Clinical trials: Placenta
Diabetic Foot Ulcer, DFU
Randomized Evaluation of Nonhealing Diabetic Foot Ulcers With Exclusive Wound Therapy
The goal of this study is to determine the between-arm difference in the proportion of subjects achieving complete closure of nonhealing diabetic foot ulcers with multiple CAMPs plus SOC versus matched controls over 12 weeks…
- Conditions
- Diabetic Foot Ulcer, DFU, Diabetic Foot Ulcer (DFU), Foot Ulcer Due to Type 1 Diabetes Mellitus
- Trial name
- RENEW (NCT07086443)
- Testing
- Activate™ Matrix, AmnioDefend™ FT Matrix, Palisade™ DM Matrix
- Where
- United States
- Volunteers
- 350 people
- Sponsor
- Sequence LifeScience, Inc.
Preeclampsia, Pregnancy Loss
Placental Organoids Development: Application in the Study of the Human Reproduction Pathophysiology.
Placental organoids represent an in vitro 3D reconstruction model of the human placenta and of its complex cellular organization to evaluate the pharmacological effect in terms of placentation, gene expression, protein synthesis…
- Conditions
- Preeclampsia, Pregnancy Loss, Preterm Birth, Healthy
- Trial name
- PLORG (NCT06893978)
- Testing
- Placenta organoids treatment
- Where
- Italy
- Volunteers
- 20 people
- Sponsor
- Fondazione Policlinico Universitario Agostino Gemelli IRCCS
Axial Spondyloarthritis (AxSpA), Non-radiographic Evidence-AxSpA
A Multicener, Postmarketing Study Evaluating the Transfer of Cimzia From the Mother to the Infant Via the Placenta
The primary purpose is to assess whether there is transfer of Certolizumab Pegol (CZP) from pregnant women receiving treatment with Cimzia® across the placenta to infants by evaluating the concentration of CZP in the plasma of…
- Conditions
- Axial Spondyloarthritis (AxSpA), Non-radiographic Evidence-AxSpA, Ankylosing Spondylitis, Crohn's Disease
- Trial name
- CRIB (NCT02019602)
- Testing
- Blood sampling from mother, Blood sampling from infant, Blood sampling from umbilical cord
- Where
- 8 sites in United States, France and 2 more
- Volunteers
- 37 people
- Sponsor
- UCB BIOSCIENCES, Inc.
Infants of Diabetic Mothers, Placenta
Placental Weight in Infants of Gestational Diabetic Mothers
This prospective cross-sectional study examined the relationship between placental weight and early neonatal outcomes, such as blood glucose levels within the first 24 hours and early neonatal morbidities in infants born to…
- Conditions
- Infants of Diabetic Mothers, Placenta, Hypoglycaemia
- Trial name
- NCT07765784
- Testing
- Blood Glucose Level
- Where
- Turkey (Türkiye)
- Volunteers
- 98 people
- Sponsor
- Kanuni Sultan Suleyman Training and Research Hospital
Intrauterine Device Migration
Post-placental Intrauterine Device Insertion During Cesarean Section
Effective, reversible postpartum contraception decreases the chance of rapid repeat pregnancy and poor perinatal outcome in a subsequent pregnancy especially in women delivered by cesarean section.The traditional 6-week…
- Trial name
- NCT03780985
- Testing
- Intrauterine device insertion, Cesarean section, Suture
- Where
- Egypt
- Volunteers
- 118 people, healthy volunteers welcome
- Sponsor
- Assiut University
Scarred Uterus
Abnormal Placenta Plant Disease Early Diagnosis and Individualized Treatment Research
As the "two-child" policy implementation, caesarean women's clinical pregnancy is a huge problem again, Especially the placenta planting abnormal disease is a serious threat to the maternal health and life.
- Trial name
- NCT02946749
- Volunteers
- 3,000 people, healthy volunteers welcome
- Sponsor
- Shanghai First Maternity and Infant Hospital
Preterm Birth Complication, Neonatal Morbidity and Mortality
Delayed Versus Immediate Cord Clamping in Preterm Birth
The goal of this study is to evaluate whether delayed cord clamping improves early neonatal outcomes compared with immediate clamping in preterm birth.
- Conditions
- Preterm Birth Complication, Neonatal Morbidity and Mortality, Cord Clamping, Delayed Cord Clamping
- Trial name
- PREM-CORD (NCT07699666)
- Testing
- Delayed Umbilical Cord Clamping, Immediate Umbilical Cord Clamping
- Where
- Tunisia
- Volunteers
- 200 people
- Sponsor
- Faculty of Medicine of Tunis
Congenital Diaphragmatic Hernia
Initiation of Resuscitation While Attached to the Cord With Congenital Diaphragmatic Hernia
This study aims to measure the cardio-respiratory physiological consequences of initiating resuscitation during placental transfusion (PT) with an intact umbilical cord in infants with congenital diaphragmatic hernia (CDH).
- Trial name
- INSPIRE-CDH (NCT03094039)
- Testing
- Ventilatory support while attached to the cord, Immediate cord clamping
- Where
- Canada
- Sponsor
- University of Alberta
Multiple Sclerosis, Clinically Isolated Syndrome
A Study Evaluating B Cell Levels In Infants Potentially Exposed To Ocrelizumab During Pregnancy
This study will evaluate the potential placental transfer of ocrelizumab in pregnant women with clinically isolated syndrome (CIS) or multiple sclerosis (MS) [in line with the locally approved indications] whose last dose of…
- Trial name
- MINORE (NCT04998812)
- Testing
- Ocrelizumab
- Where
- 11 sites in United States, France and 3 more
- Volunteers
- 70 people
- Sponsor
- Hoffmann-La Roche
Placenta Accreta
Conservative Management of Morbidly Adherent Anterior Situated Placenta
Placenta accreta is defined as abnormal trophoblast invasion of part or the entire placenta into the myometrium of the uterine wall.
- Trial name
- NCT04579172
- Testing
- Cervico- isthmic compression suture, Anterior wall uterine resection:
- Where
- Egypt
- Volunteers
- 40 people
- Sponsor
- Mansoura University Hospital
Pre-Eclampsia
Role and Expression of MXRA5 in Placental Connective Tissue Remodelling in Preeclampsia
1. To measure the level of expression of MXRA5 and ANXA4 genes in preeclampsia (PE). 2. To detect the effect of heavy metals (lead (Pb) and arsenic (AR)) on these two genes in the pathology of PE. 3.
- Trial name
- NCT04287998
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Assiut University
Placenta Previa, Vaginal Bleeding
The Rate and Predictors of Vaginal Bleeding Among Women With Placenta Previa
Placenta previa is usually diagnosed when the placenta implanted in the lower uterine segment, thus partially or totally overlying the internal os . It occurs with an incidence of 0.3-0.5%.
- Conditions
- Placenta Previa, Vaginal Bleeding, Antepartum Hemorrhage
- Trial name
- NCT05645848
- Testing
- Ultrasonography
- Volunteers
- 250 people
- Sponsor
- Assiut University
Twin to Twin Transfusion Syndrome
Laser Photocoagulation in Twin to Twin Transfusion Syndrome
Humanitarian use device (HUD): Use of the fetoscopy instrument sets for selective laser photocoagulation in the treatment of Twin to Twin Transfusion Syndrome (TTTS).
- Trial name
- TTTS (NCT02506049)
- Testing
- S-LPC:Selective Laser Photocoagulation
- Where
- 2 sites in United States
- Volunteers
- 1 people
- Sponsor
- University of Tennessee
Decrease Maternal Morbidity
Transverse B-Lynch in Management of Placenta Accreta
Placenta accreta is considered a severe pregnancy complication that may be associated with massive and potentially life-threatening intrapartum and postpartum hemorrhage.
- Trial name
- NCT02943421
- Testing
- Transverse B-Lynch suture
- Where
- Egypt
- Volunteers
- 50 people
- Sponsor
- Assiut University
Placenta Diseases
MARS: Magnetic Resonance Study: A Novel Assessment of Placental Function
The objective of this study is to evaluate functional MRI as a tool to study placental transfer of oxygen and nutrients during the third trimester of pregnancy in obese women, women with pregestational diabetes and healthy low…
- Trial name
- NCT03764878
- Testing
- functional MRI
- Where
- United States
- Volunteers
- 15 people, healthy volunteers welcome
- Sponsor
- Endeavor Health
Preemptive Therapy of Patients At Risk for Acute Kidney Injury Following Cardiac Surgery
Phase 1B/2 Clinical Trial Assessing the Safety, Tolerability and Preliminary Efficacy of the Intravenous Administration of Allogeneic Placental Mesenchymal Cells for the Preemptive Treatment of Patients At Risk for Acute Kidney Injury Following Cardiac Surgery
This clinical trial is designed to evaluate KELI-101 versus placebo for the prevention of acute kidney disease leading to chronic kidney disease in subjects at high risk for acute kidney injury following cardiac surgery.
- Trial name
- MesAKI (NCT06678399)
- Testing
- KELI-101
- Volunteers
- 91 people
- Sponsor
- Kelifarma
Pregnancy in Diabetics, Placenta
Fetal Growth and Placental Function in Pregnancies Complicated by Diabetes
Diabetic pregnancies are often complicated by placental dysfunction with reduced transfer of oxygen from the mother to the fetus, which may compromise fetal growth and organ development.
- Conditions
- Pregnancy in Diabetics, Placenta, Fetal Growth, Magnetic Resonance Imaging
- Trial name
- FaPDi (NCT04801121)
- Where
- Denmark
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Sidsel Linneberg Rathcke
Amyotrophic Lateral Sclerosis
Safety of Cultured Allogeneic Adult Umbilical Cord or Placental Derived Mesenchymal Stem Cell Intrathecal Injection for ALS
This trial will study the safety and efficacy of intrathecal injection of cultured allogeneic adult umbilical cord or placental derived mesenchymal stem cells for the treatment of amyotrophic lateral sclerosis
- Trial name
- NCT05003921
- Testing
- cultured allogeneic adult umbilical cord or placental derived mesenchymal stem cells
- Sponsor
- The Foundation for Orthopaedics and Regenerative Medicine
Placental Thickness, PLACENTA VOLUME
Placental Thickness -To-Fetal Weight Ratio as a Predictor of Adverse Pregnancy Outcome
The aim of this study is to evaluate the placental thickness-to-fetal weight ratio as a predictor of adverse pregnancy outcomes.
- Trial name
- NCT07467148
- Volunteers
- 70 people
- Sponsor
- Radia Atef Elzokm
Placenta Accreta Spectrum
Diagnostic Trial of a Vision Transformer-Based Ultrasound AI Model for Placenta Accreta Spectrum
This study develops an end-to-end Vision Transformer (ViT)-based artificial intelligence system for ultrasound-based diagnosis of placenta accreta spectrum (PAS), aiming to improve the accuracy and efficiency of prenatal…
- Trial name
- NCT07643090
- Testing
- Vision Transformer-Based End-to-End Ultrasound Artificial Intelligence Model
- Where
- China
- Volunteers
- 561 people
- Sponsor
- FANG HE