Clinical trials: Platelet Rich Fibrin
TEETH EXTRACTION
Titanium-Prepared Platelet-Rich Fibrin for Extraction Socket Healing
Alveolar ridge preservation after tooth extraction is important for maintaining bone volume and facilitating future implant placement.
- Trial name
- TPRF-SOCKET (NCT07712497)
- Testing
- Titanium-Prepared Platelet-Rich Fibrin (T-PRF)
- Where
- Turkey (Türkiye)
- Volunteers
- 30 people
- Sponsor
- Eskisehir Osmangazi University
Necrotic Pulp, Regenerative Endodontic Procedures
Periapical Bleeding Versus PRF Techniques in Regenerative Endodontic Therapy: A Randomized Controlled Trial
This study investigates a biological approach that allows infected and necrotic teeth to heal themselves instead of being treated with traditional root canal therapy.
- Conditions
- Necrotic Pulp, Regenerative Endodontic Procedures, Mature Teeth, Apical Periodontitis
- Trial name
- NCT06886438
- Testing
- RVS, L-PRF, i-PRF
- Where
- Turkey (Türkiye)
- Volunteers
- 48 people
- Sponsor
- Saglik Bilimleri Universitesi
Periodontal Diseases
Treatment of Periodontal Intrabony Defects With A-PRF+ or EMD
The aim of this randomized clinical trial was to clinically evaluate and compare the healing of intrabony defects after treatment with advanced platelet-rich fibrin (A-PRF+) to enamel matrix derivatives (EMD) in periodontitis…
- Trial name
- NCT04404374
- Testing
- A-PRF/EMD
- Where
- Hungary
- Volunteers
- 30 people
- Sponsor
- Semmelweis University
Low Back Pain
Comparison Between Platelet-rich Fibrin and Steroid for Intra-articular Injection for Sacroiliac Joint Dysfunction
Low back pain is one of the commonest complaints nowadays affecting nearly 20% of the population, Sacroiliac joint has been accused of being the primary cause of pain in about 10%: 27% of this population.
- Trial name
- NCT04757740
- Testing
- intra-articular Platelet rich fibrin and lidocaine, methylprednisolone acetate and lidocaine
- Where
- Egypt
- Volunteers
- 94 people
- Sponsor
- Fayoum University Hospital
Venous Leg Ulcers
A Prospective, Randomized Clinical Trial of PRP Concepts Fibrin Bio-Matrix in Chronic Non-Healing Venous Leg Ulcers
To assess the efficacy of the PRP Concepts Fibrin Bio-Matrix and compare its performance with usual and customary practice for the treatment of chronic non-healing venous leg ulcers (VLU).
- Trial name
- NCT02312518
- Testing
- PRP Concepts Fibrin Bio-Matrix, Usual and Customary Practice
- Where
- United States
- Volunteers
- 200 people
- Sponsor
- PRP Concepts, LLC
Chronic Suppurative Otitis Media
Platelet Rich Fibrin Augmented Tympanoplasty Versus Cartilage Tympanoplasty
This study was performed to compare healing and hearing outcomes of two tympanoplasty techniques, performed for patients with total or subtotal tympanic membrane perforations.
- Trial name
- NCT05967845
- Testing
- cartilage tympanoplasty, platelet rich fibrin augmented tympanoplasty
- Where
- Egypt
- Volunteers
- 156 people
- Sponsor
- Mansoura University
Platelet-Rich Fibrin
Titanium-prepared Platelet-rich Fibrin in Periodontal Regeneration
In this study, the possible effect of blood group distribution on the content of blood biomaterial was investigated. 64 volunteers were included in the study. Various parameters were evaluated.
- Trial name
- NCT05409495
- Testing
- periodontal surgical procedure (open flap debridement), periodontal surgical procedure (OFD +autogenous Titanium-prepared platelet-rich fibrin (OFD+ T-PRF))
- Where
- Turkey (Türkiye)
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Ataturk University
Free Gingival Graft
Palatal Wound Healing Evaluation After Application of Platelet Rich Fibrin Versus 0.2% Hyaluronic Acid Dressings
Free gingival graft (FGG) was first proposed by Bjorn 1963 and Nabers 1966. FGG is indicated to correct mucogingival problems such as inadequate or lack of attached gingiva and gingival recession.
- Trial name
- NCT04390100
- Testing
- hyaluronic acid (Gengiegel 0.2% oral gel ), Platelet rich fibrin, Gel foam
- Where
- Egypt
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Ain Shams University
Periodontal Disease, Periodontitis
Evaluation of the Influence of PRF (Platelet-rich Fibrin) on the Clinical Parameters and the Concentration of Selected Inflammation Mediators in GCF (Gingival Crevice Fluid) of Patients With Periodontitis
Assessment of the influence of injectable platelet-rich fibrin (i-PRF) on the clinical parameters and the inflammation mediators levels in the gingival crevicular fluid (GCF) in patients with periodontitis.
- Trial name
- PRFperio (NCT06920849)
- Testing
- SRP+iPRF, SRP
- Where
- Poland
- Volunteers
- 40 people
- Sponsor
- Medical University of Bialystok
Tooth Extraction
IMMEDIATE IMPLANT With Different Types of Membrane
Forty patients will be selected from the outpatient's clinic of Oral and Maxillofacial Surgery Department, Faculty of Dentistry, Mansoura University for replacement of non-restorable tooth in posterior mandibular area with…
- Trial name
- NCT07396350
- Testing
- immediate implant with dentin-derived barrier membrane, immediate implant with eprf membrane
- Where
- Egypt
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Mansoura University
Gingival Recession
CGF and PRF in the Gingival Recessions Treatment
This study hypothesized that CGFs' placement together with CAF may enhance the healing of soft tissues better than use of PRF together with CAF.
- Trial name
- NCT04261634
- Testing
- Concentrated Growth Factor Membrane, Platelet Rich Fibrin
- Volunteers
- 18 people, healthy volunteers welcome
- Sponsor
- Bulent Ecevit University
Autogenous Tooth Bone Graft, Immediate Implant Placement
Effect of "Autogenous Leukocyte Platelet Rich Fibrin- Tooth Graft" Combination Around Immediately Placed Implants
Immediate implant placement into fresh extraction sockets is gaining popularity because of fewer clinical procedures and maintenance of bone architecture compared to conventional methods, thus reducing the treatment time and…
- Conditions
- Autogenous Tooth Bone Graft, Immediate Implant Placement, L-PRF
- Trial name
- NCT04795102
- Testing
- immediate implant placement with ATBG and L-PRF, immediate implant placement with ATBG
- Where
- Egypt
- Volunteers
- 26 people, healthy volunteers welcome
- Sponsor
- Dalia Rasheed Issa
Low-output External Gastrointestinal Fistula
Glue Application in the Treatment of Low-Output Fistulas
Adjuvant use of fibrin glue (FG) in the fistula tract has been shown to promote closure of low-output enterocutaneous fistulas (ECFs).
- Trial name
- FG-treatment (NCT01828892)
- Testing
- Endoscopy exploration and glue application, Endoscopy exploration, Antibiotics (ceftazidime, cefotaxime, or meropenem, with or without vancomycin)
- Where
- China
- Volunteers
- 30 people
- Sponsor
- Jinling Hospital, China
Thin Gingival Phenotype
Injectable Platelet-Rich Fibrin Versus Hyaluronic Acid for Thin Gingival Phenotype
Thin gingival phenotype may increase susceptibility to soft-tissue complications in the presence of local anatomical or mechanical risk factors.
- Trial name
- NCT07879534
- Testing
- Injectable Platelet Rich Fibrin, Hyaluronic Acid
- Where
- Cameroon
- Volunteers
- 11 people
- Sponsor
- University of Yaounde 1
Furcation Defects
PRF+1% MF for Class II Mandibular Furcation Defects
The aim of the present trial is to evaluate the efficacy of PRF with 1% MF in treatment of mandibular class II furcation defects and its comparison to PRF and access therapy alone.
- Trial name
- NCT03207698
- Testing
- Open flap debridement (OFD), OFD with Platelet rich fibrin (PRF), OFD with Platelet rich fibrin (PRF)+1% Metformin (Drug) in gel form
- Where
- India
- Volunteers
- 75 people, healthy volunteers welcome
- Sponsor
- Government Dental College and Research Institute, Bangalore
Impact Molar, Mandible Cyst
Bone Defects Reconstruction After Dentigerous Cyst Enucleation With Autogenous Demineralized Dentin Matrix- ADDM and Advanced Platelet-Rich Fibrin- A-PRF.
This prospective clinical study evaluates bone healing following dentigerous cyst enucleation associated with impacted mandibular third molar extraction.
- Conditions
- Impact Molar, Mandible Cyst, Bone Regeneration, Platelet Rich Fibrin
- Trial name
- Cystregen (NCT07652216)
- Testing
- Impacted third molar extraction, Advanced Platelet-Rich Fibrin (A-PRF), Mandibular dentigerous cyst enucleation
- Where
- Poland
- Volunteers
- 35 people
- Sponsor
- Jagiellonian University
Alopecia
Enhancing Hair Density With Platelet Rich Fibrin Matrix (PRFM)
Clinical alopecia occurs due to miniaturization of the hair shafts as well as loss of active production of hair shafts. PRFM has been shown to induce dermal angiogenesis, and anecdotal findings of improvement of hair appearance…
- Trial name
- NCT01590238
- Testing
- PRFM treatment
- Where
- United States
- Volunteers
- 15 people, healthy volunteers welcome
- Sponsor
- The New York Eye & Ear Infirmary
Medication Related Osteonecrosis of the Jaw
Best Treatment Choice for Osteonecrosis of the Jaw
BETCON is a pragmatic randomized controlled open-label multi-center study in patients with newly diagnosed stage I-II MRONJ designed to answer the question whether minimally invasive management with LPRF membranes or primary…
- Trial name
- BETCON (NCT04512638)
- Testing
- Antibiotics, Chlorhexidine mouthwash, Minimally invasive surgery with LPRF
- Where
- 4 sites in Belgium
- Volunteers
- 125 people
- Sponsor
- Tim Van den Wyngaert
Socket Preservation
Clinical and Radiographic Evaluation of Advanced Platelet Rich Fibrin in the Preservation of Alveolar Ridge Following Atraumatic Tooth Extraction
compare the effect of application of A-PRF in socket preservation after atraumatic tooth extraction and natural healing regarding to bone remodeling .
- Trial name
- NCT04197895
- Testing
- Socket preservation with APRF, natural healing
- Volunteers
- 36 people, healthy volunteers welcome
- Sponsor
- Nahed Gamal Saleh Abdelaal
Tooth Extraction, Dental Implants
Platelet Rich Fibrin and Concentrated Growth Factors on Osseointegration of Immediate Implants
This study will involve 14 patients with mandibular premolars indicated for extraction and immediate replacement. The patients will be randomly allocated into two groups and each patient will receive one implant.
- Trial name
- NCT05101954
- Testing
- Concentrated Growth Factors (CGF), Platelet-Rich Fibrin (PRF)
- Where
- Egypt
- Volunteers
- 14 people
- Sponsor
- Hams Hamed Abdelrahman