Clinical trials: Plasma Concentration
Type 2 Diabetes
Study of Metformin Pharmacogenetics in Twins
The trough concentration of metformin will be examined in monozygotic and dizygotic twins. Current twin study will determine the total weight of genetics on the trough concentration of metformin.
- Trial name
- NCT01869621
- Testing
- Metformin
- Where
- Denmark
- Volunteers
- 34 people, healthy volunteers welcome
- Sponsor
- University of Southern Denmark
Healthy Volunteer
Effect of LIMICOL®-NG on Plasma LDL-cholesterol Concentration in Subjects with Moderate Hypercholesterolemia
The goal of this clinical trial is to observe a decrease in plasma LDL cholesterol concentration of 10% (or 0.20g/L) in subjects with untreated moderate hypercholesterolemia after 3 months of consumption of the Limicol®-NG food…
- Trial name
- LIPIGUARD (NCT06894251)
- Testing
- LIMICOL® NG
- Where
- France
- Volunteers
- 35 people, healthy volunteers welcome
- Sponsor
- Institut Pasteur de Lille
Obesity (BMI>30), Metabolically Healthy Obesity
Plasma Taurine in Older Women With Obesity: Impact of Metabolic Phenotype and Combined Exercise
Population aging has been accompanied by a rise in obesity and other chronic diseases, increasing cardiovascular risk particularly among women, who exhibit a higher prevalence in older age groups compared to men.
- Conditions
- Obesity (BMI>30), Metabolically Healthy Obesity, Metabolically Unhealty Obese
- Trial name
- non applicable (NCT07711899)
- Testing
- Physical Training of 16 weeks
- Volunteers
- 36 people, healthy volunteers welcome
- Sponsor
- University of Sao Paulo
Biological Availability, Amorphous Solid Dispersions
Bioavailability Mechanistic Study of Hot-Melt Extruded Amorphous Solid Dispersions
It is the aim of the study to investigate the functioning of a drug delivery system (drug-rich particles forming hot-melt extruded amorphous solid dispersions) with respect to mechanisms of bioavailability of poorly soluble drug…
- Trial name
- BEAD (NCT03886766)
- Testing
- Hot-melt extruded amorphous solid dispersion of Efavirenz, Hot-melt extruded amorphous solid dispersion of Efavirenz homogenized to drug rich particles, Efavirenz solution
- Where
- Switzerland
- Volunteers
- 16 people, healthy volunteers welcome
- Sponsor
- University Hospital, Basel, Switzerland
Zinc Deficiency
Effects of Liquid Zinc Supplementation and Dispersible Zinc Tablets on Plasma Zinc Concentration
The study aims to compare the effects of two different formulations of zinc supplements on plasma zinc concentrations among young Burkinabe children.
- Trial name
- NCT00944853
- Testing
- Liquid zinc syrup, Zinc tablet
- Where
- Burkina Faso
- Volunteers
- 462 people, healthy volunteers welcome
- Sponsor
- University of California, Davis
Pharmacokinetics
A Study To Estimate The Time Course Of PF-00241939 Concentration In The Blood After Dosing With Oral Inhalation From Dry Powder Inhalers
The purpose of this study is to investigate the time course of PF-00241939 concentrations in the blood following dosing by oral inhalation using dry powder inhalers.
- Trial name
- NCT01181700
- Testing
- Treatment A, Treatment B, Treatment C
- Where
- Singapore
- Volunteers
- 42 people, healthy volunteers welcome
- Sponsor
- Pfizer
Healthy Volunteers
Study to Assess the Intrapulmonary Pharmacokinetics of SPR206 in Healthy Volunteers
To evaluate the intrapulmonary pharmacokinetics (PK), including epithelial lining fluid (ELF) and alveolar macrophage (AM) concentrations, of SPR206 as well as plasma concentrations of SPR206 in healthy adult volunteers.
- Trial name
- NCT04868292
- Testing
- SPR206
- Where
- United Kingdom
- Volunteers
- 34 people, healthy volunteers welcome
- Sponsor
- Spero Therapeutics
Healthy Chinese Volunteers
Study to Assess the Safety and Plasma Concentration of YM178 OCAS Tablet (Mirabegron) in Healthy Chinese Volunteers
To evaluate the safety and plasma concentration change of YM178 after single- and repeated-administration as oral absorption controlled tablet in healthy Chinese subjects.
- Trial name
- NCT01720212
- Testing
- YM178
- Where
- China
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Astellas Pharma China, Inc.
HIV
Concentrations of Raltegravir in the Semen of HIV-Infected Men
The objective of this study is to determine if concentrations of raltegravir in semen exceed the 50% and 95% inhibitory concentrations of HIV during the dose interval.
- Trial name
- NCT01045265
- Testing
- Seminal plasma pharmacokinetics
- Where
- 2 sites in Canada
- Volunteers
- 16 people, healthy volunteers welcome
- Sponsor
- Canadian Immunodeficiency Research Collaborative
PAIN
A First In Human Study In Healthy People To Evaluate Safety, Toleration And Time Course Of Plasma Concentration Of Single Oral Doses Of PF-06273340
The purpose of this study in healthy people is to evaluate safety, toleration and time course of plasma concentration of single oral doses of PF-06273340.
- Trial name
- NCT01601834
- Where
- Belgium
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Pfizer