
- ANDDROID (NCT02969447)
- Testing
- Administration of 10 units of intra venous oxytocin after fetal expulsion
- Where
- France
- Volunteers
- 27 people
- Sponsor
- University Hospital, Bordeaux
Placenta Accreta Management
Observation of Strategies in Placenta Accreta Spectrum Management
Placenta accreta spectrum (PAS) disorders represent a significant obstetric challenge, characterized by abnormal adherence of the placenta to the uterine wall, leading to potentially life-threatening hemorrhage (ACOG 2020; RCOG…
- Trial name
- NCT07236710
- Volunteers
- 300 people
- Sponsor
- Assiut University
Myelodysplastic Syndromes
Safety and Efficacy Study of Umbilical Cord/Placenta-Derived Mesenchymal Stem Cells to Treat Myelodysplastic Syndromes
The purpose of this study is to evaluate the safety and efficacy of mesenchymal stem cells (MSCs) derived from human umbilical cord/placenta at a dose of 1.0E+6 MSC/kg on the subjects for refractory anemia (RA) and refractory…
- Trial name
- NCT01129739
- Testing
- Human umbilical cord-derived MSCs, cyclosporine A (CsA)
- Where
- China
- Volunteers
- 30 people
- Sponsor
- Shandong University
Obesity, Type 2 Diabetes
Maternal Adipose Tissue and Placental Dysfunction Programs the Fetus for Type 2 Diabetes (PlacentA-DM)
The purpose of this study is to discover the characteristics of pregnant women which increases risk for their babies to develop diabetes, later on in life.
- Trial name
- PlacentA-DM (NCT02211651)
- Where
- United States
- Volunteers
- 3 people, healthy volunteers welcome
- Sponsor
- AdventHealth Translational Research Institute
Preterm Labor, Preterm Birth
Interest of a Vaginal Swab in Detection of Placental Alpha-Microglobulin-1 in the Prediction of Preterm Birth
Preterm labor is the first cause of hospitalization during the pregnancy, and at the origin of more than 60 000 births before 37 weeks of amenorrhea every year in France.
- Trial name
- MAPOSURE (NCT03401255)
- Testing
- Partosure test
- Where
- 2 sites in France
- Volunteers
- 341 people
- Sponsor
- Nantes University Hospital
Bladder Injury, Accreta, Placenta
Cystoinflation to Prevent Bladder Injury in Cases of Placenta Accreta Spectrum
Placenta accreta spectrum (PAS) disorders are associated with a high risk of bladder injury .leading to increased morbidity. Cystoinflation, involving controlled retrograde bladder filling, has been proposed as a technique to…
- Trial name
- NCT07050082
- Testing
- Bladder dissection after filling with 200 cc saline solution, Bladder dissection with empty bladder
- Where
- Egypt
- Volunteers
- 84 people
- Sponsor
- Cairo University