Clinical trials: Placental Transfusion
Neurodevelopmental Abnormality
Umbilical Cord Milking in Non-Vigorous Infants Developmental Followup (MINVIFU)
A sub-study to evaluate longer-term developmental outcomes in non-vigorous term and near-term newborns who receive umbilical cord milking in comparison to those who undergo early cord clamping at delivery.
- Trial name
- MINVIFU (NCT03621943)
- Testing
- Umbilical Cord Milking, Early Cord Clamping
- Where
- 10 sites in United States, Canada and 1 more
- Volunteers
- 1,207 people
- Sponsor
- Sharp HealthCare
Hypoxic-Ischemic Encephalopathy, Birth Asphyxia
Comparative Outcomes Related to Delivery-room Cord Milking In Low-resourced Kountries
The investigators will conduct a study on non-vigorous infants at birth to determine if umbilical cord milking (UCM) results in lower rate of moderate to severe hypoxic ischemic encephalopathy (HIE) or death than early clamping…
- Trial name
- CORDMILK (NCT03657394)
- Testing
- Umbilical cord milking
- Where
- 9 sites in India
- Volunteers
- 3,442 people
- Sponsor
- Nemours Children's Clinic
Placental Transfusion, Stem Cells
Placental Transfusion Methods and Stem Cells
To measure the levels of endothelial progenitor cells and CD34+ hematopoietic stem cells levels, and placental residual volume by delayed cord clamping, umbilical cord milking or immediate cord clamping in newborns at different…
- Trial name
- NCT03983902
- Testing
- Delayed cord clamping, Umbilical cord milking, Immediate cord clamping
- Volunteers
- 96 people
- Sponsor
- Ankara University
Iron Deficiency, Child Development
Infant Brain Study Follow-Up at 3 and 4 Years of Age
When immediate clamping of the umbilical cord (ICC) occurs at birth, 20 to 30% of the fetal-placental blood volume is left behind in the placenta.
- Trial name
- NCT02619006
- Testing
- Delayed Cord Clamping or Cord Milking
- Volunteers
- 10 people
- Sponsor
- University of Rhode Island
Abnormal Vascular Flow
Effects of Milking the Umbilical Cord on Systemic Blood Flow
Premature babies are at risk for bleeding in their brains, which can result in developmental delays or other neurological problems such as cerebral palsy.
- Trial name
- NCT01434732
- Testing
- Umbilical Cord Milking, Immediate Cord Clamping
- Where
- United States
- Volunteers
- 60 people
- Sponsor
- Sharp HealthCare
Monochorionic Diamniotic Placenta, Monochorial Monoamniotic Placenta
Database of Monochorionic Pregnancies
The purpose of this study is to collect and analyze data regarding natural history, indications for fetal interventions, and maternal and fetal/neonatal outcomes associated with complicated monochorionic twin pregnancy.
- Conditions
- Monochorionic Diamniotic Placenta, Monochorial Monoamniotic Placenta, Twin; Complicating Pregnancy, Twin to Twin Transfusion Syndrome
- Trial name
- NCT05543499
- Where
- United States
- Volunteers
- 1,200 people
- Sponsor
- University of Miami
Twin Pregnancy, Antepartum Condition or Complication, Twin to Twin Transfusion as Antepartum Condition
Multicenter Prospective Cohort Study of Twin Maternal-Child Dyads in China
Multicenter Prospective Cohort Study of Twin Maternal-Child Dyads in China (ChiTwiMC) is supported by National Key Research and Development Program of China - Reproductive Health and Women's and Children's Health Protection…
- Conditions
- Twin Pregnancy, Antepartum Condition or Complication, Twin to Twin Transfusion as Antepartum Condition, Pre-Term, Pre-Eclampsia
- Trial name
- ChiTwiMC (NCT06414655)
- Where
- 11 sites in China
- Volunteers
- 2,000 people, healthy volunteers welcome
- Sponsor
- Peking University Third Hospital
Anemia
Placental Transfusion in Term Infants: A Pilot Study
The proposed study is a pilot prospective controlled trial to measure the blood volume left in the placenta after varying cord clamping times when the infant is placed skin-to-skin on the maternal abdomen.
- Trial name
- NCT01924572
- Testing
- cord clamping at 2 minutes, cord clamping at 5 minutes, cord milking
- Where
- United States
- Volunteers
- 32 people, healthy volunteers welcome
- Sponsor
- University of Rhode Island
Placental Transfusion
Placental Transfusion and Cord Clamping
To compare the evolution of the infant's weight before delayed cord clamping (2 minutes after birth) as an indirect measure of the volume of placental transfusion in a group of healthy and fullterm newborns, placed at the level…
- Trial name
- NCT01497353
- Testing
- Position at introitus level, position at Maternal Abdomen
- Where
- 3 sites in Argentina
- Volunteers
- 400 people, healthy volunteers welcome
- Sponsor
- Fundacion para la Salud Materno Infantil
Anemia
Milking the Umbilical Cord at Term Cesarean Birth
The purpose of this pilot study is to determine if umbilical cord milking at the time of scheduled cesarean section effects the hemoglobin and hematocrit levels of full-term infants as determined by hemoglobin and hematocrit…
- Trial name
- NCT01630993
- Testing
- Umbilical Cord Milking
- Where
- United States
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- University of Rhode Island
Placental Insufficiency, Preterm Infant
Impact of Umbilical Cord Milking in Preterm Neonates With Placental Insufficiency
To investigate the effect of umbilical cord milking (UCM) on peripheral hematologic parameters including hematopoietic progenitor cells in premature infants ≤ 34 weeks gestational age with placental insufficiency.
- Trial name
- NCT03731611
- Testing
- Umbilical Cord Milking
- Where
- 2 sites in Egypt
- Volunteers
- 90 people
- Sponsor
- Mansoura University Children Hospital
Placental Transfusion
Delivery Room Assistance With the Placental Circulation Intact
Preterm newborns receiving placental transfusion at birth (a volume of blood coming from the placenta towards the newborn till the cord is left unclamped) have better neonatal outcomes (in particular reduction of intraventricular…
- Trial name
- PCI-T (NCT02671305)
- Testing
- placental circulation intact, cord milking
- Where
- 8 sites in Italy
- Volunteers
- 212 people
- Sponsor
- University of Florence
Twin Monochorionic Diamniotic Placenta
Safety and Efficacy of Fetoscopes Used in Fetoscopic Selective Laser Photocoagulation
The purpose of this study is to evaluate the safety and efficacy of the investigational fetoscopes used in patients undergoing fetoscopic selective laser photocoagulation for complicated monochorionic-diamniotic pregnancies.
- Trial name
- NCT06022510
- Testing
- Fetoscopy Sets for Anterior and Posterior Placentas
- Where
- United States
- Sponsor
- Michael A Belfort
Premature Infant, Umbilical Cord
Umbilical Cord Milking vs Delayed Cord Clamping in Preterm Infants Born by Cesarean Section
The purpose of this study is to determine whether the umbilical cord milking in preterm infants born by cesarian section less than 34 weeks is more effective than delayed cord clamping to obtain higher levels of hemoglobin.
- Conditions
- Premature Infant, Umbilical Cord, Milking, Delayed Clamping
- Trial name
- NCT02187510
- Testing
- Umbilical cord milking, Delayed cord clamping
- Where
- Spain
- Volunteers
- 40 people
- Sponsor
- Corporacion Parc Tauli
Twin Dichorionic Diamniotic Placenta, Twin Monochorionic Monoamniotic Placenta
Austrian Registry on the Outcome of Monochorionic Pregnancies
About one third of twin pregnancies are resulting from a single fertilized oocyte. Two third of these monozygotic twins share a common placenta and are therefore called monochorionic.
- Conditions
- Twin Dichorionic Diamniotic Placenta, Twin Monochorionic Monoamniotic Placenta, Twin-To-Twin Transfusion Syndrome, Twin Pregnancy With Antenatal Problem
- Trial name
- MonoReg (NCT03171909)
- Where
- 13 sites in Austria
- Volunteers
- 1,000 people, healthy volunteers welcome
- Sponsor
- Medical University of Graz
Hypoxic-Ischemic Encephalopathy
Role of Umbilical Cord Milking in the Management of Hypoxic-ischemic Encephalopathy in Neonates
The purpose of this study is to investigate the efficacy and safety of umbilical cord milking in depressed neonates at birth for prevention of hypoxic ischemic encephalopathy.
- Trial name
- NCT03123081
- Testing
- Umbilical Cord Milking
- Where
- India
- Volunteers
- 400 people
- Sponsor
- Jubilee Mission Medical College and Research Institute
Placental Transfusion
Delayed Cord Clamping and Use of Oxytocin
The purpose of this study is to determine if oxytocin administration immediately after delivery of the infant modifies the volume of placental transfusion in healthy term infants.
- Trial name
- NCT02618499
- Testing
- Timing of administration of post partum Oxytocin
- Where
- Argentina
- Volunteers
- 180 people
- Sponsor
- Fundacion para la Salud Materno Infantil
Hypoxic-Ischemic Encephalopathy, Perinatal Asphyxia
Umbilical Cord Milking Versus Immediate Cord Clamping in Full Term Neonates (≥ 37 Weeks) Requiring Resuscitation
The objective of the study is to compare the incidence of Hypoxic ischemic encephalopathy (all stages) among singleton term neonates (≥ 37 weeks) requiring resuscitation who will undergo Umbilical cord milking as compared to…
- Trial name
- NCT06090968
- Testing
- Umbilical cord milking, Immediate cord clamping
- Where
- India
- Volunteers
- 200 people
- Sponsor
- Lady Hardinge Medical College
Twin to Twin Transfusion Syndrome
Laser Photocoagulation in Twin to Twin Transfusion Syndrome
Humanitarian use device (HUD): Use of the fetoscopy instrument sets for selective laser photocoagulation in the treatment of Twin to Twin Transfusion Syndrome (TTTS).
- Trial name
- TTTS (NCT02506049)
- Testing
- S-LPC:Selective Laser Photocoagulation
- Where
- 2 sites in United States
- Volunteers
- 1 people
- Sponsor
- University of Tennessee
Preterm Birth
The Australian Placental Transfusion Study (APTS): Should Very Pre Term Babies Receive a Placental Blood Transfusion at Birth Via Deferring Cord Clamping Versus Standard Cord Clamping Procedures?
To establish if placental transfusion, using deferred cord clamping for 60 seconds or more while holding the baby at or below the level of the placenta, will improve survival without disability compared with standard early cord…
- Trial name
- APTS (NCT02606058)
- Testing
- Deferred cord clamping
- Where
- 26 sites in United States, Australia and 5 more
- Volunteers
- 1,637 people
- Sponsor
- University of Sydney