Clinical trials: Platelet Reactivity
Coronary Artery Disease
Tongxinluo Improve High on Clopidogrel Platelet Reactivity Patients With Coronary Heart Disease
Tongxinluo is a kind of Chinese patent drug,which could promote blood circulation.Recent reports suggested that tongxinluo's effectiveness in reducing the thrombin activity.In this prospective randomized study,all patients in…
- Trial name
- Talent (NCT01721590)
- Testing
- Tongxinluo
- Where
- 3 sites in China
- Volunteers
- 134 people
- Sponsor
- Han Yaling
Discrete Coronary Artery Stenosis, Coronary Angiography of Multiple Detectors
Implications of the Presence of Non-obstructive Atherosclerotic Plaques on Platelet and Vascular Reactivity
Approximately 50% of coronary events occur in previously asymptomatic patients. Thus, the early detection of the individuals at higher risk became an important research target within the current cardiology.
- Conditions
- Discrete Coronary Artery Stenosis, Coronary Angiography of Multiple Detectors, Platelet Aggregation, Spontaneous, Cardiovascular Risk Factor
- Trial name
- NCT03632785
- Where
- Brazil
- Volunteers
- 90 people
- Sponsor
- University of Sao Paulo
Platelet Reactivity
Low-dose of Ticagrelor and Standard-dose Clopidogrel on Platelet Effects in Chinese Patients With Stable CAD.
Ticagrelor has been demonstrated to provide a more rapid and more powerful inhibition of platelet aggregation compared with clopidogrel in coronary artery disease (CAD) patients.
- Trial name
- NCT03679091
- Testing
- low-dose ticagrelor, Clopidogrel
- Where
- China
- Volunteers
- 36 people, healthy volunteers welcome
- Sponsor
- First Affiliated Hospital of Harbin Medical University
Coronary Artery Disease (CAD)
Prasugrel Versus High Dose Clopidogrel in Patients With Stable Coronary Artery Disease and High Platelet Reactivity While on Chronic Clopidogrel Treatment
Clopidogrel administration is considered standard of care in patients with stable coronary artery disease post PCI. However , a significant proportion of patients is considered clopidogrel resistant and this is shown to be…
- Trial name
- NCT01304472
- Testing
- Prasugrel, Clopidogrel
- Where
- 2 sites in Greece
- Volunteers
- 25 people
- Sponsor
- University of Patras
Hypercholesterolemia
Investigation of the Effect of Dietary Nitrate Treatment on Endothelial Function and Platelet Reactivity in Hypercholesterolemics.
Diets rich in fruit and vegetables reduce the risk of strokes and heart attacks, however the exact cause of this beneficial effect is uncertain.
- Trial name
- NCT01493752
- Testing
- beetroot juice
- Where
- United Kingdom
- Volunteers
- 69 people
- Sponsor
- Queen Mary University of London
Acute Myocardial Infarction
REsistance to Aspirin and Clopidogrel in acuTe Myocardial Infarction
The purpose of this study is to compare 3 point-of-care methods for monitoring antiplatelet therapy to golden standard (Light transmittance aggregometry-LTA) in high risk population of acute myocardial infarction patients.
- Trial name
- REACT-MI (NCT01381185)
- Testing
- Aspirin 200mg qd, Clopidogrel 2x75mg qd
- Where
- 2 sites in Czechia
- Volunteers
- 154 people
- Sponsor
- University Hospital Ostrava
Primary Total Hip and Knee Arthroplasty
Pilot Study Evaluating Alterations in Thrombogenicity and Platelet Reactivity Following Lower Extremity Arthroplasty
This is a prospective, randomized study from pre-surgery to 6 weeks post-surgery designed to detect changes in coagulability following elective total knee and hip arthroplasty.
- Trial name
- NCT01809054
- Testing
- Arixtra, Pneumatic compression stockings, Aspirin
- Where
- 2 sites in United States
- Volunteers
- 54 people
- Sponsor
- LifeBridge Health
Severe Aortic Valve Stenosis, Transcatheter Aortic Valve Implantation
Platelet Reactivity After TAVI: A Multicenter Pilot Study
A high platelet reactivity in patients with severe symptomatic Aortic Stenosis (AS) selected for TAVI (Transcatheter aortic valve implantation) procedure has been demonstrated previously, and the use of double antiaggregation…
- Conditions
- Severe Aortic Valve Stenosis, Transcatheter Aortic Valve Implantation, Transcatheter Aortic Valve Replacement
- Trial name
- REAC-TAVI (NCT02224066)
- Testing
- Ticagrelor 90 mg twice per day during three months following TAVI, Aspirin 100 mg plus Clopidogrel 75 mg daily during three months following TAVI
- Where
- 7 sites in Spain
- Volunteers
- 65 people
- Sponsor
- Hospital de Meixoeiro
Aspirin, Circadian Rhythm
Aspirin AM or PM: Effect on Circadian Rhythm of Platelet Reactivity
Low-dose aspirin is a cornerstone in the secondary prevention of cardiovascular disease (CVD) and is usually taken on awakening, although evidence regarding optimal time of intake is lacking.
- Conditions
- Aspirin, Circadian Rhythm, Platelet Activation, Cardiovascular Diseases
- Trial name
- NCT01900639
- Testing
- change time of intake of aspirin
- Where
- Netherlands
- Volunteers
- 14 people, healthy volunteers welcome
- Sponsor
- Leiden University Medical Center
Acute Coronary Syndrome, Coronary Angioplasty
Customized Choice of Oral P2Y12 Receptor Blocker
A subset of patients recruited in the main MATRIX study will be randomized after intervention but before discharge to standard of care (the treating physician will decide which oral P2Y12 inhibitor will be added on top of…
- Trial name
- PRU-MATRIX (NCT01477775)
- Testing
- Oral P2Y12 receptor blocker, Customized choice for the oral P2Y12 receptor blocker
- Where
- 11 sites in Italy
- Volunteers
- 4,000 people
- Sponsor
- Italian Society of Invasive Cardiology
Peripheral Artery Disease
Post-operative Treatment of Diabetic Peripheral Arterial Disease Guided by Platelet Reactivity Unit
To compare the effect of PRU(platelet (P2Y12) reaction units)-guided treatment on the change in 1. time of initial leg pain and time of termination of exercise test by pain, evaluated on the graded stationary bicycle test, 2.
- Trial name
- NCT02762864
- Testing
- platelet (P2Y12) reaction units, ticagrelor, Comparator
- Volunteers
- 200 people
- Sponsor
- Chang Gung Memorial Hospital
Platelet Aggregation, Acute Myocardial Infarction
Effect of Exercise on Platelet Reactivity After Myocardial Infarction
This project aims to evaluate, in recent post-acute myocardial infarction (AMI) patients on dual antiplatelet therapy, the impact of regular exercise training on platelet aggregability and the correlation between the level of…
- Conditions
- Platelet Aggregation, Acute Myocardial Infarction, Exercise Training
- Trial name
- NCT02958657
- Testing
- Exercise Training
- Where
- Brazil
- Volunteers
- 90 people
- Sponsor
- University of Sao Paulo General Hospital
Coronary Disease
Platelet Reactivity After Cessation of Clopid in the Setting of Coronary Stent Implantation I: PRACTICE I
Single center randomized parallel group study to determine if: 1. there is a temporary increase in platelet reactivity after abrupt discontinuation of clopidogrel due to a potential rebound phenomenon. 2.
- Trial name
- PRACTICE I (NCT00684359)
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- Medstar Health Research Institute
Atrial Fibrillation
Platelet-activation and Optimal Inhibition in Patients With Atrial Fibrillation Undergoing Left Atrial Appendage Occlusion
The POPULAR-LAAO registry is an open-label observational prospective registry to investigate hemostatic processes following left atrial appendage occlusion.
- Trial name
- POPULAR-LAAO (NCT04705688)
- Where
- Netherlands
- Volunteers
- 120 people
- Sponsor
- R&D Cardiologie
HIV
Tenofovir Abacavir Platelet Activation Study
Some but not all observational studies have found that current exposure to abacavir is associated with increased risk of cardiovascular events such as myocardial infarction, stroke and cardiovascular death.
- Trial name
- TAPAS (NCT02093585)
- Testing
- abacavir (600 mg QD), tenofovir (245 mg QD)
- Where
- Denmark
- Volunteers
- 43 people
- Sponsor
- Jan Gerstoft
Coronary Artery Disease
Clinical Significance of Platelet Reactivity on Clopidogrel During Off-pump Coronary Artery Bypass
Objective: To evaluate the early and late prognoses of patients according to platelet reactivity after clopidogrel administration and determine whether the measurement of platelet inhibition predicted 1-year clinical outcomes…
- Trial name
- NCT01959191
- Testing
- Dual antiplatelet therapy including aspirin and clopidogrel after off-pump coronary bypass surgery
- Where
- South Korea
- Volunteers
- 859 people
- Sponsor
- Yonsei University
Critical Limb Ischemia
Aspirin and Clopidogrel Reactivity in Patients With Critical Limb Ischemia (CLI)
Critical Limb Ischemia (CLI) is defined as limb pain that occurs at rest, or impending limb loss that is caused by severe compromise of blood flow to the affected extremity.
- Trial name
- NCT02094755
- Testing
- Blood draw only
- Where
- United States
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- University of Southern California
Coronary Artery Disease, Chronic Obstructive Pulmonary Disease
ComparisoN of ticAgrelor vs. Clopidogrel in endoTHeliAl Function of COPD patieNts
This is an investigator-initiated, prospective, single-centre, randomised, phase II, open-label study, testing the superiority of ticagrelor, as compared to clopidogrel, in modulating on-P2Y12 treatment platelet reactivity…
- Trial name
- NATHAN-NEVER (NCT02519608)
- Testing
- Aspirin 100 mg, Ticagrelor, Clopidogrel
- Where
- Italy
- Volunteers
- 44 people
- Sponsor
- University Hospital of Ferrara
Coronary Artery Disease
OPTImal Management of Antithrombotic Agents: OPTIMA-2 Trial
High on-treatment platelet reactivity (HOPR) is associated with increased risk of cardiovascular events in patients undergoing percutaneous coronary intervention (PCI).
- Trial name
- OPTIMA-2 (NCT01955200)
- Testing
- Clopidogrel, Cilostazol, Ticagrelor
- Where
- China
- Volunteers
- 1,724 people
- Sponsor
- The First Affiliated Hospital with Nanjing Medical University
Acute Coronary Syndrome (ACS), High On-treatment Platelet Reactivity (HTPR)
The Effect of IV Cangrelor and Oral Ticagrelor Study
Major heart attacks are caused by a number of factors, the two major of which are furring up of a coronary artery with atheroma and then sudden clot formation on this area leading to a blockage and interruption of blood flow.
- Conditions
- Acute Coronary Syndrome (ACS), High On-treatment Platelet Reactivity (HTPR), Microvascular Obstruction (MVO), ST-segment Elevation Myocardial Infarction (STEMI)
- Trial name
- NCT02733341
- Testing
- Cangrelor, Ticagrelor
- Where
- United Kingdom
- Volunteers
- 100 people
- Sponsor
- The Royal Wolverhampton Hospitals NHS Trust