Clinical trials: Placenta
Placenta Previa
Modified Cervical Inversion During CS in Placenta Previa
There is an increasing rates of placenta previa nowadays
- Trial name
- NCT03772184
- Testing
- Cervical inversion
- Where
- Egypt
- Volunteers
- 240 people, healthy volunteers welcome
- Sponsor
- Aljazeera Hospital
Placental Insufficiency, Enoxaparin
Enoxaparin in the Prevention of Placental Insufficiency in Pregnant Women
Assessment of the effectiveness of Enoxaparin, at a preventive dose, combined with Aspirin treatment versus Aspirin only treatment in reducing placental insufficiency in pregnant women.
- Trial name
- PRESANCE (NCT03528967)
- Testing
- Enoxaparin 40 mg / 0.4 mL Prefilled Syringe, Aspirin 100 mg Oral Tablet, Enteric Coated
- Where
- Tunisia
- Volunteers
- 89 people
- Sponsor
- Les Laboratoires des Médicaments Stériles
Knee Osteoarthritis
Efficacy of Bone-marrow-derived and Placenta-derived Multipotent Mesenchymal Stem / Stromal Cells for Osteoarthritis
To define the clinical effects of intra-articular transplantation of bone-marrow-derived (BM-MMSCs) and placenta-derived multipotent mesenchymal stem / stromal cells (P-MMSCs) for knee osteoarthritis.
- Trial name
- NCT04453111
- Testing
- Placenta-derived MMSCs, Bone marrow-derived MMSCs, Hyalgan 20 mg in 2 ML Prefilled Syringe
- Where
- Ukraine
- Volunteers
- 45 people
- Sponsor
- Institute of Cell Therapy
Rheumatoid Arthritis
Safety of Cultured Allogeneic Adult Umbilical Cord or Placental Derived Mesenchymal Stem Cell Intravenous Infusion and Intra-Articular Injection for RA
This trial will study the safety and efficacy of intravenous infusion and intra-articular injection of cultured allogeneic adult umbilical cord or placental derived mesenchymal stem cells for the treatment of Rheumatoid Arthritis
- Trial name
- NCT05003934
- Testing
- cultured allogeneic adult umbilical cord or placental derived mesenchymal stem cells
- Where
- 2 sites in United States, Greece
- Volunteers
- 20 people
- Sponsor
- The Foundation for Orthopaedics and Regenerative Medicine
Inflammation, Infection
Vitamin D Status Impacts Inflammation and Risk of Infections During Pregnancy
The goal of this study is to characterize the function and efficacy of the bioactive nutrient, vitamin D, in relation to infection and inflammatory status across pregnancy.
- Trial name
- NCT01815047
- Testing
- Vitamin D3 Supplementation
- Where
- United States
- Volunteers
- 85 people, healthy volunteers welcome
- Sponsor
- Cornell University
Placenta Previa
Non-invasive Hemoglobin Monitoring in Cesarean Section
Non-invasive hemoglobin monitoring will be performed in patients who underwent cesarean section with placenta previa and this will be compared with actual laboratory findings.
- Trial name
- NCT03409822
- Testing
- Masimo SpHb™ monitor
- Where
- South Korea
- Volunteers
- 39 people
- Sponsor
- Seoul National University Bundang Hospital
Solid Tumors
Phase I Study on Monoclonal Antibody TB-403 Directed Against PlGF in Patients With Solid Tumours
TB-403 is a monoclonal antibody directed against Placental Growth Factor (PlGF). The antibody binds to PlGF and inhibits the binding to it's receptor, VEGF-1.
- Trial name
- NCT00702494
- Testing
- TB-403
- Where
- 2 sites in Denmark
- Volunteers
- 21 people
- Sponsor
- BioInvent International AB
Opioid Use Disorder, Substance-Related Disorders
Multimodal Fetal and Placental Imaging and Biomarkers of Clinical Outcomes in Opioid Use Disorder
The goal of this observational study is to learn about the long term effects of prenatal opioid exposure. The main objectives are: Long term goal: to improve the safety and efficacy of maternal Opioid Use Disorder (OUD) and…
- Conditions
- Opioid Use Disorder, Substance-Related Disorders, Pregnancy Related, Narcotic-Related Disorders
- Trial name
- NCT06415994
- Testing
- Buprenorphine or Methadone Treatment, Fetal and Placental MRI, Child Developmental Assessment
- Where
- 2 sites in United States
- Volunteers
- 250 people, healthy volunteers welcome
- Sponsor
- Senthil Sadhasivam
Fistula Perianal
Human Placenta Mesenchymal Stem Cells Derived Exosomes Injection for Treatment of Complex Anal Fistula
The goal of this clinical trial is to learn if human placenta mesenchymal stem cells (MSC)-derived exosomes work to treat complex perianal fistula in adults without Crohn's disease.
- Trial name
- NCT06568653
- Testing
- exosome, routine conventional fistulotomy
- Volunteers
- 40 people
- Sponsor
- Tehran University of Medical Sciences
Mechanical Complication of Intrauterine Device
Immediate Post-placental Insertion of IUCD During Cesarean Delivery Versus 6 Week Post-Cesarean Insertion
The aim of current study is to compare the rates of IUCD expulsion and complications in immediate post-placental insertion versus delayed IUCD insertion (6-weeks after cesarean delivery)
- Trial name
- NCT03404622
- Testing
- IUCD
- Where
- Egypt
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- ALshaimaa Aboalhassan Ali
Anemia, Sickle Cell
Role of Placenta Growth Factor in Sickle Acute Chest Syndrome
The purpose of this research study is to find out whether Placenta Growth Factor (PlGF) and related tests can predict the development of acute chest syndrome (ACS) in patients with sickle cell disease (SCD) during a period where…
- Trial name
- NCT00448370
- Where
- United States
- Volunteers
- 136 people
- Sponsor
- Children's Hospital Medical Center, Cincinnati
Contraception
Immediate Post-placental Insertion of the Copper T 380A After Cesarean Delivery Versus 6 Week Post-cesarean Insertion
The purpose of this study is to determine, in a pilot setting, if this study is feasible in terms of recruitment, willingness to be randomized, provision of contraceptive methods, and follow-up.
- Trial name
- NCT01293760
- Testing
- Immediate insertion, 6 weeks interval insertion
- Where
- Uganda
- Volunteers
- 68 people, healthy volunteers welcome
- Sponsor
- Planned Parenthood League of Massachusetts
Placenta Accreta, ESPB
Evaluating the Intraoperative Analgesic Effect of Ultrasound Guided Erector Spinae Plane Block in Parturient Undergoing Elective Cesarean Section for Placenta Accreta Under General Anesthesia.
Due to the significant risk of massive bleeding complicated by profound hypotension and coagulopathy and a high likelihood of hysterectomy during caesarean delivery, general anesthesia is generally regarded as the anesthetic of…
- Conditions
- Placenta Accreta, ESPB, C-section, General Anesthesia
- Trial name
- NCT07748741
- Testing
- ultra sound guided Erector spinae plane block
- Where
- Egypt
- Volunteers
- 70 people
- Sponsor
- Kasr El Aini Hospital
Cesarean Section Complications
Association of Placenta Removal Method and Postpartum Leucocytosis
Cesarean delivery is one of the most common major abdominal operation in women worldwide. The incidence of postpartum infection has been estimated to be 1-4% after vaginal delivery and 10-20% after Cesarean delivery.
- Trial name
- NCT04323241
- Testing
- Controlled cord traction
- Where
- Turkey (Türkiye)
- Volunteers
- 300 people, healthy volunteers welcome
- Sponsor
- Haydarpasa Numune Training and Research Hospital
Fetal Growth Retardation, Fetal Growth Complications
Acute Effects of Maternal Exercise and the Growth Restricted Pregnancy
Objectives / Specific Aims The purpose of this study is to investigate the acute effects of a single bout of moderate intensity maternal exercise on fetal well-being in a pregnancy affected by fetal growth restriction.
- Conditions
- Fetal Growth Retardation, Fetal Growth Complications, Placental Insufficiency
- Trial name
- NCT06039319
- Testing
- Physical activity
- Where
- United States
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- University of Tennessee Graduate School of Medicine
Pregnancy in Diabetic, Placenta Diseases
Characterization of Placental Diffusion
DW-MRI Allows a quantitative comparison of diffusion as an expression of tissue hypoxia. The investigators aim is to compare changes in placental diffusion in pregnant women with uncontrolled diabetes compared to healthy pregnant…
- Trial name
- NCT06992245
- Testing
- DW-MRI
- Where
- Israel
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Hillel Yaffe Medical Center
Hemorrhage From Placenta Previa, With Delivery
Role of Prophylactic Tranexamic Acid in Reducing Blood Loss During Elective Caesarean Section for Placenta Praevia Major
Prophylactic tranexamic acid will reduce blood loss during Caesarean section for placenta praevia
- Trial name
- NCT04350645
- Testing
- Tranexamic acid injection, Normal Saline 0.9%
- Where
- Malaysia
- Volunteers
- 30 people
- Sponsor
- Universiti Kebangsaan Malaysia Medical Centre
Placenta Accreta
Single-step Placenta Accreta Resective Technique Tourniqueted vs Absence, Conservative Uterine Surgery
Background: An optimal international standard for PAS surgery is not yet available, and the establishment of a suitable surgical method is an important focus of in PAS management.
- Trial name
- SPARTACUS (NCT06185894)
- Testing
- Uterovesical tourniquet before uterine devascularization steps, Conventional conservative surgery
- Where
- Egypt
- Volunteers
- 40 people
- Sponsor
- Cairo University
Pregnancy; Pre-eclampsia, Mild
Role of Placental Growth Factor (PlGF) in the Management of Non-Severe Preeclampsia
Preeclampsia is an important disease that develops during pregnancy and it is one of the main contributors to maternal and fetal complications. The only known definitive treatment is delivery.
- Trial name
- MAP (NCT02373839)
- Testing
- Measurement of PlGF
- Where
- Spain
- Volunteers
- 300 people
- Sponsor
- Fetal Medicine Research Center, Spain
Preeclampsia, Severe Preeclampsia
Pre-Eclampsia And Growth Restriction: a Longitudinal Study
Preeclampsia may have several causes leading to different characteristics of the pathology. Differentiation between the "type of preeclampsia" would help to treat patients more accurately.
- Conditions
- Preeclampsia, Severe Preeclampsia, Fetal Growth Restriction, Preterm Birth
- Trial name
- PEARL (NCT02379832)
- Where
- Canada
- Volunteers
- 76 people, healthy volunteers welcome
- Sponsor
- CHU de Quebec-Universite Laval