Clinical trials: Platelet Function
Menopause, Cardiac Function Impaired
Effects of Exercise Training on Cardiovascular Health in Middle-aged Women
The hypothesis of the present study is that physical training can oppose detrimental changes in cardiovascular and metabolic health associated with estrogen loss after menopause.
- Conditions
- Menopause, Cardiac Function Impaired, Cardiovascular Diseases, Blood Platelet Disorders
- Trial name
- NCT02135575
- Testing
- Spinning
- Where
- Denmark
- Volunteers
- 36 people, healthy volunteers welcome
- Sponsor
- University of Copenhagen
Cardiovascular Diseases
In Vitro Interaction Between Ticagrelor and Its Active Metabolite and Their Effects on Salicylic Acid
This is a in-vitro study to evaluate the pharmacodynamic interaction between ticagrelor and its active metabolite (AR-C124910XX) and their effects on the pharmacodynamics of salicylic acid.
- Trial name
- In_vitro_PAT (NCT01777516)
- Where
- South Korea
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Asan Medical Center
Arteriosclerosis, Acute Myocardial Infarction
Menopause Related Influences on Leukocyte Distribution, Monocyte Function and Platelet Reactivity
Women and men show marked differences in cardiovascular risk profile and outcome. Women experience fewer cardiovascular events than men before menopause, but this relationship seems to reverse at menopause.
- Conditions
- Arteriosclerosis, Acute Myocardial Infarction, Cardiovascular Events, Menopause
- Trial name
- NCT05985447
- Where
- Germany
- Volunteers
- 180 people, healthy volunteers welcome
- Sponsor
- Heinrich-Heine University, Duesseldorf
Dilutional Coagulopathy
Hemodilution and Coagulopathy With 3 Colloids
Aim of this in vitro trial is to assess the effect on blood coagulation after 60 % dilution with different colloids (HES 130/0.42, Gelatin and Gelatin balanced) and investigate reversibility by replacement of fibrinogen (FBG)…
- Trial name
- NCT01727830
- Testing
- Induced Coagulopathy by HES (Tetraspan), Gelatin (Physiogel), Gelatin balanced (Physiogel balanced)
- Where
- Switzerland
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- University of Zurich
Platelet Function, Thrombosis
PFA-100 Responsive to Effect of Energy Drinks on Platelet Function
This study evaluates the responsiveness of the Platelet Function Analyzer (PFA-100) to the effect of energy drinks on platelet function.
- Trial name
- NCT02997111
- Testing
- PFA-100
- Where
- United States
- Volunteers
- 13 people, healthy volunteers welcome
- Sponsor
- St. Louis University
Drug Resistance
Laboratory Aspirin Resistance in Diabetics and Non-Diabetics
Despite treatment with aspirin a large number of patients suffer a myocardial infarction. It has been speculated that these patients might be "resistant" to aspirin, and studies have indicated that this phenomenon is related to a…
- Trial name
- NCT00563875
- Testing
- acetylsalicylic acid
- Where
- Denmark
- Volunteers
- 210 people, healthy volunteers welcome
- Sponsor
- University of Aarhus
Diabetes, Metabolic Syndrome
Characterization of Low Density Lipoprotein and Mechanism of the Pro Aggregant Effect Through Oxidant Stress and Lipid Exchange
Case control design: lipidomic study in 12 type 2 diabetics with metabolic syndrome, 12 metabolic syndrome without diabetes, 12 subjects with type 1 diabetes and 12 controls
- Trial name
- ECLIPSE (NCT00932087)
- Testing
- Blood sample
- Where
- France
- Volunteers
- 48 people, healthy volunteers welcome
- Sponsor
- Hospices Civils de Lyon
Healthy, Postmenopausal Women
Dried Cabernet Grapes and Cardiovascular Risk Markers
This study assesses the acute effects of dried Cabernet grape intake on vascular function and platelet reactivity in postmenopausal women.
- Trial name
- RZN (NCT03065166)
- Testing
- Raisin Treatment, Bagel Control
- Where
- United States
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- University of California, Davis
COVID-19
Platelet Aggregation in COVID-19 Patients
Context: Hypercoagulable state associated with COVID-19 is one of the pathologic events that noticed in different waves of COVID-19 pandemics and leads to serious consequences in mortality and morbidity Aim: To evaluate platelet…
- Trial name
- NCT06097429
- Testing
- blood sample for platelet aggregation
- Where
- Egypt
- Volunteers
- 75 people, healthy volunteers welcome
- Sponsor
- Mansoura University
Coronary Artery Disease
Pharmacokinetic Assessment of Simultaneous Administration of Clopidogrel and Aspirin
This is a randomized, open-label, single-dose, two-sequence, two-period crossover study to investigate the pharmacokinetics between a tablet containing 75 mg of Clopidogrel and 100 mg of Aspirin and the simultaneous…
- Trial name
- NCT01388660
- Testing
- Cloas, Plavix/Astrix
- Where
- South Korea
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Ajou University School of Medicine
Platelet Aggregation, Spontaneous, Atherosclerosis
Effects of Fish Oil on Platelet Function and Coagulation
Many patients undergoing surgery use naturopathic drugs, including fish oil. Fish oil has been reported to increase bleeding in patients through inhibiting platelet aggregation and prolonging of clot formation time.
- Conditions
- Platelet Aggregation, Spontaneous, Atherosclerosis, Surgery
- Trial name
- FOILP (NCT03048981)
- Testing
- Fish oil
- Where
- Sweden
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- Region Skane
Cardiovascular Diseases
Effect of Ingesting a Tomato Pomace Extract on Platelet Aggregation
This study evaluates the acute and longer term effects of a tomato pomace extract on platelet aggregation in health subjects.
- Trial name
- Tomasa (NCT02986165)
- Testing
- Low dose pomace extract, High dose pomace extract
- Where
- Chile
- Volunteers
- 99 people, healthy volunteers welcome
- Sponsor
- Centro de Estudios en Alimentos Procesados
PRF, Hypospadias
A Multicenter Randomized Controlled Trial Comparing Platelet-Rich Fibrin and Ventral Dartos Flap as Intermediate Layers in Tabularized Incised Plate (TIP) Urethroplasty for Distal Hypospadias With Mild Penile Curvature
Distal hypospadias is the most common form of hypospadias. The Tubularized Incised Plate (TIP) repair is the standard surgical technique for this condition; however, complications such as fistula formation and meatal stenosis…
- Conditions
- PRF, Hypospadias, Distal Hypospadias, Hypospadias Repair
- Trial name
- PRF (NCT07045545)
- Testing
- - Group A: Platelet-rich fibrin membrane prepared intraoperatively and applied over neourethra, Group B: Ventral dartos flap rotated over neourethra
- Where
- Uzbekistan
- Volunteers
- 5 people, healthy volunteers welcome
- Sponsor
- National Children's Medical Center, Uzbekistan
Healthy
Pharmacodynamics of CGT 2168 Compared With Plavix®
CG106 is a Phase I open-label, randomized, multiple-dose, two-way crossover study to characterize the pharmacodynamics and pharmacokinetics of the investigational fixed-dose combination product CGT 2168 (clopidogrel, 75 mg and…
- Trial name
- NCT00620802
- Testing
- CGT-2168, Plavix
- Where
- United States
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Cogentus Pharmaceuticals
Trauma, Austere Environment
Storage Temperature and Quality of Leucoreduced Whole Blood
In a combat situation the need for safe and high-quality blood products is increasing. WB (Whole Blood) is used in many trauma situations, but we wish to investigate whether there is an even better whole blood product.
- Conditions
- Trauma, Austere Environment, Blood Bank, Buddy Transfusion
- Trial name
- BFF (NCT01892670)
- Testing
- Donation of 1 whole blood unit
- Where
- Norway
- Volunteers
- 87 people, healthy volunteers welcome
- Sponsor
- Haukeland University Hospital
Chronic Kidney Diseases, Heart Attack
Chronic Kidney Disease (CKD) Platelet Study
This study evaluates how aspirin, clopidogrel and ticagrelor work in people with chronic kidney disease (CKD) compared to people with normal kidneys.
- Conditions
- Chronic Kidney Diseases, Heart Attack, Stroke, Ischemic
- Trial name
- NCT03649711
- Testing
- Ticagrelor 90mg, Clopidogrel 75mg, Aspirin 81 mg
- Where
- 2 sites in United States
- Volunteers
- 76 people, healthy volunteers welcome
- Sponsor
- University of Arkansas
Diabetes, Platelet Function
Effects of Pioglitazone on Platelet Function
The purpose of this study is to determine how pioglitazone and aspirin affect platelets in the blood of diabetic and non-diabetic subjects. Platelets are small cells in the blood that help with blood clotting.
- Conditions
- Diabetes, Platelet Function, Healthy
- Trial name
- UHEM08014 (NCT00861341)
- Testing
- Aspirin, Pioglitazone
- Where
- United States
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- University of Rochester
Hypercholesterolemia, Endothelial Dysfunction
Effects of Nutraceutical Therapies on Endothelial Function, Platelet Aggregation, and Coronary Flow Reserve
Hypercholesterolemia is considered one of the most important cardiovascular risk factors. Cardiovascular prevention include a class I indication to statins in addition to non-pharmacologic intervention and prevention strategies…
- Trial name
- NUTRENDO (NCT02969070)
- Testing
- LopiGLIK™ therapy, Armolipid Plus® therapy
- Where
- Italy
- Volunteers
- 28 people, healthy volunteers welcome
- Sponsor
- Federico II University
Infertility, IVF
Will Autologous Platelet Rich Plasma Able To Restore Ovarian Function?
A-PRP (Autologous Platelet Rich Plasma) is becoming widely used in a variety of medical procedures seeking tissue remodeling and/or healing as an intervention.
- Conditions
- Infertility, IVF, Premature Ovarian Failure, Anti-Mullerian Hormone Deficiency
- Trial name
- NCT04381299
- Testing
- autologous platelet rich plasma, saline solution
- Where
- United Arab Emirates
- Volunteers
- 35 people, healthy volunteers welcome
- Sponsor
- ART Fertility Clinics LLC
Smoking
Effect of Electronic Cigarettes on Platelets, Endothelium and Inflammation
The primary purpose of this study is to evaluate the acute effects of electronic cigarette (e-cigarette) smoking on measurable biomarkers of platelet function, vascular endothelial function and inflammation in healthy active…
- Trial name
- NCT02662075
- Testing
- E-cigarette/tobacco Smoking Exposure
- Where
- United States
- Volunteers
- healthy volunteers welcome
- Sponsor
- NYU Langone Health