Clinical trials: Placental Development
Gestational Diabetes, Pregestational Diabetes
Possible Epigenetic Changes in Offspring of Women With Pregestational and Gestational Diabetes
Pregestational diabetes (PGD) during pregnancy may be associated with an increased rate of spontaneous abortions, intrauterine death and congenital anomalies among the offspring.
- Conditions
- Gestational Diabetes, Pregestational Diabetes, IDM (Infant of Diabetic Mothers), Neurodevelopmental Outcome
- Trial name
- NCT01255384
- Where
- Israel
- Volunteers
- 300 people, healthy volunteers welcome
- Sponsor
- Hadassah Medical Organization
Chorioamnionitis, Cerebral Palsy
Early Identification of Brain Insult in Chorioamnionitis
Premature breaking of the amniotic fluids during pregnancy caries high risk for infection of the amniotic fluid. One of the results of chorioamnionitis is brain injury of the fetus.
- Trial name
- NCT01778725
- Where
- Israel
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- Sheba Medical Center
Iron Deficiency
Delayed Cord Clamping and Infant Brain Study
The purpose of this study is to determine if delaying cord clamping at the birth of term infants effects the early brain development (myelin deposition)as determined by quantitative MRI at 4 and 10 months and developmental…
- Trial name
- IBS (NCT01620008)
- Testing
- Delayed Cord Clamping
- Where
- United States
- Volunteers
- 106 people, healthy volunteers welcome
- Sponsor
- University of Rhode Island
Chorioamnionitis, Chorioamnionitis Affecting Fetus or Newborn
Amniotic Fluid & the Preterm Gut
Background: Necrotizing enterocolitis (NEC) and sepsis in preterm infants have been linked to intestinal immaturity and preclinical gut microbiota alterations.
- Conditions
- Chorioamnionitis, Chorioamnionitis Affecting Fetus or Newborn, Necrotizing Enterocolitis of Newborn, Neonatal Sepsis, Early-Onset
- Trial name
- AMFIBIE (NCT07152106)
- Where
- 2 sites in Netherlands
- Volunteers
- 275 people, healthy volunteers welcome
- Sponsor
- Maxima Medical Center
Placental Development Pregnancy Outcome
Peri-implantation Abstinence and Placental Health
This study examined whether avoiding sexual intercourse during the time when a fertilized egg may attach to the uterus affects placental development and pregnancy outcomes.
- Trial name
- NCT07843173
- Testing
- Couples were instructed to avoid sexual intercourse for 14 days after ovulation during each study cycle, covering the expected peri-implantation period.
- Where
- Malaysia
- Volunteers
- 94 people, healthy volunteers welcome
- Sponsor
- Universiti Sains Malaysia
Preterm Labor
Nanovectors to Prevent Placental Passage of Tocolytic Agents
The purpose of the study is to find out whether indomethacin encapsulated within a nanovector can stop contractions in pregnant human uterine tissue. Preterm delivery is a major contributor to newborn deaths.
- Trial name
- NCT02199756
- Where
- United States
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- The University of Texas Health Science Center, Houston
COVID-19, Maternal Vaccine Exposure
Priming of the NEonatal Immune System by Transfer of Maternal Immunity
Newborn babies and infants are susceptible to infections as their immune system is still immature. Maternal immune factors for example antibodies and immune cells mitigate this vulnerability.
- Conditions
- COVID-19, Maternal Vaccine Exposure, Respiratory Infections in Children
- Trial name
- NEST (NCT05429047)
- Testing
- Tozinameran, COVID-19, No SARS-CoV-2 exposure
- Where
- Germany
- Volunteers
- 560 people, healthy volunteers welcome
- Sponsor
- Hannover Medical School
Placenta Diseases, Diagnosis, Pregnancy Related
Placenta Perfusion and Sufficiency Study
Ultrasonography will be used to determine the total blood flow to and from the uterus. This is done by measuring the blood vessels coming from and going to the uterus.
- Conditions
- Placenta Diseases, Diagnosis, Pregnancy Related, Female, Human
- Trial name
- P2SS (NCT06042348)
- Testing
- Trans abdominal ultrasound
- Where
- Netherlands
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- Maxima Medical Center
Premature Birth, Preeclampsia
A Randomized Trial of Docosahexaenoic Acid Supplementation During Pregnancy to Prevent Deep Placentation Disorders
This study evaluates the effectiveness of maternal supplementation with Docosahexaenoic acid (DHA) early in pregnancy to reduce the incidence of deep placentation disorders: preterm birth, preterm labor, preterm premature rupture…
- Conditions
- Premature Birth, Preeclampsia, Fetal Growth Retardation, Stillbirth
- Trial name
- NCT02336243
- Testing
- Docosahexaenoic acid (DHA)
- Where
- 5 sites in Chile
- Volunteers
- 2,400 people, healthy volunteers welcome
- Sponsor
- Pontificia Universidad Catolica de Chile
Intrauterine Development
The Reus-Tarragona Birth Cohort Study of Early Development and Ageing.
The recent fall in birth and death rates has led to demographic changes such as low fertility and high life expectancy . The WHO reports the median age of the European population to be the highest in the world and predicts that…
- Trial name
- NCT01778205
- Testing
- Observational
- Where
- 2 sites in Spain
- Volunteers
- 831 people, healthy volunteers welcome
- Sponsor
- Institut Investigacio Sanitaria Pere Virgili
Pregnancy, Malaria
L-ArGinine to pRevent advErse prEgnancy Outcomes (AGREE)
There are few safe, effective, and affordable interventions to improve pregnancy outcomes in low resource settings where the highest rates of poor birth outcomes occur.
- Conditions
- Pregnancy, Malaria, Nutrition, Placental Development
- Trial name
- AGREE (NCT05934318)
- Testing
- L-citrulline
- Where
- Kenya
- Volunteers
- 2,960 people, healthy volunteers welcome
- Sponsor
- Liverpool School of Tropical Medicine
Adherent Placenta
Surgical Classification of Abnormal Placentation
Reaching the proper pre-operative diagnosis for abnormal placentation in crucial to markedly decrease the intra-operative complications as well as the maternal morbidity and mortality.
- Trial name
- NCT02736058
- Testing
- Trans- abdominal sonography, Trans-vaginal sonography, post-operative pathological specimen examination
- Where
- Egypt
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Cairo University
Pregnancy Related
Fetal MRI Acquisition and Sequence Development
Testing of new magnetic resonance imaging (MRI) pulse sequences (image acquisition software) for imaging the fetus to improve workflow and image quality in fetal imaging and diagnosis.
- Trial name
- FMASD (NCT05253742)
- Testing
- No intervention - the investigators are evaluating a new image acquisition method on an MRI scanner
- Volunteers
- healthy volunteers welcome
- Sponsor
- Massachusetts General Hospital
Pre-Eclampsia, Fetal Growth Retardation
Comparison of Doses of Acetylsalicylic Acid in Women With Previous History of Preeclampsia
Placental insufficiency is the source of preeclampsia (PE) and intrauterine growth retardation (IUGR). Current data demonstrate a significant beneficial effect of prophylactic use of aspirin on the recurrence of placental…
- Conditions
- Pre-Eclampsia, Fetal Growth Retardation, Premature Birth, Placental Insufficiency
- Trial name
- NCT01352234
- Testing
- Acetylsalicylic Acid 160 mg, Acetylsalicylic Acid 80 mg
- Where
- Canada
- Volunteers
- 104 people, healthy volunteers welcome
- Sponsor
- CHU de Quebec-Universite Laval
Obstetric Labor, Premature
Inflammation and Cell Maturation in Preterm Delivery Placentas - in Vitro and in Vivo Effect of Progesterone
The aim of this study is to investigate the In Vitro and In Vivo effect of progesterone on immature myeloid cells (IMC), inflammation characteristics and maturation into dendritic cells (DC).
- Trial name
- NCT03211338
- Testing
- Culture with progesterone, Culture without progesterone, Culture with growth factors
- Where
- Israel
- Volunteers
- 115 people, healthy volunteers welcome
- Sponsor
- Hillel Yaffe Medical Center
Preeclampsia, Pregnancy Complications
The Correlation Between Immunological Reaction of the Seminal Fluid in the Mother's Blood and Pregnancy Complications
It is known that if there isn't an efficient exposure to the paternal antigens before conception, there is an increased risk for the pre-eclampsia (PE) cascade and other pregnancy complications to take place.
- Conditions
- Preeclampsia, Pregnancy Complications, Insemination; Complication, Immune Tolerance
- Trial name
- NCT04314518
- Where
- 2 sites in Israel
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Sheba Medical Center
Bronchopulmonary Dysplasia
The Role of Volatile Organic Compounds (VOCs), Airway Mucins and the Microbiome in the Early Prediction of Bronchopulmonary Dysplasia (BPD)
Bronchopulmonary dysplasia (BPD), the most common respiratory complication of extremely preterm birth, significantly impacts healthcare with high morbidity and mortality rates.
- Trial name
- INFANCY (NCT06342752)
- Testing
- Breath test, Throat swabs, Placental samples
- Where
- Belgium
- Volunteers
- 140 people, healthy volunteers welcome
- Sponsor
- University Hospital, Antwerp
Preeclampsia
Second Trimester Maternal Serum Homocysteine Levels and Uterine Artery Doppler for Prediction of Preeclampsia and Placentation Disorders
The current study included the singleton pregnancies (without history of previous risk factors), had their homocysteine measured as part of a serum-screening program in addition to uterine artery Doppler.
- Trial name
- NCT02854501
- Volunteers
- 500 people, healthy volunteers welcome
- Sponsor
- Cairo University
Pregnancy, Healthy
Effect of Physical Exercise Program on Fetoplacental Growth
The aim of this study is to examine the effect of a supervised physical exercise program during pregnancy on fetoplacental growth.
- Trial name
- NCT02420288
- Testing
- Exercise Group
- Where
- Spain
- Volunteers
- 124 people, healthy volunteers welcome
- Sponsor
- Universidad Politecnica de Madrid
Healthy
Placenta Development Study
This study will help us learn more about how the placenta develops.
- Trial name
- NCT03614312
- Where
- United States
- Volunteers
- 15 people, healthy volunteers welcome
- Sponsor
- Arkansas Children's Hospital Research Institute