Clinical trials: Plasma Concentration
Healthy Male Subjects
Mass Balance Study of FYU-981
To assess the plasma pharmacokinetics, the routes extent of elimination, and the metabolites of FYU-981 after a single 1 mg oral dose of 14C-FYU-981 in healthy male subjects.
- Trial name
- NCT02901366
- Testing
- 14C-FYU-981
- Where
- Japan
- Volunteers
- 6 people, healthy volunteers welcome
- Sponsor
- Fuji Yakuhin Co., Ltd.
Healthy Resistance-Trained Males
Comparison of Plant and Animal Proteins on Amino Acid Concentrations
The study purpose is to assess various protein blends, which differ in protein quality, and the impact on blood amino acid response in male subjects.
- Trial name
- NCT03673839
- Testing
- Animal Proteins (crossover), Plant-based protein blends type 1 (crossover), Plant-based protein blends type 2 (crossover)
- Where
- Canada
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Danone North America
Healthy, Plasma Concentration of YM060
A Study to Compare Oral Absorption of YM060 Between Orally-disintegrating Tablet (Without Water) and Conventional Tablet
A study to compare time-course changes of plasma concentration of YM060 after intake of conventional tablet and orally-disintegrating tablet. Orally-disintegrating tablets will be administered without water.
- Trial name
- NCT01392794
- Testing
- YM060
- Where
- Japan
- Volunteers
- 36 people, healthy volunteers welcome
- Sponsor
- Astellas Pharma Inc
Healthy Volunteers
Study to Assess the Intrapulmonary Pharmacokinetics of SPR859 by Comparing the Plasma, Epithelial Lining Fluid (ELF), and Alveolar Macrophages (AM) Concentrations Following the Oral Administration of Five Doses of SPR994 in Healthy, Nonsmoking Volunteers
To evaluate the intrapulmonary pharmacokinetics (PK), including ELF and AM concentrations, of SPR859 (tebipenem) compared to plasma concentrations of SPR859 (tebipenem) (the active moiety in plasma of the prodrug SPR994) in…
- Trial name
- NCT04710407
- Testing
- TBPM-PI-HBr
- Where
- United States
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Spero Therapeutics
Opioid-Related Disorders, Pain, Acute
A Comparison of Plasma Concentrations of Hydrocodone and Acetaminophen After Administration of a New and a Marketed Tablet Formulation Under Fasted and Fed Conditions in Healthy Adults
This clinical trial is being conducted to compare concentrations of hydrocodone and acetaminophen in the blood after administration of a new and a marketed tablet formulation under fasted and fed conditions in healthy adults.
- Conditions
- Opioid-Related Disorders, Pain, Acute, Pain, Postoperative
- Trial name
- NCT03137017
- Testing
- Norco 5Mg-325Mg Tablet, GRT7014 - Abuse Deterrent Tablet
- Where
- United States
- Volunteers
- healthy volunteers welcome
- Sponsor
- Grünenthal GmbH
Lipid Absorption and Metabolism
Plasma Diurnal Variation in and Absorption of EPA and DHA
This study will evaluate the absorption of two different dietary supplements containing the omega 3 fatty acids eicosapentaenoic acid and docosahexaenoic acid over 24 hours via venous blood plasma following a single dose taken at…
- Trial name
- NCT02661698
- Testing
- Omega-3 oil: DHA enriched, Omega-3 oil: EPA enriched
- Where
- United Kingdom
- Volunteers
- 39 people, healthy volunteers welcome
- Sponsor
- Northumbria University
Healthy Subjects
Measurement of HTL0016878 in Cerebrospinal Fluid
A Phase 1, open-label, randomised, single oral dose study to determine the concentration of HTL0016878 in CSF and plasma in healthy male subjects following dosing with HTL0016878 10 mg or 20 mg oral solution
- Trial name
- NCT04849286
- Testing
- HTL0016878
- Where
- United Kingdom
- Volunteers
- 16 people, healthy volunteers welcome
- Sponsor
- Nxera Pharma UK Limited
Vitamin A Deficiency
Vitamin A Bioavailability in Lactating Women With Marginal Vitamin A Status
The study will assess the relative bioavailability and bioefficacy of cryptoxanthin (CX) and beta-carotene (BC) from food sources for increasing breast milk carotenoid and retinol concentrations in lactating Bangladeshi women.
- Trial name
- NCT01420406
- Testing
- 0 mg retinol activity equivalents, 12 mg of BC, 6 mg of CX
- Where
- Bangladesh
- Volunteers
- 140 people, healthy volunteers welcome
- Sponsor
- USDA, Western Human Nutrition Research Center
Insulin Sensitivity
The Role of TLR4 on Lipid-induced Insulin Resistance
The purpose of this study is to determine whether pharmacologic inhibition of Toll-like receptor 4 (TLR4) with eritoran for injection (E5564) prevents lipid-induced insulin resistance in lean, normal glucose tolerant (NGT)…
- Trial name
- Eritoran1 (NCT02321111)
- Testing
- Eritoran, D5W (5% Dextrose in water)
- Where
- United States
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- The University of Texas Health Science Center at San Antonio
Healthy, Plasma Concentration of YM060
A Study to Compare Oral Absorption of YM060 Between Orally-disintegrating Tablet and Conventional Tablet Under With Water Intake
A study to compare time-course changes of plasma concentration of YM060 orally-disintegrating tablet with those of conventional tablet. Tablets will be administered with water.
- Trial name
- NCT01394653
- Testing
- YM060
- Where
- Japan
- Volunteers
- 36 people, healthy volunteers welcome
- Sponsor
- Astellas Pharma Inc
Healthy
The Effect of Rifapentine on Raltegravir
The aim of this study is to study the effect of rifapentine on plasma concentrations of raltegravir.
- Trial name
- NCT00809718
- Testing
- Raltegravir and rifapentine
- Where
- 2 sites in United States
- Volunteers
- 27 people, healthy volunteers welcome
- Sponsor
- The University of Texas Health Science Center at San Antonio
Autoimmune Hepatitis, Cirrhosis
Effect of High-protein High-fiber Diet in Patients With Autoimmune Hepatitis
Autoimmune hepatitis is a chronic disease of the liver caused by an alteration of the immune response that attacks the body's own hepatocytes, progressively, leading to cirrhosis and liver failure.
- Trial name
- NCT01655121
- Testing
- High protein high fiber diet
- Where
- Mexico
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Instituto Nacional de Ciencias Medicas y Nutricion Salvador Zubiran
Infertility, Female
Plasma Concentrations of Calcium, Phosphate, FGF23, Klotho, 25 (OH) D3 and 1,25 (OH) 2D3 from Patients Who Wants to Have Children
1,25-dihydroxy-vitamin D3 (1,25 (OH) 2D3) or calcitriol regulates plasma calcium and phosphate concentrations in the blood by stimulating intestinal absorption and renal reabsorption of calcium and phosphate.
- Trial name
- NCT03173235
- Testing
- Plasma level of vitamin D
- Where
- Germany
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- University Hospital Tuebingen
Renal Impairment, Healthy Volunteers
Study to Assess the Plasma Concentration of Rilzabrutinib Given as a Tablet to Adult Participants With Severe Renal Impairment Compared to Matched Participants With Normal Renal Function
The purpose of this Phase 1, open-label, 2-arm study is to assess the effect of severe RI on PK, safety, and tolerability of rilzabrutinib compared with normal renal function, in male and female participants aged from 18 to 75…
- Trial name
- NCT07853131
- Testing
- rilzabrutinib
- Where
- United States
- Volunteers
- 16 people, healthy volunteers welcome
- Sponsor
- Sanofi
Vascular Diseases, Leukoaraiosis
Concentration of Trimethylamine Oxide (TMAO) in Blood Plasma as a Risk Factor for Vascular Cerebral Damage
The primary aim of the current research project is to answer the question, whether plasma trimethylamine N-oxide (TMAO) level may be used as a marker of ischemic changes in the brain.
- Conditions
- Vascular Diseases, Leukoaraiosis, Ischemia, Cerebral
- Trial name
- NCT03903601
- Testing
- Magnetic Resonance Imaging (MRI), Blood samples collection, Neuropsychological tests
- Where
- Poland
- Volunteers
- 300 people, healthy volunteers welcome
- Sponsor
- Gdansk University of Physical Education and Sport
Healthy
Lycopene as a Dietary Compliance Biomarker
Rationale: To determine the plasma lycopene concentration before and after an oral intake of lycopene in order to use this measurement as a life style compliance marker.
- Trial name
- NCT07117110
- Testing
- Supplement, Tomato soup
- Where
- Netherlands
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- Erasmus Medical Center
Healthy
Microdose and First-In-Human (FIH) Study of Recombinant Human Placental Alkaline Phosphatase (hRESCAP)
In the present study human recombinant placental alkaline phosphatase (hRESCAP) will be investigated. Alkaline Phosphatase is naturally present in the body and reported to use lipopolysaccharde (LPS, bacterial endotoxins) and…
- Trial name
- NCT01889147
- Testing
- hRESCAP
- Where
- Netherlands
- Volunteers
- 4 people, healthy volunteers welcome
- Sponsor
- TNO
Infections
Assess the Plasma, Epithelial Lining, and Alveolar Macrophage Concentrations of Intravenous Meropenem-Pralubactam (Meropenem/FL058) in China Healthy Adult Participants
The goal of this clinical trial is to evaluate the Epithelial Lining Fluid concentrations and permeability of Intravenous Meropenem-Pralubactam(Meropenem/FL058) in China Healthy Adult Participants.
- Trial name
- NCT07124468
- Testing
- Meropenem-Pralubactam
- Where
- China
- Volunteers
- 16 people, healthy volunteers welcome
- Sponsor
- Qilu Pharmaceutical Co., Ltd.
Parkinson's Disease
Study of Subcutaneous Continuous Administration of Levodopa/Carbidopa Solution (ND0612) in Healthy Volunteers
It will be a single dose, single-center, randomized, double-blind, placebo-controlled dose escalation study of SC continuously-delivered LD/CD solution (ND-0612) for 24 hours in healthy volunteers. Objectives are to determine: 1.
- Trial name
- NCT01486628
- Testing
- ND0612
- Where
- Israel
- Volunteers
- 36 people, healthy volunteers welcome
- Sponsor
- NeuroDerm Ltd.
Reflux Oesophagitis
Effect of 5, 10 or 25 mg of YF476 Daily for 14 Days on Stomach Acidity in Healthy Volunteers
The objective of the study was to assess whether the tolerance to the effect of YF476 on gastric pH observed with repeated doses in a previous study in healthy volunteers can be avoided by using smaller doses of YF476.
- Trial name
- NCT01597674
- Testing
- YF476
- Where
- United Kingdom
- Volunteers
- 49 people, healthy volunteers welcome
- Sponsor
- Trio Medicines Ltd.