Clinical trials: Platelet Aggregation
Aging
Bread Supplemented With Chilean Beans to Decrease Postprandial Glycoxidative Responses: A Pilot Intervention
The goal of this trial is to assess in healthy subjects between 60 and 70 years the effect of glycemic and glycoxidative postprandial responses and platelet aggregation after intake of bread supplemented with Chilean beans flour…
- Trial name
- NCT05955131
- Testing
- Nutritional acute postprandial intervention: Control bread, Nutritional acute postprandial intervention: bread suppelmented with Chilean beans, Nutritional acute postprandial intervention: Control glucose
- Where
- Chile
- Volunteers
- 25 people, healthy volunteers welcome
- Sponsor
- University of Talca
Blood Platelets, Clopidogrel
PACT (Platelet Activity After Clopidogrel Termination)
Clopidogrel is a medication that is used to decrease the ability of platelets to form blood clots. The theory has been proposed that, in patients with coronary artery disease or stroke, increased platelet function after…
- Trial name
- PACT (NCT00619073)
- Testing
- clopidogrel + aspirin, Aspirin
- Where
- United States
- Volunteers
- 15 people, healthy volunteers welcome
- Sponsor
- University of Massachusetts, Worcester
Cardio-protection
In Vitro and in Vivo Evaluation of the Anti-Inflammatory and Antithrombotic Synergy of Vitamin C and Bioflavonoids in Healthy Subjects
This study aimed to evaluate the antioxidant potential, and especially the anti-inflammatory and antiplatelet biological efficacy and synergy of a high dose (1 g) vitamin C - low dose (50 mg) bioflavonoid (VCF) based supplement…
- Trial name
- VCF (NCT07061431)
- Testing
- High Dose of Vitamin C with ir without 50 mg of flavonoids
- Where
- Greece
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Democritus University of Thrace
COVID-19
Platelet Aggregation in COVID-19 Patients
Context: Hypercoagulable state associated with COVID-19 is one of the pathologic events that noticed in different waves of COVID-19 pandemics and leads to serious consequences in mortality and morbidity Aim: To evaluate platelet…
- Trial name
- NCT06097429
- Testing
- blood sample for platelet aggregation
- Where
- Egypt
- Volunteers
- 75 people, healthy volunteers welcome
- Sponsor
- Mansoura University
Healthy Volunteers
Effect of Hyperoxemia on Platelet Function in Healthy Volunteers
Prospective, controlled, randomized crossover volunteer study to investigate the effect of hyperoxemia due to inhalation of oxygen (80% inspiratory fraction) via reservoir-face-mask on blood coagulation, especially platelet…
- Trial name
- NCT01057420
- Testing
- oxygen inhalation
- Where
- Switzerland
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- University of Zurich
Healthy
Platelet Function and Safety After IV and Oral Diclofenac, IV Ketorolac and Oral Aspirin in Adult Volunteers
This study will assess platelet function and safety in healthy male volunteers following doses of intravenous diclofenac compared to oral diclofenac (Cataflam), intravenous ketorolac and oral aspirin.
- Trial name
- NCT00548678
- Testing
- intravenous diclofenac sodium (DIC075V), ketorolac, oral diclofenac (Cataflam)
- Where
- United States
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Javelin Pharmaceuticals
Cardiovascular Risk Factor
The Acute Effects of Meals Rich in Saturated or Unsaturated Fatty Acids on Postprandial Lipaemia in Healthy Men
Current dietary recommendations suggest that lowering intake of saturated fats or replacing it with unsaturated fats will decrease the risk of developing cardiovascular disease.
- Trial name
- CocoHeart (NCT05264233)
- Testing
- Coconut oil, Butter, Vegetable oil
- Where
- United Kingdom
- Volunteers
- 13 people, healthy volunteers welcome
- Sponsor
- University of Reading
Dilutional Coagulopathy
Hemodilution and Coagulopathy With 3 Colloids
Aim of this in vitro trial is to assess the effect on blood coagulation after 60 % dilution with different colloids (HES 130/0.42, Gelatin and Gelatin balanced) and investigate reversibility by replacement of fibrinogen (FBG)…
- Trial name
- NCT01727830
- Testing
- Induced Coagulopathy by HES (Tetraspan), Gelatin (Physiogel), Gelatin balanced (Physiogel balanced)
- Where
- Switzerland
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- University of Zurich
Cardiovascular Risk Factor
Consumption of Oral Artificial Sweeteners on Platelet Aggregation and Polyol Excretion
The principal goal for the study is to examine whether ingestion of a beverage containing artificial sweeteners alters in vitro platelet aggregation.
- Trial name
- COSETTE (NCT04731363)
- Testing
- xylitol, 30g, erythritol, 30g, xylitol, 5g
- Where
- United States
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- The Cleveland Clinic
Drug Interaction
PPI and Clopidogrel Response
Clopidogrel, in combination with aspirin, is currently the recommended treatment for secondary prevention of ischemic events in high-risk patients and for prevention of coronary artery stent thrombosis.
- Trial name
- NCT01170533
- Testing
- omeprazole and pantoprazole
- Where
- United States
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- University of Florida
Atherosclerosis
SB-659032 Platelet Aggregation Study
This study is designed to assess whether inhibition of plasma Lp-PLA2 activity impacts platelet function as assessed by ex vivo platelet aggregation tests and in vivo plasma biomarkers.
- Trial name
- NCT01745458
- Testing
- SB-659032
- Where
- Australia
- Volunteers
- 26 people, healthy volunteers welcome
- Sponsor
- GlaxoSmithKline
Cardiovascular Disease
Dark Chocolate and Platelet Function in Humans
Cardiovascular disease is a major cause of mortality worldwide and responsible for one out of three global deaths. A main characteristic of cardiovascular disease is impaired blood flow and formation of blood clots.
- Trial name
- NCT01099150
- Testing
- Dark chocolate enriched in flavan-3-ols and procyanidins, Standard dark chocolate, White chocolate
- Where
- United Kingdom
- Volunteers
- 42 people, healthy volunteers welcome
- Sponsor
- University of Aberdeen
Myocardial Infarction
Platelet Leukocyte Aggregates in Acute Cardiac Syndrome vs Healthy Volunteers
This project aims to refine previous studies including the investigators work recently published in August 2012 Journal Thrombosis and Thrombolysis.
- Trial name
- NCT01797016
- Where
- Israel
- Volunteers
- 59 people, healthy volunteers welcome
- Sponsor
- Ziv Hospital
Cardiometabolic Health
Effect of Differently Fed Farmed Gilthead Sea Bream Consumption
The trial was a double-blind randomized dietary intervention study with a 1:1 allocation ratio, conducted in accordance with the Declaration of Helsinki.
- Trial name
- NCT05417191
- Testing
- Conventional fish, Enriched fish
- Where
- Greece
- Volunteers
- 38 people, healthy volunteers welcome
- Sponsor
- Harokopio University
Hypercholesterolemia, Endothelial Dysfunction
Effects of Nutraceutical Therapies on Endothelial Function, Platelet Aggregation, and Coronary Flow Reserve
Hypercholesterolemia is considered one of the most important cardiovascular risk factors. Cardiovascular prevention include a class I indication to statins in addition to non-pharmacologic intervention and prevention strategies…
- Trial name
- NUTRENDO (NCT02969070)
- Testing
- LopiGLIK™ therapy, Armolipid Plus® therapy
- Where
- Italy
- Volunteers
- 28 people, healthy volunteers welcome
- Sponsor
- Federico II University