Clinical trials: Plasmodium Knowlesi Infection
Malaria
Effect of Paracetamol on Renal Function in Plasmodium Knowlesi Malaria
Acute kidney injury is a common complication of severe Plasmodium knowlesi malaria, and an important contributor to mortality. The exact pathogenic mechanisms of AKI in knowlesi malaria are not known, however it is hypothesised…
- Trial name
- PACKNOW (NCT03056391)
- Testing
- Paracetamol
- Where
- 4 sites in Malaysia
- Volunteers
- 360 people
- Sponsor
- Menzies School of Health Research
Uncomplicated Knowlesi Malaria
P. Knowlesi Trial of Artemether-lumefantrine vs Chloroquine
Preliminary studies have supported the background efficacy of local standard anti-malarial medications in the treatment of uncomplicated knowlesi malaria, however there are no current WHO treatment guidelines for this infection.
- Trial name
- CAN KNOW (NCT02001012)
- Testing
- Artemether-lumefantrine combination, Chloroquine
- Where
- 3 sites in Malaysia
- Volunteers
- 123 people
- Sponsor
- Menzies School of Health Research
Uncomplicated Plasmodium Knowlesi Malaria
P. Knowlesi Trial of Artesunate-mefloquine Versus Chloroquine
Preliminary studies have supported the background efficacy of local standard anti-malarial medications in the treatment of uncomplicated knowlesi malaria, however this has not been tested systematically and there are no current…
- Trial name
- ACT KNOW (NCT01708876)
- Testing
- Artesunate-mefloquine, Chloroquine, Primaquine
- Where
- 3 sites in Malaysia
- Volunteers
- 250 people
- Sponsor
- Menzies School of Health Research
Plasmodium Knowlesi Infection
Molecular Diagnostic Methods for Detection of Plasmodium Knowlesi
This study aims to determine the sensitivity, specificity, and practical value of two new molecular diagnostic assays compared to a more classical nested molecular diagnostic assay and the routine microscopy (both of which are…
- Trial name
- NCT03988296
- Where
- 3 sites in Malaysia
- Volunteers
- 116 people
- Sponsor
- Duke University