Clinical trials: Placenta
Malaria
Efficacy of Combination Therapy for Prevention of Effects of Malaria During Pregnancy
This study is an investigation to compare the efficacy of two different intermittent sulfadoxine/pyrimethamine (SP) treatment regimens and intermittent sulfadoxine/pyrimethamine (SP) + artesunate (SP/AS) treatment of HIV negative…
- Trial name
- NCT00164255
- Testing
- sulfadoxine/pyrimethamine, sulfadoxine/pyrimethamine plus artesunate
- Where
- 2 sites in Tanzania
- Volunteers
- 1,614 people, healthy volunteers welcome
- Sponsor
- Centers for Disease Control and Prevention
Morbidly Adherent Placenta
Comparison Between Bladder Dissection Before and After Uterine Incision in Cesarean Section for Morbidly Adherent Placenta
Comparison between bladder dissection at the beginning of cesarean section For morbidly adherent placenta and between delaying dissection until planning for cesarean hysterectomy
- Trial name
- NCT03676855
- Testing
- bladder dissection
- Where
- Egypt
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Ain Shams University
Fetal Growth Retardation
Comparison of Pesticide and Pharmaceutical Contaminants Levels in Placenta and Cord Blood Samples of Pregnant Women With Fetal Growth Retardation and Healthy Pregnant Women
Aim: In this study, pesticide and pharmaceutical contaminants levels in the placenta and cord blood of pregnant women with fetal growth retardation and healthy pregnant women will be compared in placenta and cord blood samples…
- Trial name
- NCT05088148
- Testing
- . Pesticide and Pharmaceutical analysis
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Kutahya Health Sciences University
Cardiovascular Diseases, Heart Diseases
Regulation of Placental Vascular Reactivity in Pregnancy-induced Hypertension
To elucidate the role of an imbalance in vasodilator prostacyclin (PGI2) and vasoconstrictor thromboxane (TxA2) in pregnancy-induced hypertension
- Conditions
- Cardiovascular Diseases, Heart Diseases, Hypertension, Pregnancy Toxemias
- Trial name
- NCT00005208
- Sponsor
- National Heart, Lung, and Blood Institute (NHLBI)
Chorioamnionitis
Comparison of Once Daily Versus 8 Hour Dosing of Gentamicin for the Treatment of Intrapartum Chorioamnionitis
To compare once daily versus 8 hour dosing of gentamicin for the treatment of chorioamnionitis.
- Trial name
- NCT00185991
- Testing
- gentamicin
- Where
- United States
- Volunteers
- 126 people
- Sponsor
- Stanford University
Pre-Eclampsia, HELLP Syndrome
Evaluation of the Serum Markers sFLt1 and PlGF for the Prediction of the Complications of the Placental Vascular Pathologies in the 3rd Quarter of the Pregnancy.
The pre-eclampsia is a frequent pathology, concerning approximately 5 % of the pregnancies.The pre-eclampsia can evolve into severe maternal and\or foetal complications and is a major cause of mortality.
- Conditions
- Pre-Eclampsia, HELLP Syndrome, Fetal Death, Eclampsia
- Trial name
- PRECOPE (NCT03455387)
- Testing
- sampling of the serum marker sFlt1 and PlGF
- Where
- 7 sites in France
- Volunteers
- 233 people
- Sponsor
- Centre Hospitalier Metropole Savoie
Placenta Accreta, Unspecified Trimester
Association of Ultrasonographic Parameters With FIGO Clinical Grading System for Placenta Accreta Spectrum
To evaluate the association of ultrasonographic parameters suggestive of placenta accreta with intraoperative clinical diagnosis of placenta accreta according to the the clinical grading system for placenta accreta spectrum (PAS)…
- Trial name
- NCT04801706
- Testing
- Ultrasound
- Volunteers
- 158 people, healthy volunteers welcome
- Sponsor
- Assiut University
Histological Placental Inflamation With or Without Fever
Intrapartum Fever and Histopathological Placental Findings
Intrapartum fever associated with epidural anesthesia is caused by non infectious causes therefore without histological findings
- Trial name
- NCT01175187
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Wolfson Medical Center
Myelodysplastic Syndromes
A Study to Evaluate the MNV-201 in Patients With Low Risk MDS
Myelodysplastic syndromes (MDS) are a group of bone marrow failures that occur when the blood-forming cells in the bone marrow become abnormal leading to an abnormal differentiation and production of one or more blood cell types.
- Trial name
- NCT06465160
- Testing
- MNV-201 (Autologous CD34+ Cells Enriched with allogenic Placenta Derived Mitochondria)
- Where
- Israel
- Volunteers
- 15 people
- Sponsor
- Minovia Therapeutics Ltd.
Chronic Histiocytosis
Search Elevated Serum Alkaline Phosphatase as a Marker of Prenatal Intervillositis Chronic Histiocytic
Background : Chronic histiocytic intervillositis is a rare placental disease linked with poor perinatal outcome. In a recent study, a major antenatal increased alkaline phosphatase was suspected in patients affected by chronic…
- Trial name
- IHC (NCT02668120)
- Where
- France
- Volunteers
- 54 people, healthy volunteers welcome
- Sponsor
- University Hospital, Lille
Obstetric Delivery
Placental Cord Drainage Versus no Placental Drainage in the Management of Third Stage of Labour
The aim of this work is to compare the effectiveness of placental cord drainage with no drainage in reducing the duration and blood loss in 3rd stage of labour.
- Trial name
- PLCD (NCT03137810)
- Testing
- placental cord drainage, non placemtal cord drainage
- Where
- Egypt
- Volunteers
- 180 people
- Sponsor
- Ain Shams University
Polycystic Ovary Syndrome (PCOS), Polycystic Ovary Syndrome
Safety of Cultured Allogeneic Adult Umbilical Cord or Placental Derived Mesenchymal Stem Cells for PCOS
This trial will study the safety and efficacy of cultured allogeneic adult umbilical cord or placental derived mesenchymal stem cells delivered intravenously for the treatment of Polycystic Ovary Syndrome.
- Conditions
- Polycystic Ovary Syndrome (PCOS), Polycystic Ovary Syndrome, PCOS
- Trial name
- NCT06143527
- Testing
- Cultured allogeneic adult umbilical cord or placental derived mesenchymal stem cells
- Where
- 2 sites in United States, Greece
- Volunteers
- 20 people
- Sponsor
- The Foundation for Orthopaedics and Regenerative Medicine
Endometritis
Prophylactic Antibiotics for Manual Removal of Retained Placenta in Vaginal Birth: a Randomized Controlled Trial
Background: There is scarce evidence regarding the necessity of antibiotic prophylaxis in manual revision of the uterus after labor in cases of residual placenta.
- Trial name
- NCT01945450
- Testing
- Antibiotic prophylaxis, Ampicillin, Gentamycin
- Where
- Israel
- Volunteers
- 300 people
- Sponsor
- Hadassah Medical Organization
Thyroid Metabolism
The Reduced Thyroid Function of the Premature Newborn: Relation With Molecular Changes in the Placenta and Maternal Thyroid Hormone Status and Neurodevelopmental Implications
Transient hypothyroxinemia of prematurity (THOP) is a typical entity of the preterm infant, affecting the majority of preterm infants, born less than 30 weeks of gestational age.
- Trial name
- NCT01466023
- Where
- Belgium
- Volunteers
- 319 people, healthy volunteers welcome
- Sponsor
- Universitaire Ziekenhuizen KU Leuven
Hemorrhagic Cystitis, Stem Cell Transplantation
A Double Blind Randomized Study Using Placenta Derived Decidual Stromal Cells for Hemorrhagic Cystitis
A prospective double blind randomized study comparing placenta derived decidual stromal cells with placebo for hemorrhagic cystitis after allogeneic hematopoietic cell transplantation.
- Conditions
- Hemorrhagic Cystitis, Stem Cell Transplantation, Decidual Stromal Cells
- Trial name
- NCT02174536
- Testing
- Decidual stromal cells
- Where
- Sweden
- Volunteers
- 20 people
- Sponsor
- Karolinska Institutet
Labor Complication
Intrapartum Ultrasound in Labor: Sonography Only, Few Internal Examinations
This is a prospective, randomized trial to determine whether the use of sonographic parameters during labor results in less intrapartum infection compared to traditional invasive examination.
- Trial name
- SOFIE (NCT06261710)
- Testing
- Sonography in labour
- Where
- Germany
- Volunteers
- 356 people, healthy volunteers welcome
- Sponsor
- Larry Hinkson
Placenta Accreta
Conservative Surgery for Placenta Accreta
A stepwise surgical approach for conservative management of placenta previa accreta.
- Trial name
- NCT04981483
- Testing
- conservative surgery for uterus in placenta accreta
- Where
- Egypt
- Volunteers
- 62 people, healthy volunteers welcome
- Sponsor
- Ain Shams University
Meconium-stained Amniotic Fluid, Chorioamnionitis
Comparing Infectious Morbidity Among Women With Meconium-stained Amniotic Fluid at Term, Between Those Treated With Prophylactic Antibiotics Zinacef vs. Placebo
Our randomized controlled double blind clinical trail aims to compare maternal and neonatal infectious morbidity between women with meconium-stained amniotic fluid treated with zinacef vs. placebo.
- Trial name
- NCT06849037
- Testing
- zinacef tretment
- Where
- Israel
- Volunteers
- 182 people, healthy volunteers welcome
- Sponsor
- Western Galilee Hospital-Nahariya
Diabete Mellitus, Foot Ulcer Chronic
Efficacy of Placental Membrane Dressings in Accelerating Diabetic Foot Healing
Evaluation of Efficacy of Placental Membrane Dressings in Accelerating Diabetic Foot Healing
- Trial name
- NCT07326553
- Testing
- Placental Membrane
- Where
- 2 sites in United States
- Volunteers
- 30 people
- Sponsor
- BioXTek
Pregnancy
LUMIERE on the PLACENTA
The frequency of IUGR is between 3 and 10% of births. The etiologies and mechanisms of IUGR are multiple. The placental insufficiency, that is the defect of perfusion, is, however, the principal mechanism, far in front of other…
- Trial name
- NCT04166448
- Testing
- Fetal MRI
- Where
- France
- Sponsor
- Assistance Publique - Hôpitaux de Paris