Clinical trials: Placenta
Estimating Rates of Expulsion
Postplacental Mirena IUD Insertion and Estimating Expulsion Rates.
This study aims to demonstrate that the expulsion rate is increased but acceptable when inserting Mirena IUDs immediately postpartum, termed 'postplacental IUD insertion'.
- Trial name
- NCT01230242
- Testing
- Levonorgestrel Intrauterine Device
- Volunteers
- 4 people, healthy volunteers welcome
- Sponsor
- Rebecca Hunt
Pathophysiology of Placenta Accreta
Impact of Netrin-1 in the Pathophysiology of Placenta Accreta Spectrum
The main goal of this study is to assess the role of Netrin 1, neogenin and ZEB1 in PAS-associated invasion
- Trial name
- NCT04628169
- Testing
- no intervention applied
- Where
- Egypt
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Assiut University
Malaria
Collection of Biological Material From Pregnant Women in a Malarial Region
Background: Malaria is a disease caused by a parasite that infects the blood. It affects millions of people every year and frequently harms or kills pregnant woman and infants.
- Trial name
- NCT01862783
- Where
- Uganda
- Volunteers
- 1,270 people, healthy volunteers welcome
- Sponsor
- National Institute of Allergy and Infectious Diseases (NIAID)
Labor Pain
The Effect of Oxycodone to the Placental Circulation at Early Labour
Oxycodone is used to treat pain in early labor, however the effect of oxycodone to placental or fetal circulation has not been evaluated. Oxycodone is increasingly used to treat labor pain in the early phase.
- Trial name
- oksisynnII (NCT02573831)
- Testing
- Oxycodone
- Where
- Finland
- Volunteers
- 22 people
- Sponsor
- Kuopio University Hospital
Folate, Folate Bioavailability
PREconception Folic Acid Clinical Efficacy (PREFACE) Trial
A study to help understand what forms of folic acid are most effective to increase folate status during pregnancy for the best protection against neural tube defects
- Conditions
- Folate, Folate Bioavailability, Clinical Trials, Pregnancy
- Trial name
- PREFACE (NCT06641245)
- Testing
- Folic Acid, 5-MTHF (5-methyltetrahydrofolate)
- Volunteers
- 272 people
- Sponsor
- University of British Columbia
Monochorionic Diamniotic Placenta, Monochorial Monoamniotic Placenta
MoDi Twin Placental Imaging
Twin-twin transfusion syndrome (TTTS) can arise in monochorionic, diamniotic (MoDi), those identical twins arising from division of a single fertilized ovum at 4-8 days gestational age (GA) or monochorionic, monoamniotic (MoMo or…
- Conditions
- Monochorionic Diamniotic Placenta, Monochorial Monoamniotic Placenta, Monochorionic Twins, Ultrasound Doppler
- Trial name
- NCT07667647
- Testing
- Verasonics Vantage 256 Ultrasound
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- Carilion Clinic
Apgar; 0-3 at 1 Minute, Metabolic Acidosis
Autologous Stem Cells in Newborns With Oxygen Deprivation
The purpose of this study is to determine whether the plasticity of autologous intravenous application of cord blood stem cells would improve the clinical course of asphyxiated newborns.
- Conditions
- Apgar; 0-3 at 1 Minute, Metabolic Acidosis, Hypoxia, Brain, Multiple Organ Failure
- Trial name
- NCT01506258
- Testing
- Application of Stem Cells, Observation
- Where
- Mexico
- Volunteers
- 20 people
- Sponsor
- Hospital Universitario Dr. Jose E. Gonzalez
Obesity
miRNA in Fetal Overgrowth
The purpose of this study is to determine whether placental and umbilical cord blood miRNA expression is altered in women with obesity with macrosomic neonates to when compared to miRNA expression from control patients.
- Trial name
- MIFO (NCT01935076)
- Testing
- Neonatal exposure to maternal obesity
- Where
- United States
- Volunteers
- 82 people
- Sponsor
- University of Pennsylvania
Malaria, Antepartum, Maternal Malaria During Pregnancy - Baby Not Yet Delivered
Community-based Screening and Treatment of Malaria in Pregnancy: a Cluster-randomized Trial
Malaria is a common disease in Africa and a major health problem. Pregnant women are also at risk of malaria. Malaria in pregnancy is life threatening to both the mother and the baby she is carrying.
- Conditions
- Malaria, Antepartum, Maternal Malaria During Pregnancy - Baby Not Yet Delivered, Small for Gestational Age (Disorder)
- Trial name
- COSMIC (NCT01941264)
- Testing
- community based screening and treatment
- Where
- 3 sites in Benin, Burkina Faso and 1 more
- Volunteers
- 4,265 people, healthy volunteers welcome
- Sponsor
- Royal Tropical Institute
Placenta Accreta
Evaluation of Planned Conservative Surgical Management of Placenta Accreta Spectrum in Women's Health Center, Assiut University Hospital
In recent years, with the application of an abdominal artery balloon and the improvement of surgical techniques, efforts are made to preserve the uterus for patients PAS.
- Trial name
- NCT06712576
- Volunteers
- 150 people
- Sponsor
- Assiut University
Suspected Placental Dysfunction, Ruled Out, Pregnancy Complications
Interest of sFlt1/PlGF Ratio at Obstetric Emergencies
In patients with suspected placental vascular disease who do not require hospitalization, the use of the sFlt-1 (Soluble FMS like tyrosin-kinase-1)/PlGF (Placental Growth Factor)/ assay can most likely help teams to define the…
- Conditions
- Suspected Placental Dysfunction, Ruled Out, Pregnancy Complications, Pre-Eclampsia
- Trial name
- AngioCHIC (NCT04170660)
- Testing
- Diagnostic test
- Where
- France
- Volunteers
- 150 people
- Sponsor
- Centre Hospitalier Intercommunal Creteil
Preeclampsia, Premature Birth
Cohort Study on the Levels of Placental Growth Factor and Nucleosomes in Early Pregnancy and Adverse Pregnancy Outcomes
Objective: This study aims to investigate the association between maternal serum placental growth factor (PLGF) and nucleosome levels in early pregnancy and adverse pregnancy outcomes, and to evaluate their predictive value for…
- Conditions
- Preeclampsia, Premature Birth, Fetal Growth Restriction, Recurrent Miscarriage
- Trial name
- NCT07841197
- Testing
- Measurement of plasma nucleosome and placental growth factor (PLGF) levels
- Volunteers
- 900 people, healthy volunteers welcome
- Sponsor
- Second Affiliated Hospital of Wenzhou Medical University
Chronic Liver Disease
Part A: In Patients With Chronic Liver Diseases, LAENNEC (Human Placenta Hydrolysate) is to Assess Safety and Tolerability After the Doses of Doses. Part B: Part A, it is to Determine the Optimal Dose by Evaluating Two Capacity and Placebo Groups.
Part A: In Patients With Chronic Liver Diseases, LAENNEC (Human Placenta Hydrolysate) is to Assess Safety and Tolerability After the Doses of Doses.
- Trial name
- NCT05532124
- Testing
- LAENNEC (Human Placenta Hydrolysate), normal saline
- Where
- 7 sites in South Korea
- Volunteers
- 49 people
- Sponsor
- Green Cross Wellbeing
Placenta Accreta
Comparison Between Hysterectomy and Conservative Management in Treatment of Placenta Accreta Regarding Maternal Complication
AIM OF THE WORK The aim of the study is to compare the maternal morbidity and mortality between obstetric hysterectomy and conservative surgery for pregnant ladies > 28 weeks with placenta accreta during caesarean section at Ain…
- Trial name
- NCT03327818
- Testing
- hysterectomy, uterine conservative study
- Volunteers
- 491 people
- Sponsor
- Ain Shams Maternity Hospital
Chronic Fatigue Syndrome, Idiopathic Chronic Fatigue
Investigator Initiated Clinical Study to Explore the Efficacy and Safety of Human Placenta Hydrolysate in the Chronic Fatigue Patients
GCJBP Laennec Injection contains a variety of cytokines derived from human placenta, amino acids, peptides, nucleobases, and carbohydrates. This product is approved for improving liver function.
- Trial name
- NCT01742013
- Testing
- GCJBP Laennec Inj.
- Where
- 2 sites in South Korea
- Volunteers
- 78 people
- Sponsor
- Ho Cheol Shin, M.D., Ph.D.
Endometritis Postpartum, Endometritis
Antibiotic Prophylaxis in Ragged Placental Membranes
In some centres, women are routinely given a course of antibiotics postnatally if ragged placental membranes were present at delivery. The investigators examined the necessity such an intervention.
- Conditions
- Endometritis Postpartum, Endometritis, Membranes; Retained
- Trial name
- NCT03459599
- Testing
- Prophylactic antibiotics, No prophylaxis (Amox-clav withheld)
- Volunteers
- 716 people, healthy volunteers welcome
- Sponsor
- Sarawak General Hospital
Postpartum Hemorrhage, Maternal Morbidity
Secondary Postpartum Hemorrhage
Postpartum hemorrhage (PPH) remains one of the leading causes of maternal mortality and morbidity worldwide, including in France, where it accounts for approximately 20% of maternal mortality.
- Conditions
- Postpartum Hemorrhage, Maternal Morbidity, Retained Placenta, Postpartum Endometritis
- Trial name
- SPPH (NCT03840889)
- Testing
- Data collection
- Where
- 10 sites in France
- Volunteers
- 80 people
- Sponsor
- University Hospital, Clermont-Ferrand
Placental Expulsion Time
Influence of Acupuncture in the Placental Expulsion Time
In this study, a single blind randomized trial is carried out in order to compare placental detachment times when Ren Mai 6 is stimulated and when a different placebo point is used.
- Trial name
- NCT02000752
- Testing
- Acupuncture
- Where
- Spain
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- Fundacion para la Investigacion Biomedica del Hospital Universitario Principe de Asturias
Healthy Mothers Who Have Had Both Vaginal and Cesarean Deliveries
Comparison of Oxytocin Receptor Immunoreactivity in Placentas Obtained From Women Having Cesarean and Natural Birth
Our study examines the effects of oxytocin hormone receptors. mechanisms of placental tissue cells and therefore intrauterine development.
- Trial name
- NCT06275438
- Testing
- The delivery being performed via cesarean section surgery rather than natural childbirth
- Where
- Turkey (Türkiye)
- Volunteers
- 32 people, healthy volunteers welcome
- Sponsor
- Kafkas University
Cerebral Palsy, Intraventricular Hemorrhage
Beneficial Effects of Antenatal Magnesium Sulfate (BEAM Trial)
As many more premature infants survive, the numbers of these infants with health problems increases. The rate of cerebral palsy (CP) in extremely premature infants is approximately 20%.
- Conditions
- Cerebral Palsy, Intraventricular Hemorrhage, Periventricular Leukomalacia, Pulmonary Edema
- Trial name
- BEAM (NCT00014989)
- Testing
- magnesium sulfate
- Where
- 17 sites in United States
- Volunteers
- 2,136 people
- Sponsor
- The George Washington University Biostatistics Center