Clinical trials: Platelet Function Tests
Healthy
Influence of CYP2C19 Genetic Variants on Clopidogrel in Healthy Subjects
To test pharmacodynamic response to clopidogrel 150mg once daily during 7 days in healthy subjects carriers of a mutated allele (*2) associated with CYP2C19 deficiency and non responders to the usual regimen of 75 mg once daily
- Trial name
- NCT00413608
- Testing
- Clopidogrel
- Where
- France
- Volunteers
- 140 people, healthy volunteers welcome
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Platelet Function Test
Effect of Herbal Products on Platelet Function and Clotting
This is a research study on the effect of some commonly used "blood activating" herbal products on platelet function and coagulation profile, ie whether it causes an increase in bleeding tendency, either used alone or in…
- Trial name
- NCT02008981
- Testing
- Curcuma longa, Angelica sinensis, Siwu Tang
- Where
- Singapore
- Volunteers
- 75 people, healthy volunteers welcome
- Sponsor
- Singapore General Hospital
Healthy
In-Vivo Bleeding Volume Test for Platelet-Aspirin Interaction
Purpose of the present research project is to study a new in-vivo test for abnormal platelet function and to study the effect of certain drugs on clinical bleeding.
- Trial name
- Aspirin-BVT (NCT01047722)
- Testing
- Aspirin ingestion followed by doing a Bleeding Volume Test
- Where
- 2 sites in United States
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Klein, Jeffrey A., M.D.
Platelet Aggregation, Spontaneous, Atherosclerosis
Effects of Fish Oil on Platelet Function and Coagulation
Many patients undergoing surgery use naturopathic drugs, including fish oil. Fish oil has been reported to increase bleeding in patients through inhibiting platelet aggregation and prolonging of clot formation time.
- Conditions
- Platelet Aggregation, Spontaneous, Atherosclerosis, Surgery
- Trial name
- FOILP (NCT03048981)
- Testing
- Fish oil
- Where
- Sweden
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- Region Skane
Healthy Subjects
Effects of Recombinant Human Erythropoietin on Platelet Function in Healthy Subjects
The purpose of this study is to see if a naturally-occurring hormone called erythropoietin changes the action of platelets in the blood.
- Trial name
- NCT00368238
- Testing
- Recombinant human erythropoietin alfa (drug), Aspirin (drug), Clopidogrel (drug)
- Where
- United States
- Volunteers
- 96 people, healthy volunteers welcome
- Sponsor
- Yale University
Pharmacodynamics
Clopidogrel And Ticagrelor in Healthy Subjects
To evaluate the pharmacodynamics of a lower Ticagrelor dose in healthy Korean volunteers compared with standard Clopidogrel agent.
- Trial name
- NCT02086903
- Testing
- Ticagrelor 90 mg, Clopidogrel 600 mg
- Where
- South Korea
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- Dong-A University
Healthy
Pharmacodynamic Study of Cilostazol in Healthy Volunteers
The primary objective of this study is to investigate the effects of Cilostazol, Acetylsalycylic acid and Clopidogrel alone as well as combinations of Cilostazol/Acetylsalicylic acid and Cilostazol/ Clopidogrel on ex-vivo…
- Trial name
- CiloMecT (NCT02554721)
- Testing
- Cilostazol, Acetylsalicylic acid, Clopidogrel
- Where
- Germany
- Volunteers
- 77 people, healthy volunteers welcome
- Sponsor
- Otsuka Pharmaceutical Co., Ltd.
Cardiovascular Diseases, Atherosclerosis
Aspirin Dose and Atherosclerosis in Patients With Heart Disease
The purpose of the study is to test higher versus lower doses of aspirin on markers of atherosclerosis in patients who have had a heart attack.
- Conditions
- Cardiovascular Diseases, Atherosclerosis, Myocardial Infarction
- Trial name
- TAD (NCT00272337)
- Testing
- Aspirin
- Where
- 2 sites in United States
- Volunteers
- 37 people, healthy volunteers welcome
- Sponsor
- Florida Atlantic University
Platelet Function and Reactivity Tests
Comparison of Antiplatelet Effects of Sotagliflozin to FDA-approved Antiplatelet Drugs
This study will identify the potential benefits of regulating platelet activation with sotagliflozin compared to other FDA-approved drugs known to limit platelet activation.
- Trial name
- NCT06933056
- Testing
- Sotagliflozin (SOTA) followed by 3 drugs in a random order, Aspirin followed by 3 drugs in a random order, Clopidogrel followed by 3 drugs in a random order
- Where
- United States
- Volunteers
- 21 people, healthy volunteers welcome
- Sponsor
- University of Michigan
Healthy
Impact of a High-fat Meal on Assessment of Clopidogrel-induced Platelet Inhibition in Healthy Subjects
The purpose of this study is to determine whether a high-fat meal affects the ability of platelet function tests to measure platelet inhibition by clopidogrel.
- Trial name
- NCT01307657
- Testing
- high fat meal
- Where
- United States
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- University of Nebraska
Oculocerebrorenal Syndrome
Study of the Pathophysiological Mechanisms Involved in Bleeding Events
Lowe syndrome is associated with mutations in the OCRL1 gene, which encodes OCRL1, a phosphatidylinositol-4, 5-bisphosphate (PtdIns(4, 5)P (2))5-phosphatase.
- Trial name
- LOWE (NCT01314560)
- Testing
- Blood sample
- Where
- France
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Platelet Dysfunction
The Effect of Dapagliflozin on Platelet Function testinG Profiles in Diabetic PatiEnts.
Sodium GLucose Transport 2 inhibitors (SGLT2I), including dapagliflozin, reduce the likelihood of hospitalization for heart failure and death in persons with type 2 diabetes, of which the mechanism has not been fully elucidated.
- Trial name
- EDGE (NCT04400760)
- Testing
- DAPA Tx
- Where
- Trinidad and Tobago
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- The University of The West Indies
Eclampsia Preeclampsia
Magnesium and Platelet Function Testing
Magnesium has built up the reputation of a 'natural calcium antagonist'. However, the exact effect of magnesium on coagulation and more specifically on platelet function is still disputed.
- Trial name
- MgCedVD (NCT03143647)
- Testing
- Collect a study-specific blood sample of healthy subjects
- Where
- Belgium
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Ziekenhuis Oost-Limburg
Healthy
Pharmacodynamics of CGT 2168 Compared With Plavix®
CG106 is a Phase I open-label, randomized, multiple-dose, two-way crossover study to characterize the pharmacodynamics and pharmacokinetics of the investigational fixed-dose combination product CGT 2168 (clopidogrel, 75 mg and…
- Trial name
- NCT00620802
- Testing
- CGT-2168, Plavix
- Where
- United States
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Cogentus Pharmaceuticals