Clinical trials: Placenta Diseases
Preeclampsia
A Study to Evaluate the Use of Placenta Protein 13 (PP13) in the First Trimester of Pregnancy as a Diagnostic Aiding Tool in the Assessment of the Risk for Developing Preeclampsia in Women With Low and Unknown Risk
The purpose of this study is to evaluate whether it is possible to detect changes in the concentration of PP13 in the blood of pregnant women who may go on to develop the complication of preeclampsia later on in the pregnancy…
- Trial name
- NCT00572793
- Where
- United States
- Volunteers
- 431 people, healthy volunteers welcome
- Sponsor
- Carl Weiner, MD
Fetal Growth Retardation
Comparison of Pesticide and Pharmaceutical Contaminants Levels in Placenta and Cord Blood Samples of Pregnant Women With Fetal Growth Retardation and Healthy Pregnant Women
Aim: In this study, pesticide and pharmaceutical contaminants levels in the placenta and cord blood of pregnant women with fetal growth retardation and healthy pregnant women will be compared in placenta and cord blood samples…
- Trial name
- NCT05088148
- Testing
- . Pesticide and Pharmaceutical analysis
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Kutahya Health Sciences University
Preeclampsia, Severe Preeclampsia
Pre-Eclampsia And Growth Restriction: a Longitudinal Study
Preeclampsia may have several causes leading to different characteristics of the pathology. Differentiation between the "type of preeclampsia" would help to treat patients more accurately.
- Conditions
- Preeclampsia, Severe Preeclampsia, Fetal Growth Restriction, Preterm Birth
- Trial name
- PEARL (NCT02379832)
- Where
- Canada
- Volunteers
- 76 people, healthy volunteers welcome
- Sponsor
- CHU de Quebec-Universite Laval
Third Stage of Delivery
Maternal Outcomes Following Manual Lysis of the Placenta.
Comparison of maternal outcomes following manual lysis of placenta 15 vs 30 minutes after delivery. A primary outcome of the drop in hemoglobin will be compared between the two groups.
- Trial name
- NCT03626844
- Testing
- Manual Lysis of Placenta after 15 minutes (Intervention), Manual Lysis of Placenta after 30 minutes (Control)
- Where
- Israel
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Holy Family Hospital, Nazareth, Israel
Placenta Accreta Spectrum
High vs. Low Segmental Hysterotomy: Impact on Uterine Wall Defects Post-Cesarean
The purpose of this clinical trial is to compare the incidence of defects in the uterine wall at the site of the scar (niche) and surgical complications when using high-segment versus low-segment hysterotomy, with both…
- Trial name
- HISEAL (NCT06620432)
- Testing
- Low segment hysterotomy, High segment hysterotomy, Crossed hysterorrhaphy
- Where
- Colombia
- Volunteers
- 168 people, healthy volunteers welcome
- Sponsor
- Fundacion Clinica Valle del Lili
Retained Placenta
Intravenous Nitroglycerin for Retained Placenta Extraction: a Multicenter Study
Primary objective The primary objective of this study is to see whether intravenous (IV) NTG 100-200 microgram can effectively help extract retained placenta as compared to placebo, in a randomized controlled multicenter study.
- Trial name
- NCT00707928
- Testing
- nitroglycerine, NSS
- Where
- Thailand
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Mahidol University
Postpartum Hemorrhage
The Effect of Placental Cord Drainage on Postpartum Blood Loss
To determine if placental cord drainage decreases the blood loss after spontaneous vaginal delivery
- Trial name
- NCT05610345
- Testing
- Placental Blood Drainage, Placenta Blood Not Drained
- Where
- United States
- Volunteers
- 71 people, healthy volunteers welcome
- Sponsor
- University of Tennessee
Chronic Hepatitis B
Vaccine+HBIG Versus Vaccine+Placebo for Newborns of HBsAg+ Mothers
Prevention of perinatal transmission is essential to decrease the global burden of chronic HBV. Recombinant HBV vaccine and hepatitis B immunoglobulin (HBIG) given after delivery to the newborns of HBsAg positive mothers is the…
- Trial name
- NCT01412567
- Testing
- Vaccine+HBIG
- Where
- India
- Volunteers
- 259 people, healthy volunteers welcome
- Sponsor
- Govind Ballabh Pant Hospital
Pregnancy, Pregnancy Complications
PregSource: Crowdsourcing to Understand Pregnancy
PregSource uses a crowd-sourcing approach, asking pregnant women to enter information regularly and directly about their pregnancies throughout gestation and the early infancy of their babies into online surveys and trackers via…
- Conditions
- Pregnancy, Pregnancy Complications, Morning Sickness, Diabetes, Gestational
- Trial name
- PregSource (NCT02577536)
- Testing
- No Interventions
- Where
- United States
- Volunteers
- 2,359 people, healthy volunteers welcome
- Sponsor
- Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)
Pre-Eclampsia
L-Arginine in Pre-Eclampsia
Pre-eclampsia is a disorder unique to pregnancy affecting both the mother and the fetus. Hypertension, proteinuria and edema are the most common and well-known maternal clinical symptoms. The incidence is approximately 6-8%.
- Trial name
- NCT00157521
- Testing
- L-arginine
- Where
- 2 sites in Italy
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Mario Negri Institute for Pharmacological Research
Placenta Percreta
Internal Iliac Artery Ligation and Abnormally Invasive Placenta
This trial is set to detect the impact of bilateral internal iliac artery ligation on the amount of intra-operative blood loss during the hysterectomy procedure done for the management of abnormally invasive placenta
- Trial name
- NCT02728232
- Testing
- internal iliac artery ligation, Cesarean Hysterectomy
- Where
- Egypt
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Cairo University
Placenta Accreta, Third Trimester
Relationship Between Maternal Soluble Trigger Receptor Expressed on Myeloid Cells-1 (sTREM-1) and Placenta Accreta Spectrum
We planed to evaluate soluble the triggering receptors expressed on myeloid cell-1 (s TREM-1) levels in serum of pregnant women diagnosed with placenta accreta spectrum and compare it with healthy pregnant women's s TREM-1 serum…
- Trial name
- NCT05376410
- Where
- Turkey (Türkiye)
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- Necmettin Erbakan University
Gestational Diabetes Mellitus in Pregnancy
Shear Wave Elastography in Gestational Diabetes Mellitus
Our aim was to investigate and compare placental elasticity by using Shear wave elastography (SWE) in patients with gestational diabetes mellitus (GDM) with and without insulin to non-diabetic controls.
- Trial name
- NCT04455880
- Testing
- SWE is a novel noninvasive dynamic ultrasound technique which refers to measurement for quantitative analysis of tissue elasticity
- Where
- Turkey (Türkiye)
- Volunteers
- 319 people, healthy volunteers welcome
- Sponsor
- Gulsum Uysal
Pre-Eclampsia, HELLP Syndrome
PlacEntal Acute Atherosis RefLecting Subclinical Atherosclerosis
Pregnancy is considered a cardiovascular (CV) stress test, and complicated pregnancies are associated with an increased risk for cardiovascular disease (CVD) later in life.
- Conditions
- Pre-Eclampsia, HELLP Syndrome, Intrauterine Growth Restriction, Pregnancy
- Trial name
- PEARLS (NCT05500989)
- Where
- Netherlands
- Volunteers
- 226 people, healthy volunteers welcome
- Sponsor
- Maastricht University Medical Center
Placenta Previa
Efficacy of Topical Tranexamic Acid in Reducing Blood Loss During CS in Patients With Placenta Previa
Objectives: To evaluate the efficacy of topical tranexamic acid applied on the placental bed after placental delivery to reduce blood loss during cesarean delivery in women with placenta previa.
- Trial name
- NCT06515535
- Testing
- Topical tranexamic acid, Intravenous tranexamic acid
- Volunteers
- 56 people, healthy volunteers welcome
- Sponsor
- Cairo University
Morbidly Adherent Placenta
Role of Ultrasound in Diagnosis of Placenta Previa and MAP
Placenta accreta occurs when the placental implantation is abnormal. The marked rise in incidence has been assumed the increasing prevalence of cesarean delivery in recent years.
- Trial name
- NCT03416296
- Where
- Egypt
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- Aljazeera Hospital
Low Birth Weight Infants
Alkaline Phosphatase Level in Pregnancy and Its Association With Birth Weight
Alkaline phosphatase is known to be produced by syncytiotrophoblasts in the placenta and its levels are normally increased in pregnancy.
- Trial name
- NCT03187938
- Testing
- Testing of Alkaline Phosphatase Levels
- Where
- United States
- Volunteers
- 292 people, healthy volunteers welcome
- Sponsor
- TriHealth Inc.
Placenta Previa, Placenta Accreta Spectrum
Syncytiotrophoblast-derived Extracellular Vesicles in Placenta Previa and Accreta Spectrum
The main goal of this case-control study is to quantify the levels of circulating syncytiotrophoblast-derived extracellular vesicles (STBEVs) in maternal blood in a population of women with placenta previa and placenta accreta…
- Trial name
- PAS (NCT06867874)
- Testing
- Blood sample
- Where
- Italy
- Volunteers
- 70 people, healthy volunteers welcome
- Sponsor
- Fondazione Policlinico Universitario Agostino Gemelli IRCCS
Gestational Diabetes, Pregestational Diabetes
Possible Epigenetic Changes in Offspring of Women With Pregestational and Gestational Diabetes
Pregestational diabetes (PGD) during pregnancy may be associated with an increased rate of spontaneous abortions, intrauterine death and congenital anomalies among the offspring.
- Conditions
- Gestational Diabetes, Pregestational Diabetes, IDM (Infant of Diabetic Mothers), Neurodevelopmental Outcome
- Trial name
- NCT01255384
- Where
- Israel
- Volunteers
- 300 people, healthy volunteers welcome
- Sponsor
- Hadassah Medical Organization
Placental Disease
Imaging Innovations for Placental Assessment in Response to Environmental Pollution (PARENTs)
How environmental pollution contributes to poor pregnancy outcome is poorly understood. The first trimester of pregnancy is a particularly vulnerable time period for the developing fetus and a mother's exposure to air pollution…
- Trial name
- PARENTs (NCT02786420)
- Where
- United States
- Volunteers
- 199 people, healthy volunteers welcome
- Sponsor
- University of California, Los Angeles