Clinical trials: Placenta
Complications; Cesarean Section
Spinal Aesthesia in Women With Placenta Previa Percreta
Placenta previa percreta is a dangerous complication during surgery. Due to the high risk of hemorrhage, most parturients with placenta previa have to accept cesarean section.
- Trial name
- SAW (NCT02686242)
- Testing
- spinal anesthesia, general anesthesia
- Where
- China
- Volunteers
- 68 people
- Sponsor
- Air Force Military Medical University, China
Electronic Fetal Monitoring, Fetal Hypoxia
Oxygen for Intrauterine Resuscitation of Category II Fetal Heart Tracings
Maternal oxygen administration for concerning fetal heart rate tracing (FHT) patterns is common practice on Labor and Delivery units in the United States.
- Conditions
- Electronic Fetal Monitoring, Fetal Hypoxia, Fetal-Placental Circulation
- Trial name
- O2C2 (NCT02741284)
- Testing
- Room air, 10L Oxygen by nonrebreather mask
- Where
- United States
- Volunteers
- 114 people, healthy volunteers welcome
- Sponsor
- Washington University School of Medicine
Placenta Accreta Spectrum, Placenta Previa
Hematological and Coagulation Markers in Predicting Placenta Accreta Spectrum in Placenta Previa
Placenta accreta spectrum (PAS) is a serious pregnancy complication where the placenta attaches too deeply into the wall of the uterus.
- Trial name
- NCT07826247
- Volunteers
- 130 people
- Sponsor
- Assiut University
Placenta Previa
The Placenta Previa and Fetal Weight
Placenta previa is a placenta that implants at lower uterine segment, it occurs in about 0.3-0.5% of pregnancies at term. It is a significant risk for development of maternal morbidity, as well as maternal mortality secondary to…
- Trial name
- NCT03321435
- Testing
- placenta previa patient, normal women
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Assiut University
Placenta Previa
Nifedipine Versus Magnesium Sulfate for Prevention of Preterm Labor in Symptomatic Placenta Previa
Antepartum hemorrhage is defined as bleeding from or within the female genital tract, occurring from 28+0 weeks of pregnancy and till delivery of the fetus.
- Trial name
- NCT03542552
- Testing
- Magnesium Sulfate, Nifedipine
- Where
- Egypt
- Volunteers
- 176 people
- Sponsor
- Assiut University
Vaginosis, Bacterial, Premature Birth
Maternal Effects of Bacterial Vaginosis (BV) Treatment in Pregnancy
The goal of this study is to examine acceptability and efficacy of 2 kinds of BV treatment among women at low risk for preterm delivery. The objectives are: 1.
- Conditions
- Vaginosis, Bacterial, Premature Birth, Birth Weight, Chorioamnionitis
- Trial name
- NCT00153517
- Testing
- oral versus vaginal metronidazole
- Where
- United States
- Volunteers
- 126 people
- Sponsor
- Centers for Disease Control and Prevention
Gestational Diabetes, DUCTUS VENOSUS VOLUME
Placenta, Fetal Liver, Sectional Ductus Venosus Volumes Examined by Three-dimensional Ultrasound in the Second Trimester
Investigators measured the placenta, fetal liver and ductus venosus volumes of pregnant women with GDM diagnosis and normal glycemic indices in the second trimester.Investigators aimed to correlate measurements with…
- Conditions
- Gestational Diabetes, DUCTUS VENOSUS VOLUME, PLACENTA VOLUME, 3D SONOGRAPHY
- Trial name
- NCT06178250
- Testing
- 3D sonography
- Where
- Turkey (Türkiye)
- Volunteers
- 139 people, healthy volunteers welcome
- Sponsor
- Sanliurfa Mehmet Akif Inan Education and Research Hospital
Preterm Labor
Intramuscular Hydroxyprogesterone Caproate and Placenta Previa
Antepartum hemorrhage is defined as bleeding from or within the female genital tract, occurring from 24+0 weeks of pregnancy and till delivery of the fetus.
- Trial name
- NCT03130504
- Testing
- 17α hydroxy progesterone caproate
- Where
- Egypt
- Volunteers
- 130 people
- Sponsor
- Assiut University
Osteoarthritis, Knee
Efficacy and Safety Trial of PTP-001 (MOTYS) for Symptomatic Knee Osteoarthritis
Evaluation of safety, tolerability and efficacy of a single intra-articular (IA) injection of PTP-001, an allogeneic placental tissue particulate, in individuals with knee osteoarthritis (OA).
- Trial name
- NCT05100225
- Testing
- PTP-001
- Where
- 14 sites in Australia, Canada and 1 more
- Volunteers
- 210 people
- Sponsor
- Bioventus LLC
Preterm Birth, Microbial Colonization
Vaginal, Placental and Neonatal Buccal Mycobiota and Microbiome in Preterm Birth
Microbiota contributes to the immunological, hormonal and metabolic homeostasis of the host. As in all natural orifices in the body, there is also a microbiota and mycobiota specific to the vagina.
- Trial name
- NCT04165252
- Testing
- Collection of vaginal, neonatal buccal and placental samples
- Where
- Turkey (Türkiye)
- Volunteers
- 92 people, healthy volunteers welcome
- Sponsor
- Koç University
Postpartum Hemorrhage, Carbetocin
Timing of Carbetocin Administration in Postpartum Hemorrhage
Postpartum haemorrhage (PPH) is one of the major contributors to maternal mortality and morbidity worldwide. Active management of the third stage of labour has been proven to be effective in the prevention of PPH.
- Trial name
- NCT06776926
- Testing
- Carbetocin
- Where
- Turkey (Türkiye)
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Mehmet Mete Kırlangıç
Miscarriage, Recurrent, Premature Labor
PAR Family Polymorphisms and Placental Invasion Disorders
The present study will be undertaken to establish whether genetic variations of PAR1 could be involved in the occurrence of any of the "placental syndromes" of preterm delivery, preeclampsia, and/or small for gestational age…
- Trial name
- NCT00425867
- Testing
- PAR1 polymoprhisms and placental invasion
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Shaare Zedek Medical Center
Severe Intra-uterine Growth Restriction, Preterm Birth
Impact of Early and Severe Fetal Growth Restriction on Neurodevelopmental Outcomes in Preterm Infants
Very early onset intra uterine growth restriction (IUGR) affects 5-10% of pregnancies and is the second leading cause of perinatal mortality.
- Conditions
- Severe Intra-uterine Growth Restriction, Preterm Birth, Neurodevelopmental Disorders, Placental Insufficiency
- Trial name
- NCT05381272
- Volunteers
- 20 people
- Sponsor
- Central Hospital, Nancy, France
Knee Osteoarthritis
Safety Study of PTP-001 for Treating Knee Osteoarthritis
Evaluation of safety, tolerability, and efficacy of a single intra-articular (IA) injection of PTP-001, an allogeneic placental tissue particulate, in individuals with knee osteoarthritis (OA).
- Trial name
- NCT04632966
- Testing
- Biological: PTP-001
- Where
- 2 sites in United States
- Volunteers
- 20 people
- Sponsor
- Bioventus LLC
Hemorrhagic Cystitis
A Pilot Study Using Placenta Derived Decidual Stromal Cells for Hemorrhagic Cystitis
The purpose of this study is to evaluate the safety and efficacy using placenta derived decidual stromal cell therapy for hemorrhagic cystitis after allogeneic hematopoietic cell transplantation.
- Trial name
- NCT02172963
- Testing
- Decidual Stromal Cell therapy
- Where
- Sweden
- Volunteers
- 12 people
- Sponsor
- Karolinska Institutet
HIV Infections
Antibiotics to Reduce Chorioamnionitis-Related Perinatal HIV Transmission
The purpose of this study is to see if antibiotic drugs given to treat an infection of the uterus during pregnancy can reduce the chances of HIV being passed from an HIV-positive mother to her baby.
- Trial name
- NCT00021671
- Testing
- Erythromycin, Nevirapine, Ampicillin sodium
- Where
- United States
- Volunteers
- 3,720 people, healthy volunteers welcome
- Sponsor
- National Institute of Allergy and Infectious Diseases (NIAID)
Preterm Premature Rupture of Membrane, Placenta Diseases
Biochemical and Histological Changes in Pregnant Women With Preterm Premature Rupture of Membrane
Although preterm premature rupture of membranes (PPROM) is one of the most common causes of preterm birth, it can also lead to serious maternal and neonatal complications.
- Trial name
- NCT06639919
- Where
- Turkey (Türkiye)
- Volunteers
- 36 people, healthy volunteers welcome
- Sponsor
- Manisa Celal Bayar University
Obstetric Labor Complications, Staging of Placental Invasion
Ultrasound Staging in the Placenta Accreta
The investigators evaluated the efficacy of a staging system introduced by the American Institute of ultrasound in medicine 2015 including sonographic parameters associated with morbidly adherent placenta for antenatal prediction…
- Trial name
- NCT04253197
- Testing
- Ultrasound
- Where
- Egypt
- Volunteers
- 75 people
- Sponsor
- Beni-Suef University
Placenta Accreta
Comparison of Bladder Filling vs. Non-Filling in Cesarean Hysterectomy for Placenta Percreta
The placenta accreta spectrum (PAS) which includes accreta, increta, and percreta represents a significant obstetric challenge. PAS complicates as many as 1 per 500 pregnancies and this risk is increased with prior cesarean…
- Trial name
- NCT04210479
- Testing
- Filled-bladder, non filled-bladder
- Volunteers
- 64 people
- Sponsor
- Hatem AbuHashim
Chorioamnionitis Affecting Fetus or Newborn
Chorioamnionitis and Proinflammatory S100A12
Histologic chorioamnionitis (HCA) may lead to the fetal inflammatory response syndrome (FIRS) and increased levels of proinflammatory molecules.
- Trial name
- S100A12 (NCT02996279)
- Volunteers
- 69 people
- Sponsor
- Catholic University of the Sacred Heart