Clinical trials: Placenta
Pregnancy, Healthy
Effect of Physical Exercise Program on Fetoplacental Growth
The aim of this study is to examine the effect of a supervised physical exercise program during pregnancy on fetoplacental growth.
- Trial name
- NCT02420288
- Testing
- Exercise Group
- Where
- Spain
- Volunteers
- 124 people, healthy volunteers welcome
- Sponsor
- Universidad Politecnica de Madrid
Morbidly Adherent Placenta
Psychological Outcome of Women With Morbidly Adherent Placenta Following Hystrectomy
The purpose of this study is to investigate the risk of postoperative psychiatric disorders of depression, anxiety outcomes and sexual dysfunctions and self esteem disturbance in women with morbidly adherent placenta following…
- Trial name
- NCT03976453
- Where
- Egypt
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- Ain Shams Maternity Hospital
Cadmium, Placenta
Cadmium Exposure During Pregnancy and Fetal Growth
Cadmium is a toxic heavy metal naturally present in the environment, whose human exposure has increased over recent decades due to diffuse anthropogenic contamination, particularly related to industrial activities and the use of…
- Conditions
- Cadmium, Placenta, Fetal Growth, Birth Weight
- Trial name
- CADNAT (NCT07855237)
- Testing
- maternal blood samples, Placental tissue samples, maternal urine samples
- Where
- France
- Volunteers
- 50 people
- Sponsor
- Centre Hospitalier Universitaire, Amiens
Maternal Infection During Pregnancy (Diagnosis), Neonatal Infection
Immediate Versus Delayed Induction in Term-PROM Using or Not Antibiotic Prophylaxis
The primary aim of this study is to determine if antibiotics combined with immediate induction can significantly reduce the rate of maternal and neonatal infection compared with immediate induction alone in women presenting with…
- Trial name
- NCT02985086
- Testing
- Cefoxitin, oxytocin/misoprostol
- Where
- 2 sites in Portugal
- Volunteers
- 568 people, healthy volunteers welcome
- Sponsor
- Hospital de Santa Maria, Portugal
Diabetic Foot Ulcer
Sterilised, Porcine Placental Tissue in the Treatment of Chronic Diabetic Foot Ulcers
A Prospective, Non-Randomized, Multi-Center Observational Study To determine the safety and effectiveness of InnovaMatrix AC porcine placental ECM therapy for the treatment of chronic, non-healing diabetic foot ulcers (DFUs)…
- Trial name
- NCT05687656
- Testing
- InnovaMatrix AC porcine placental ECM therapy
- Where
- 5 sites in United States
- Volunteers
- 30 people
- Sponsor
- ConvaTec Inc.
Placental Transfusion, Stem Cells
Placental Transfusion Methods and Stem Cells
To measure the levels of endothelial progenitor cells and CD34+ hematopoietic stem cells levels, and placental residual volume by delayed cord clamping, umbilical cord milking or immediate cord clamping in newborns at different…
- Trial name
- NCT03983902
- Testing
- Delayed cord clamping, Umbilical cord milking, Immediate cord clamping
- Volunteers
- 96 people
- Sponsor
- Ankara University
Placenta Accreta, Placenta Percreta
Cell-free Fetal DNA Concentration in Cases of Abnormal Placental Invasion .
Cell free fetal DNA might predict abnormal placental invasion
- Conditions
- Placenta Accreta, Placenta Percreta, Placenta Increta, Placenta Previa
- Trial name
- NCT03638024
- Testing
- Maternal plasma cell free fetal DNA levels
- Where
- Egypt
- Volunteers
- 50 people
- Sponsor
- Ain Shams Maternity Hospital
Antenatal Care, Maternal Health
AI Blind-Sweep Ultrasound for Antenatal Screening by Non-Specialist Health Workers in Rural DR Congo
FS2 evaluates the diagnostic accuracy and implementation feasibility of an AI-assisted blind-sweep obstetric ultrasound (SPAQ E-con AI), operated by trained non-specialist health workers, for antenatal screening in rural…
- Conditions
- Antenatal Care, Maternal Health, Gestational Age, Placenta Praevia
- Trial name
- FS2 (NCT07677670)
- Testing
- SPAQ E-con AI blind-sweep ultrasound
- Where
- Democratic Republic of the Congo
- Volunteers
- 3,000 people, healthy volunteers welcome
- Sponsor
- SOIK Corporation Sarl
Premature Rupture of Membranes (PROM)
Planned Early Induction of Labor vs Expectant Management for PROM
The goal of this randomized controlled trial is to compare planned early induction of labor with expectant management in women with term premature rupture of membranes (PROM) at 37-42 weeks of gestation.
- Trial name
- NCT07802041
- Testing
- Induction of labor with PGE2, Expectant management
- Where
- Pakistan
- Volunteers
- 734 people
- Sponsor
- Pakistan Institute of Medical Sciences
Pregnant Women
Placental Transfer of Tenofovir
The purposes of this study are to determine whether transporters expression levels and drug interaction between TDF and FTC could contribute to modulate the placental transfer of this drug or.
- Trial name
- TDF-PTP (NCT02020083)
- Where
- France
- Volunteers
- 369 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Placenta Previa
Clinical Outcomes of Placenta Previa - an Individualized Scoring System
The objective of the study is to develop a machine learning -based prediction model for patients with placenta previa . The model will be based on patient characteristics, clinical assessment, and disease features to predict…
- Trial name
- NCT06589180
- Volunteers
- 1,000 people
- Sponsor
- Assiut University
Pregnancy, Cesarean Section
A Comparison of Manual vs. Spontaneous Removal of the Placenta at Cesarean Section
The purpose of this study is to determine if there are differences in operative blood loss with manual vs. spontaneous removal of the placenta during cesarean section.
- Trial name
- NCT00375986
- Testing
- Manual placental removal at Cesarean delivery, Spontaneous placental removal at Cesarean delivery
- Where
- United States
- Volunteers
- 150 people
- Sponsor
- University of Rochester
Anemia, Pregnancy Anemia
Prospective Study on Feto-maternal outcoMe In aNemIc womEn
Background Blood transfusions in pregnancy are usually urgent, unpredictable, and occur in otherwise healthy women. There is evidence of increasing rates of maternal red blood cell (RBC) transfusion around childbirth both in…
- Conditions
- Anemia, Pregnancy Anemia, Pregnancy Bleeding, Transfusion-dependent Anemia
- Trial name
- MINNIE (NCT05739097)
- Testing
- iron deficiency, coagulation abnormalities
- Where
- 2 sites in Italy
- Volunteers
- 2,000 people
- Sponsor
- Casa Sollievo della Sofferenza IRCCS
Malaria
Trial to Evaluate the Safety and Immunogenicity of a Placental Malaria Vaccine Candidate (PRIMVAC ) in Healthy Adults
The primary objective of the study is to evaluate the safety of 3 different dosages (20µg - 50µg and 100µg) of a placental malaria vaccine candidate (PRIMVAC vaccine) adjuvanted either with Alhydrogel® or GLA-SE, and administered…
- Trial name
- PRIMALVAC (NCT02658253)
- Testing
- PRIMVAC, GLA-SE, Alhydrogel
- Where
- 2 sites in Burkina Faso, France
- Volunteers
- 68 people, healthy volunteers welcome
- Sponsor
- Institut National de la Santé Et de la Recherche Médicale, France
Pregnancy, Obese
Validation of Ultrasound in Predicting a Low Lying Placenta Throughout Pregnancy
This is a prospective observational study comparing venous Doppler flow in the lower extremities of pregnant women. Pregnant women with a BMI >/= 30 will be compared to those with a BMI < 30.
- Trial name
- NCT02689739
- Testing
- venous duplex ultrasound
- Where
- United States
- Volunteers
- healthy volunteers welcome
- Sponsor
- The University of Texas Medical Branch, Galveston
Pregnancy, Pregnancy Complications
GROSS-HIST : Quantification of the Main Circulating Histones During Normal Pregnancy and Pregnancies With Placenta-mediated Complications
Pregnancy generates an increased thrombotic risk, and placental-mediated diseases are a risk factor for cardiovascular diseases, in particular: pre-eclampsia (PE), intrauterine growth retardation (IUGR), retroplacental hematomas…
- Conditions
- Pregnancy, Pregnancy Complications, Healthy Volunteers
- Trial name
- GROSS-HIST (NCT04205383)
- Testing
- biological analyses
- Where
- France
- Volunteers
- 115 people, healthy volunteers welcome
- Sponsor
- Centre Hospitalier Universitaire de Nīmes
Fetal Macrosomia
Prediction of Fetal Macrosomia by US
Fetal macrosomia defined as birth weight above 90th centile ,macrosomia occurs in 42-62%of pregnancy complicated by type 1 diabetes mellitus ,in 30-56% of pregnancy complicated by type 2 diabetes mellitus .
- Trial name
- NCT03451838
- Testing
- Ultrasound, HbA1c level in blood
- Where
- Egypt
- Volunteers
- 102 people
- Sponsor
- Aljazeera Hospital
Placenta Accreta Spectrum
Role of Uterotonics in Reducing Intraoperative Blood Loss in Patients With PASD Undergoing Cesarean Hysterectomy
Objectives: To evaluate the effect of oxytocin in reducing intraoperative blood loss in patients with PAS disorders planned for cesarean hysterectomy.
- Trial name
- NCT06493968
- Testing
- oxytocin
- Where
- Egypt
- Volunteers
- 70 people, healthy volunteers welcome
- Sponsor
- Cairo University
Placenta Accreta Spectrum
The Application of Comprehensive Prevention and Treatment Strategy of Placenta Accreta Spectrum Disorders
Placenta accreta spectrum (PAS) disorders are pathological attachment of the placenta to myometrium, where trophoblastic cells invade the uterine placental interface.
- Trial name
- NCT06477497
- Volunteers
- 33 people, healthy volunteers welcome
- Sponsor
- Peking Union Medical College Hospital
Diabetic Foot Ulcer
AMNIOEXCEL® Plus vs A Marketed Comparator vs SOC in the Management of Diabetic Foot Ulcers
This is a multicenter, randomized, parallel-group study comparing the outcomes associated with the use of AMNIOEXCEL Plus Placental Allograft Membrane, a marketed comparator and SOC alone in the management of diabetic foot ulcers…
- Trial name
- NCT03547635
- Testing
- AMNIOEXCEL Plus Amniotic Membrane, A Marketed Comparator, Standard of Care
- Where
- 7 sites in United States
- Volunteers
- 116 people
- Sponsor
- Integra LifeSciences Corporation