Clinical trials: Placenta
COVID-19, Placenta Diseases
Angiogenic Factors in the Placentas of Women With COVID-19
Aim: There have been few studies since the beginning of the pandemic researching the histopathologies and conducting molecular investigations of the placentas of SARS-CoV-2 positive pregnant women.
- Conditions
- COVID-19, Placenta Diseases, Angiogenesis
- Trial name
- NCT06644521
- Where
- Turkey (Türkiye)
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Manisa Celal Bayar University
Placenta Praevia, Vaginismus
Transperineal Ultrasound to Assess the Progress of Labour
This is a prospective observational study of transperineal ultrasound between 24-42 weeks gestation and a prospective longitudinal observational study in all term (37-42 weeks) labouring women.
- Trial name
- NCT02430038
- Where
- United Kingdom
- Volunteers
- 584 people, healthy volunteers welcome
- Sponsor
- Imperial College London
Placenta Previa
Causal Relationship Between Plasma VEGF Family Proteins and Placenta Previa: A Two-Sample Mendelian Randomization Study
This study aims to investigate the causal relationship between plasma vascular endothelial growth factor (VEGF) family proteins and placenta previa using a two-sample Mendelian randomization (MR) approach.
- Trial name
- VEGF PP (NCT06620068)
- Volunteers
- 207,473 people
- Sponsor
- Guangzhou Institute of Respiratory Disease
Fetal Conditions, Maternal; Procedure
A Prospective Study on the Role of Karl Storz Curved and Straight Fetoscopes (11508AAK and 11506AAK) for Fetoscopic Intrauterine Procedures
In this research study, the investigators want to learn more about the role of new innovative surgical devices, the Karl Storz Curved and Straight Fetoscopes for in-utero surgery.
- Conditions
- Fetal Conditions, Maternal; Procedure, Pregnancy Related, Twin to Twin Transfusion Syndrome
- Trial name
- NCT06056635
- Testing
- Karl Storz Curved Scope, Karl Storz Straight Scope
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- Boston Children's Hospital
Pathophysiology of Placenta Accreta
Impact of Netrin-1 in the Pathophysiology of Placenta Accreta Spectrum
The main goal of this study is to assess the role of Netrin 1, neogenin and ZEB1 in PAS-associated invasion
- Trial name
- NCT04628169
- Testing
- no intervention applied
- Where
- Egypt
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Assiut University
Placenta Accreta, Post Partum Hemorrhage
Conservative Management of Placenta Accreta Spectrum
The resective-constructive surgery, detailed in prior research by Palacios-Jaraquemada JM, involves excising the placenta and its attachment on the myometrium, with modifications including the systematic use of a double JJ probe…
- Conditions
- Placenta Accreta, Post Partum Hemorrhage, Blood Loss Massive
- Trial name
- NCT06253832
- Testing
- conservative surgery for placenta accreta spectrum, hysterectomy
- Where
- Tunisia
- Volunteers
- 36 people
- Sponsor
- Tunis University
Placenta Previa
Clinical Outcomes of Placenta Previa - an Individualized Scoring System
The objective of the study is to develop a machine learning -based prediction model for patients with placenta previa . The model will be based on patient characteristics, clinical assessment, and disease features to predict…
- Trial name
- NCT06589180
- Volunteers
- 1,000 people
- Sponsor
- Assiut University
Placenta Accreta, Placenta Diseases
Plasma Concentration of Biological Markers in Placenta Accreta Spectrum
The purpose of this exploratory study is to determine how well maternal serum biomarkers and placental micro-particles (MP) correlate with placenta accreta spectrum (PAS) at the time of cesarean delivery in women with suspected…
- Trial name
- NCT04525534
- Testing
- There is no other intervention, only clinical treatment.
- Where
- United States
- Volunteers
- 19 people, healthy volunteers welcome
- Sponsor
- University of Arkansas
Placenta Accreta
Tamponade vs Partial Myometrial Resection of Lower Uterine Segment in Management of Placenta Accreta Spectrum Cases
To compare the efficacy of lower uterine tamponade and partial lower myometrial resection in the management of intraoperative bleeding in cases with placenta accreta spectrum .
- Trial name
- NCT06575023
- Testing
- Tamponade of lower uterine segment in management of placenta accreta spectrum cases, partial myometrial resection of lower uterine segment in management of placenta accreta spectrum cases
- Volunteers
- 222 people
- Sponsor
- Assiut University
Cesarean Section; Complications, Placenta Previa
Long Term Comparison of Two Different Techniques of Uterine Cesarean Incision Closure
Cesarean section (C/S) is an operation most commonly performed in Obstetrics and Gynecology Clinics. Complications related with incomplete healing of Kerr uterine incision after C/S (adhesions, separation (dehiscence)…
- Conditions
- Cesarean Section; Complications, Placenta Previa, Placenta Accreta
- Trial name
- NCT01289262
- Testing
- Purse string closure technique, Continuously locked closure technique
- Where
- Turkey (Türkiye)
- Volunteers
- 168 people
- Sponsor
- Dr. Lutfi Kirdar Kartal Training and Research Hospital
Placenta Accreta
Lower Placental Edge Thickness in Relation to Gestational Age at Delivery in Placenta Accreta (Prospective Cohort Study)
The aim of our study is to determine correlation between lower placental edge thickness measured by ultrasound and gestational age at delivery and predict the risk of emergency preterm birth in patients having placenta previa…
- Trial name
- NCT06248385
- Testing
- 2D ultrasound
- Where
- Egypt
- Volunteers
- 50 people
- Sponsor
- Ain Shams University
Placenta Previa
Sonographic Parameters and Risk of Antepartum Hemorrhage in Asymptomatic Women With Placenta Previa: A Cohort Study
The aim of this study is to evaluate the effectiveness of ultrasonographic parameters (cervical length, placental thickness and distance placental edge from internal os of the cervix) in predicting the risk of antepartum…
- Trial name
- NCT05802251
- Testing
- Ultrasonographic parameters
- Where
- Egypt
- Volunteers
- 68 people
- Sponsor
- Ain Shams University
Placenta Previa
Efficacy of Topical Tranexamic Acid in Reducing Blood Loss During CS in Patients With Placenta Previa
Objectives: To evaluate the efficacy of topical tranexamic acid applied on the placental bed after placental delivery to reduce blood loss during cesarean delivery in women with placenta previa.
- Trial name
- NCT06515535
- Testing
- Topical tranexamic acid, Intravenous tranexamic acid
- Volunteers
- 56 people, healthy volunteers welcome
- Sponsor
- Cairo University
Placenta Accreta Spectrum
Role of Uterotonics in Reducing Intraoperative Blood Loss in Patients With PASD Undergoing Cesarean Hysterectomy
Objectives: To evaluate the effect of oxytocin in reducing intraoperative blood loss in patients with PAS disorders planned for cesarean hysterectomy.
- Trial name
- NCT06493968
- Testing
- oxytocin
- Where
- Egypt
- Volunteers
- 70 people, healthy volunteers welcome
- Sponsor
- Cairo University
Placenta Accreta Spectrum
Comparison Between Cervical Tourniquet and Uterine Artery Ligation Prior to Segmental Resection Approach
The study will compare a modified surgical approach for preserving fertility and minimizing hemorrhage in morbidly adherent placenta during cesarean section with a cervical tourniquet against uterine artery ligation.
- Trial name
- NCT06483724
- Testing
- cervical tourniquet, uterine artery ligation
- Volunteers
- 82 people
- Sponsor
- Minia University
Placenta Accreta Spectrum
The Application of Comprehensive Prevention and Treatment Strategy of Placenta Accreta Spectrum Disorders
Placenta accreta spectrum (PAS) disorders are pathological attachment of the placenta to myometrium, where trophoblastic cells invade the uterine placental interface.
- Trial name
- NCT06477497
- Volunteers
- 33 people, healthy volunteers welcome
- Sponsor
- Peking Union Medical College Hospital
Placenta Accreta
Simplified Conservative Measures in Managing Morbidly Adherent Placenta in Beni-Suef University
To evaluate the efficacy of modified uterine artery ligation and myometrial compression as a conservative measure in improving the prognosis of the morbidly adherent placenta.
- Trial name
- NCT06465836
- Testing
- O, lreay suture, modified O, lreay suture
- Where
- Egypt
- Volunteers
- 172 people
- Sponsor
- Nesreen Abdel Fattah Abdullah Shehata
Smoking, Tobacco, Placenta Diseases
Effects of Smoking on Placenta and Lactation
Maternal smoking during pregnancy although it is known to be associated with fetal growth restriction, it's effect on postpartum breastfeeding is not yet clear.
- Conditions
- Smoking, Tobacco, Placenta Diseases, Breastfeeding, Fetal Conditions
- Trial name
- NCT06456645
- Where
- Turkey (Türkiye)
- Volunteers
- 70 people, healthy volunteers welcome
- Sponsor
- Manisa Celal Bayar University
Fetal Growth Retardation, Preeclampsia
Management of Early-onset Fetal Growth Restriction: Angiogenic Factors Versus Feto-placental Doppler
This is a multicentre, open-label, randomized controlled trial. A total of 340 singleton pregnancies with an EFW ≤10th percentile between 26+0 and 31+6 weeks will be recruited and randomly allocated to either the control or the…
- Conditions
- Fetal Growth Retardation, Preeclampsia, Placenta Diseases
- Trial name
- earlyGRAFD (NCT05284474)
- Testing
- soluble fms-like tyrosine kinase to placental growth factor ratio (sFlt-1/PlGF)
- Where
- 27 sites in Spain
- Volunteers
- 340 people
- Sponsor
- Hospital Universitari Vall d'Hebron Research Institute
Placenta Accreta
Single-step Placenta Accreta Resective Technique Tourniqueted vs Absence, Conservative Uterine Surgery
Background: An optimal international standard for PAS surgery is not yet available, and the establishment of a suitable surgical method is an important focus of in PAS management.
- Trial name
- SPARTACUS (NCT06185894)
- Testing
- Uterovesical tourniquet before uterine devascularization steps, Conventional conservative surgery
- Where
- Egypt
- Volunteers
- 40 people
- Sponsor
- Cairo University