Clinical trials: Plaque, open to volunteers
Alzheimer Disease, Amyloid
A Master Protocol Studying Multiple Amyloid-Targeting Therapies in Healthy Participants and Participants With Alzheimer's Disease
The purpose of this Master Protocol is to support multiple studies looking at safety and tolerability of different drugs in healthy participants and participants with Alzheimer's disease, and if they remove clumps of protein…
- Conditions
- Alzheimer Disease, Amyloid, Plaque, Amyloid, Healthy Volunteers
- Trial name
- NCT07787169
- Testing
- LY4405094, Florbetapir F18, Florbetaben F 18
- Where
- 19 sites in United States, China and 1 more
- Volunteers
- 179 people, healthy volunteers welcome
- Sponsor
- Eli Lilly and Company
Atherosclerotic Plaque, Diabetes Mellitus, Type 2
Pakistan Study of Premature Coronary Atherosclerosis in Young Adults
Coronary heart disease (CHD) is a major cause of morbidity, disability, mortality, and health expenditures worldwide. A wealth of studies has demonstrated that people of South Asian ancestry have a higher risk of CHD and…
- Conditions
- Atherosclerotic Plaque, Diabetes Mellitus, Type 2, Hypertension, Stroke
- Trial name
- PAKSEHAT (NCT05156736)
- Where
- Pakistan
- Volunteers
- 2,000 people, healthy volunteers welcome
- Sponsor
- Tabba Heart Institute
Dental Plaque, Patient Reported Outcome
The Antiplaque and Antigingivitis Effect of Pure Green Tea Mouth Wash Compared to Placebo and Essential Oils Mouth Washes
The goal of this clinical trial is to to evaluate the antiplaque and antigingivitis effect of pure green tea mouthwash compared to placebo and essential oils mouthwashes in healthy patients.
- Conditions
- Dental Plaque, Patient Reported Outcome, Gingival Inflammation and Bleeding, Gingival Inflammation
- Trial name
- NCT07364565
- Testing
- Pure Green Tea Mouthwash, Listerine Total Care Mouthwash, Listerine Green Tea Mouthwash
- Where
- Jordan
- Volunteers
- 44 people, healthy volunteers welcome
- Sponsor
- King Abdullah University Hospital
Plaque Removal
Evaluating Plaque Removal in Adolescents Using Bamboo and Conventional Plastic Toothbrushes
evaluation of bamboo and conventional toothbrushes in plaque removal
- Trial name
- prevention (NCT07155798)
- Testing
- bamboo toothbrush, conventional toothbrush
- Where
- Egypt
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Heba Helal
Dental Plaque, Oral Biofilm
Investigation of Biofilm Formation on Temporary push-on Rings of Implant Crowns
This in-vivo study investigates early (48h), mature (2 weeks) and long-term (3 months) biofilm formation and composition on temporary push-on cones (exchangeable conical rings) made of noble-alloy-based materials (Pagalinor, PA)…
- Conditions
- Dental Plaque, Oral Biofilm, Peri-implantitis
- Trial name
- NCT05122897
- Testing
- Rings made of PA (test), Rings made of TAN (control)
- Where
- Switzerland
- Volunteers
- 33 people, healthy volunteers welcome
- Sponsor
- University Hospital, Basel, Switzerland
Orthodontic Pain (D013850), Malocclusion
Comparison of Three Orthodontic Separators for Pain, Plaque, and Tooth Separation
Orthodontic separators are small devices placed between teeth before fitting braces to create space for bands. This procedure may cause pain, discomfort, and changes in oral hygiene, which can affect plaque buildup and daily…
- Conditions
- Orthodontic Pain (D013850), Malocclusion, Orthodontic Treatment
- Trial name
- SEP-ORTHO (NCT07532044)
- Testing
- Elastomeric Separator, Kesling Separator, Tie wire separator
- Where
- Pakistan
- Volunteers
- 144 people, healthy volunteers welcome
- Sponsor
- Islamabad Medical and Dental College
Specific Learning Disabilities, Dental Plaque
Plaque Removal Efficiency in Children With Specific Learning Disabilities
This study aims to evaluate the effectiveness of toothbrushing education on plaque removal in children aged 7-12 years with specific learning disabilities (SLD) and to compare their plaque removal performance with healthy…
- Conditions
- Specific Learning Disabilities, Dental Plaque, Oral Hygiene
- Trial name
- PRE-SLD (NCT07611942)
- Testing
- Standardized Toothbrushing Education
- Where
- Turkey (Türkiye)
- Volunteers
- 70 people, healthy volunteers welcome
- Sponsor
- Alanya Alaaddin Keykubat University
Alzheimer Disease
Beta Amyloid PET Imaging for Alzheimer Disease With [18F]-Fluselenamyl
The purpose of this research study is to determine the safety of a radiotracer 18F-Fluselenamyl using positron emission tomography (PET) imaging.
- Trial name
- NCT06439992
- Testing
- 18F-Fluselenamyl
- Where
- United States
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Washington University School of Medicine
Peri-Implant Health
Plaque and Bleeding on Probing Around Implants Supporting Fixed Full-Arch Dental Prostheses
This observational study examines plaque, hard deposits (calculus), and gum bleeding around dental implants supporting fixed full-arch dental prostheses.
- Trial name
- NCT07898956
- Testing
- Prosthetic Maintenance History
- Where
- Italy
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Nicola Alberto Valente, DDS, MS, PhD
Carotid Artery Stenosis
Optimization Strategy of Carotid Artery Stenosis
The goal of this observational study is to learn about how to utilize multiple evaluation techniques in carotid artery stenosis patients for optimizing assessment of diagnosis and treatment strategy.
- Trial name
- COAS-CAS (NCT05629000)
- Testing
- Carotid revascularization, MRI-PWI, CTA
- Where
- China
- Volunteers
- 1,000 people, healthy volunteers welcome
- Sponsor
- Peking Union Medical College Hospital
Periodontitis
Predictive Role of the Full-mouth Plaque Score on the Outcomes of Non-surgical Periodontal Therapy.
Oral hygiene quality is a key determinant of outcomes in both non-surgical and surgical periodontal therapy. Previous studies have demonstrated the negative impact of site-specific plaque accumulation on periodontal parameters.
- Trial name
- NCT07524504
- Testing
- Non-surgical periodontal therapy (NSPT)
- Where
- Italy
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- G. d'Annunzio University
Oral Health Behavior Change
SEHAT Virtual Oral Health Promotion for School Adolescents in Pakistan
The goal of this cluster-randomized trial is to learn if the SEHAT program works to improve oral health among school adolescents in Pakistan. It will also assess how the program affects oral health behaviors and knowledge.
- Trial name
- SEHAT (NCT07536958)
- Testing
- SEHAT Virtual Oral Health Education, Conventional Oral Health Education
- Where
- Pakistan
- Volunteers
- 1,500 people, healthy volunteers welcome
- Sponsor
- Shifa College of Dentistry
Dental Plaque, Bleeding of Subgingival Space
Antibacterial Photodynamic Therapy as an Adjunctive Treatment on Oral Hygiene in Elderly Persons
On average, the dental condition of elderly people is poor due to various reasons. The importance of oral health maintenance of the ageing population has been recognized by the World Health Organization (WHO), as oral health…
- Conditions
- Dental Plaque, Bleeding of Subgingival Space, Oral Complication
- Trial name
- NCT06576063
- Testing
- Lumoral Treatment, Standard oral hygiene methods
- Where
- 3 sites in Finland
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Koite Health Oy
Gingivitis, Plaque
COMORAL® the Oral Irrigation Unit Clinical Trial
This is a clinical study to evaluate the safety and effectiveness of COMORAL®, the intraoral water-spraying cleaning device that is developed to remove plaque around teeth in the oral cavity.
- Trial name
- COMORAL (NCT05031260)
- Testing
- applying COMORAL®
- Volunteers
- 42 people, healthy volunteers welcome
- Sponsor
- University of California, Los Angeles
Dental Plaque, Gingivitis
A Study Investigating Gingival Crevicular Fluid Biomarkers Following Use of a Commercially Available Toothpaste Containing Stannous Fluoride
The aim of this study is to evaluate the feasibility, sensitivity, and interpretability of gingival crevicular fluid (GCF) cytokine biomarkers as early indicators of tissue recovery following use of commercial dentifrice compared…
- Trial name
- NCT07842042
- Testing
- Test Toothpaste, Regular Fluoride Toothpaste
- Where
- United Kingdom
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- HALEON
Gingivitis, Healthy Adult
Comparative Evaluation of the Anti-Plaque and Anti-Gingivitis Effects of Nanobiofusion Gingival Gel (NBF), Placebo Gel, and Commercial Toothpaste
The goal of this clinical trial is to learn if Nanibiofusion Gingival Gel (NBF) is able to reduce dental plaque and gum inflammation in adults.
- Trial name
- NCT07850232
- Testing
- Nano Bio-Fusion (NBF) Gingival Gel, Commercial fluoride toothpaste
- Where
- Jordan
- Volunteers
- 45 people, healthy volunteers welcome
- Sponsor
- King Abdullah University Hospital
Caries,Dental, Pain
Comparative Evaluation of SMART Hall Technique Vs. Conventional SS Crown in Primary Molars: a Randomized Clinical Trial
Dental caries, particularly in primary molars, significantly affects children's oral health and overall well-being. Traditional management with stainless steel crowns (SSCs) involves significant tooth reduction and advanced…
- Conditions
- Caries,Dental, Pain, Plaque, Dental, Gingival Bleeding
- Trial name
- RCT (NCT06453005)
- Testing
- SMART Hall Technique or procedure
- Where
- India
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- C K S Teja Institute Of Dental Sciences & Research
Dental Plaque, Dental Caries
Intraoral Scan and CBCT-Aided Diagnosis of Dental Plaque and Caries
This prospective clinical study aims to evaluate the diagnostic accuracy of intraoral scans (IOS) for the detection of dental plaque and caries.
- Trial name
- NCT07555223
- Testing
- intraoral scan
- Where
- Belgium
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- University Ghent
Dental Plaque Accumulation
In Situ Evaluation of Plaque Accumulation on Innovative Nanostructured Metal Implant Surfaces
Participants will get a customized maxillary tray carrying 2 pairs of metal disks with a nanostructured surface. They will wear the trays continuously for 72 hours except when eating, drinking or brushing their teeth.
- Trial name
- INDIS (NCT07784803)
- Testing
- Maxillary tray
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Malmö University
Alzheimer s Disease, Major Depressive Disorder (MDD)
VR Pupillometry in Cognitive Impairment
With disease-modifying therapies emerging for dementia and related conditions, identifying cognitive decline as early as possible is increasingly important.
- Conditions
- Alzheimer s Disease, Major Depressive Disorder (MDD), Mild Cognitive Impairment, Dementia
- Trial name
- NCT07402356
- Where
- Germany
- Volunteers
- 140 people, healthy volunteers welcome
- Sponsor
- Max-Planck-Institute of Psychiatry