Clinical trials: Placenta
COVID-19, SARS-CoV-2 Infection
COVID-19 on Placental Gene Expression and Pathology
Little is known regarding the effect of antenatal COVID-19 on pregnancy outcomes. The purpose of this study is to determine of COVID-19 alters histopathology and gene expression of the placenta, as evidenced by analysis at time…
- Trial name
- PROSPER (NCT04585945)
- Testing
- Positive for SARS-CoV-2 infection
- Where
- United States
- Volunteers
- 68 people
- Sponsor
- Prisma Health-Upstate
Pregnancy
Transplacental Transfer of Drugs Used in Pregnant Women
The most important guideline for drug prescription concerning pregnant women is 'drugs should be given only if the maternal benefits outweigh the potential risk to the fetus'.
- Trial name
- NCT02622802
- Testing
- paracetamol, Erythromycin, Azithromycin
- Where
- Belgium
- Volunteers
- 250 people
- Sponsor
- University Hospital, Gasthuisberg
Placenta Previa
Intra-myometrial Vasopressin During Cesarean Section in Placenta Previa
Placenta previa can have serious adverse consequences for the mother, including an increased risk of maternal mobility, antenatal and intrapartum hemorrhage, and the mother may, therefore, require a blood transfusion or even an…
- Trial name
- NCT03725553
- Testing
- Intramyometrial Vasopressin
- Where
- Egypt
- Volunteers
- 120 people
- Sponsor
- Aswan University Hospital
Mother Fetus Relations
Placental Passage of Free and Esterified Phytosterols in Humans
Total plasma cholesterol rises by 60 % with progressing pregnancy in humans. Because lipid-lowering drugs are contraindicated during pregnancy, natural compounds, such as phytosterols, may be a safe and effective alternative to…
- Trial name
- PTS (NCT03705767)
- Volunteers
- 68 people, healthy volunteers welcome
- Sponsor
- Università Politecnica delle Marche
Placenta Previa
Causal Relationship Between Plasma VEGF Family Proteins and Placenta Previa: A Two-Sample Mendelian Randomization Study
This study aims to investigate the causal relationship between plasma vascular endothelial growth factor (VEGF) family proteins and placenta previa using a two-sample Mendelian randomization (MR) approach.
- Trial name
- VEGF PP (NCT06620068)
- Volunteers
- 207,473 people
- Sponsor
- Guangzhou Institute of Respiratory Disease
Placenta Accreta
Placenta Accreta Spectrum Protocol
Aim of this project is to study diagnosis and management approaches of PAS and to assess safety and efficacy of different conservative approaches compared to planned hysterectomy.
- Trial name
- NCT04384510
- Testing
- Planned Cesarean hysterectomy, Conservative management
- Where
- Egypt
- Volunteers
- 1,500 people
- Sponsor
- Assiut University
Placenta Accreta
Placenta Accreta Spectrum Disorders: A. Chohan Continuous Squeezing Suture (ACCSS)
Placenta Accreta Spectrum (PAS) disorders are rising in incidence due to increased rate of repeat caesarean sections. Peripartum hysterectomy remains the only definitive treatment of massive postpartum haemorrhage related to this…
- Trial name
- ACCSS (NCT05070689)
- Testing
- ACCSS
- Where
- Pakistan
- Volunteers
- 20 people
- Sponsor
- Sharif Medical Research Center
Placenta Accreta
Conservative Surgery for Abnormally Invasive Placenta: A New Technique
Placental borders and mapping by ultrasonography and Doppler ultrasonography (placental mapping) preop. And verified intraoperatively .
- Trial name
- NCT04193618
- Testing
- Conservative surgery for placenta accretta
- Where
- Egypt
- Volunteers
- 100 people
- Sponsor
- Cairo University
Diabetic Foot Ulcer (DFU), Lower Extremity
Matrion Decellularized Placental Membrane Versus Conventional Wound Management in Subjects With Diabetic Foot Ulcers
This study will evaluate Matrion™ (LifeNet Health, Inc., Virginia Beach, VA), a placental membrane product, as a treatment for diabetic foot ulcers compared to conventional wound care.
- Trial name
- NCT07116876
- Testing
- Graft Application, Wound Dressing Material
- Where
- 17 sites in United States
- Volunteers
- 120 people
- Sponsor
- LifeNet Health
Graft vs Host Disease
A Phase 2 Study Using Placenta Derived Decidual Stromal Cells for Graft Versus Host Disease
The purpose of this study is to evaluate the safety and efficacy using decidual stromal cell therapy for graft versus host disease after allogeneic hematopoietic stem cell transplantation.
- Trial name
- NCT02172924
- Testing
- Early Decidual stromal cell therapy, Late Decidual stromal cell therapy
- Where
- Sweden
- Volunteers
- 30 people
- Sponsor
- Karolinska Institutet
Monochorionic Twins
Unequal Placental Sharing in Monochorionic Diamniotic Twins: an Observational Study
This is an observational study in 3 cohorts of monochorionic diamniotic (MCDA) twins. The aim of the study is to assess whether unequal placental sharing can be predicted in pregnancy and whether it is predictive of pregnancy…
- Trial name
- TWINSHARE (NCT03024918)
- Where
- Belgium
- Volunteers
- 393 people
- Sponsor
- Universitaire Ziekenhuizen KU Leuven
Placenta Retained, Uterine Diseases
Effectiveness of Hyaluronic Acid Gel in the Prevention of Intrauterine Adhesions After Second Trimester Abortion
This prospective, randomized, controlled study evaluates the efficacy of self-crosslinked hyaluronic acid gel to prevent the development of de-novo intrauterine adhesions following curettage for retained product after second…
- Trial name
- NCT02868437
- Testing
- intrauterine self-cross-linked hyaluronic acid gel
- Volunteers
- 60 people
- Sponsor
- Istanbul University
Temporomandibular Disorder
Efficacy and Safety of JHG002 for Chronic Temporomandibular Joint Dysfunction: A Multicenter Randomized Controlled Trial
This study is a 2-arm parallel, assessor blinded, multi-centre, randomised controlled trial.
- Trial name
- NCT04087005
- Testing
- hominis placental pharmacopuncture
- Where
- 2 sites in South Korea
- Volunteers
- 82 people
- Sponsor
- Jaseng Medical Foundation
Peripheral Artery Disease, Peripheral Vascular Disease
Safety of Intramuscular Injections (IM) of Allogeneic PLX-PAD Cells for the Treatment of Critical Limb Ischemia (CLI)
The purpose of this study is to determine the safety of PLX-PAD, Intra-muscular injections for the treatment of CLI patients.
- Conditions
- Peripheral Artery Disease, Peripheral Vascular Disease, Critical Limb Ischemia
- Trial name
- NCT00951210
- Testing
- PLX-PAD
- Where
- 2 sites in United States
- Volunteers
- 12 people
- Sponsor
- Pluristem Ltd.
Abruptio Placentae; Affecting Fetus or Newborn
Normotensive and Hypertensive Placental Abruptions
Placental abruption is a significant cause of both maternal morbidity and neonatal morbidity and mortality. Most abruptions accept to be related to a chronic placental disease process.
- Trial name
- NCT04449601
- Testing
- clinical assesment
- Volunteers
- 115 people, healthy volunteers welcome
- Sponsor
- Hatice Akkaya
Placenta Accreta
PDIUC Protocol for Placental Accreta
The aim of this study is to evaluate a novel protocol to conserve the uterus during Cesarean delivery indicated for placenta accreta.
- Trial name
- PDIUC (NCT03273569)
- Testing
- PDI-UC protocol
- Volunteers
- 30 people
- Sponsor
- Assiut University
Placenta Accreta
Risk Factors for Occurrence of Placenta Accrete Spectrum Following Primary Cesarean Delivery
This study will be conducted on a group of patients undergoing repeat elective caesarean delivery attending at Mansoura university hospital.
- Trial name
- NCT04264169
- Where
- Egypt
- Volunteers
- 200 people
- Sponsor
- Mansoura University Hospital
Placenta Accreta, Blood Pressure
CNAP vs IABP in Pregnant Women With Placenta Accreta
The objective of this study is to investigate a technique to monitor blood pressure in women undergoing cesarean delivery with suspected placenta accreta spectrum.
- Conditions
- Placenta Accreta, Blood Pressure, Hemorrhage, Hemorrhage, Postpartum
- Trial name
- NCT04671680
- Testing
- LiDCO CNAP Monitoring Equipment
- Where
- United States
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Beth Israel Deaconess Medical Center
Covid19, Pregnancy Complications
Spanish Registry of Pregnant Women With COVID-19
Study title Spanish Registry of Pregnant Women with COVID-19 Protocol number and version Number 55/20. Version V8. Sponsors This registry is a project promoted by Dr.
- Conditions
- Covid19, Pregnancy Complications, Premature Rupture of Membrane, Abruptio Placentae
- Trial name
- OBS COVID (NCT04558996)
- Where
- Spain
- Volunteers
- 3,000 people, healthy volunteers welcome
- Sponsor
- Puerta de Hierro University Hospital
Placenta Accreta Spectrum
Spinal Versus General Anesthesia in Pregnancies With Placenta Accreta Spectrum: A Retrospective Comparative Study
Placenta accreta spectrum (PAS) is a serious pregnancy complication in which the placenta grows abnormally into the uterine wall.
- Trial name
- SAGA-PAS (NCT07406841)
- Testing
- spinal anesthesia, General Anesthesia
- Volunteers
- 50 people
- Sponsor
- Gaziantep City Hospital