Clinical trials: Placenta
Pregnancy Complications
Study of Drug Concentration of Ondansetron and Cefazolin in Mothers and Neonates
This study proposes to look at the pharmacokinetics of two drugs (Cefazolin and ondansetron) given routinely to pregnant women who are planning to deliver via cesarean section.
- Trial name
- NCT01357369
- Testing
- Phlebotomy
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- Stanford University
Intrauterine Growth Restriction
Correlation of Uterine and Umbilical Arteries Doppler With Placental Pathology in IUGR
When indicated, a conservative management plan of IUGR was undertaken. Doppler studies were performed within the last week before delivery The results of Umbilical artery (UA) Doppler velocimetry were categorized as normal …
- Trial name
- NCT03081754
- Testing
- Doppler velocimetry
- Where
- Egypt
- Volunteers
- 75 people, healthy volunteers welcome
- Sponsor
- Ahmed Maged
Placental Insufficiency, NEC - Necrotizing Enterocolitis
Splanchnic Oxygenation Response to Enteral Feeds in Preterm Infants With Abnormal Antenatal Doppler.
Antenatal absent or reversed end-diastolic flow (AREDF) velocity through the umbilical arteries places preterm infants at significant risk for developing gastrointestinal complications, such as feeding intolerance, necrotizing…
- Conditions
- Placental Insufficiency, NEC - Necrotizing Enterocolitis, Newborn, Premature, Feeding Disorder Neonatal
- Trial name
- AREDF-SO (NCT02971566)
- Where
- Italy
- Volunteers
- 20 people
- Sponsor
- IRCCS Azienda Ospedaliero-Universitaria di Bologna
No Placental Abruption, No Hemorrhage
Proof of Concept Study of a Sucker Hemostatic Intra Uterine in Postpartum Hemorrhage After Abruptio Placenta Assisted
The postpartum hemorrhage (PPH) is the major complication of the delivery. In clinical practice, if after giving birth, the placenta is not expelled naturally, an active management should be triggered.
- Trial name
- HEMOGYN (NCT01589744)
- Testing
- Suction cup Hemostatic Intra-Uterine, device not marked CE (not marketed)
- Where
- France
- Volunteers
- 1 people, healthy volunteers welcome
- Sponsor
- AdministrateurCIC
Pregnancy Related
Collection of Donated Placenta for Isolation of Mitochondria for Research and for Future Use in Mitochondrial Augmentation Therapies
Placenta will be collected and from these, mitochondrial will be harvested. Mitochondria will be used in mitochondrial augmentation therapy.
- Trial name
- NCT03762512
- Where
- Israel
- Volunteers
- 300 people, healthy volunteers welcome
- Sponsor
- Minovia Therapeutics Ltd.
Placenta Previa
ADAMTS,Proteoglycan and Oxidant / Antioxidant Enzyme Levels of Placenta Previa Totalis (Accreta, Increta, Percreta).
Placenta previa totalis (accreta, increta, percreta); ADAMTS and proteoglycans and the oxidant / antioxidant enzyme levels.
- Trial name
- NCT02270593
- Where
- Turkey (Türkiye)
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Zekai Tahir Burak Women's Health Research and Education Hospital
Preeclampsia
The Expression of Aquaporin 3, 8 and 9 in Placenta in Normal and Preeclamptic Pregnancies: Perinatal and Neonatal Outcomes.
The etiologic agent responsible for the development of preeclampsia remains unknown. Aquaporins, members of integral membrane proteins, are responsible of water molecules movements through the plasma membrane channels, energy…
- Trial name
- NCT02045316
- Where
- Turkey (Türkiye)
- Volunteers
- 210 people
- Sponsor
- Rakhshanda Aslanova
Pre-Eclampsia, Placenta Diseases
Trial of Early Screening Test for Pre-eclampsia and Growth Restriction
A study of aspirin use in pregnancy to prevent high blood pressure and growth restriction of the fetus
- Conditions
- Pre-Eclampsia, Placenta Diseases, Eclampsia Preeclampsia, Fetal Growth Retardation
- Trial name
- TEST (NCT03674606)
- Testing
- Low dose aspirin
- Where
- 2 sites in Ireland
- Volunteers
- 546 people, healthy volunteers welcome
- Sponsor
- University College Dublin
Placenta Accreta Spectrum
High vs. Low Segmental Hysterotomy: Impact on Uterine Wall Defects Post-Cesarean
The purpose of this clinical trial is to compare the incidence of defects in the uterine wall at the site of the scar (niche) and surgical complications when using high-segment versus low-segment hysterotomy, with both…
- Trial name
- HISEAL (NCT06620432)
- Testing
- Low segment hysterotomy, High segment hysterotomy, Crossed hysterorrhaphy
- Where
- Colombia
- Volunteers
- 168 people, healthy volunteers welcome
- Sponsor
- Fundacion Clinica Valle del Lili
GVHD
Effect of PMSCs and Their Secretome for the Treatment of GvHD
In this clinical trial study, 60 patients with GvHD referred to Shahid Qazi Hospital in Tabriz, were randomly divided into 2 intervention and control groups (n= 30 in each) that received secretome and distilled water by…
- Trial name
- GvHD (NCT06469411)
- Testing
- Secretome (set of substances released from the cell to its surroundings) of mesenchymal stem cells retrieved from the placenta (containing 400 microgram protein/ milliliter), 4 cc distilled water dissolved in albumin 20%
- Where
- Iran
- Volunteers
- 60 people
- Sponsor
- Tabriz University of Medical Sciences
Vaginal Bleeding, Prolonged Pregnancy
Tranexamic Acid as an Intervention in Abruptio Placenta
Abruptio placenta is one of the common causes of antepartum haemorrhage which is more common in the second half of pregnancy and causes a high maternal and neonatal morbidity and mortality
- Trial name
- NCT05840471
- Testing
- Tranexamic acid injection, Dextrose 5% in water
- Where
- Iraq
- Volunteers
- 116 people
- Sponsor
- Hawler Medical University
Low-Lying; Placenta, Hemorrhage, Complicating Delivery
Mode of Delivery in Women With Low-lying Placenta
Multicentre study; observational, longitudinal prospective, case-control
- Trial name
- MODEL-PLACENTA (NCT04827433)
- Where
- 17 sites in Italy
- Volunteers
- 2,550 people
- Sponsor
- University of Milano Bicocca
Placenta Diseases
Placental Volume Analysis During Pregnanay
Placenta grows with advancing gestational age amonitoring of placental growth is important in pregnancy evaluation
- Trial name
- NCT03731949
- Testing
- Ultrasonography
- Where
- Egypt
- Volunteers
- 500 people, healthy volunteers welcome
- Sponsor
- Aljazeera Hospital
Preterm Premature Rupture of Membrane, Pregnancy, High Risk
Improvement of PPROM Management With Prophylactic Antimicrobial Therapy (iPROMPT)
To conduct an unblinded pragmatic randomized controlled trial (pRCT) "Improvement of PPROM Management with Prophylactic Antimicrobial Therapy (iPROMPT)" of a seven-day course of ceftriaxone, clarithromycin, and metronidazole…
- Conditions
- Preterm Premature Rupture of Membrane, Pregnancy, High Risk, Preterm Birth
- Trial name
- NCT06396078
- Testing
- Ceftriaxone 1000 MG, Clarithromycin 500mg, Metronidazole 500 mg
- Where
- 2 sites in United States
- Volunteers
- 56 people
- Sponsor
- Ohio State University
Post Partum Hemorrhage
Surgical Technique To Control Postpartum Hemorrhage
Placenta accreta is an obstetrical complication where the placenta becomes firmly adherent to the uterine wall. Placenta accreta can lead to considerable maternal morbidity and mortality due to hemorrhage, infection, or other…
- Trial name
- NCT03241849
- Testing
- Modified surgical technique for placenta accreta
- Where
- Egypt
- Volunteers
- 110 people
- Sponsor
- Assiut University
MVM-FGR
A Cohort of Maternal Vascular Malperfusion-related FGR (CoMVMFGR)
Based on a precise diagnostic standard process, through a multicenter study, we will establish a cohort focusing on placenta-mediated fetal growth restriction (FGR).
- Trial name
- NCT06104748
- Where
- China
- Volunteers
- 500 people
- Sponsor
- Shanghai First Maternity and Infant Hospital
Pressure Injury
Prospective Case Series Evaluating the Efficacy and Safety of NeoThelium FT for Chronic Pressure Ulcers
This is a prospective case series evaluating the efficacy and safety of NeoThelium FT Amnion Skin Graft in the Mangement of Chronic Pressure Ulcers
- Trial name
- NCT07158658
- Testing
- NeoThelium FT (HCT/P 361)
- Where
- 2 sites in United States
- Volunteers
- 10 people
- Sponsor
- NuScience Medical Biologics, LLC
Pregnancy Disease, Preeclampsia
Dietary Salicylates and Preeclampsia
Preeclampsia (PE) is an important pregnancy complication and cause of maternal and perinatal mortality and morbidity. The underlying etiology and pathophysiology of preeclampsia is incompletely understood but it involves…
- Conditions
- Pregnancy Disease, Preeclampsia, Diet Habit
- Trial name
- PreSal (NCT06239363)
- Where
- Poland
- Volunteers
- 500 people, healthy volunteers welcome
- Sponsor
- Poznan University of Life Sciences
Postpartum Hemorrhage
TRAnexamic Acid for Preventing Blood Loss Following a Cesarean Delivery in Women With Placenta pREVIA
Several randomized, controlled trials, mostly involving women undergoing cesarean delivery, have shown that the prophylactic intravenous administration of 1 g of tranexamic acid after childbirth reduced blood loss.
- Trial name
- TRAAPrevia (NCT04304625)
- Testing
- Tranexamic Acid / Sodium chloride
- Where
- France
- Volunteers
- 1,380 people
- Sponsor
- University Hospital, Bordeaux
Preterm Birth, Twin Dichorionic Diamniotic Placenta
Vaginal Progesterone in Twin With Short Cervix
Aim of the work The aim of this study is to assess the efficacy of the use of vaginal progesterone as a method of prevention of preterm labour in twin gestations with short cervix .
- Trial name
- NCT02697331
- Testing
- Progesterone
- Where
- Egypt
- Volunteers
- 144 people, healthy volunteers welcome
- Sponsor
- Ain Shams University